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Phase II Studies with Refametinib or Refametinib plus Sorafenib in Patients with RAS-mutated Hepatocellular Carcinoma.

Lim HY, Merle P, Weiss KH, Yau TC, Ross P, Mazzaferro V, Blanc JF, Ma YT, Yen CJ, Kocsis J, Choo SP, Sukeepaisarnjaroen W, Gérolami R, Dufour JF, Gane E, Ryoo BY, Peck-Radosavljevic M, Dao T, Yeo W, Lamlertthon W, Thongsawat S, Teufel M, Roth K, Reis D, Childs BH, Krissel H, Llovet JM.

Clin Cancer Res. 2018 Jun 27. pii: clincanres.3588.2017. doi: 10.1158/1078-0432.CCR-17-3588. [Epub ahead of print]


Tasting the Tree of Life: Development of a Collaborative, Cross-Campus, Science Outreach Meal Event.

Clement WL, Elliott KT, Cordova-Hoyos O, Distefano I, Kearns K, Kumar R, Leto A, Tumaliuan J, Franchetti L, Kulesza E, Tineo N, Mendes P, Roth K, Osborn JM.

J Microbiol Biol Educ. 2018 Mar 30;19(1). pii: 19.1.27. doi: 10.1128/jmbe.v19i1.1408. eCollection 2018.


Assessing nontechnical skills in otolaryngology emergencies through simulation-based training.

Wu KY, Kim S, Fung K, Roth K.

Laryngoscope. 2018 Mar 24. doi: 10.1002/lary.27174. [Epub ahead of print]


The Development of Attentional Biases for Faces in Infancy: A Developmental Systems Perspective.

Reynolds GD, Roth KC.

Front Psychol. 2018 Feb 28;9:222. doi: 10.3389/fpsyg.2018.00222. eCollection 2018. Review.


RESPIRE 2: a phase III placebo-controlled randomised trial of ciprofloxacin dry powder for inhalation in non-cystic fibrosis bronchiectasis.

Aksamit T, De Soyza A, Bandel TJ, Criollo M, Elborn JS, Operschall E, Polverino E, Roth K, Winthrop KL, Wilson R.

Eur Respir J. 2018 Jan 25;51(1). pii: 1702053. doi: 10.1183/13993003.02053-2017. Print 2018 Jan.


RESPIRE 1: a phase III placebo-controlled randomised trial of ciprofloxacin dry powder for inhalation in non-cystic fibrosis bronchiectasis.

De Soyza A, Aksamit T, Bandel TJ, Criollo M, Elborn JS, Operschall E, Polverino E, Roth K, Winthrop KL, Wilson R.

Eur Respir J. 2018 Jan 25;51(1). pii: 1702052. doi: 10.1183/13993003.02052-2017. Print 2018 Jan.


Diurnal pattern in skin Na+ and water content is associated with salt-sensitive hypertension in ETB receptor-deficient rats.

Speed JS, Hyndman KA, Kasztan M, Johnston JG, Roth KJ, Titze JM, Pollock DM.

Am J Physiol Regul Integr Comp Physiol. 2018 Apr 1;314(4):R544-R551. doi: 10.1152/ajpregu.00312.2017. Epub 2017 Dec 13.


Multiple breath washout testing in adults with pulmonary disease and healthy controls - can fewer measurements eventually be more?

Trinkmann F, Götzmann J, Saur D, Schroeter M, Roth K, Stach K, Borggrefe M, Saur J, Akin I, Michels JD.

BMC Pulm Med. 2017 Dec 11;17(1):185. doi: 10.1186/s12890-017-0543-y.


Advances in Serodiagnostic Testing for Lyme Disease Are at Hand.

Branda JA, Body BA, Boyle J, Branson BM, Dattwyler RJ, Fikrig E, Gerald NJ, Gomes-Solecki M, Kintrup M, Ledizet M, Levin AE, Lewinski M, Liotta LA, Marques A, Mead PS, Mongodin EF, Pillai S, Rao P, Robinson WH, Roth KM, Schriefer ME, Slezak T, Snyder J, Steere AC, Witkowski J, Wong SJ, Schutzer SE.

Clin Infect Dis. 2018 Mar 19;66(7):1133-1139. doi: 10.1093/cid/cix943.


Bacterial Community Dynamics in Dichloromethane-Contaminated Groundwater Undergoing Natural Attenuation.

Wright J, Kirchner V, Bernard W, Ulrich N, McLimans C, Campa MF, Hazen T, Macbeth T, Marabello D, McDermott J, Mackelprang R, Roth K, Lamendella R.

Front Microbiol. 2017 Nov 22;8:2300. doi: 10.3389/fmicb.2017.02300. eCollection 2017.


Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model.

Fales KR, Njoroge FG, Brooks HB, Thibodeaux S, Torrado A, Si C, Toth JL, Mc Cowan JR, Roth KD, Thrasher KJ, Frimpong K, Lee MR, Dally RD, Shepherd TA, Durham TB, Margolis BJ, Wu Z, Wang Y, Atwell S, Wang J, Hui YH, Meier TI, Konicek SA, Geeganage S.

J Med Chem. 2017 Dec 14;60(23):9599-9616. doi: 10.1021/acs.jmedchem.7b01046. Epub 2017 Nov 9.


Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL.

Karpel-Massler G, Ishida CT, Bianchetti E, Zhang Y, Shu C, Tsujiuchi T, Banu MA, Garcia F, Roth KA, Bruce JN, Canoll P, Siegelin MD.

Nat Commun. 2017 Oct 20;8(1):1067. doi: 10.1038/s41467-017-00984-9.


Discovery of a Highly Selective NAMPT Inhibitor That Demonstrates Robust Efficacy and Improved Retinal Toxicity with Nicotinic Acid Coadministration.

Zhao G, Green CF, Hui YH, Prieto L, Shepard R, Dong S, Wang T, Tan B, Gong X, Kays L, Johnson RL, Wu W, Bhattachar S, Del Prado M, Gillig JR, Fernandez MC, Roth KD, Buchanan S, Kuo MS, Geeganage S, Burkholder TP.

Mol Cancer Ther. 2017 Dec;16(12):2677-2688. doi: 10.1158/1535-7163.MCT-16-0674. Epub 2017 Oct 20.


Neural correlates of individuation and categorization of other-species faces in infancy.

Dixon KC, Reynolds GD, Romano AC, Roth KC, Stumpe AL, Guy MW, Mosteller SM.

Neuropsychologia. 2017 Oct 3. pii: S0028-3932(17)30369-X. doi: 10.1016/j.neuropsychologia.2017.09.037. [Epub ahead of print]


High dietary sodium causes dyssynchrony of the renal molecular clock in rats.

Speed JS, Hyndman KA, Roth K, Heimlich JB, Kasztan M, Fox BM, Johnston JG, Becker BK, Jin C, Gamble KL, Young ME, Pollock JS, Pollock DM.

Am J Physiol Renal Physiol. 2018 Jan 1;314(1):F89-F98. doi: 10.1152/ajprenal.00028.2017. Epub 2017 Sep 27.


Implementation and utilization of the molecular tumor board to guide precision medicine.

Harada S, Arend R, Dai Q, Levesque JA, Winokur TS, Guo R, Heslin MJ, Nabell L, Nabors LB, Limdi NA, Roth KA, Partridge EE, Siegal GP, Yang ES.

Oncotarget. 2017 Jun 14;8(34):57845-57854. doi: 10.18632/oncotarget.18471. eCollection 2017 Aug 22. Review.


Factors determining outcome of corrective osteotomy for malunited paediatric forearm fractures: a systematic review and meta-analysis.

Roth KC, Walenkamp MMJ, van Geenen RCI, Reijman M, Verhaar JAN, Colaris JW.

J Hand Surg Eur Vol. 2017 Oct;42(8):810-816. doi: 10.1177/1753193417711684. Epub 2017 Jun 15. Review.


Assessing the impact of the introduction of an electronic hospital discharge system on the completeness and timeliness of discharge communication: a before and after study.

Mehta RL, Baxendale B, Roth K, Caswell V, Le Jeune I, Hawkins J, Zedan H, Avery AJ.

BMC Health Serv Res. 2017 Sep 5;17(1):624. doi: 10.1186/s12913-017-2579-3.


Overcoming barriers to levonorgestrel-releasing intrauterine system placement: an evaluation of placement of LNG-IUS 8 using the modified EvoInserter® in a majority nulliparous population.

Gemzell-Danielsson K, Apter D, Lukkari-Lax E, Roth K, Serrani M.

Contraception. 2017 Dec;96(6):426-431. doi: 10.1016/j.contraception.2017.08.004. Epub 2017 Aug 24.


Homo- and heteropolymer self-assembly of recombinant trichocytic keratins.

Parker RN, Roth KL, Kim C, McCord JP, Van Dyke ME, Grove TZ.

Biopolymers. 2017 Oct;107(10). doi: 10.1002/bip.23037. Epub 2017 Jul 24.


Emergence of robustness in networks of networks.

Roth K, Morone F, Min B, Makse HA.

Phys Rev E. 2017 Jun;95(6-1):062308. doi: 10.1103/PhysRevE.95.062308. Epub 2017 Jun 30.


Inhibition of Mitochondrial Matrix Chaperones and Antiapoptotic Bcl-2 Family Proteins Empower Antitumor Therapeutic Responses.

Karpel-Massler G, Ishida CT, Bianchetti E, Shu C, Perez-Lorenzo R, Horst B, Banu M, Roth KA, Bruce JN, Canoll P, Altieri DC, Siegelin MD.

Cancer Res. 2017 Jul 1;77(13):3513-3526. doi: 10.1158/0008-5472.CAN-16-3424. Epub 2017 May 18.


The RESPIRE trials: Two phase III, randomized, multicentre, placebo-controlled trials of Ciprofloxacin Dry Powder for Inhalation (Ciprofloxacin DPI) in non-cystic fibrosis bronchiectasis.

Aksamit T, Bandel TJ, Criollo M, De Soyza A, Elborn JS, Operschall E, Polverino E, Roth K, Winthrop KL, Wilson R.

Contemp Clin Trials. 2017 Jul;58:78-85. doi: 10.1016/j.cct.2017.05.007. Epub 2017 May 8.


Synthesis of Diverse N-Acryloyl Azetidines and Evaluation of Their Enhanced Thiol Reactivities.

Palkowitz MD, Tan B, Hu H, Roth K, Bauer RA.

Org Lett. 2017 May 5;19(9):2270-2273. doi: 10.1021/acs.orglett.7b00788. Epub 2017 Apr 20.


Factors associated with lingual tonsil hypertrophy in Canadian adults.

Harris MS, Rotenberg BW, Roth K, Sowerby LJ.

J Otolaryngol Head Neck Surg. 2017 Apr 17;46(1):32. doi: 10.1186/s40463-017-0209-z.


Model of brain activation predicts the neural collective influence map of the brain.

Morone F, Roth K, Min B, Stanley HE, Makse HA.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3849-3854. doi: 10.1073/pnas.1620808114. Epub 2017 Mar 28.


LIN28 Zinc Knuckle Domain Is Required and Sufficient to Induce let-7 Oligouridylation.

Wang L, Nam Y, Lee AK, Yu C, Roth K, Chen C, Ransey EM, Sliz P.

Cell Rep. 2017 Mar 14;18(11):2664-2675. doi: 10.1016/j.celrep.2017.02.044.


Malignant Proliferating Trichilemmal Tumor Treated with Radical Radiotherapy: A Case Report and Literature Review.

Sutherland D, Roth K, Yu E.

Cureus. 2017 Jan 26;9(1):e999. doi: 10.7759/cureus.999.


Patient perspectives on ipilimumab across the melanoma treatment trajectory.

Shuk E, Shoushtari AN, Luke J, Postow MA, Callahan M, Harding JJ, Roth KG, Flavin M, Granobles A, Christian J, Gold G, Schoenhammer M, Gordon M, Cimaglia N, Dyson R, Goodman-Davis N, Colgan MN, Jefferson IS, Munhoz R, D'Angelo S, Wolchok J, Chapman P, Chi P, Carvajal RD, Hay JL.

Support Care Cancer. 2017 Jul;25(7):2155-2167. doi: 10.1007/s00520-017-3621-z. Epub 2017 Mar 1.


Cargo delivery on demand from photodegradable MOF nano-cages.

Epley CC, Roth KL, Lin S, Ahrenholtz SR, Grove TZ, Morris AJ.

Dalton Trans. 2017 Apr 11;46(15):4917-4922. doi: 10.1039/c6dt04787d.


BH3 mimetics suppress CXCL12 expression in human malignant peripheral nerve sheath tumor cells.

Graham CD, Kaza N, Pruitt HC, Gibson LM, Klocke BJ, Shevde LA, Carroll SL, Roth KA.

Oncotarget. 2017 Jan 31;8(5):8670-8678. doi: 10.18632/oncotarget.14398.


Vitamin D Deficiency: The Missing Etiological Factor in the Development of Juvenile Osteochondrosis Dissecans?

Maier GS, Lazovic D, Maus U, Roth KE, Horas K, Seeger JB.

J Pediatr Orthop. 2016 Dec 22. doi: 10.1097/BPO.0000000000000921. [Epub ahead of print]


Applications of patient-specific 3D printing in medicine.

Heller M, Bauer HK, Goetze E, Gielisch M, Roth KE, Drees P, Maier GS, Dorweiler B, Ghazy A, Neufurth M, Müller WE, Schröder HC, Wang X, Vahl CF, Al-Nawas B.

Int J Comput Dent. 2016;19(4):323-339.


The American Journal of Pathology, Value Beyond Simple Metrics.

Roth KA.

Am J Pathol. 2017 Jan;187(1):2-3. doi: 10.1016/j.ajpath.2016.10.018.


Phase I/II Study of Refametinib (BAY 86-9766) in Combination with Gemcitabine in Advanced Pancreatic cancer.

Van Laethem JL, Riess H, Jassem J, Haas M, Martens UM, Weekes C, Peeters M, Ross P, Bridgewater J, Melichar B, Cascinu S, Saramak P, Michl P, Van Brummelen D, Zaniboni A, Schmiegel W, Dueland S, Giurescu M, Garosi VL, Roth K, Schulz A, Seidel H, Rajagopalan P, Teufel M, Childs BH.

Target Oncol. 2017 Feb;12(1):97-109. doi: 10.1007/s11523-016-0469-y.


A single-arm phase III study exploring the efficacy and safety of LNG-IUS 8, a low-dose levonorgestrel intrauterine contraceptive system (total content 13.5 mg), in an Asia-Pacific population.

Fan G, Kang S, Ren M, Weisberg E, Lukkari-Lax E, Roth K, Shin S.

Contraception. 2017 Apr;95(4):371-377. doi: 10.1016/j.contraception.2016.11.005. Epub 2016 Nov 29.


Dairy farmers' perceptions toward the implementation of on-farm Johne's disease prevention and control strategies.

Ritter C, Jansen J, Roth K, Kastelic JP, Adams CL, Barkema HW.

J Dairy Sci. 2016 Nov;99(11):9114-9125. doi: 10.3168/jds.2016-10896. Epub 2016 Aug 31.


Is there an association between low serum 25-OH-D levels and the length of hospital stay in orthopaedic patients after arthroplasty?

Maier GS, Maus U, Lazovic D, Horas K, Roth KE, Kurth AA.

J Orthop Traumatol. 2016 Dec;17(4):297-302. Epub 2016 Jun 13.


Understanding Lung Development, Injury, and Repair.

Chauhan C, Roth KA.

Am J Pathol. 2016 Oct;186(10):2518. doi: 10.1016/j.ajpath.2016.08.002. Epub 2016 Aug 22.


Tamoxifen Induces Cytotoxic Autophagy in Glioblastoma.

Graham CD, Kaza N, Klocke BJ, Gillespie GY, Shevde LA, Carroll SL, Roth KA.

J Neuropathol Exp Neurol. 2016 Oct;75(10):946-954. Epub 2016 Aug 11.


A multicentre, open-label, randomised phase III study comparing a new levonorgestrel intrauterine contraceptive system (LNG-IUS 8) with combined oral contraception in young women of reproductive age.

Borgatta L, Buhling KJ, Rybowski S, Roth K, Rosen K.

Eur J Contracept Reprod Health Care. 2016 Oct;21(5):372-9. doi: 10.1080/13625187.2016.1212987. Epub 2016 Aug 5.



Alexandre PK, Hwang S, Roth KB, Gallo JJ, Eaton WW.

J Health Hum Serv Adm. 2016 Summer;39(1):72-94.


Tourniquet Effectiveness When Placed Over the Joint Service Lightweight Integrated Suit Technology.

Peponis T, Ramly E, Roth KA, King DR.

J Spec Oper Med. 2016 summer;16(2):17-9.


Risk factors for pelvic insufficiency fractures and outcome after conservative therapy.

Maier GS, Kolbow K, Lazovic D, Horas K, Roth KE, Seeger JB, Maus U.

Arch Gerontol Geriatr. 2016 Nov-Dec;67:80-5. doi: 10.1016/j.archger.2016.06.020. Epub 2016 Jul 15.


Seed-mediated biomineralizaton toward the high yield production of gold nanoprisms.

Geng X, Roth KL, Freyman MC, Liu J, Grove TZ.

Chem Commun (Camb). 2016 Jul 28;52(63):9829-32. doi: 10.1039/c6cc04708d.


Carlina acaulis Exhibits Antioxidant Activity and Counteracts Aβ Toxicity in Caenorhabditis elegans.

Link P, Roth K, Sporer F, Wink M.

Molecules. 2016 Jul 2;21(7). pii: E871. doi: 10.3390/molecules21070871.


Messages that matter: Age differences in affective responses to framed health messages.

Mikels JA, Shuster MM, Thai ST, Smith-Ray R, Waugh CE, Roth K, Keilly A, Stine-Morrow EA.

Psychol Aging. 2016 Jun;31(4):409-14. doi: 10.1037/pag0000040.


Correction: Estradiol Enhances CD4+ T-Cell Anti-Viral Immunity by Priming Vaginal DCs to Induce Th17 Responses via an IL-1-Dependent Pathway.

Anipindi VC, Bagri P, Roth K, Dizzell SE, Nguyen PV, Shaler CR, Chu DK, Jiménez-Saiz R, Liang H, Swift SL, Nazli A, Kafka JK, Bramson J, Xing Z, Jordana M, Wan Y, Snider DP, Stampfli MR, Kaushic C.

PLoS Pathog. 2016 Jun 8;12(6):e1005706. doi: 10.1371/journal.ppat.1005706. eCollection 2016 Jun.


The Priority position paper: Protecting Europe's food chain from prions.

Requena JR, Kristensson K, Korth C, Zurzolo C, Simmons M, Aguilar-Calvo P, Aguzzi A, Andreoletti O, Benestad SL, Böhm R, Brown K, Calgua B, Del Río JA, Espinosa JC, Girones R, Godsave S, Hoelzle LE, Knittler MR, Kuhn F, Legname G, Laeven P, Mabbott N, Mitrova E, Müller-Schiffmann A, Nuvolone M, Peters PJ, Raeber A, Roth K, Schmitz M, Schroeder B, Sonati T, Stitz L, Taraboulos A, Torres JM, Yan ZX, Zerr I.

Prion. 2016 May 3;10(3):165-81. doi: 10.1080/19336896.2016.1175801.


Estradiol Enhances CD4+ T-Cell Anti-Viral Immunity by Priming Vaginal DCs to Induce Th17 Responses via an IL-1-Dependent Pathway.

Anipindi VC, Bagri P, Roth K, Dizzell SE, Nguyen PV, Shaler CR, Chu DK, Jiménez-Saiz R, Liang H, Swift S, Nazli A, Kafka JK, Bramson J, Xing Z, Jordana M, Wan Y, Snider DP, Stampfli MR, Kaushic C.

PLoS Pathog. 2016 May 5;12(5):e1005589. doi: 10.1371/journal.ppat.1005589. eCollection 2016 May. Erratum in: PLoS Pathog. 2016 Jun;12(6):e1005706.

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