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Items: 1 to 50 of 86

1.

Discovery of BI-2545: A Novel Autotaxin Inhibitor That Significantly Reduces LPA Levels in Vivo.

Kuttruff CA, Ferrara M, Bretschneider T, Hoerer S, Handschuh S, Nosse B, Romig H, Nicklin P, Roth GJ.

ACS Med Chem Lett. 2017 Nov 8;8(12):1252-1257. doi: 10.1021/acsmedchemlett.7b00312. eCollection 2017 Dec 14.

2.

Design, synthesis and evaluation of MCH receptor 1 antagonists--Part I: Optimization of HTS hits towards an in vivo efficacious tool compound BI 414.

Müller SG, Heckel A, Kley JT, Lehmann T, Lustenberger P, Oost T, Roth GJ, Rudolf K, Arndt K, Lenter M, Lotz RR, Maier GM, Markert M, Schindler M, Stenkamp D.

Bioorg Med Chem Lett. 2015 Aug 15;25(16):3264-9. doi: 10.1016/j.bmcl.2015.05.077. Epub 2015 Jun 6.

PMID:
26112443
3.

Design, synthesis and evaluation of MCH receptor 1 antagonists--Part III: Discovery of pre-clinical development candidate BI 186908.

Oost T, Heckel A, Kley JT, Lehmann T, Müller S, Roth GJ, Rudolf K, Arndt K, Budzinski R, Lenter M, Lotz RR, Maier GM, Markert M, Thomas L, Stenkamp D.

Bioorg Med Chem Lett. 2015 Aug 15;25(16):3275-80. doi: 10.1016/j.bmcl.2015.05.065. Epub 2015 May 29.

PMID:
26105194
4.

Design, synthesis and evaluation of MCH receptor 1 antagonists--Part II: Optimization of pyridazines toward reduced phospholipidosis and hERG inhibition.

Roth GJ, Heckel A, Kley JT, Lehmann T, Müller SG, Oost T, Rudolf K, Arndt K, Budzinski R, Lenter M, Lotz RR, Schindler M, Thomas L, Stenkamp D.

Bioorg Med Chem Lett. 2015 Aug 15;25(16):3270-4. doi: 10.1016/j.bmcl.2015.05.074. Epub 2015 May 30.

PMID:
26077492
5.

Nintedanib: from discovery to the clinic.

Roth GJ, Binder R, Colbatzky F, Dallinger C, Schlenker-Herceg R, Hilberg F, Wollin SL, Kaiser R.

J Med Chem. 2015 Feb 12;58(3):1053-63. doi: 10.1021/jm501562a. Epub 2015 Jan 14. Review.

PMID:
25474320
6.

Inhibition of acetyl-CoA carboxylase 2 enhances skeletal muscle fatty acid oxidation and improves whole-body glucose homeostasis in db/db mice.

Glund S, Schoelch C, Thomas L, Niessen HG, Stiller D, Roth GJ, Neubauer H.

Diabetologia. 2012 Jul;55(7):2044-53. doi: 10.1007/s00125-012-2554-9. Epub 2012 Apr 25.

PMID:
22532389
7.

Phenocopy--a strategy to qualify chemical compounds during hit-to-lead and/or lead optimization.

Baum P, Schmid R, Ittrich C, Rust W, Fundel-Clemens K, Siewert S, Baur M, Mara L, Gruenbaum L, Heckel A, Eils R, Kontermann RE, Roth GJ, Gantner F, Schnapp A, Park JE, Weith A, Quast K, Mennerich D.

PLoS One. 2010 Dec 10;5(12):e14272. doi: 10.1371/journal.pone.0014272.

8.

Design, synthesis, and evaluation of indolinones as inhibitors of the transforming growth factor β receptor I (TGFβRI).

Roth GJ, Heckel A, Brandl T, Grauert M, Hoerer S, Kley JT, Schnapp G, Baum P, Mennerich D, Schnapp A, Park JE.

J Med Chem. 2010 Oct 28;53(20):7287-95. doi: 10.1021/jm100812a.

PMID:
20919678
9.

Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120).

Roth GJ, Heckel A, Colbatzky F, Handschuh S, Kley J, Lehmann-Lintz T, Lotz R, Tontsch-Grunt U, Walter R, Hilberg F.

J Med Chem. 2009 Jul 23;52(14):4466-80. doi: 10.1021/jm900431g.

PMID:
19522465
10.

Bortezomib, dexamethasone, and fibroblast growth factor receptor 3-specific tyrosine kinase inhibitor in t(4;14) myeloma.

Bisping G, Wenning D, Kropff M, Gustavus D, Müller-Tidow C, Stelljes M, Munzert G, Hilberg F, Roth GJ, Stefanic M, Volpert S, Mesters RM, Berdel WE, Kienast J.

Clin Cancer Res. 2009 Jan 15;15(2):520-31. doi: 10.1158/1078-0432.CCR-08-1612.

11.

BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy.

Hilberg F, Roth GJ, Krssak M, Kautschitsch S, Sommergruber W, Tontsch-Grunt U, Garin-Chesa P, Bader G, Zoephel A, Quant J, Heckel A, Rettig WJ.

Cancer Res. 2008 Jun 15;68(12):4774-82. doi: 10.1158/0008-5472.CAN-07-6307.

12.

Paracrine interactions of vascular endothelial growth factor and platelet-derived growth factor in endothelial and lung cancer cells.

Reinmuth N, Rensinghoff S, Raedel M, Fehrmann N, Schwöppe C, Kessler T, Bisping G, Hilberg F, Roth GJ, Berdel W, Thomas M, Mesters RM.

Int J Oncol. 2007 Sep;31(3):621-6.

PMID:
17671690
13.

Inhibition of PDGF, VEGF and FGF signalling attenuates fibrosis.

Chaudhary NI, Roth GJ, Hilberg F, Müller-Quernheim J, Prasse A, Zissel G, Schnapp A, Park JE.

Eur Respir J. 2007 May;29(5):976-85. Epub 2007 Feb 14.

14.

Growth inhibition and induction of apoptosis in acute myeloid leukemia cells by new indolinone derivatives targeting fibroblast growth factor, platelet-derived growth factor, and vascular endothelial growth factor receptors.

Kulimova E, Oelmann E, Bisping G, Kienast J, Mesters RM, Schwäble J, Hilberg F, Roth GJ, Munzert G, Stefanic M, Steffen B, Brandts C, Müller-Tidow C, Kolkmeyer A, Büchner T, Serve H, Berdel WE.

Mol Cancer Ther. 2006 Dec;5(12):3105-12.

15.

Megakaryocyte polyploidization is associated with decreased expression of polo-like kinase (PLK).

Yagi M, Roth GJ.

J Thromb Haemost. 2006 Sep;4(9):2028-34. Epub 2006 Jun 20.

16.

Targeting receptor kinases by a novel indolinone derivative in multiple myeloma: abrogation of stroma-derived interleukin-6 secretion and induction of apoptosis in cytogenetically defined subgroups.

Bisping G, Kropff M, Wenning D, Dreyer B, Bessonov S, Hilberg F, Roth GJ, Munzert G, Stefanic M, Stelljes M, Scheffold C, Müller-Tidow C, Liebisch P, Lang N, Tchinda J, Serve HL, Mesters RM, Berdel WE, Kienast J.

Blood. 2006 Mar 1;107(5):2079-89. Epub 2005 Nov 8.

PMID:
16278310
17.

The oncogenic TLS-ERG fusion protein exerts different effects in hematopoietic cells and fibroblasts.

Zou J, Ichikawa H, Blackburn ML, Hu HM, Zielinska-Kwiatkowska A, Mei Q, Roth GJ, Chansky HA, Yang L.

Mol Cell Biol. 2005 Jul;25(14):6235-46.

18.

A new "kid" on the platelet thrombin receptor "block": glycoprotein Ib-IX-V.

Roth GJ.

Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1330-1. No abstract available.

19.
20.

Sustained ex vivo expansion of hematopoietic stem cells mediated by thrombopoietin.

Yagi M, Ritchie KA, Sitnicka E, Storey C, Roth GJ, Bartelmez S.

Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8126-31.

21.

Antiplatelet therapy. Aspirin, ticlopidine/clopidogrel, and anti-integrin agents.

Calverley DC, Roth GJ.

Hematol Oncol Clin North Am. 1998 Dec;12(6):1231-49, vi. Review.

PMID:
9922934
22.

Structure and expression of the human septin gene HCDCREL-1.

Yagi M, Zieger B, Roth GJ, Ware J.

Gene. 1998 Jun 8;212(2):229-36.

PMID:
9611266
23.

Human signaling protein 14-3-3zeta interacts with platelet glycoprotein Ib subunits Ibalpha and Ibbeta.

Calverley DC, Kavanagh TJ, Roth GJ.

Blood. 1998 Feb 15;91(4):1295-303.

PMID:
9454760
24.
25.
26.
27.
28.

The platelet glycoprotein Ib-V-IX system: regulation of gene expression.

Roth GJ, Yagi M, Bastian LS.

Stem Cells. 1996;14 Suppl 1:188-93. Review.

29.

Human platelet glycoproteins V and IX: mapping of two leucine-rich glycoprotein genes to chromosome 3 and analysis of structures.

Yagi M, Edelhoff S, Disteche CM, Roth GJ.

Biochemistry. 1995 Dec 12;34(49):16132-7.

PMID:
8519770
31.

Human platelet glycoprotein V: its role in enhancing expression of the glycoprotein Ib receptor.

Calverley DC, Yagi M, Stray SM, Roth GJ.

Blood. 1995 Aug 15;86(4):1361-7.

PMID:
7632943
32.

Structural characterization and chromosomal location of the gene encoding human platelet glycoprotein Ib beta.

Yagi M, Edelhoff S, Disteche CM, Roth GJ.

J Biol Chem. 1994 Jul 1;269(26):17424-7.

33.

The wanderings of a platelet gene: what is "neo" Ib beta telling us?

Roth GJ.

J Clin Invest. 1994 Jun;93(6):2301-2. No abstract available.

34.

Aspirin, platelets, and thrombosis: theory and practice.

Roth GJ, Calverley DC.

Blood. 1994 Feb 15;83(4):885-98. Review. No abstract available.

PMID:
8111062
35.
37.

Characterization of the gene encoding human platelet glycoprotein IX.

Hickey MJ, Roth GJ.

J Biol Chem. 1993 Feb 15;268(5):3438-43.

38.

Platelets and blood vessels: the adhesion event.

Roth GJ.

Immunol Today. 1992 Mar;13(3):100-5. Review.

PMID:
1622541
39.

Developing relationships: arterial platelet adhesion, glycoprotein Ib, and leucine-rich glycoproteins.

Roth GJ.

Blood. 1991 Jan 1;77(1):5-19. Review. No abstract available.

PMID:
1984803
40.

The effects of changes in health care delivery on the reported incidence of cutaneous melanoma in western Washington State.

Karagas MR, Thomas DB, Roth GJ, Johnson LK, Weiss NS.

Am J Epidemiol. 1991 Jan;133(1):58-62.

PMID:
1983899
41.
42.

Liver histology in patients receiving low dose pulse methotrexate for the treatment of rheumatoid arthritis.

Willkens RF, Leonard PA, Clegg DO, Tolman KG, Ward JR, Marks CR, Greene ML, Roth GJ, Jackson CG, Cannon GW, et al.

Ann Rheum Dis. 1990 Aug;49(8):591-3.

43.

Human platelet glycoprotein V: a surface leucine-rich glycoprotein related to adhesion.

Roth GJ, Church TA, McMullen BA, Williams SA.

Biochem Biophys Res Commun. 1990 Jul 16;170(1):153-61.

PMID:
2372284
44.

Long-term side effects after treatment of testicular cancer.

Fosså SD, Kreuser ED, Roth GJ, Raghavan D.

Prog Clin Biol Res. 1990;357:321-30. Review. No abstract available.

PMID:
2217475
45.
46.

Circulating human blood platelets retain appreciable amounts of poly (A)+ RNA.

Roth GJ, Hickey MJ, Chung DW, Hickstein DD.

Biochem Biophys Res Commun. 1989 Apr 28;160(2):705-10.

PMID:
2470371
47.
48.

cDNA sequence for the alpha M subunit of the human neutrophil adherence receptor indicates homology to integrin alpha subunits.

Hickstein DD, Hickey MJ, Ozols J, Baker DM, Back AL, Roth GJ.

Proc Natl Acad Sci U S A. 1989 Jan;86(1):257-61.

49.

Isolation and characterization of human platelet glycoprotein IX.

Roth GJ, Ozols J, Nugent DJ, Williams SA.

Biochem Biophys Res Commun. 1988 Oct 31;156(2):931-9.

PMID:
3056407
50.

Case-control study of borderline ovarian tumors: reproductive history and exposure to exogenous female hormones.

Harlow BL, Weiss NS, Roth GJ, Chu J, Daling JR.

Cancer Res. 1988 Oct 15;48(20):5849-52.

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