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Single-fluorophore biosensors for sensitive and multiplexed detection of signalling activities.

Mehta S, Zhang Y, Roth RH, Zhang JF, Mo A, Tenner B, Huganir RL, Zhang J.

Nat Cell Biol. 2018 Oct;20(10):1215-1225. doi: 10.1038/s41556-018-0200-6. Epub 2018 Sep 24.


Cognitive performance of juvenile monkeys after chronic fluoxetine treatment.

Golub MS, Hackett EP, Hogrefe CE, Leranth C, Elsworth JD, Roth RH.

Dev Cogn Neurosci. 2017 Aug;26:52-61. doi: 10.1016/j.dcn.2017.04.008. Epub 2017 May 1.


Dynamic imaging of AMPA receptor trafficking in vitro and in vivo.

Roth RH, Zhang Y, Huganir RL.

Curr Opin Neurobiol. 2017 Aug;45:51-58. doi: 10.1016/j.conb.2017.03.008. Epub 2017 Apr 12. Review.


Homer1a drives homeostatic scaling-down of excitatory synapses during sleep.

Diering GH, Nirujogi RS, Roth RH, Worley PF, Pandey A, Huganir RL.

Science. 2017 Feb 3;355(6324):511-515. doi: 10.1126/science.aai8355. Epub 2017 Feb 2.


Synaptic Organization of the Neuronal Circuits of the Claustrum.

Kim J, Matney CJ, Roth RH, Brown SP.

J Neurosci. 2016 Jan 20;36(3):773-84. doi: 10.1523/JNEUROSCI.3643-15.2016.


A potential compensatory role for endogenous striatal tyrosine hydroxylase-positive neurons in a nonhuman primate model of Parkinson's disease.

Bubak AN, Redmond DE Jr, Elsworth JD, Roth RH, Collier TJ, Bjugstad KB, Blanchard BC, Sladek JR Jr.

Cell Transplant. 2015;24(4):673-80. doi: 10.3727/096368915X687741. Epub 2015 Mar 24.


Low circulating levels of bisphenol-A induce cognitive deficits and loss of asymmetric spine synapses in dorsolateral prefrontal cortex and hippocampus of adult male monkeys.

Elsworth JD, Jentsch JD, Groman SM, Roth RH, Redmond ED Jr, Leranth C.

J Comp Neurol. 2015 Jun 1;523(8):1248-57. doi: 10.1002/cne.23735. Epub 2015 Feb 17.


Primate phencyclidine model of schizophrenia: sex-specific effects on cognition, brain derived neurotrophic factor, spine synapses, and dopamine turnover in prefrontal cortex.

Elsworth JD, Groman SM, Jentsch JD, Leranth C, Redmond DE Jr, Kim JD, Diano S, Roth RH.

Int J Neuropsychopharmacol. 2014 Oct 31;18(6). pii: pyu048. doi: 10.1093/ijnp/pyu048.


In the blink of an eye: relating positive-feedback sensitivity to striatal dopamine D2-like receptors through blink rate.

Groman SM, James AS, Seu E, Tran S, Clark TA, Harpster SN, Crawford M, Burtner JL, Feiler K, Roth RH, Elsworth JD, London ED, Jentsch JD.

J Neurosci. 2014 Oct 22;34(43):14443-54. doi: 10.1523/JNEUROSCI.3037-14.2014.


Pregnancy, a risky time: keep calm, clean, and carry on!

Elsworth JD, Roth RH.

Biol Psychiatry. 2013 Oct 1;74(7):478-9. doi: 10.1016/j.biopsych.2013.07.027. No abstract available.


Comparison of fetal mesencephalic grafts, AAV-delivered GDNF, and both combined in an MPTP-induced nonhuman primate Parkinson's model.

Redmond DE Jr, McEntire CR, Kingsbery JP, Leranth C, Elsworth JD, Bjugstad KB, Roth RH, Samulski RJ, Sladek JR Jr.

Mol Ther. 2013 Dec;21(12):2160-8. doi: 10.1038/mt.2013.180. Epub 2013 Aug 5.


Survival and integration of neurons derived from human embryonic stem cells in MPTP-lesioned primates.

Wakeman DR, Weiss S, Sladek JR, Elsworth JD, Bauereis B, Leranth C, Hurley PJ, Roth RH, Redmond DE.

Cell Transplant. 2014;23(8):981-94. doi: 10.3727/096368913X664865. Epub 2013 Apr 2.


Coordinated expression of dopamine transporter and vesicular monoamine transporter in the primate striatum during development.

Elsworth JD, Redmond DE Jr, Roth RH.

Synapse. 2013 Sep;67(9):580-5. doi: 10.1002/syn.21662. Epub 2013 Apr 18.


Prenatal exposure to bisphenol A impacts midbrain dopamine neurons and hippocampal spine synapses in non-human primates.

Elsworth JD, Jentsch JD, Vandevoort CA, Roth RH, Redmond DE Jr, Leranth C.

Neurotoxicology. 2013 Mar;35:113-20. doi: 10.1016/j.neuro.2013.01.001. Epub 2013 Jan 18.


Loss of asymmetric spine synapses in prefrontal cortex of motor-asymptomatic, dopamine-depleted, cognitively impaired MPTP-treated monkeys.

Elsworth JD, Leranth C, Redmond DE Jr, Roth RH.

Int J Neuropsychopharmacol. 2013 May;16(4):905-12. doi: 10.1017/S1461145712000892. Epub 2012 Sep 4.


Susceptibility to a parkinsonian toxin varies during primate development.

Morrow BA, Roth RH, Redmond DE Jr, Diano S, Elsworth JD.

Exp Neurol. 2012 May;235(1):273-81. doi: 10.1016/j.expneurol.2012.02.005. Epub 2012 Feb 14.


MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function.

Miller BH, Zeier Z, Xi L, Lanz TA, Deng S, Strathmann J, Willoughby D, Kenny PJ, Elsworth JD, Lawrence MS, Roth RH, Edbauer D, Kleiman RJ, Wahlestedt C.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3125-30. doi: 10.1073/pnas.1113793109. Epub 2012 Feb 6.


Asenapine effects on cognitive and monoamine dysfunction elicited by subchronic phencyclidine administration.

Elsworth JD, Groman SM, Jentsch JD, Valles R, Shahid M, Wong E, Marston H, Roth RH.

Neuropharmacology. 2012 Mar;62(3):1442-52. doi: 10.1016/j.neuropharm.2011.08.026. Epub 2011 Aug 23.


Loss of asymmetric spine synapses in dorsolateral prefrontal cortex of cognitively impaired phencyclidine-treated monkeys.

Elsworth JD, Hajszan T, Leranth C, Roth RH.

Int J Neuropsychopharmacol. 2011 Nov;14(10):1411-5. doi: 10.1017/S1461145711000939. Epub 2011 Jun 27.


Reduced locomotor responses to cocaine in ghrelin-deficient mice.

Abizaid A, Mineur YS, Roth RH, Elsworth JD, Sleeman MW, Picciotto MR, Horvath TL.

Neuroscience. 2011 Sep 29;192:500-6. doi: 10.1016/j.neuroscience.2011.06.001. Epub 2011 Jun 12.


Phencyclidine-induced loss of asymmetric spine synapses in rodent prefrontal cortex is reversed by acute and chronic treatment with olanzapine.

Elsworth JD, Morrow BA, Hajszan T, Leranth C, Roth RH.

Neuropsychopharmacology. 2011 Sep;36(10):2054-61. doi: 10.1038/npp.2011.96. Epub 2011 Jun 15.


Impact of methamphetamine on dopamine neurons in primates is dependent on age: implications for development of Parkinson's disease.

Morrow BA, Roth RH, Redmond DE, Elsworth JD.

Neuroscience. 2011 Aug 25;189:277-85. doi: 10.1016/j.neuroscience.2011.05.046. Epub 2011 Jun 1.


Aged monkeys as a partial model for Parkinson's disease.

Hurley PJ, Elsworth JD, Whittaker MC, Roth RH, Redmond DE Jr.

Pharmacol Biochem Behav. 2011 Sep;99(3):324-32. doi: 10.1016/j.pbb.2011.05.007. Epub 2011 May 18.


GPA protects the nigrostriatal dopamine system by enhancing mitochondrial function.

Horvath TL, Erion DM, Elsworth JD, Roth RH, Shulman GI, Andrews ZB.

Neurobiol Dis. 2011 Jul;43(1):152-62. doi: 10.1016/j.nbd.2011.03.005. Epub 2011 Mar 13.


Cellular repair in the parkinsonian nonhuman primate brain.

Redmond DE Jr, Weiss S, Elsworth JD, Roth RH, Wakeman DR, Bjugstad KB, Collier TJ, Blanchard BC, Teng YD, Synder EY, Sladek JR Jr.

Rejuvenation Res. 2010 Apr-Jun;13(2-3):188-94. doi: 10.1089/rej.2009.0960. Review.


Comparative transduction efficiency of AAV vector serotypes 1-6 in the substantia nigra and striatum of the primate brain.

Markakis EA, Vives KP, Bober J, Leichtle S, Leranth C, Beecham J, Elsworth JD, Roth RH, Samulski RJ, Redmond DE Jr.

Mol Ther. 2010 Mar;18(3):588-93. doi: 10.1038/mt.2009.286. Epub 2009 Dec 15.


Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism.

Andrews ZB, Erion D, Beiler R, Liu ZW, Abizaid A, Zigman J, Elsworth JD, Savitt JM, DiMarchi R, Tschoep M, Roth RH, Gao XB, Horvath TL.

J Neurosci. 2009 Nov 11;29(45):14057-65. doi: 10.1523/JNEUROSCI.3890-09.2009.


Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non-human primate after overexpression of GDNF.

Redmond DE Jr, Elsworth JD, Roth RH, Leranth C, Collier TJ, Blanchard B, Bjugstad KB, Samulski RJ, Aebischer P, Sladek JR Jr.

J Comp Neurol. 2009 Jul 1;515(1):31-40. doi: 10.1002/cne.22028.


Clonidine and guanfacine attenuate phencyclidine-induced dopamine overflow in rat prefrontal cortex: mediating influence of the alpha-2A adrenoceptor subtype.

Jentsch JD, Sanchez D, Elsworth JD, Roth RH.

Brain Res. 2008 Dec 30;1246:41-6. doi: 10.1016/j.brainres.2008.10.006. Epub 2008 Oct 18.


Embryonic substantia nigra grafts show directional outgrowth to cografted striatal grafts and potential for pathway reconstruction in nonhuman primate.

Sladek JR Jr, Bjugstad KB, Collier TJ, Bundock EA, Blanchard BC, Elsworth JD, Roth RH, Redmond DE Jr.

Cell Transplant. 2008;17(4):427-44.


Human neural stem cells migrate along the nigrostriatal pathway in a primate model of Parkinson's disease.

Bjugstad KB, Teng YD, Redmond DE Jr, Elsworth JD, Roth RH, Cornelius SK, Snyder EY, Sladek JR Jr.

Exp Neurol. 2008 Jun;211(2):362-9. doi: 10.1016/j.expneurol.2008.01.025. Epub 2008 Feb 14.


AAV2-mediated gene transfer of GDNF to the striatum of MPTP monkeys enhances the survival and outgrowth of co-implanted fetal dopamine neurons.

Elsworth JD, Redmond DE Jr, Leranth C, Bjugstad KB, Sladek JR Jr, Collier TJ, Foti SB, Samulski RJ, Vives KP, Roth RH.

Exp Neurol. 2008 May;211(1):252-8. doi: 10.1016/j.expneurol.2008.01.026. Epub 2008 Feb 15.


Prenatal exposure to cocaine is associated with increased number of spine synapses in rat prelimbic cortex.

Morrow BA, Hajszan T, Leranth C, Elsworth JD, Roth RH.

Synapse. 2007 Oct;61(10):862-5.


Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells.

Redmond DE Jr, Bjugstad KB, Teng YD, Ourednik V, Ourednik J, Wakeman DR, Parsons XH, Gonzalez R, Blanchard BC, Kim SU, Gu Z, Lipton SA, Markakis EA, Roth RH, Elsworth JD, Sladek JR Jr, Sidman RL, Snyder EY.

Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12175-80. Epub 2007 Jun 22.


Prenatal cocaine exposure enhances responsivity of locus coeruleus norepinephrine neurons: role of autoreceptors.

Elsworth JD, Morrow BA, Nguyen VT, Mitra J, Picciotto MR, Roth RH.

Neuroscience. 2007 Jun 29;147(2):419-27. Epub 2007 Jun 1. Erratum in: Neuroscience. 2008 Oct 15;156(3):800.


Clozapine normalizes prefrontal cortex dopamine transmission in monkeys subchronically exposed to phencyclidine.

Elsworth JD, Jentsch JD, Morrow BA, Redmond DE Jr, Roth RH.

Neuropsychopharmacology. 2008 Feb;33(3):491-6. Epub 2007 May 16.


Apoptotic natural cell death in developing primate dopamine midbrain neurons occurs during a restricted period in the second trimester of gestation.

Morrow BA, Roth RH, Redmond DE Jr, Sladek JR Jr, Elsworth JD.

Exp Neurol. 2007 Apr;204(2):802-7. Epub 2007 Jan 19.


Repeated phencyclidine in monkeys results in loss of parvalbumin-containing axo-axonic projections in the prefrontal cortex.

Morrow BA, Elsworth JD, Roth RH.

Psychopharmacology (Berl). 2007 Jun;192(2):283-90. Epub 2007 Jan 30.


Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite.

Abizaid A, Liu ZW, Andrews ZB, Shanabrough M, Borok E, Elsworth JD, Roth RH, Sleeman MW, Picciotto MR, Tschöp MH, Gao XB, Horvath TL.

J Clin Invest. 2006 Dec;116(12):3229-39. Epub 2006 Oct 19.


Uncoupling protein-2 promotes nigrostriatal dopamine neuronal function.

Andrews ZB, Rivera A, Elsworth JD, Roth RH, Agnati L, Gago B, Abizaid A, Schwartz M, Fuxe K, Horvath TL.

Eur J Neurosci. 2006 Jul;24(1):32-6.


Subchronic phencyclidine treatment decreases the number of dendritic spine synapses in the rat prefrontal cortex.

Hajszan T, Leranth C, Roth RH.

Biol Psychiatry. 2006 Sep 15;60(6):639-44. Epub 2006 Jun 30.


Neural stem cells implanted into MPTP-treated monkeys increase the size of endogenous tyrosine hydroxylase-positive cells found in the striatum: a return to control measures.

Bjugstad KB, Redmond DE Jr, Teng YD, Elsworth JD, Roth RH, Blanchard BC, Snyder EY, Sladek JR Jr.

Cell Transplant. 2005;14(4):183-92.


Development of A9/A10 dopamine neurons during the second and third trimesters in the African green monkey.

Morrow BA, Redmond DE Jr, Roth RH, Elsworth JD.

J Comp Neurol. 2005 Jul 25;488(2):215-23.


Alpha-2 adrenoceptor activation inhibits phencyclidine-induced deficits of spatial working memory in rats.

Marrs W, Kuperman J, Avedian T, Roth RH, Jentsch JD.

Neuropsychopharmacology. 2005 Aug;30(8):1500-10.


Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease.

Andrews ZB, Horvath B, Barnstable CJ, Elsworth J, Yang L, Beal MF, Roth RH, Matthews RT, Horvath TL.

J Neurosci. 2005 Jan 5;25(1):184-91. Erratum in: J Neurosci. 2005 Feb 23;25(8):table of contents.


Spatiotemporal patterns of gene expression during fetal monkey brain development.

Redmond DE Jr, Zhao JL, Randall JD, Eklund AC, Eusebi LO, Roth RH, Gullans SR, Jensen RV.

Brain Res Dev Brain Res. 2003 Dec 19;146(1-2):99-106.


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