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Items: 46


Charge of the Proton Channel.

Rothberg BS.

Biophys J. 2018 Jun 19;114(12):2759-2761. doi: 10.1016/j.bpj.2018.05.008. No abstract available.


Molecular determinants of Ca2+ sensitivity at the intersubunit interface of the BK channel gating ring.

Li Q, Li Y, Wei H, Pan HM, Vouga AG, Rothberg BS, Wu Y, Yan J.

Sci Rep. 2018 Jan 11;8(1):509. doi: 10.1038/s41598-017-19029-8.


Permeating disciplines: Overcoming barriers between molecular simulations and classical structure-function approaches in biological ion transport.

Howard RJ, Carnevale V, Delemotte L, Hellmich UA, Rothberg BS.

Biochim Biophys Acta Biomembr. 2018 Apr;1860(4):927-942. doi: 10.1016/j.bbamem.2017.12.013. Epub 2017 Dec 16. Review.


A slick, slack pathway through the pore.

Rothberg BS.

J Physiol. 2017 Apr 1;595(7):2337-2338. doi: 10.1113/JP273497. Epub 2017 Mar 5. No abstract available.


Understanding the conformational motions of RCK gating rings.

Giraldez T, Rothberg BS.

J Gen Physiol. 2017 Apr 3;149(4):431-441. doi: 10.1085/jgp.201611726. Epub 2017 Feb 28. Review.


The STIM1-binding site nexus remotely controls Orai1 channel gating.

Zhou Y, Cai X, Loktionova NA, Wang X, Nwokonko RM, Wang X, Wang Y, Rothberg BS, Trebak M, Gill DL.

Nat Commun. 2016 Dec 8;7:13725. doi: 10.1038/ncomms13725.


Sterol hindrance of Orai activation.

Hooper R, Rothberg BS, Soboloff J.

Sci Signal. 2016 Mar 8;9(418):fs4. doi: 10.1126/scisignal.aaf2357. Review.


STIM1 dimers undergo unimolecular coupling to activate Orai1 channels.

Zhou Y, Wang X, Wang X, Loktionova NA, Cai X, Nwokonko RM, Vrana E, Wang Y, Rothberg BS, Gill DL.

Nat Commun. 2015 Sep 24;6:8395. doi: 10.1038/ncomms9395.


An old probe sheds new light on BK channel pore structure.

McManus OB, Rothberg BS.

J Gen Physiol. 2014 Dec;144(6):499-501. doi: 10.1085/jgp.201411306. Epub 2014 Nov 10. No abstract available.


Neuronal STIMulation at rest.

Hooper R, Rothberg BS, Soboloff J.

Sci Signal. 2014 Jul 22;7(335):pe18. doi: 10.1126/scisignal.2005556. Review.


Initial steps of inactivation at the K+ channel selectivity filter.

Thomson AS, Heer FT, Smith FJ, Hendron E, Bernèche S, Rothberg BS.

Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):E1713-22. doi: 10.1073/pnas.1317573111. Epub 2014 Apr 14.


Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site.

Wang X, Wang Y, Zhou Y, Hendron E, Mancarella S, Andrake MD, Rothberg BS, Soboloff J, Gill DL.

Nat Commun. 2014;5:3183. doi: 10.1038/ncomms4183.


Structural basis of allosteric interactions among Ca2+-binding sites in a K+ channel RCK domain.

Smith FJ, Pau VP, Cingolani G, Rothberg BS.

Nat Commun. 2013;4:2621. doi: 10.1038/ncomms3621.


Isotope labeling strategies for analysis of an ion channel cytoplasmic domain by NMR spectroscopy.

Abarca-Heidemann K, Duchardt-Ferner E, Woehnert J, Rothberg BS.

Methods Mol Biol. 2013;998:289-300. doi: 10.1007/978-1-62703-351-0_23.


Analysis of Ca(2+)-binding sites in the MthK RCK domain by X-ray crystallography.

Smith FJ, Rothberg BS.

Methods Mol Biol. 2013;998:277-87. doi: 10.1007/978-1-62703-351-0_22.


Orai channel pore properties and gating by STIM: implications from the Orai crystal structure.

Rothberg BS, Wang Y, Gill DL.

Sci Signal. 2013 Mar 19;6(267):pe9. doi: 10.1126/scisignal.2003971.


MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival.

Mallilankaraman K, Doonan P, Cárdenas C, Chandramoorthy HC, Müller M, Miller R, Hoffman NE, Gandhirajan RK, Molgó J, Birnbaum MJ, Rothberg BS, Mak DO, Foskett JK, Madesh M.

Cell. 2012 Oct 26;151(3):630-44. doi: 10.1016/j.cell.2012.10.011.


Crystal structure of a Ba(2+)-bound gating ring reveals elementary steps in RCK domain activation.

Smith FJ, Pau VP, Cingolani G, Rothberg BS.

Structure. 2012 Dec 5;20(12):2038-47. doi: 10.1016/j.str.2012.09.014. Epub 2012 Oct 18.


The BK channel: a vital link between cellular calcium and electrical signaling.

Rothberg BS.

Protein Cell. 2012 Dec;3(12):883-92. doi: 10.1007/s13238-012-2076-8. Epub 2012 Sep 21. Review.


STIM proteins: dynamic calcium signal transducers.

Soboloff J, Rothberg BS, Madesh M, Gill DL.

Nat Rev Mol Cell Biol. 2012 Sep;13(9):549-65. doi: 10.1038/nrm3414. Review.


Structure and function of multiple Ca2+-binding sites in a K+ channel regulator of K+ conductance (RCK) domain.

Pau VP, Smith FJ, Taylor AB, Parfenova LV, Samakai E, Callaghan MM, Abarca-Heidemann K, Hart PJ, Rothberg BS.

Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17684-9. doi: 10.1073/pnas.1107229108. Epub 2011 Oct 12.


Voltage-dependent inactivation gating at the selectivity filter of the MthK K+ channel.

Thomson AS, Rothberg BS.

J Gen Physiol. 2010 Nov;136(5):569-79. doi: 10.1085/jgp.201010507. Epub 2010 Oct 11.


Allosteric mechanism of Ca2+ activation and H+-inhibited gating of the MthK K+ channel.

Pau VP, Abarca-Heidemann K, Rothberg BS.

J Gen Physiol. 2010 May;135(5):509-26. doi: 10.1085/jgp.200910387.


Bimane fluorescence scanning suggests secondary structure near the S3-S4 linker of BK channels.

Semenova NP, Abarca-Heidemann K, Loranc E, Rothberg BS.

J Biol Chem. 2009 Apr 17;284(16):10684-93. doi: 10.1074/jbc.M808891200. Epub 2009 Feb 25.


Mechanism of increased BK channel activation from a channel mutation that causes epilepsy.

Wang B, Rothberg BS, Brenner R.

J Gen Physiol. 2009 Mar;133(3):283-94. doi: 10.1085/jgp.200810141. Epub 2009 Feb 9.


Return of the electric binding site.

Rothberg BS.

J Gen Physiol. 2008 Nov;132(5):487-9. doi: 10.1085/jgp.200810135. No abstract available.


Molecular architecture and divalent cation activation of TvoK, a prokaryotic potassium channel.

Parfenova LV, Abarca-Heidemann K, Crane BM, Rothberg BS.

J Biol Chem. 2007 Aug 17;282(33):24302-9. Epub 2007 Jun 22.


A role for the S0 transmembrane segment in voltage-dependent gating of BK channels.

Koval OM, Fan Y, Rothberg BS.

J Gen Physiol. 2007 Mar;129(3):209-20. Epub 2007 Feb 12.


Modulation of MthK potassium channel activity at the intracellular entrance to the pore.

Parfenova LV, Crane BM, Rothberg BS.

J Biol Chem. 2006 Jul 28;281(30):21131-8. Epub 2006 May 25.


Mechanism of beta4 subunit modulation of BK channels.

Wang B, Rothberg BS, Brenner R.

J Gen Physiol. 2006 Apr;127(4):449-65.


Allosteric modulation of ion channels: the case of maxi-K.

Rothberg BS.

Sci STKE. 2004 Mar 30;2004(227):pe16. Review.


Inactivation in HCN channels results from reclosure of the activation gate: desensitization to voltage.

Shin KS, Maertens C, Proenza C, Rothberg BS, Yellen G.

Neuron. 2004 Mar 4;41(5):737-44.


Movements near the gate of a hyperpolarization-activated cation channel.

Rothberg BS, Shin KS, Yellen G.

J Gen Physiol. 2003 Nov;122(5):501-10. Epub 2003 Oct 13.


Voltage-controlled gating at the intracellular entrance to a hyperpolarization-activated cation channel.

Rothberg BS, Shin KS, Phale PS, Yellen G.

J Gen Physiol. 2002 Jan;119(1):83-91.


Testing for detailed balance (microscopic reversibility in ion channel gating.

Rothberg BS, Magleby KL.

Biophys J. 2001 Jun;80(6):3025-6. No abstract available.


Gating kinetics of single large-conductance Ca2+-activated K+ channels in high Ca2+ suggest a two-tiered allosteric gating mechanism.

Rothberg BS, Magleby KL.

J Gen Physiol. 1999 Jul;114(1):93-124. Erratum in: J Gen Physiol 1999 Aug;114(2):337.


Investigating single-channel gating mechanisms through analysis of two-dimensional dwell-time distributions.

Rothberg BS, Magleby KL.

Methods Enzymol. 1998;293:437-56. No abstract available.


Long-term effects of chronic ethanol on muscarinic receptor binding in rat brain.

Rothberg BS, Hunter BE, Walker DW, Anderson JF, Anderson KJ.

Alcohol Clin Exp Res. 1996 Dec;20(9):1613-7.


Chronic ethanol treatment differentially affects muscarinic receptor responses in rat hippocampus.

Rothberg BS, Hunter BE.

Neurosci Lett. 1991 Nov 11;132(2):243-6.


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