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Items: 1 to 50 of 159

1.

Small Heat Shock Proteins, Amyloid Fibrils, and Nicotine Stimulate a Common Immune Suppressive Pathway with Implications for Future Therapies.

Rothbard JB, Kurnellas MP, Ousman SS, Brownell S, Rothbard JJ, Steinman L.

Cold Spring Harb Perspect Med. 2019 Jul 1;9(7). pii: a034223. doi: 10.1101/cshperspect.a034223. Review.

PMID:
30249602
2.

An amyloidogenic hexapeptide derived from amylin attenuates inflammation and acute lung injury in murine sepsis.

Mahapatra S, Ying L, Ho PP, Kurnellas M, Rothbard J, Steinman L, Cornfield DN.

PLoS One. 2018 Jul 10;13(7):e0199206. doi: 10.1371/journal.pone.0199206. eCollection 2018.

3.

Identification of a common immune regulatory pathway induced by small heat shock proteins, amyloid fibrils, and nicotine.

Rothbard JB, Rothbard JJ, Soares L, Fathman CG, Steinman L.

Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):7081-7086. doi: 10.1073/pnas.1804599115. Epub 2018 Jun 18.

4.

Genetic background modulates outcome of therapeutic amyloid peptides in treatment of neuroinflammation.

Kraus A, Race B, Phillips K, Winkler C, Saturday G, Kurnellas M, Rothbard JB, Groveman BR, Steinman L, Caughey B.

J Neuroimmunol. 2016 Sep 15;298:42-50. doi: 10.1016/j.jneuroim.2016.06.010. Epub 2016 Jun 27.

PMID:
27609274
5.

Amyloid fibrils activate B-1a lymphocytes to ameliorate inflammatory brain disease.

Kurnellas MP, Ghosn EE, Schartner JM, Baker J, Rothbard JJ, Negrin RS, Herzenberg LA, Fathman CG, Steinman L, Rothbard JB.

Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15016-23. doi: 10.1073/pnas.1521206112. Epub 2015 Nov 30.

6.

Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2.

Ahmed SS, Volkmuth W, Duca J, Corti L, Pallaoro M, Pezzicoli A, Karle A, Rigat F, Rappuoli R, Narasimhan V, Julkunen I, Vuorela A, Vaarala O, Nohynek H, Pasini FL, Montomoli E, Trombetta C, Adams CM, Rothbard J, Steinman L.

Sci Transl Med. 2015 Jul 1;7(294):294ra105. doi: 10.1126/scitranslmed.aab2354.

PMID:
26136476
7.

Self-Assembling Peptides Form Immune Suppressive Amyloid Fibrils Effective in Autoimmune Encephalomyelitis.

Kurnellas MP, Rothbard JB, Steinman L.

Curr Top Behav Neurosci. 2015;26:221-32. doi: 10.1007/7854_2015_377. Review.

PMID:
25981913
8.

Mechanisms of action of therapeutic amyloidogenic hexapeptides in amelioration of inflammatory brain disease.

Kurnellas MP, Schartner JM, Fathman CG, Jagger A, Steinman L, Rothbard JB.

J Exp Med. 2014 Aug 25;211(9):1847-56. doi: 10.1084/jem.20140107. Epub 2014 Jul 29.

9.

Janus faces of amyloid proteins in neuroinflammation.

Steinman L, Rothbard JB, Kurnellas MP.

J Clin Immunol. 2014 Jul;34 Suppl 1:S61-3. doi: 10.1007/s10875-014-0034-3. Epub 2014 Apr 8. Review.

10.

CRYAB modulates the activation of CD4+ T cells from relapsing-remitting multiple sclerosis patients.

Quach QL, Metz LM, Thomas JC, Rothbard JB, Steinman L, Ousman SS.

Mult Scler. 2013 Dec;19(14):1867-77. doi: 10.1177/1352458513489853. Epub 2013 Jun 4.

PMID:
23736536
11.

Amyloid fibrils composed of hexameric peptides attenuate neuroinflammation.

Kurnellas MP, Adams CM, Sobel RA, Steinman L, Rothbard JB.

Sci Transl Med. 2013 Apr 3;5(179):179ra42. doi: 10.1126/scitranslmed.3005681.

12.

Piet Mondrian's trees and the evolution in understanding multiple sclerosis, Charcot Prize Lecture 2011.

Steinman L, Axtell RC, Barbieri D, Bhat R, Brownell SE, de Jong BA, Dunn SE, Grant JL, Han MH, Ho PP, Kuipers HF, Kurnellas MP, Ousman SS, Rothbard JB.

Mult Scler. 2013 Jan;19(1):5-14. doi: 10.1177/1352458512470730.

PMID:
23303879
13.

Chaperone activity of small heat shock proteins underlies therapeutic efficacy in experimental autoimmune encephalomyelitis.

Kurnellas MP, Brownell SE, Su L, Malkovskiy AV, Rajadas J, Dolganov G, Chopra S, Schoolnik GK, Sobel RA, Webster J, Ousman SS, Becker RA, Steinman L, Rothbard JB.

J Biol Chem. 2012 Oct 19;287(43):36423-34. doi: 10.1074/jbc.M112.371229. Epub 2012 Sep 6.

14.

Therapeutic effects of systemic administration of chaperone αB-crystallin associated with binding proinflammatory plasma proteins.

Rothbard JB, Kurnellas MP, Brownell S, Adams CM, Su L, Axtell RC, Chen R, Fathman CG, Robinson WH, Steinman L.

J Biol Chem. 2012 Mar 23;287(13):9708-21. doi: 10.1074/jbc.M111.337691. Epub 2012 Feb 3.

15.

Systemic augmentation of alphaB-crystallin provides therapeutic benefit twelve hours post-stroke onset via immune modulation.

Arac A, Brownell SE, Rothbard JB, Chen C, Ko RM, Pereira MP, Albers GW, Steinman L, Steinberg GK.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13287-92. doi: 10.1073/pnas.1107368108. Epub 2011 Jul 26.

16.

αB-crystallin improves murine cardiac function and attenuates apoptosis in human endothelial cells exposed to ischemia-reperfusion.

Velotta JB, Kimura N, Chang SH, Chung J, Itoh S, Rothbard J, Yang PC, Steinman L, Robbins RC, Fischbein MP.

Ann Thorac Surg. 2011 Jun;91(6):1907-13. doi: 10.1016/j.athoracsur.2011.02.072.

PMID:
21619989
17.

Chaperone activity of α B-crystallin is responsible for its incorrect assignment as an autoantigen in multiple sclerosis.

Rothbard JB, Zhao X, Sharpe O, Strohman MJ, Kurnellas M, Mellins ED, Robinson WH, Steinman L.

J Immunol. 2011 Apr 1;186(7):4263-8. doi: 10.4049/jimmunol.1003934. Epub 2011 Feb 25.

18.

Quantitation of cellular and topical uptake of luciferin-oligoarginine conjugates.

Rothbard JB, Jones LR.

Methods Mol Biol. 2011;683:487-504. doi: 10.1007/978-1-60761-919-2_35.

PMID:
21053152
19.

Binding of biotinylated peptides to MHC class II proteins on cell surfaces.

Rothbard JB, Busch R.

Curr Protoc Immunol. 2001 May;Chapter 18:Unit 18.1. doi: 10.1002/0471142735.im1801s25.

PMID:
18432744
20.

Real-time analysis of uptake and bioactivatable cleavage of luciferin-transporter conjugates in transgenic reporter mice.

Wender PA, Goun EA, Jones LR, Pillow TH, Rothbard JB, Shinde R, Contag CH.

Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10340-5. Epub 2007 Jun 11.

21.

Molecular transporters: synthesis of oligoguanidinium transporters and their application to drug delivery and real-time imaging.

Goun EA, Pillow TH, Jones LR, Rothbard JB, Wender PA.

Chembiochem. 2006 Oct;7(10):1497-515. Review. No abstract available.

PMID:
16972294
22.

Releasable luciferin-transporter conjugates: tools for the real-time analysis of cellular uptake and release.

Jones LR, Goun EA, Shinde R, Rothbard JB, Contag CH, Wender PA.

J Am Chem Soc. 2006 May 24;128(20):6526-7.

PMID:
16704230
23.

The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides. 1986.

Townsend AR, Rothbard J, Gotch FM, Bahadur G, Wraith D, McMichael AJ.

J Immunol. 2006 May 1;176(9):5141-50. No abstract available.

24.

Dendrimeric molecular transporters: synthesis and evaluation of tunable polyguanidino dendrimers that facilitate cellular uptake.

Wender PA, Kreider E, Pelkey ET, Rothbard J, Vandeusen CL.

Org Lett. 2005 Oct 27;7(22):4815-8.

PMID:
16235896
25.

Adaptive translocation: the role of hydrogen bonding and membrane potential in the uptake of guanidinium-rich transporters into cells.

Rothbard JB, Jessop TC, Wender PA.

Adv Drug Deliv Rev. 2005 Feb 28;57(4):495-504. Epub 2005 Jan 11. Review.

PMID:
15722160
26.

Role of membrane potential and hydrogen bonding in the mechanism of translocation of guanidinium-rich peptides into cells.

Rothbard JB, Jessop TC, Lewis RS, Murray BA, Wender PA.

J Am Chem Soc. 2004 Aug 11;126(31):9506-7.

PMID:
15291531
27.

Delivery of antimicrobials into parasites.

Samuel BU, Hearn B, Mack D, Wender P, Rothbard J, Kirisits MJ, Mui E, Wernimont S, Roberts CW, Muench SP, Rice DW, Prigge ST, Law AB, McLeod R.

Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14281-6. Epub 2003 Nov 17.

28.

L-Arginine polymers enhance coronary flow and reduce oxidative stress following cardiac transplantation in rats.

Kown MH, Lijkwan MA, Jahncke CL, Murata S, Rothbard JB, Robbins RC.

J Thorac Cardiovasc Surg. 2003 Oct;126(4):1065-70.

29.

Arginine-based molecular transporters: the synthesis and chemical evaluation of releasable taxol-transporter conjugates.

Kirschberg TA, VanDeusen CL, Rothbard JB, Yang M, Wender PA.

Org Lett. 2003 Sep 18;5(19):3459-62.

PMID:
12967299
30.

Guanidinium rich peptide transporters and drug delivery.

Wright LR, Rothbard JB, Wender PA.

Curr Protein Pept Sci. 2003 Apr;4(2):105-24. Review.

PMID:
12678850
31.

Short polymers of arginine rapidly translocate into vascular cells: effects on nitric oxide synthesis.

Uemura S, Rothbard JB, Matsushita H, Tsao PS, Fathman CG, Cooke JP.

Circ J. 2002 Dec;66(12):1155-60.

32.

Oligocarbamate molecular transporters: design, synthesis, and biological evaluation of a new class of transporters for drug delivery.

Wender PA, Rothbard JB, Jessop TC, Kreider EL, Wylie BL.

J Am Chem Soc. 2002 Nov 13;124(45):13382-3.

PMID:
12418880
33.

Arginine-rich molecular transporters for drug delivery: role of backbone spacing in cellular uptake.

Rothbard JB, Kreider E, VanDeusen CL, Wright L, Wylie BL, Wender PA.

J Med Chem. 2002 Aug 15;45(17):3612-8.

PMID:
12166934
34.

L-arginine polymer mediated inhibition of graft coronary artery disease after cardiac transplantation.

Kown MH, van Der Steenhoven T, Uemura S, Jahncke CL, Hoyt GE, Rothbard JB, Robbins RC.

Transplantation. 2001 Jun 15;71(11):1542-8.

PMID:
11435962
35.

L-arginine polymers inhibit the development of vein graft neointimal hyperplasia.

Kown MH, Yamaguchi A, Jahncke CL, Miniati D, Murata S, Grunenfelder J, Koransky ML, Rothbard JB, Robbins RC.

J Thorac Cardiovasc Surg. 2001 May;121(5):971-80.

36.

Polyarginine enters cells more efficiently than other polycationic homopolymers.

Mitchell DJ, Kim DT, Steinman L, Fathman CG, Rothbard JB.

J Pept Res. 2000 Nov;56(5):318-25.

PMID:
11095185
37.

The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters.

Wender PA, Mitchell DJ, Pattabiraman K, Pelkey ET, Steinman L, Rothbard JB.

Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13003-8.

38.

Rapid and efficient vascular transport of arginine polymers inhibits myointimal hyperplasia.

Uemura S, Fathman CG, Rothbard JB, Cooke JP.

Circulation. 2000 Nov 21;102(21):2629-35.

PMID:
11085967
39.

Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation.

Rothbard JB, Garlington S, Lin Q, Kirschberg T, Kreider E, McGrane PL, Wender PA, Khavari PA.

Nat Med. 2000 Nov;6(11):1253-7.

PMID:
11062537
40.

Alcohol and the marriage effect.

Leonard KE, Rothbard JC.

J Stud Alcohol Suppl. 1999 Mar;13:139-46. Review.

PMID:
10225498
41.

Definition of MHC and T cell receptor contacts in the HLA-DR4restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice.

Andersson EC, Hansen BE, Jacobsen H, Madsen LS, Andersen CB, Engberg J, Rothbard JB, McDevitt GS, Malmström V, Holmdahl R, Svejgaard A, Fugger L.

Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7574-9.

42.

Introduction of soluble proteins into the MHC class I pathway by conjugation to an HIV tat peptide.

Kim DT, Mitchell DJ, Brockstedt DG, Fong L, Nolan GP, Fathman CG, Engleman EG, Rothbard JB.

J Immunol. 1997 Aug 15;159(4):1666-8.

PMID:
9257826
43.

Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401.

Wicker LS, Chen SL, Nepom GT, Elliott JF, Freed DC, Bansal A, Zheng S, Herman A, Lernmark A, Zaller DM, Peterson LB, Rothbard JB, Cummings R, Whiteley PJ.

J Clin Invest. 1996 Dec 1;98(11):2597-603.

44.

Quantitative analysis of T cell activation: role of TCR/ligand density and TCR affinity.

Kim DT, Rothbard JB, Bloom DD, Fathman CG.

J Immunol. 1996 Apr 15;156(8):2737-42.

PMID:
8609391
45.

Specificity of an HLA-DRB1*0401-restricted T cell response to type II collagen.

Fugger L, Rothbard JB, Sonderstrup-McDevitt G.

Eur J Immunol. 1996 Apr;26(4):928-33.

PMID:
8625990
47.

Differential stability of HLA-DR alleles independent of endogenous peptides.

Devaux B, Wilson KJ, Aguilar B, Jorgensen B, Rothbard JB.

J Immunol. 1995 Aug 15;155(4):1921-9.

PMID:
7636243
48.

Prediction of peptide affinity to HLA DRB1*0401.

Marshall KW, Wilson KJ, Liang J, Woods A, Zaller D, Rothbard JB.

J Immunol. 1995 Jun 1;154(11):5927-33.

PMID:
7751636
49.

Specific T cell recognition of minimally homologous peptides: evidence for multiple endogenous ligands.

Evavold BD, Sloan-Lancaster J, Wilson KJ, Rothbard JB, Allen PM.

Immunity. 1995 Jun;2(6):655-63.

50.

Characterization of epitopes recognized by hapten-specific CD4+ T cells.

Cavani A, Hackett CJ, Wilson KJ, Rothbard JB, Katz SI.

J Immunol. 1995 Feb 1;154(3):1232-8.

PMID:
7529797

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