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Items: 1 to 50 of 406

1.

Eosinophil progenitor levels correlate with tissue pathology in pediatric eosinophilic esophagitis.

Schwartz JT, Morris DW, Collins MH, Rothenberg ME, Fulkerson PC.

J Allergy Clin Immunol. 2018 Nov 8. pii: S0091-6749(18)31576-8. doi: 10.1016/j.jaci.2018.10.036. [Epub ahead of print]

PMID:
30414854
2.

RPC4046, a Monoclonal Antibody Against IL13, Reduces Histologic and Endoscopic Activity in Patients With Eosinophilic Esophagitis.

Hirano I, Collins MH, Assouline-Dayan Y, Evans L, Gupta S, Schoepfer AM, Straumann A, Safroneeva E, Grimm M, Smith H, Tompkins CA, Woo A, Peach R, Frohna P, Gujrathi S, Penenberg DN, Li C, Opiteck GJ, Olson A, Aranda R, Rothenberg ME, Dellon ES; HEROES Study Group.

Gastroenterology. 2018 Nov 2. pii: S0016-5085(18)35208-9. doi: 10.1053/j.gastro.2018.10.051. [Epub ahead of print] No abstract available.

PMID:
30395812
3.

Esophageal Organoids from Human Pluripotent Stem Cells Delineate Sox2 Functions during Esophageal Specification.

Trisno SL, Philo KED, McCracken KW, Catá EM, Ruiz-Torres S, Rankin SA, Han L, Nasr T, Chaturvedi P, Rothenberg ME, Mandegar MA, Wells SI, Zorn AM, Wells JM.

Cell Stem Cell. 2018 Oct 4;23(4):501-515.e7. doi: 10.1016/j.stem.2018.08.008. Epub 2018 Sep 20.

PMID:
30244869
4.

Tefillin Use Induces Remote Ischemic Preconditioning Pathways in Healthy Males.

Owens AP, Robbins N, Saum K, Jones SM, Kirschner AW, Woo DJG, McCoy C, Slone S, Rothenberg ME, Urbina EM, Tranter M, Rubinstein J.

Am J Physiol Heart Circ Physiol. 2018 Sep 14. doi: 10.1152/ajpheart.00347.2018. [Epub ahead of print]

PMID:
30216115
5.

MicroRNA-21 Ablation Exacerbates Aldosterone-Mediated Cardiac Injury, Remodeling and Dysfunction.

Syed M, Ball JP, Mathis KW, Hall ME, Ryan MJ, Rothenberg ME, Yanes Cardozo LL, Romero DG.

Am J Physiol Endocrinol Metab. 2018 Aug 28. doi: 10.1152/ajpendo.00155.2018. [Epub ahead of print]

PMID:
30153065
6.

Chromatin regulates IL-33 release and extracellular cytokine activity.

Travers J, Rochman M, Miracle CE, Habel JE, Brusilovsky M, Caldwell JM, Rymer JK, Rothenberg ME.

Nat Commun. 2018 Aug 14;9(1):3244. doi: 10.1038/s41467-018-05485-x.

7.

Phenotypic Characterization of Eosinophilic Esophagitis in a Large Multicenter Patient Population from the Consortium for Food Allergy Research.

Chehade M, Jones SM, Pesek RD, Burks AW, Vickery BP, Wood RA, Leung DYM, Furuta GT, Fleischer DM, Henning AK, Dawson P, Lindblad RW, Sicherer SH, Abonia JP, Sherrill JD, Sampson HA, Rothenberg ME.

J Allergy Clin Immunol Pract. 2018 Sep - Oct;6(5):1534-1544.e5. doi: 10.1016/j.jaip.2018.05.038. Epub 2018 Aug 1.

PMID:
30075341
8.

Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference.

Dellon ES, Liacouras CA, Molina-Infante J, Furuta GT, Spergel JM, Zevit N, Spechler SJ, Attwood SE, Straumann A, Aceves SS, Alexander JA, Atkins D, Arva NC, Blanchard C, Bonis PA, Book WM, Capocelli KE, Chehade M, Cheng E, Collins MH, Davis CM, Dias JA, Di Lorenzo C, Dohil R, Dupont C, Falk GW, Ferreira CT, Fox A, Gonsalves NP, Gupta SK, Katzka DA, Kinoshita Y, Menard-Katcher C, Kodroff E, Metz DC, Miehlke S, Muir AB, Mukkada VA, Murch S, Nurko S, Ohtsuka Y, Orel R, Papadopoulou A, Peterson KA, Philpott H, Putnam PE, Richter JE, Rosen R, Rothenberg ME, Schoepfer A, Scott MM, Shah N, Sheikh J, Souza RF, Strobel MJ, Talley NJ, Vaezi MF, Vandenplas Y, Vieira MC, Walker MM, Wechsler JB, Wershil BK, Wen T, Yang GY, Hirano I, Bredenoord AJ.

Gastroenterology. 2018 Oct;155(4):1022-1033.e10. doi: 10.1053/j.gastro.2018.07.009. Epub 2018 Sep 6. Review.

PMID:
30009819
9.

Epithelial origin of eosinophilic esophagitis.

Rochman M, Azouz NP, Rothenberg ME.

J Allergy Clin Immunol. 2018 Jul;142(1):10-23. doi: 10.1016/j.jaci.2018.05.008. Review.

PMID:
29980278
10.

Randomized Phase I Healthy Volunteer Study of UTTR1147A (IL-22Fc): A Potential Therapy for Epithelial Injury.

Rothenberg ME, Wang Y, Lekkerkerker A, Danilenko DM, Maciuca R, Erickson R, Herman A, Stefanich E, Lu TT.

Clin Pharmacol Ther. 2018 Jun 28. doi: 10.1002/cpt.1164. [Epub ahead of print]

PMID:
29952004
11.

Genetic variants at the 16p13 locus confer risk for eosinophilic esophagitis.

Kottyan LC, Maddox A, Braxton JR, Stucke EM, Mukkada V, Putnam PE, Abonia JP, Chehade M, Wood RA, Pesek RD, Vickery BP, Furuta GT, Dawson P, Sampson HA, Martin LJ, Kelly JA, Kimberly RP, Sivils K, Gaffney PM, Kaufman K, Harley JB, Rothenberg ME.

Genes Immun. 2018 Jun 8. doi: 10.1038/s41435-018-0034-z. [Epub ahead of print]

PMID:
29904099
12.

The antiprotease SPINK7 serves as an inhibitory checkpoint for esophageal epithelial inflammatory responses.

Azouz NP, Ynga-Durand MA, Caldwell JM, Jain A, Rochman M, Fischesser DM, Ray LM, Bedard MC, Mingler MK, Forney C, Eilerman M, Kuhl JT, He H, Biagini Myers JM, Mukkada VA, Putnam PE, Khurana Hershey GK, Kottyan LC, Wen T, Martin LJ, Rothenberg ME.

Sci Transl Med. 2018 Jun 6;10(444). pii: eaap9736. doi: 10.1126/scitranslmed.aap9736.

PMID:
29875205
13.

Alignment of parent- and child-reported outcomes and histology in eosinophilic esophagitis across multiple CEGIR sites.

Aceves SS, King E, Collins MH, Yang GY, Capocelli KE, Abonia JP, Atkins D, Bonis PA, Carpenter CL, Dellon ES, Eby MD, Falk GW, Gonsalves N, Gupta SK, Hirano I, Kocher K, Krischer JP, Leung J, Lipscomb J, Menard-Katcher P, Mukkada VA, Pan Z, Spergel JM, Sun Q, Wershil BK, Rothenberg ME, Furuta GT; Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR).

J Allergy Clin Immunol. 2018 Jul;142(1):130-138.e1. doi: 10.1016/j.jaci.2018.05.014. Epub 2018 May 29.

PMID:
29852258
14.

New developments in patients with eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERS Symposium at the 2018 American Academy of Allergy, Asthma & Immunology Meeting.

Spergel JM, Aceves SS, Kliewer K, Gonsalves N, Chehade M, Wechsler JB, Groetch M, Friedlander J, Dellon ES, Book W, Hirano I, Muir AB, Cianferoni A, Spencer L, Liacouras CA, Cheng E, Kottyan L, Wen T, Platts-Mills T, Rothenberg ME.

J Allergy Clin Immunol. 2018 Jul;142(1):48-53. doi: 10.1016/j.jaci.2018.05.005. Epub 2018 May 24.

PMID:
29803797
15.

Esophageal IgG4 levels correlate with histopathologic and transcriptomic features in eosinophilic esophagitis.

Rosenberg CE, Mingler MK, Caldwell JM, Collins MH, Fulkerson PC, Morris DW, Mukkada VA, Putnam PE, Shoda T, Wen T, Rothenberg ME.

Allergy. 2018 Sep;73(9):1892-1901. doi: 10.1111/all.13486. Epub 2018 Jun 17.

PMID:
29790577
16.

Eosinophil Development, Disease Involvement, and Therapeutic Suppression.

Fulkerson PC, Rothenberg ME.

Adv Immunol. 2018;138:1-34. doi: 10.1016/bs.ai.2018.03.001. Epub 2018 Apr 22.

PMID:
29731004
17.

Eosinophilic oesophagitis endotype classification by molecular, clinical, and histopathological analyses: a cross-sectional study.

Shoda T, Wen T, Aceves SS, Abonia JP, Atkins D, Bonis PA, Caldwell JM, Capocelli KE, Carpenter CL, Collins MH, Dellon ES, Eby MD, Gonsalves N, Gupta SK, Falk GW, Hirano I, Menard-Katcher P, Kuhl JT, Krischer JP, Leung J, Mukkada VA, Spergel JM, Trimarchi MP, Yang GY, Zimmermann N, Furuta GT, Rothenberg ME; Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR).

Lancet Gastroenterol Hepatol. 2018 Jul;3(7):477-488. doi: 10.1016/S2468-1253(18)30096-7. Epub 2018 May 3.

PMID:
29730081
18.

Solute carrier family 9, subfamily A, member 3 (SLC9A3)/sodium-hydrogen exchanger member 3 (NHE3) dysregulation and dilated intercellular spaces in patients with eosinophilic esophagitis.

Zeng C, Vanoni S, Wu D, Caldwell JM, Wheeler JC, Arora K, Noah TK, Waggoner L, Besse JA, Yamani AN, Uddin J, Rochman M, Wen T, Chehade M, Collins MH, Mukkada VA, Putnam PE, Naren AP, Rothenberg ME, Hogan SP.

J Allergy Clin Immunol. 2018 May 4. pii: S0091-6749(18)30633-X. doi: 10.1016/j.jaci.2018.03.017. [Epub ahead of print]

PMID:
29729938
19.

Revisiting the NIH Taskforce on the Research needs of Eosinophil-Associated Diseases (RE-TREAD).

Khoury P, Akuthota P, Ackerman SJ, Arron JR, Bochner BS, Collins MH, Kahn JE, Fulkerson PC, Gleich GJ, Gopal-Srivastava R, Jacobsen EA, Leiferman KM, Francesca LS, Mathur SK, Minnicozzi M, Prussin C, Rothenberg ME, Roufosse F, Sable K, Simon D, Simon HU, Spencer LA, Steinfeld J, Wardlaw AJ, Wechsler ME, Weller PF, Klion AD.

J Leukoc Biol. 2018 Jul;104(1):69-83. doi: 10.1002/JLB.5MR0118-028R. Epub 2018 Apr 19. Review.

PMID:
29672914
20.

Whole-exome sequencing uncovers oxidoreductases DHTKD1 and OGDHL as linkers between mitochondrial dysfunction and eosinophilic esophagitis.

Sherrill JD, Kc K, Wang X, Wen T, Chamberlin A, Stucke EM, Collins MH, Abonia JP, Peng Y, Wu Q, Putnam PE, Dexheimer PJ, Aronow BJ, Kottyan LC, Kaufman KM, Harley JB, Huang T, Rothenberg ME.

JCI Insight. 2018 Apr 19;3(8). pii: 99922. doi: 10.1172/jci.insight.99922. [Epub ahead of print]

21.

Individuals affected by eosinophilic gastrointestinal disorders have complex unmet needs and frequently experience unique barriers to care.

Hiremath G, Kodroff E, Strobel MJ, Scott M, Book W, Reidy C, Kyle S, Mack D, Sable K, Abonia P, Spergel J, Gupta SK, Furuta TG, Rothenberg ME, Dellon ES.

Clin Res Hepatol Gastroenterol. 2018 Oct;42(5):483-493. doi: 10.1016/j.clinre.2018.03.003. Epub 2018 Mar 31.

PMID:
29615329
22.

DP1 receptor signaling prevents the onset of intrinsic apoptosis in eosinophils and functions as a transcriptional modulator.

Peinhaupt M, Roula D, Theiler A, Sedej M, Schicho R, Marsche G, Sturm EM, Sabroe I, Rothenberg ME, Heinemann A.

J Leukoc Biol. 2018 Jul;104(1):159-171. doi: 10.1002/JLB.3MA1017-404R. Epub 2018 Apr 1.

23.

Eosinophil depletion suppresses radiation-induced small intestinal fibrosis.

Takemura N, Kurashima Y, Mori Y, Okada K, Ogino T, Osawa H, Matsuno H, Aayam L, Kaneto S, Park EJ, Sato S, Matsunaga K, Tamura Y, Ouchi Y, Kumagai Y, Kobayashi D, Suzuki Y, Yoshioka Y, Nishimura J, Mori M, Ishii KJ, Rothenberg ME, Kiyono H, Akira S, Uematsu S.

Sci Transl Med. 2018 Feb 21;10(429). pii: eaan0333. doi: 10.1126/scitranslmed.aan0333.

PMID:
29467297
24.

News Beyond Our Pages.

Rothenberg ME, Bousquet J.

J Allergy Clin Immunol. 2018 Feb;141(2):520-521. doi: 10.1016/j.jaci.2017.12.977. No abstract available.

PMID:
29413257
25.

Creating a multi-center rare disease consortium - the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR).

Cheng K, Gupta SK, Kantor S, Kuhl JT, Aceves SS, Bonis PA, Capocelli KE, Carpenter C, Chehade M, Collins MH, Dellon ES, Falk GW, Gopal-Srivastava R, Gonsalves N, Hirano I, King EC, Leung J, Krischer JP, Mukkada VA, Schoepfer A, Spergel JM, Straumann A, Yang GY, Furuta GT, Rothenberg ME.

Transl Sci Rare Dis. 2017 Dec 18;2(3-4):141-155. doi: 10.3233/TRD-170016.

26.

IL-33 is induced in undifferentiated, non-dividing esophageal epithelial cells in eosinophilic esophagitis.

Travers J, Rochman M, Caldwell JM, Besse JA, Miracle CE, Rothenberg ME.

Sci Rep. 2017 Dec 14;7(1):17563. doi: 10.1038/s41598-017-17541-5.

27.

Eosinophilic esophagitis (EoE) genetic susceptibility is mediated by synergistic interactions between EoE-specific and general atopic disease loci.

Martin LJ, He H, Collins MH, Abonia JP, Biagini Myers JM, Eby M, Johansson H, Kottyan LC, Khurana Hershey GK, Rothenberg ME.

J Allergy Clin Immunol. 2018 May;141(5):1690-1698. doi: 10.1016/j.jaci.2017.09.046. Epub 2017 Nov 10.

PMID:
29129581
28.

MicroRNA.

Lu TX, Rothenberg ME.

J Allergy Clin Immunol. 2018 Apr;141(4):1202-1207. doi: 10.1016/j.jaci.2017.08.034. Epub 2017 Oct 23.

PMID:
29074454
29.

Disease-Related Predictors of Health-Related Quality of Life in Youth With Eosinophilic Esophagitis.

Lynch MK, Barnes MJ, Dimmitt RA, Martin L, Rothenberg ME, Goodin BR.

J Pediatr Psychol. 2018 May 1;43(4):464-471. doi: 10.1093/jpepsy/jsx128.

PMID:
29048518
30.

Synaptopodin is upregulated by IL-13 in eosinophilic esophagitis and regulates esophageal epithelial cell motility and barrier integrity.

Rochman M, Travers J, Abonia JP, Caldwell JM, Rothenberg ME.

JCI Insight. 2017 Oct 19;2(20). pii: 96789. doi: 10.1172/jci.insight.96789. [Epub ahead of print]

31.

Advances in mechanisms of allergic disease in 2016.

Rothenberg ME, Saito H, Peebles RS Jr.

J Allergy Clin Immunol. 2017 Dec;140(6):1622-1631. doi: 10.1016/j.jaci.2017.08.029. Epub 2017 Oct 13. Review.

PMID:
29038009
32.

Early-life environmental exposures interact with genetic susceptibility variants in pediatric patients with eosinophilic esophagitis.

Jensen ET, Kuhl JT, Martin LJ, Langefeld CD, Dellon ES, Rothenberg ME.

J Allergy Clin Immunol. 2018 Feb;141(2):632-637.e5. doi: 10.1016/j.jaci.2017.07.010. Epub 2017 Oct 10.

PMID:
29029802
33.

Novel immunologic mechanisms in eosinophilic esophagitis.

Caldwell JM, Paul M, Rothenberg ME.

Curr Opin Immunol. 2017 Oct;48:114-121. doi: 10.1016/j.coi.2017.08.006. Epub 2017 Sep 29. Review. No abstract available.

34.

A flow cytometry-based diagnosis of eosinophilic esophagitis.

Wen T, Kuhl J, Putnam P, Mukkada V, Farrell M, Kaul A, Cole C, Rothenberg ME.

J Allergy Clin Immunol. 2017 Dec;140(6):1736-1739.e3. doi: 10.1016/j.jaci.2017.07.022. Epub 2017 Aug 19. No abstract available.

PMID:
28826772
35.

MicroRNA-21: Expression in oligodendrocytes and correlation with low myelin mRNAs in depression and alcoholism.

Miguel-Hidalgo JJ, Hall KO, Bonner H, Roller AM, Syed M, Park CJ, Ball JP, Rothenberg ME, Stockmeier CA, Romero DG.

Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt B):503-514. doi: 10.1016/j.pnpbp.2017.08.009. Epub 2017 Aug 9.

36.

Clinical Applications of the Eosinophilic Esophagitis Diagnostic Panel.

Wen T, Rothenberg ME.

Front Med (Lausanne). 2017 Jul 14;4:108. doi: 10.3389/fmed.2017.00108. eCollection 2017. Review.

37.

Pathophysiology of Eosinophilic Esophagitis.

O'Shea KM, Aceves SS, Dellon ES, Gupta SK, Spergel JM, Furuta GT, Rothenberg ME.

Gastroenterology. 2018 Jan;154(2):333-345. doi: 10.1053/j.gastro.2017.06.065. Epub 2017 Jul 27. Review.

PMID:
28757265
38.

CD300f:IL-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent IL-4 production.

Rozenberg P, Reichman H, Zab-Bar I, Itan M, Pasmanik-Chor M, Bouffi C, Qimron U, Bachelet I, Fulkerson PC, Rothenberg ME, Munitz A.

Sci Rep. 2017 Jul 19;7(1):5922. doi: 10.1038/s41598-017-06397-4.

39.

Oxidized LDL activated eosinophil polarize macrophage phenotype from M2 to M1 through activation of CD36 scavenger receptor.

Qin M, Wang L, Li F, Yang M, Song L, Tian F, Yukht A, Shah PK, Rothenberg ME, Sharifi BG.

Atherosclerosis. 2017 Aug;263:82-91. doi: 10.1016/j.atherosclerosis.2017.05.011. Epub 2017 May 20.

40.

Prenatal, intrapartum, and postnatal factors are associated with pediatric eosinophilic esophagitis.

Jensen ET, Kuhl JT, Martin LJ, Rothenberg ME, Dellon ES.

J Allergy Clin Immunol. 2018 Jan;141(1):214-222. doi: 10.1016/j.jaci.2017.05.018. Epub 2017 Jun 7.

PMID:
28601683
41.

In Memory and Celebration: Dr. James J. Lee.

Rosenberg HF, Fryer AD, Munitz A, Bochner BS, Jacoby DB, Levi-Schaffer F, Gleich GJ, Furuta GT, Rothenberg ME, Lacy P, Fulkerson PC, Hogan SP, Ackerman SJ, Foster PS.

Clin Exp Allergy. 2017 Jul;47(7):980-981. doi: 10.1111/cea.12959. No abstract available.

PMID:
28547822
42.

Infant feeding: Swinging the Pendulum from Late to Early Introduction of Food.

Katz Y, Rothenberg ME.

Isr Med Assoc J. 2016 Nov;18(11):684-688. Review. No abstract available.

43.

News Beyond Our Pages.

Rothenberg ME, Bousquet J.

J Allergy Clin Immunol. 2017 Mar;139(3):762-763. doi: 10.1016/j.jaci.2017.01.002. No abstract available.

PMID:
28328488
44.

Correction: ERBIN deficiency links STAT3 and TGF-β pathway defects with atopy in humans.

Lyons JJ, Liu Y, Ma CA, Yu X, O'Connell MP, Lawrence MG, Zhang Y, Karpe K, Zhao M, Siegel AM, Stone KD, Nelson C, Jones N, DiMaggio T, Darnell DN, Mendoza-Caamal E, Orozco L, Hughes JD, McElwee J, Hohman RJ, Frischmeyer-Guerrerio PA, Rothenberg ME, Freeman AF, Holland SM, Milner JD.

J Exp Med. 2017 Apr 3;214(4):1201. doi: 10.1084/jem.2016143503082017c. Epub 2017 Mar 13. No abstract available.

45.

Genetics of eosinophilic esophagitis.

Kottyan LC, Rothenberg ME.

Mucosal Immunol. 2017 May;10(3):580-588. doi: 10.1038/mi.2017.4. Epub 2017 Feb 22. Review.

46.

Calpain-14 and its association with eosinophilic esophagitis.

Litosh VA, Rochman M, Rymer JK, Porollo A, Kottyan LC, Rothenberg ME.

J Allergy Clin Immunol. 2017 Jun;139(6):1762-1771.e7. doi: 10.1016/j.jaci.2016.09.027. Epub 2017 Jan 25. Review.

47.

ERBIN deficiency links STAT3 and TGF-β pathway defects with atopy in humans.

Lyons JJ, Liu Y, Ma CA, Yu X, O'Connell MP, Lawrence MG, Zhang Y, Karpe K, Zhao M, Siegel AM, Stone KD, Nelson C, Jones N, DiMaggio T, Darnell DN, Mendoza-Caamal E, Orozco L, Hughes JD, McElwee J, Hohman RJ, Frischmeyer-Guerrerio PA, Rothenberg ME, Freeman AF, Holland SM, Milner JD.

J Exp Med. 2017 Mar 6;214(3):669-680. doi: 10.1084/jem.20161435. Epub 2017 Jan 26. Erratum in: J Exp Med. 2017 Apr 3;214(4):1201.

48.

Profound loss of esophageal tissue differentiation in patients with eosinophilic esophagitis.

Rochman M, Travers J, Miracle CE, Bedard MC, Wen T, Azouz NP, Caldwell JM, Kc K, Sherrill JD, Davis BP, Rymer JK, Kaufman KM, Aronow BJ, Rothenberg ME.

J Allergy Clin Immunol. 2017 Sep;140(3):738-749.e3. doi: 10.1016/j.jaci.2016.11.042. Epub 2017 Jan 17.

49.

SBI2 HCS/HCA 3D Imaging: Best Practices and Unmet Needs Colloquium.

Hoffman AF, Simpson KJ, Horvath P, Lovitt C, Silver S, Easton E, LaBarbera DV, Mendez M, Rothenberg ME, Seldin J, Wardwell-Swanson J, Fennell M.

Assay Drug Dev Technol. 2017 Jan;15(1):1-7. doi: 10.1089/adt.2016.29054.afh. No abstract available.

PMID:
28092461
50.

Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation.

Caldwell JM, Collins MH, Kemme KA, Sherrill JD, Wen T, Rochman M, Stucke EM, Amin L, Tai H, Putnam PE, Jiménez-Dalmaroni MJ, Wormald MR, Porollo A, Abonia JP, Rothenberg ME.

Mucosal Immunol. 2017 Sep;10(5):1190-1201. doi: 10.1038/mi.2016.120. Epub 2017 Jan 4.

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