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Psychosomatische Institutsambulanzen (PsIA) – und (k)ein Ende. Ein guter Anfang, der nun weiterentwickelt werden will.

Rothe HM, Cuntz U, Driessen M, Jäger B, Krüger C, Längle G, Bergmann G, Heuft G.

Z Psychosom Med Psychother. 2020 Feb;66(1):32-46. doi: 10.13109/zptm.2020.66.1.32. German.


Use of human liver and EpiSkin™ S9 subcellular fractions as a screening assays to compare the in vitro hepatic and dermal metabolism of 47 cosmetics-relevant chemicals.

Eilstein J, Grégoire S, Fabre A, Arbey E, Géniès C, Duplan H, Rothe H, Ellison C, Cubberley R, Schepky A, Lange D, Klaric M, Hewitt NJ, Jacques-Jamin C.

J Appl Toxicol. 2020 Mar;40(3):416-433. doi: 10.1002/jat.3914. Epub 2020 Jan 8.


Measurement of the penetration of 56 cosmetic relevant chemicals into and through human skin using a standardized protocol.

Hewitt NJ, Grégoire S, Cubberley R, Duplan H, Eilstein J, Ellison C, Lester C, Fabian E, Fernandez J, Géniès C, Jacques-Jamin C, Klaric M, Rothe H, Sorrell I, Lange D, Schepky A.

J Appl Toxicol. 2020 Mar;40(3):403-415. doi: 10.1002/jat.3913. Epub 2019 Dec 22.


Comparison of the metabolism of 10 cosmetics-relevant chemicals in EpiSkin™ S9 subcellular fractions and in vitro human skin explants.

Géniès C, Jacques-Jamin C, Duplan H, Rothe H, Ellison C, Cubberley R, Schepky A, Lange D, Klaric M, Hewitt NJ, Grégoire S, Arbey E, Fabre A, Eilstein J.

J Appl Toxicol. 2020 Feb;40(2):313-326. doi: 10.1002/jat.3905. Epub 2019 Nov 7.


[Facial necrosis caused by orthopoxvirus : Differential diagnosis and dermatohistopathological correlation of infectious facial ulcers].

Niebel D, Hornung T, Schmithausen R, Rothe H, Parcina M, Wenzel J, Exner M, Bieber T.

Hautarzt. 2019 Sep;70(9):715-722. doi: 10.1007/s00105-019-4409-5. German.


Use of a Simple in vitro Test to Assess Loss of Chemical due to Volatility during an in vitro Human Skin Absorption Study.

Grégoire S, Cubberley R, Duplan H, Eilstein J, Hewitt NJ, Jacques-Jamin C, Genies C, Klaric M, Rothe H, Ellison C, Fernandez J, Schepky A.

Skin Pharmacol Physiol. 2019;32(3):117-124. doi: 10.1159/000497105. Epub 2019 Mar 19.


[Staffing level: Survey among psychosomatic-psychotherapeutic institutions in Germany].

Friederich HC, Heuft G, Cuntz U, Hildenbrand G, Rothe HM, Blum K, Krüger C, Hochlehnert A, Kruse J, Raible C.

Z Psychosom Med Psychother. 2018 Dec;64(4):334-349. doi: 10.13109/zptm.2018.64.4.334. German.


Biomimetic Designer Scaffolds Made of D,L-Lactide-ɛ-Caprolactone Polymers by 2-Photon Polymerization.

Hauptmann N, Lian Q, Ludolph J, Rothe H, Hildebrand G, Liefeith K.

Tissue Eng Part B Rev. 2019 Jun;25(3):167-186. doi: 10.1089/ten.TEB.2018.0284. Epub 2019 May 2. Review.


Comparison of the metabolism of 10 chemicals in human and pig skin explants.

Géniès C, Jamin EL, Debrauwer L, Zalko D, Person EN, Eilstein J, Grégoire S, Schepky A, Lange D, Ellison C, Roe A, Salhi S, Cubberley R, Hewitt NJ, Rothe H, Klaric M, Duplan H, Jacques-Jamin C.

J Appl Toxicol. 2019 Feb;39(2):385-397. doi: 10.1002/jat.3730. Epub 2018 Oct 21.


Principles for the safety evaluation of cosmetic powders.

Steiling W, Almeida JF, Assaf Vandecasteele H, Gilpin S, Kawamoto T, O'Keeffe L, Pappa G, Rettinger K, Rothe H, Bowden AM.

Toxicol Lett. 2018 Nov;297:8-18. doi: 10.1016/j.toxlet.2018.08.011. Epub 2018 Aug 17. Review.


Activity concentrations of 238U and 226Ra in two European black shales and their experimentally-derived leachates.

Wilke FDH, Schettler G, Vieth-Hillebrand A, Kühn M, Rothe H.

J Environ Radioact. 2018 Oct;190-191:122-129. doi: 10.1016/j.jenvrad.2018.05.005.


A strategy for systemic toxicity assessment based on non-animal approaches: The Cosmetics Europe Long Range Science Strategy programme.

Desprez B, Dent M, Keller D, Klaric M, Ouédraogo G, Cubberley R, Duplan H, Eilstein J, Ellison C, Grégoire S, Hewitt NJ, Jacques-Jamin C, Lange D, Roe A, Rothe H, Blaauboer BJ, Schepky A, Mahony C.

Toxicol In Vitro. 2018 Aug;50:137-146. doi: 10.1016/j.tiv.2018.02.017. Epub 2018 Mar 2. Review.


Cinacalcet HCl therapy in East Asian patients and rs1042636 carriers.

Rothe HM.

Clin Exp Nephrol. 2018 Aug;22(4):983. doi: 10.1007/s10157-018-1539-5. Epub 2018 Feb 6. No abstract available.


Application of in vitro skin penetration measurements to confirm and refine the quantitative skin sensitization risk assessment of methylisothiazolinone.

Rothe H, Ryan CA, Page L, Vinall J, Goebel C, Scheffler H, Toner F, Roper C, Kern PS.

Regul Toxicol Pharmacol. 2017 Dec;91:197-207. doi: 10.1016/j.yrtph.2017.10.024. Epub 2017 Nov 6.


Comparison of the Skin Penetration of 3 Metabolically Stable Chemicals Using Fresh and Frozen Human Skin.

Jacques-Jamin C, Duplan H, Rothe H, Vaillant O, Eilstein J, Grégoire S, Cubberley R, Lange D, Ellison C, Klaric M, Hewitt N, Schepky A.

Skin Pharmacol Physiol. 2017;30(5):234-245. doi: 10.1159/000475472. Epub 2017 Jul 27.


Influence of the Microstructure and Silver Content on Degradation, Cytocompatibility, and Antibacterial Properties of Magnesium-Silver Alloys In Vitro.

Liu Z, Schade R, Luthringer B, Hort N, Rothe H, Müller S, Liefeith K, Willumeit-Römer R, Feyerabend F.

Oxid Med Cell Longev. 2017;2017:8091265. doi: 10.1155/2017/8091265. Epub 2017 Jun 22.


Benefit on motor and non-motor behavior in a specialized unit for Parkinson's disease.

Müller T, Öhm G, Eilert K, Möhr K, Rotter S, Haas T, Küchler M, Lütge S, Marg M, Rothe H.

J Neural Transm (Vienna). 2017 Jun;124(6):715-720. doi: 10.1007/s00702-017-1701-3. Epub 2017 Feb 28.


Ecto-5' -Nucleotidase CD73 (NT5E), vitamin D receptor and FGF23 gene polymorphisms may play a role in the development of calcific uremic arteriolopathy in dialysis patients - Data from the German Calciphylaxis Registry.

Rothe H, Brandenburg V, Haun M, Kollerits B, Kronenberg F, Ketteler M, Wanner C.

PLoS One. 2017 Feb 17;12(2):e0172407. doi: 10.1371/journal.pone.0172407. eCollection 2017.


Comparison of protocols measuring diffusion and partition coefficients in the stratum corneum.

Rothe H, Obringer C, Manwaring J, Avci C, Wargniez W, Eilstein J, Hewitt N, Cubberley R, Duplan H, Lange D, Jacques-Jamin C, Klaric M, Schepky A, Grégoire S.

J Appl Toxicol. 2017 Jul;37(7):806-816. doi: 10.1002/jat.3427. Epub 2017 Jan 31.


[Lymph node metastases in ypT1/2 rectal cancer after neoadjuvant chemoradiotherapy : The Achilles heel of organ-preserving operative procedures?].

Sprenger T, Rothe H, Beissbarth T, Conradi LC, Kauffels A, Homayounfar K, Behnes CL, Rödel C, Liersch T, Ghadimi M.

Chirurg. 2016 Jul;87(7):593-601. doi: 10.1007/s00104-016-0170-9. German.


Stage-Dependent Frequency of Lymph Node Metastases in Patients With Rectal Carcinoma After Preoperative Chemoradiation: Results from the CAO/ARO/AIO-94 Trial and From a Comparative Prospective Evaluation With Extensive Pathological Workup.

Sprenger T, Rothe H, Conradi LC, Beissbarth T, Kauffels A, Kitz J, Homayounfar K, Wolff H, Ströbel P, Ghadimi M, Wittekind C, Sauer R, Rödel C, Liersch T.

Dis Colon Rectum. 2016 May;59(5):377-85. doi: 10.1097/DCR.0000000000000570.


Comparison of protocols for measuring cosmetic ingredient distribution in human and pig skin.

Gerstel D, Jacques-Jamin C, Schepky A, Cubberley R, Eilstein J, Grégoire S, Hewitt N, Klaric M, Rothe H, Duplan H.

Toxicol In Vitro. 2016 Aug;34:153-160. doi: 10.1016/j.tiv.2016.03.012. Epub 2016 Mar 31.


Calcific uraemic arteriolopathy (calciphylaxis): data from a large nationwide registry.

Brandenburg VM, Kramann R, Rothe H, Kaesler N, Korbiel J, Specht P, Schmitz S, Krüger T, Floege J, Ketteler M.

Nephrol Dial Transplant. 2017 Jan 1;32(1):126-132. doi: 10.1093/ndt/gfv438.


Assessing the safety of cosmetic chemicals: Consideration of a flux decision tree to predict dermally delivered systemic dose for comparison with oral TTC (Threshold of Toxicological Concern).

Williams FM, Rothe H, Barrett G, Chiodini A, Whyte J, Cronin MT, Monteiro-Riviere NA, Plautz J, Roper C, Westerhout J, Yang C, Guy RH.

Regul Toxicol Pharmacol. 2016 Apr;76:174-86. doi: 10.1016/j.yrtph.2016.01.005. Epub 2016 Jan 26.


Suitability of the in vitro Caco-2 assay to predict the oral absorption of aromatic amine hair dyes.

Obringer C, Manwaring J, Goebel C, Hewitt NJ, Rothe H.

Toxicol In Vitro. 2016 Apr;32:1-7. doi: 10.1016/j.tiv.2015.11.007. Epub 2015 Nov 12.


Cervical Strip Biopsy for High-Grade Cervical Intraepithelial Lesions: a Valid Alternative to Conventional Punch Technique.

Schneider A, Wagner K, Rakozy C, Stolte C, Bothur-Schäfer P, Welcker T, Choly N, Roesgen A, Rothe H, Böhmer G.

Geburtshilfe Frauenheilkd. 2015 Oct;75(10):1063-1068. doi: 10.1055/s-0035-1557816.


Correlation between VITOM(®) videocolposcopy and histopathology for pathognomonic grading criteria.

Schneider A, Rakozy C, Stolte C, Bothur-Schäfer P, Rothe H, Welcker T, Choly N, Roesgen A, Böhmer G.

Arch Gynecol Obstet. 2015 Dec;292(6):1361-6. doi: 10.1007/s00404-015-3798-7. Epub 2015 Jun 26.


Extrapolation of systemic bioavailability assessing skin absorption and epidermal and hepatic metabolism of aromatic amine hair dyes in vitro.

Manwaring J, Rothe H, Obringer C, Foltz DJ, Baker TR, Troutman JA, Hewitt NJ, Goebel C.

Toxicol Appl Pharmacol. 2015 Sep 1;287(2):139-148. doi: 10.1016/j.taap.2015.05.016. Epub 2015 May 29.


Effect of feeding ractopamine hydrochloride on growth performance and responses to handling and transport in heavy-weight pigs.

Peterson CM, Pilcher CM, Rothe HM, Marchant-Forde JN, Ritter MJ, Carr SN, Puls CL, Ellis M.

J Anim Sci. 2015 Mar;93(3):1239-49. doi: 10.2527/jas.2014-8303.


Safety and effectiveness of a novel vascular closure device: a prospective study of the ExoSeal compared to the Angio-Seal and ProGlide.

Kara K, Mahabadi AA, Rothe H, Müller P, Krüger J, Neubauer H, Klein-Wiele O, Mügge A, Kahlert P, Erbel R.

J Endovasc Ther. 2014 Dec;21(6):822-8. doi: 10.1583/14-4744MR.1.


An in vitro skin penetration model for compromised skin: estimating penetration of polyethylene glycol [¹⁴C]-PEG-7 phosphate.

Dey S, Rothe H, Page L, O'Connor R, Farahmand S, Toner F, Marsh R, Wehmeyer K, Zhou S.

Skin Pharmacol Physiol. 2015;28(1):12-21. doi: 10.1159/000362284. Epub 2014 Jul 15.


Continuous Subcutaneous Apomorphine Infusion Improves Severe Restless Legs Syndrome.

Müller T, Marg M, Rothe H, Küchler M.

Mov Disord Clin Pract. 2014 Jun 4;1(3):233-234. doi: 10.1002/mdc3.12039. eCollection 2014 Sep. No abstract available.


The K-factor in chronic kidney disease: biomarkers of calcification inhibition and beyond.

Ketteler M, Rothe H, Brandenburg VM, Westenfeld R.

Nephrol Dial Transplant. 2014 Jul;29(7):1267-70. doi: 10.1093/ndt/gfu053. Epub 2014 Apr 20. No abstract available.


Biomimetic surface modification with bolaamphiphilic archaeal tetraether lipids via liposome spreading.

Bücher C, Grosse X, Rothe H, Fiethen A, Kuhn H, Liefeith K.

Biointerphases. 2014 Mar;9(1):011002. doi: 10.1116/1.4857955.


Principle considerations for the risk assessment of sprayed consumer products.

Steiling W, Bascompta M, Carthew P, Catalano G, Corea N, D'Haese A, Jackson P, Kromidas L, Meurice P, Rothe H, Singal M.

Toxicol Lett. 2014 May 16;227(1):41-9. doi: 10.1016/j.toxlet.2014.03.005. Epub 2014 Mar 20. Review.


Reduction in the free radical status and clinical benefit of repeated intrathecal triamcinolone acetonide application in patients with progressive multiple sclerosis.

Müller T, Herrling T, Lütge S, Küchler M, Lohse L, Rothe H, Haas T, Marg M, Öhm G, Jung K.

Clin Neuropharmacol. 2014 Jan-Feb;37(1):22-5. doi: 10.1097/WNF.0000000000000015.


Introduction of a methoxymethyl side chain into p-phenylenediamine attenuates its sensitizing potency and reduces the risk of allergy induction.

Goebel C, Troutman J, Hennen J, Rothe H, Schlatter H, Gerberick GF, Blömeke B.

Toxicol Appl Pharmacol. 2014 Feb 1;274(3):480-7. doi: 10.1016/j.taap.2013.11.016. Epub 2013 Dec 10.


Lymph node metastases in rectal cancer after preoperative radiochemotherapy: impact of intramesorectal distribution and residual micrometastatic involvement.

Sprenger T, Rothe H, Becker H, Beissbarth T, Homayounfar K, Gauss K, Kitz J, Wolff H, Scheel AH, Ghadimi M, Rödel C, Conradi LC, Liersch T.

Am J Surg Pathol. 2013 Aug;37(8):1283-9. doi: 10.1097/PAS.0b013e3182886ced.


Investigations on the secondary structure of polypeptide chains in polyelectrolyte multilayers and their effect on the adhesion and spreading of osteoblasts.

Grohmann S, Rothe H, Liefeith K.

Biointerphases. 2012 Dec;7(1-4):62. doi: 10.1007/s13758-012-0062-6. Epub 2012 Oct 11.


Shedding new light on vasculitis: how the LAMP story unfolded.

Rothe H.

J Nephrol. 2012 Sep-Oct;25(5):636-43. doi: 10.5301/jn.5000107. Review.


Antilipolytic effect of calcimimetics depends on the allelic variant of calcium-sensing receptor gene polymorphism rs1042636 (Arg990Gly).

Reyes M, Rothe HM, Mattar P, Shapiro WB, Cifuentes M.

Eur J Hum Genet. 2012 Apr;20(4):480-2. doi: 10.1038/ejhg.2011.221. Epub 2011 Dec 14.


Mechanisms and treatment of extraosseous calcification in chronic kidney disease.

Ketteler M, Rothe H, Krüger T, Biggar PH, Schlieper G.

Nat Rev Nephrol. 2011 Jul 19;7(9):509-16. doi: 10.1038/nrneph.2011.91. Review.


Biomimetic assembly of polyelectrolyte multilayers containing phosvitin monitored with reflectometric interference spectroscopy.

Grohmann S, Rothe H, Eisenhuth S, Hoffmann C, Liefeith K.

Biointerphases. 2011 Jun;6(2):54-62. doi: 10.1116/1.3589176.


Special aspects of cosmetic spray safety evaluations: principles on inhalation risk assessment.

Rothe H, Fautz R, Gerber E, Neumann L, Rettinger K, Schuh W, Gronewold C.

Toxicol Lett. 2011 Aug 28;205(2):97-104. doi: 10.1016/j.toxlet.2011.05.1038. Epub 2011 Jun 2. Review.


Colloidal force spectroscopy and cell biological investigations on biomimetic polyelectrolyte multilayer coatings composed of chondroitin sulfate and heparin.

Grohmann S, Rothe H, Frant M, Liefeith K.

Biomacromolecules. 2011 Jun 13;12(6):1987-97. doi: 10.1021/bm200258q. Epub 2011 May 3.


Cinacalcet treatment of primary hyperparathyroidism.

Rothe HM, Liangos O, Biggar P, Petermann A, Ketteler M.

Int J Endocrinol. 2011;2011:415719. doi: 10.1155/2011/415719. Epub 2011 Mar 6.


Thymidylate synthase as a prognostic biomarker for locally advanced rectal cancer after multimodal treatment.

Conradi LC, Bleckmann A, Schirmer M, Sprenger T, Jo P, Homayounfar K, Wolff HA, Rothe H, Middel P, Becker H, Ghadimi MB, Beissbarth T, Liersch T.

Ann Surg Oncol. 2011 Sep;18(9):2442-52. doi: 10.1245/s10434-011-1608-4. Epub 2011 Feb 23.


The hair dyes PPD and PTD fail to induce a T(H)2 immune response following repeated topical application in BALB/c mice.

Rothe H, Sarlo K, Scheffler H, Goebel C.

J Immunotoxicol. 2011 Jan-Mar;8(1):46-55. doi: 10.3109/1547691X.2010.543096.


Failure of downregulation of survivin following neoadjuvant radiochemotherapy in rectal cancer is associated with distant metastases and shortened survival.

Sprenger T, Rödel F, Beissbarth T, Conradi LC, Rothe H, Homayounfar K, Wolff HA, Ghadimi BM, Yildirim M, Becker H, Rödel C, Liersch T.

Clin Cancer Res. 2011 Mar 15;17(6):1623-31. doi: 10.1158/1078-0432.CCR-10-2592. Epub 2010 Nov 30.


Elicitation of the immune response to p-phenylenediamine in allergic patients: the role of dose and exposure time.

Goebel C, Coenraads PJ, Rothe H, Kunze G, Kock M, Schlatter H, Gerberick GF, Blömeke B.

Br J Dermatol. 2010 Dec;163(6):1205-11. doi: 10.1111/j.1365-2133.2010.10009.x. Epub 2010 Nov 4.


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