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Sonographic differentiation of complicated from uncomplicated appendicitis.

Rawolle T, Reismann M, Minderjahn MI, Bassir C, Hauptmann K, Rothe K, Reismann J.

Br J Radiol. 2019 May 29:20190102. doi: 10.1259/bjr.20190102. [Epub ahead of print]


Current Outlook on Autophagy in Human Leukemia: Foe in Cancer Stem Cells and Drug Resistance, Friend in New Therapeutic Interventions.

Rothe K, Porter V, Jiang X.

Int J Mol Sci. 2019 Jan 22;20(3). pii: E461. doi: 10.3390/ijms20030461. Review.


Eosinophilia in pediatric uncomplicated appendicitis is a time stable pattern.

Reismann J, Schädlich D, Minderjahn MI, Rothe K, Reismann M.

Pediatr Surg Int. 2019 Mar;35(3):335-340. doi: 10.1007/s00383-018-4423-1. Epub 2018 Dec 7.


Correction to: Phlegmonous appendicitis in children is characterized by eosinophilia in white blood cell counts.

Minderjahn MI, Schädlich D, Radtke J, Rothe K, Reismann M.

World J Pediatr. 2018 Sep 22. doi: 10.1007/s12519-018-0185-z. [Epub ahead of print]


Diverse mechanisms of autophagy dysregulation and their therapeutic implications: does the shoe fit?

Sathiyaseelan P, Rothe K, Yang KC, Xu J, Chow NS, Bortnik S, Choutka C, Ho C, Jiang X, Gorski SM.

Autophagy. 2018 Sep 13:1-4. doi: 10.1080/15548627.2018.1509609. [Epub ahead of print]


Phlegmonous appendicitis in children is characterized by eosinophilia in white blood cell counts.

Minderjahn MI, Schädlich D, Radtke J, Rothe K, Reismann M.

World J Pediatr. 2018 Oct;14(5):504-509. doi: 10.1007/s12519-018-0173-3. Epub 2018 Jul 24. Erratum in: World J Pediatr. 2018 Sep 22;:.


PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL+ human leukemia.

Lai D, Chen M, Su J, Liu X, Rothe K, Hu K, Forrest DL, Eaves CJ, Morin GB, Jiang X.

Sci Transl Med. 2018 Feb 7;10(427). pii: eaan8735. doi: 10.1126/scitranslmed.aan8735.


Obstruction of peritoneal dialysis catheter is associated with catheter type and independent of omentectomy: A comparative data analysis from a transplant surgical and a pediatric surgical department.

Radtke J, Schild R, Reismann M, Ridwelski RR, Kempf C, Nashan B, Rothe K, Koch M.

J Pediatr Surg. 2018 Apr;53(4):640-643. doi: 10.1016/j.jpedsurg.2017.06.028. Epub 2017 Jul 4.


Autoimmune arthritis induces paired immunoglobulin-like receptor B expression on CD4+ T cells from SKG mice.

Rothe K, Raulien N, Köhler G, Pierer M, Quandt D, Wagner U.

Eur J Immunol. 2017 Sep;47(9):1457-1467. doi: 10.1002/eji.201646747. Epub 2017 Jul 27.


A novel AHI-1-BCR-ABL-DNM2 complex regulates leukemic properties of primitive CML cells through enhanced cellular endocytosis and ROS-mediated autophagy.

Liu X, Rothe K, Yen R, Fruhstorfer C, Maetzig T, Chen M, Forrest DL, Humphries RK, Jiang X.

Leukemia. 2017 Nov;31(11):2376-2387. doi: 10.1038/leu.2017.108. Epub 2017 Apr 3.


CuboCube: Student creation of a cancer genetics e-textbook using open-access software for social learning.

Seid-Karbasi P, Ye XC, Zhang AW, Gladish N, Cheng SY, Rothe K, Pilsworth JA, Kang MA, Doolittle N, Jiang X, Stirling PC, Wasserman WW.

PLoS Biol. 2017 Mar 7;15(3):e2001192. doi: 10.1371/journal.pbio.2001192. eCollection 2017 Mar.


Canine peripheral blood CD4+CD8+ double-positive Tcell subpopulations exhibit distinct Tcell phenotypes and effector functions.

Rothe K, Bismarck D, Büttner M, Alber G, von Buttlar H.

Vet Immunol Immunopathol. 2017 Mar;185:48-56. doi: 10.1016/j.vetimm.2017.01.005. Epub 2017 Jan 24.


Pulmonary outcome of esophageal atresia patients and its potential causes in early childhood.

Dittrich R, Stock P, Rothe K, Degenhardt P.

J Pediatr Surg. 2017 Aug;52(8):1255-1259. doi: 10.1016/j.jpedsurg.2016.12.025. Epub 2017 Jan 3.


Elucidation of the biosynthesis of carnosic acid and its reconstitution in yeast.

Scheler U, Brandt W, Porzel A, Rothe K, Manzano D, Božić D, Papaefthimiou D, Balcke GU, Henning A, Lohse S, Marillonnet S, Kanellis AK, Ferrer A, Tissier A.

Nat Commun. 2016 Oct 5;7:12942. doi: 10.1038/ncomms12942.


In Reply.

Rothe K.

Dtsch Arztebl Int. 2016 Feb 19;113(7):116-7. doi: 10.3238/arztebl.2016.0116c. No abstract available.


Voiding Cystourethrography in the Diagnosis of Anorectal Malformations.

Karsten K, Rothe K, Märzheuser S.

Eur J Pediatr Surg. 2016 Dec;26(6):494-499. Epub 2016 Jan 11.


GPRC6A mediates Alum-induced Nlrp3 inflammasome activation but limits Th2 type antibody responses.

Quandt D, Rothe K, Baerwald C, Rossol M.

Sci Rep. 2015 Nov 25;5:16719. doi: 10.1038/srep16719.


Precision autophagy: Will the next wave of selective autophagy markers and specific autophagy inhibitors feed clinical pipelines?

Lebovitz CB, DeVorkin L, Bosc D, Rothe K, Singh J, Bally M, Jiang X, Young RN, Lum JJ, Gorski SM.

Autophagy. 2015;11(10):1949-52. doi: 10.1080/15548627.2015.1078962.


Latent Cytomegalovirus Infection in Rheumatoid Arthritis and Increased Frequencies of Cytolytic LIR-1+CD8+ T Cells.

Rothe K, Quandt D, Schubert K, Rossol M, Klingner M, Jasinski-Bergner S, Scholz R, Seliger B, Pierer M, Baerwald C, Wagner U.

Arthritis Rheumatol. 2016 Feb;68(2):337-46. doi: 10.1002/art.39331.


Animal and Human Bite Wounds.

Rothe K, Tsokos M, Handrick W.

Dtsch Arztebl Int. 2015 Jun 19;112(25):433-42; quiz 443. doi: 10.3238/arztebl.2015.0433. Review.


Improvements in Incontinence with Self-Management in Patients with Anorectal Malformations.

Märzheuser S, Karsten K, Rothe K.

Eur J Pediatr Surg. 2016 Apr;26(2):186-91. doi: 10.1055/s-0034-1544050. Epub 2015 Feb 5.


Allogeneic bone marrow grafts with high levels of CD4+ CD25+ FoxP3+ T cells can lead to engraftment failure.

Fricke S, Rothe K, Hilger N, Ackermann M, Oelkrug C, Fricke C, Schönfelder U, Niederwieser D, Emmrich F, Sack U.

Cytometry A. 2015 Mar;87(3):279-280. doi: 10.1002/cyto.a.22639. Epub 2015 Jan 28. No abstract available.


Selective JAK2/ABL dual inhibition therapy effectively eliminates TKI-insensitive CML stem/progenitor cells.

Lin H, Chen M, Rothe K, Lorenzi MV, Woolfson A, Jiang X.

Oncotarget. 2014 Sep 30;5(18):8637-50.


The core autophagy protein ATG4B is a potential biomarker and therapeutic target in CML stem/progenitor cells.

Rothe K, Lin H, Lin KB, Leung A, Wang HM, Malekesmaeili M, Brinkman RR, Forrest DL, Gorski SM, Jiang X.

Blood. 2014 Jun 5;123(23):3622-34. doi: 10.1182/blood-2013-07-516807. Epub 2014 Apr 22.


Occurrence of giant focal forms of congenital hyperinsulinism with incorrect visualization by (18) F DOPA-PET/CT scanning.

Kühnen P, Matthae R, Arya V, Hauptmann K, Rothe K, Wächter S, Singer M, Mohnike W, Eberhard T, Raile K, Lauffer LM, Iakoubov R, Hussain K, Blankenstein O.

Clin Endocrinol (Oxf). 2014 Dec;81(6):847-54. doi: 10.1111/cen.12473. Epub 2014 May 19.


New advances in CMV and immunosenescence.

Sansoni P, Vescovini R, Fagnoni FF, Akbar A, Arens R, Chiu YL, Cičin-Šain L, Dechanet-Merville J, Derhovanessian E, Ferrando-Martinez S, Franceschi C, Frasca D, Fulöp T, Furman D, Gkrania-Klotsas E, Goodrum F, Grubeck-Loebenstein B, Hurme M, Kern F, Lilleri D, López-Botet M, Maier AB, Marandu T, Marchant A, Matheï C, Moss P, Muntasell A, Remmerswaal EB, Riddell NE, Rothe K, Sauce D, Shin EC, Simanek AM, Smithey MJ, Söderberg-Nauclér C, Solana R, Thomas PG, van Lier R, Pawelec G, Nikolich-Zugich J.

Exp Gerontol. 2014 Jul;55:54-62. doi: 10.1016/j.exger.2014.03.020. Epub 2014 Apr 3.


Peripheral CD4CD8 double positive T cells with a distinct helper cytokine profile are increased in rheumatoid arthritis.

Quandt D, Rothe K, Scholz R, Baerwald CW, Wagner U.

PLoS One. 2014 Mar 25;9(3):e93293. doi: 10.1371/journal.pone.0093293. eCollection 2014.


Autophagy: from structure to metabolism to therapeutic regulation.

Jardon MA, Rothe K, Bortnik S, Vezenkov L, Jiang X, Young RN, Lum JJ, Gorski SM.

Autophagy. 2013 Dec;9(12):2180-2. doi: 10.4161/auto.26378. Epub 2013 Sep 30.


[Treatment for fecal incontinence in patients with anorectal malformations. Introduction of a therapeutic approach].

Märzheuser S, Grauel F, Rothe K.

Pflege Z. 2013 Oct;66(10):612-5. German.


Prenatal diagnosis and management of a massive fetal ovarian hemorrhagic cyst torsion with secondary fetal anemia.

Vitezica I, Czernik C, Rothe K, Hinkson L, Ladendorf B, Henrich W.

J Clin Ultrasound. 2014 May;42(4):219-22. doi: 10.1002/jcu.22082. Epub 2013 Sep 12.


[The professional and private situation of male and female physicians entering postgraduate medical education in Germany].

van den Bussche H, Wonneberger C, Birck S, Schultz JH, Robra BP, Schmidt A, Stosch C, Wagner R, Scherer M, Pöge K, Rothe K, Gedrose B.

Gesundheitswesen. 2014 Feb;76(2):e1-6. doi: 10.1055/s-0033-1343441. Epub 2013 Aug 16. German.


Regional deep hyperthermia for salvage treatment of children and adolescents with refractory or recurrent non-testicular malignant germ-cell tumours: an open-label, non-randomised, single-institution, phase 2 study.

Wessalowski R, Schneider DT, Mils O, Friemann V, Kyrillopoulou O, Schaper J, Matuschek C, Rothe K, Leuschner I, Willers R, Schönberger S, Göbel U, Calaminus G; MAKEI study group.

Lancet Oncol. 2013 Aug;14(9):843-52. doi: 10.1016/S1470-2045(13)70271-7. Epub 2013 Jul 1.


Human Mas-related G protein-coupled receptors-X1 induce chemokine receptor 2 expression in rat dorsal root ganglia neurons and release of chemokine ligand 2 from the human LAD-2 mast cell line.

Solinski HJ, Petermann F, Rothe K, Boekhoff I, Gudermann T, Breit A.

PLoS One. 2013;8(3):e58756. doi: 10.1371/journal.pone.0058756. Epub 2013 Mar 7.


Bilateral pneumothorax following a blunt trachea trauma.

Schwarz C, Usemann J, Stephan V, Kaiser D, Rothe K, Rückert JC, Neudecker J.

Respir Med Case Rep. 2013 Sep 25;10:56-9. doi: 10.1016/j.rmcr.2013.08.003. eCollection 2013.


Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors.

Rossol M, Pierer M, Raulien N, Quandt D, Meusch U, Rothe K, Schubert K, Schöneberg T, Schaefer M, Krügel U, Smajilovic S, Bräuner-Osborne H, Baerwald C, Wagner U.

Nat Commun. 2012;3:1329. doi: 10.1038/ncomms2339.


Hirschsprung disease in the older child: diagnostic strategies.

Maerzheuser S, Bassir C, Rothe K.

Clin Pediatr (Phila). 2012 Nov;51(11):1087-90. doi: 10.1177/0009922812458354. Epub 2012 Aug 30.


[General practitioner or specialist at home or abroad?].

van den Bussche H, Kromark K, Köhl-Hackert N, Robra B, Rothe K, Schmidt A, Stosch C, Wagner R, Wonneberger C, Scherer M, Alfermann D, Gedrose B.

Gesundheitswesen. 2012 Dec;74(12):786-92. doi: 10.1055/s-0032-1311619. Epub 2012 May 23. German.


Allogeneic bone marrow grafts with high levels of CD4(+) CD25(+) FoxP3(+) T cells can lead to engraftment failure.

Fricke S, Rothe K, Hilger N, Ackermann M, Oelkrug C, Fricke C, Schönfelder U, Niederwieser D, Emmrich F, Sack U.

Cytometry A. 2012 Jun;81(6):476-88. doi: 10.1002/cyto.a.22061. Epub 2012 Apr 20. Erratum in: Cytometry A. 2015 Mar;87(3):279-80. Cytometry A. 2015 Mar;87(3):279-280.


Morphine activates the E twenty six-like transcription factor-1/serum response factor pathway via extracellular signal-regulated kinases 1/2 in F11 cells derived from dorsal root ganglia neurons.

Rothe K, Solinski HJ, Boekhoff I, Gudermann T, Breit A.

J Pharmacol Exp Ther. 2012 Jul;342(1):41-52. doi: 10.1124/jpet.112.192757. Epub 2012 Mar 27.


[Do female medical graduates have different views on professional work and workload compared to their male colleagues? Results of a multicenter postal survey in Germany].

Gedrose B, Wonneberger C, Jünger J, Robra BP, Schmidt A, Stosch C, Wagner R, Scherer M, Pöge K, Rothe K, van den Bussche H.

Dtsch Med Wochenschr. 2012 Jun;137(23):1242-7. doi: 10.1055/s-0032-1304872. Epub 2012 Mar 23. German.


Miliary tuberculosis complicated by pulmonary cavitations and pneumothorax in a 14-month old boy.

Ballouhey Q, Lau S, Accadbled F, Wahn U, Kaiser D, Rothe K, Magdorf K.

Ann Thorac Cardiovasc Surg. 2012;18(4):355-8. Epub 2012 Jan 31.


Association of anticytomegalovirus seropositivity with more severe joint destruction and more frequent joint surgery in rheumatoid arthritis.

Pierer M, Rothe K, Quandt D, Schulz A, Rossol M, Scholz R, Baerwald C, Wagner U.

Arthritis Rheum. 2012 Jun;64(6):1740-9. doi: 10.1002/art.34346. Epub 2011 Dec 19.


Monocarboxylate transporter 8 deficiency: altered thyroid morphology and persistent high triiodothyronine/thyroxine ratio after thyroidectomy.

Wirth EK, Sheu SY, Chiu-Ugalde J, Sapin R, Klein MO, Mossbrugger I, Quintanilla-Martinez L, de Angelis MH, Krude H, Riebel T, Rothe K, Köhrle J, Schmid KW, Schweizer U, Grüters A.

Eur J Endocrinol. 2011 Oct;165(4):555-61. doi: 10.1530/EJE-11-0369. Epub 2011 Aug 3.


[Regulation of behavior in the period between the world wars: Robert Musil and Kurt Lewin].

Innerhofer R, Rothe K.

Ber Wiss. 2010 Dec;33(4):365-81. German.


Hydrocolonic sonography: a helpful diagnostic tool to implement effective bowel management.

Märzheuser S, Schmidt D, David S, Rothe K.

Pediatr Surg Int. 2010 Nov;26(11):1121-4. doi: 10.1007/s00383-010-2687-1.


Activating TSH-receptor mutation (Met453Thr) as a cause of adenomatous non-autoimmune hyperthyroidism in a 3-year-old boy.

Kraemer S, Rothe K, Pfaeffle R, Fuehrer-Sakel D, Till H, Muensterer OJ.

J Pediatr Endocrinol Metab. 2009 Mar;22(3):269-74.


All-trans retinoic acid arrests neuroblastoma cells in a dormant state. Subsequent nerve growth factor/brain-derived neurotrophic factor treatment adds modest benefit.

Cernaianu G, Brandmaier P, Scholz G, Ackermann OP, Alt R, Rothe K, Cross M, Witzigmann H, Tröbs RB.

J Pediatr Surg. 2008 Jul;43(7):1284-94. doi: 10.1016/j.jpedsurg.2008.01.007.


Endoscopy in Barrett's oesophagus: adherence to standards and neoplasia detection in the community practice versus hospital setting.

Pohl H, Aschenbeck J, Drossel R, Schröder A, Mayr M, Koch M, Rothe K, Anders M, Voderholzer W, Hoffmann J, Schulz HJ, Liehr RM, Gottschalk U, Wiedenmann B, Rösch T.

J Intern Med. 2008 Oct;264(4):370-8. doi: 10.1111/j.1365-2796.2008.01977.x. Epub 2008 May 15.


Feminizing reconstructive surgery for ambiguous genitalia: the Leipzig experience.

Hoepffner W, Rothe K, Bennek J.

J Urol. 2006 Mar;175(3 Pt 1):981-4.


TNP-470 fails to block the onset of angiogenesis and early tumor establishment in an intravital minimal disease model.

Cernaianu G, Frank S, Erbstösser K, Leonhardt S, Cross M, McIvor Z, Scholz G, Dansranjavin T, Celik I, Tannapfel A, Wittekind C, Troebs RB, Rothe K, Bennek J, Hauss J, Witzigmann H.

Int J Colorectal Dis. 2006 Mar;21(2):143-54. Epub 2005 Jun 4.


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