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An antimicrobial molecule mitigates signs of sepsis in vivo and eradicates infections from lung tissue.

Quercini L, Brunetti J, Riolo G, Bindi S, Scali S, Lampronti I, D'Aversa E, Wronski S, Pollini S, Gentile M, Lupetti P, Rossolini GM, Falciani C, Bracci L, Pini A.

FASEB J. 2020 Jan;34(1):192-207. doi: 10.1096/fj.201901896RR. Epub 2019 Nov 20.


The Urgent Need for Novel Antimicrobial Agents and Strategies to Fight Antibiotic Resistance.

D'Andrea MM, Fraziano M, Thaller MC, Rossolini GM.

Antibiotics (Basel). 2019 Dec 6;8(4). pii: E254. doi: 10.3390/antibiotics8040254.


In vitro time-kill kinetics of dalbavancin against Staphylococcus spp. biofilms over prolonged exposure times.

Di Pilato V, Ceccherini F, Sennati S, D'Agostino F, Arena F, D'Atanasio N, Di Giorgio FP, Tongiani S, Pallecchi L, Rossolini GM.

Diagn Microbiol Infect Dis. 2020 Feb;96(2):114901. doi: 10.1016/j.diagmicrobio.2019.114901. Epub 2019 Oct 15.


A standard numbering scheme for class C β-lactamases.

Mack AR, Barnes MD, Taracila MA, Hujer AM, Hujer KM, Cabot G, Feldgarden M, Haft DH, Klimke W, van den Akker F, Vila AJ, Smania A, Haider S, Papp-Wallace KM, Bradford PA, Rossolini GM, Docquier JD, Frère JM, Galleni M, Hanson ND, Oliver A, Plésiat P, Poirel L, Nordmann P, Palzkill TG, Jacoby GA, Bush K, Bonomo RA.

Antimicrob Agents Chemother. 2019 Nov 11. pii: AAC.01841-19. doi: 10.1128/AAC.01841-19. [Epub ahead of print]


Towards Rapid Sepsis Diagnosis and Patients Stratification: What's New From Microbiology and Omics Science.

Mangioni D, Peri AM, Rossolini GM, Viaggi B, Perno CF, Gori A, Bandera A.

J Infect Dis. 2019 Nov 6. pii: jiz585. doi: 10.1093/infdis/jiz585. [Epub ahead of print]


Editorial: Evolution of Genetic Mechanisms of Antibiotic Resistance.

Buroni S, Pollini S, Rossolini GM, Perrin E.

Front Genet. 2019 Oct 11;10:983. doi: 10.3389/fgene.2019.00983. eCollection 2019. No abstract available.


Staphylococcus aureus from hospital-acquired pneumonia from an Italian nationwide survey: activity of ceftobiprole and other anti-staphylococcal agents, and molecular epidemiology of methicillin-resistant isolates.

Antonelli A, Giani T, Coppi M, Di Pilato V, Arena F, Colavecchio OL, Conte V, Santerre Henriksen A, Rossolini GM; MRSA-HAP Study Group .

J Antimicrob Chemother. 2019 Dec 1;74(12):3453-3461. doi: 10.1093/jac/dkz371.


In Vitro Antimicrobial Activity of the Decontaminant HybenX® Compared to Chlorhexidine and Sodium Hypochlorite against Common Bacterial and Yeast Pathogens.

Antonelli A, Giovannini L, Baccani I, Giuliani V, Pace R, Rossolini GM.

Antibiotics (Basel). 2019 Oct 17;8(4). pii: E188. doi: 10.3390/antibiotics8040188.


Synergistic effect of photodynamic therapy at 400 nm and doxycycline against Helicobacter pylori.

Baccani I, Faraoni P, Marini M, Gnerucci A, Orsini B, Pecile P, Romano G, Fusi F, Rossolini GM, Antonelli A.

Future Microbiol. 2019 Sep;14:1199-1205. doi: 10.2217/fmb-2019-0129.


Rapid microbiological tests for bloodstream infections due to multidrug resistant Gram-negative bacteria: therapeutic implications.

Giacobbe DR, Giani T, Bassetti M, Marchese A, Viscoli C, Rossolini GM.

Clin Microbiol Infect. 2019 Oct 11. pii: S1198-743X(19)30524-5. doi: 10.1016/j.cmi.2019.09.023. [Epub ahead of print] Review.


Acute cerebellar ataxia: a rare Toscana Virus (TOSV) meningoencephalitis complication.

Suardi LR, Di Lauria N, Pozzi M, Rogasi PG, Barilaro A, Azzolini F, Prestipino E, Colao MG, Rossolini GM, Bartoloni A.

Int J Neurosci. 2019 Oct 7:1-3. doi: 10.1080/00207454.2019.1673748. [Epub ahead of print]


Ceftobiprole: drug evaluation and place in therapy.

Giacobbe DR, De Rosa FG, Del Bono V, Grossi PA, Pea F, Petrosillo N, Rossolini GM, Tascini C, Tumbarello M, Viale P, Bassetti M.

Expert Rev Anti Infect Ther. 2019 Sep;17(9):689-698. doi: 10.1080/14787210.2019.1667229. Epub 2019 Sep 25.


Strong correlation between the rates of intrinsically antibiotic-resistant species and the rates of acquired resistance in Gram-negative species causing bacteraemia, EU/EEA, 2016.

Jarlier V, Diaz Högberg L, Heuer OE, Campos J, Eckmanns T, Giske CG, Grundmann H, Johnson AP, Kahlmeter G, Monen J, Pantosti A, Rossolini GM, van de Sande-Bruinsma N, Vatopoulos A, Żabicka D, Žemličková H, Monnet DL, Simonsen GS; Ears-Net Participants.

Euro Surveill. 2019 Aug;24(33). doi: 10.2807/1560-7917.ES.2019.24.33.1800538.


Variable performance of different commercial systems for testing carbapenem susceptibility of KPC carbapenemase-producing Escherichia coli.

Antonelli A, Coppi M, Camarlinghi G, Parisio EM, Nardone M, Riccobono E, Giani T, Mattei R, Rossolini GM.

Clin Microbiol Infect. 2019 Nov;25(11):1432.e1-1432.e4. doi: 10.1016/j.cmi.2019.08.005. Epub 2019 Aug 16.


Screening for carriage of carbapenem-resistant Enterobacteriaceae in settings of high endemicity: a position paper from an Italian working group on CRE infections.

Ambretti S, Bassetti M, Clerici P, Petrosillo N, Tumietto F, Viale P, Rossolini GM.

Antimicrob Resist Infect Control. 2019 Aug 13;8:136. doi: 10.1186/s13756-019-0591-6. eCollection 2019. Review.


Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread.

David S, Reuter S, Harris SR, Glasner C, Feltwell T, Argimon S, Abudahab K, Goater R, Giani T, Errico G, Aspbury M, Sjunnebo S; EuSCAPE Working Group; ESGEM Study Group, Feil EJ, Rossolini GM, Aanensen DM, Grundmann H.

Nat Microbiol. 2019 Nov;4(11):1919-1929. doi: 10.1038/s41564-019-0492-8. Epub 2019 Jul 29.


Characterization of Tn6349, a novel mosaic transposon carrying poxtA, cfr and other resistance determinants, inserted in the chromosome of an ST5-MRSA-II strain of clinical origin.

D'Andrea MM, Antonelli A, Brenciani A, Di Pilato V, Morroni G, Pollini S, Fioriti S, Giovanetti E, Rossolini GM.

J Antimicrob Chemother. 2019 Oct 1;74(10):2870-2875. doi: 10.1093/jac/dkz278.


In Vitro Synergism of Colistin and N-acetylcysteine against Stenotrophomonas maltophilia.

Ciacci N, Boncompagni S, Valzano F, Cariani L, Aliberti S, Blasi F, Pollini S, Rossolini GM, Pallecchi L.

Antibiotics (Basel). 2019 Jul 25;8(3). pii: E101. doi: 10.3390/antibiotics8030101.


KPC-31 expressed in a ceftazidime/avibactam-resistant Klebsiella pneumoniae is associated with relevant detection issues.

Antonelli A, Giani T, Di Pilato V, Riccobono E, Perriello G, Mencacci A, Rossolini GM.

J Antimicrob Chemother. 2019 Aug 1;74(8):2464-2466. doi: 10.1093/jac/dkz156. No abstract available.


Identification of a Novel Plasmid Lineage Associated With the Dissemination of Metallo-β-Lactamase Genes Among Pseudomonads.

Di Pilato V, Antonelli A, Giani T, Henrici De Angelis L, Rossolini GM, Pollini S.

Front Microbiol. 2019 Jul 2;10:1504. doi: 10.3389/fmicb.2019.01504. eCollection 2019.


Influence of a 3-month low-calorie Mediterranean diet compared to the vegetarian diet on human gut microbiota and SCFA: the CARDIVEG Study.

Pagliai G, Russo E, Niccolai E, Dinu M, Di Pilato V, Magrini A, Bartolucci G, Baldi S, Menicatti M, Giusti B, Marcucci R, Rossolini GM, Casini A, Sofi F, Amedei A.

Eur J Nutr. 2019 Jul 10. doi: 10.1007/s00394-019-02050-0. [Epub ahead of print]


Hand, foot, and mouth disease in pregnancy: 7 years Tuscan experience and literature review.

Giachè S, Borchi B, Zammarchi L, Colao MG, Ciccone N, Sterrantino G, Rossolini GM, Bartoloni A, Trotta M.

J Matern Fetal Neonatal Med. 2019 Jul 10:1-7. doi: 10.1080/14767058.2019.1638898. [Epub ahead of print]


Early discharge criteria in patients with acute bacterial skin and skin structure infections in a large tertiary-care teaching hospital in Florence, Italy.

Lagi F, Ottino L, Mantengoli E, Distefano A, Corti G, Farese A, Dannaoui B, Ipponi A, Falai T, Rossolini GM, Bartoloni A, Bartalesi F.

Eur J Clin Microbiol Infect Dis. 2019 Sep;38(9):1781-1785. doi: 10.1007/s10096-019-03609-9. Epub 2019 Jun 20.


Genomic analysis of Neisseria meningitidis carriage isolates during an outbreak of serogroup C clonal complex 11, Tuscany, Italy.

Ambrosio L, Neri A, Fazio C, Rossolini GM, Vacca P, Riccobono E, Voller F, Miglietta A, Stefanelli P.

PLoS One. 2019 May 28;14(5):e0217500. doi: 10.1371/journal.pone.0217500. eCollection 2019.


Microbial community composition of water samples stored inside the International Space Station.

Bacci G, Amalfitano S, Levantesi C, Rossetti S, Garrelly L, Canganella F, Bianconi G; Biowyse Consortium, Di Pilato V, Rossolini GM, Mengoni A, Fani R, Perrin E.

Res Microbiol. 2019 Jun - Aug;170(4-5):230-234. doi: 10.1016/j.resmic.2019.04.003. Epub 2019 May 7.


Role of place of acquisition and inappropriate empirical antibiotic therapy on the outcome of extended-spectrum β-lactamase-producing Enterobacteriaceae infections.

Tacconelli E, Cataldo MA, Mutters NT, Carrara E, Bartoloni A, Raglio A, Cauda R, Mantengoli E, Luzzaro F, Pan A, Beccara LA, Pecile P, Tinelli M, Rossolini GM.

Int J Antimicrob Agents. 2019 Jul;54(1):49-54. doi: 10.1016/j.ijantimicag.2019.04.007. Epub 2019 Apr 12.


Influence of age on the clinical efficacy of tigecycline in severely ill patients.

Bassetti M, Guirao X, Montravers P, Rossolini GM, Sánchez García M, Sganga G, Eckmann C.

J Glob Antimicrob Resist. 2019 Sep;18:199-206. doi: 10.1016/j.jgar.2019.03.018. Epub 2019 Apr 3.


Differential Responses of Colorectal Cancer Cell Lines to Enterococcus faecalis' Strains Isolated from Healthy Donors and Colorectal Cancer Patients.

De Almeida CV, Lulli M, di Pilato V, Schiavone N, Russo E, Nannini G, Baldi S, Borrelli R, Bartolucci G, Menicatti M, Taddei A, Ringressi MN, Niccolai E, Prisco D, Rossolini GM, Amedei A.

J Clin Med. 2019 Mar 20;8(3). pii: E388. doi: 10.3390/jcm8030388.


AmpC β-lactamase-producing Enterobacterales: what a clinician should know.

Meini S, Tascini C, Cei M, Sozio E, Rossolini GM.

Infection. 2019 Jun;47(3):363-375. doi: 10.1007/s15010-019-01291-9. Epub 2019 Mar 6. Review.


Structure of the capsular polysaccharide of the KPC-2-producing Klebsiella pneumoniae strain KK207-2 and assignment of the glycosyltransferases functions.

Bellich B, Ravenscroft N, Rizzo R, Lagatolla C, D'Andrea MM, Rossolini GM, Cescutti P.

Int J Biol Macromol. 2019 Jun 1;130:536-544. doi: 10.1016/j.ijbiomac.2019.02.128. Epub 2019 Feb 22.


Exportation of MDR TB to Europe from Setting with Actively Transmitted Persistent Strains in Peru.

Acosta F, Agapito J, Cabibbe AM, Cáceres T, Sola C, Pérez-Lago L, Abascal E, Herranz M, Meza E, Klotoe B, Muñoz P, Rossolini GM, Bartoloni A, Tortoli E, Cirillo DM, Gotuzzo E, García de Viedma D.

Emerg Infect Dis. 2019 Mar;25(3):596-598. doi: 10.3201/eid2503.180574.


Common Community-acquired Bacterial Skin and Soft-tissue Infections in Children: an Intersociety Consensus on Impetigo, Abscess, and Cellulitis Treatment.

Galli L, Venturini E, Bassi A, Gattinara GC, Chiappini E, Defilippi C, Diociaiuti A, Esposito S, Garazzino S, Giannattasio A, Krzysztofiak A, Latorre S, Lo Vecchio A, Marchisio P, Montagnani C, Nicolini G, Novelli A, Rossolini GM, Tersigni C, Villani A, El Hachem M, Neri I; Italian Pediatric Infectious Diseases Society; Italian Pediatric Dermatology Society.

Clin Ther. 2019 Mar;41(3):532-551.e17. doi: 10.1016/j.clinthera.2019.01.010. Epub 2019 Feb 15. Review.


Evaluation of a new rapid fluorescence immunoassay for the diagnosis of dengue and Zika virus infection.

Zammarchi L, Colao MG, Mantella A, Capobianco T, Mazzarelli G, Ciccone N, Tekle Kiros S, Mantengoli E, Rossolini GM, Bartoloni A.

J Clin Virol. 2019 Mar;112:34-39. doi: 10.1016/j.jcv.2019.01.011. Epub 2019 Jan 29.


Bloodstream infections due to carbapenemase-producing Enterobacteriaceae in Italy: results from nationwide surveillance, 2014 to 2017.

Iacchini S, Sabbatucci M, Gagliotti C, Rossolini GM, Moro ML, Iannazzo S, D'Ancona F, Pezzotti P, Pantosti A.

Euro Surveill. 2019 Jan;24(5). doi: 10.2807/1560-7917.ES.2019.24.5.1800159.


Rapid microbial identification and antimicrobial susceptibility testing to drive better patient care: an evolving scenario.

Özenci V, Rossolini GM.

J Antimicrob Chemother. 2019 Jan 1;74(Supplement_1):i2-i5. doi: 10.1093/jac/dky529.


Evaluation of the OXA-23 K-SeT® immunochromatographic assay for the rapid detection of OXA-23-like carbapenemase-producing Acinetobacter spp.

Riccobono E, Bogaerts P, Antonelli A, Evrard S, Giani T, Rossolini GM, Glupczynski Y.

J Antimicrob Chemother. 2019 May 1;74(5):1455-1457. doi: 10.1093/jac/dkz001. No abstract available.


Ceftolozane-Tazobactam Pharmacokinetics during Extracorporeal Membrane Oxygenation in a Lung Transplant Recipient.

Arena F, Marchetti L, Henrici De Angelis L, Maglioni E, Contorni M, Cassetta MI, Novelli A, Rossolini GM.

Antimicrob Agents Chemother. 2019 Feb 26;63(3). pii: e02131-18. doi: 10.1128/AAC.02131-18. Print 2019 Mar. No abstract available.


Diagnostic stewardship for sepsis: the need for risk stratification to triage patients for fast microbiology workflows.

Mangioni D, Viaggi B, Giani T, Arena F, D'Arienzo S, Forni S, Tulli G, Rossolini GM.

Future Microbiol. 2019 Feb;14:169-174. doi: 10.2217/fmb-2018-0329. Epub 2019 Jan 10. No abstract available.


Carriage rates and risk factors during an outbreak of invasive meningococcal disease due to Neisseria meningitidis serogroup C ST-11 (cc11) in Tuscany, Italy: a cross-sectional study.

Miglietta A, Innocenti F, Pezzotti P, Riccobono E, Moriondo M, Pecile P, Nieddu F, Rossolini GM, Azzari C; Meningococcal Carriage Study Group, Balocchini E, Rezza G, Voller F, Stefanelli P.

BMC Infect Dis. 2019 Jan 8;19(1):29. doi: 10.1186/s12879-018-3598-3.


Detection in Italy of a porcine Enterococcus faecium isolate carrying the novel phenicol-oxazolidinone-tetracycline resistance gene poxtA.

Brenciani A, Fioriti S, Morroni G, Cucco L, Morelli A, Pezzotti G, Paniccià M, Antonelli A, Magistrali CF, Rossolini GM, Giovanetti E.

J Antimicrob Chemother. 2019 Mar 1;74(3):817-818. doi: 10.1093/jac/dky505. No abstract available.


High prevalence of carriage of mcr-1-positive enteric bacteria among healthy children from rural communities in the Chaco region, Bolivia, September to October 2016.

Giani T, Sennati S, Antonelli A, Di Pilato V, di Maggio T, Mantella A, Niccolai C, Spinicci M, Monasterio J, Castellanos P, Martinez M, Contreras F, Balderrama Villaroel D, Damiani E, Maury S, Rocabado R, Pallecchi L, Bartoloni A, Rossolini GM.

Euro Surveill. 2018 Nov;23(45). doi: 10.2807/1560-7917.ES.2018.23.45.1800115.


Cryptic severe Plasmodium falciparum malaria in a Moroccan man living in Tuscany, Italy, August 2018.

Zammarchi L, Di Lauria N, Bartalesi F, Suardi LR, Corti G, Mencarini J, Boccolini D, Severini C, Gradoni L, Buonamici C, Garofalo G, Bartolesi AM, Ciccone N, Berni A, Poggesi L, Niccolini F, Rossolini GM, Romi R, Bartoloni A.

Euro Surveill. 2018 Oct;23(41). doi: 10.2807/1560-7917.ES.2018.23.41.1800527.


Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing.

CRyPTIC Consortium and the 100,000 Genomes Project, Allix-Béguec C, Arandjelovic I, Bi L, Beckert P, Bonnet M, Bradley P, Cabibbe AM, Cancino-Muñoz I, Caulfield MJ, Chaiprasert A, Cirillo DM, Clifton DA, Comas I, Crook DW, De Filippo MR, de Neeling H, Diel R, Drobniewski FA, Faksri K, Farhat MR, Fleming J, Fowler P, Fowler TA, Gao Q, Gardy J, Gascoyne-Binzi D, Gibertoni-Cruz AL, Gil-Brusola A, Golubchik T, Gonzalo X, Grandjean L, He G, Guthrie JL, Hoosdally S, Hunt M, Iqbal Z, Ismail N, Johnston J, Khanzada FM, Khor CC, Kohl TA, Kong C, Lipworth S, Liu Q, Maphalala G, Martinez E, Mathys V, Merker M, Miotto P, Mistry N, Moore DAJ, Murray M, Niemann S, Omar SV, Ong RT, Peto TEA, Posey JE, Prammananan T, Pym A, Rodrigues C, Rodrigues M, Rodwell T, Rossolini GM, Sánchez Padilla E, Schito M, Shen X, Shendure J, Sintchenko V, Sloutsky A, Smith EG, Snyder M, Soetaert K, Starks AM, Supply P, Suriyapol P, Tahseen S, Tang P, Teo YY, Thuong TNT, Thwaites G, Tortoli E, van Soolingen D, Walker AS, Walker TM, Wilcox M, Wilson DJ, Wyllie D, Yang Y, Zhang H, Zhao Y, Zhu B.

N Engl J Med. 2018 Oct 11;379(15):1403-1415. doi: 10.1056/NEJMoa1800474. Epub 2018 Sep 26.


In vitro activity of N-acetylcysteine against Stenotrophomonas maltophilia and Burkholderia cepacia complex grown in planktonic phase and biofilm.

Pollini S, Di Pilato V, Landini G, Di Maggio T, Cannatelli A, Sottotetti S, Cariani L, Aliberti S, Blasi F, Sergio F, Rossolini GM, Pallecchi L.

PLoS One. 2018 Oct 1;13(10):e0203941. doi: 10.1371/journal.pone.0203941. eCollection 2018.


Characterization of a Multiresistance Plasmid Carrying the optrA and cfr Resistance Genes From an Enterococcus faecium Clinical Isolate.

Morroni G, Brenciani A, Antonelli A, D'Andrea MM, Di Pilato V, Fioriti S, Mingoia M, Vignaroli C, Cirioni O, Biavasco F, Varaldo PE, Rossolini GM, Giovanetti E.

Front Microbiol. 2018 Sep 11;9:2189. doi: 10.3389/fmicb.2018.02189. eCollection 2018.


Mortality attributable to different Klebsiella susceptibility patterns and to the coverage of empirical antibiotic therapy: a cohort study on patients admitted to the ICU with infection.

GiViTI Steering Committee, Bertolini G, Nattino G, Tascini C, Poole D, Viaggi B, Carrara G, Rossi C, Crespi D, Mondini M, Langer M, Rossolini GM, Malacarne P.

Intensive Care Med. 2018 Oct;44(10):1709-1719. doi: 10.1007/s00134-018-5360-0. Epub 2018 Sep 25.


Auranofin and its Analogues Show Potent Antimicrobial Activity against Multidrug-Resistant Pathogens: Structure-Activity Relationships.

Marzo T, Cirri D, Pollini S, Prato M, Fallani S, Cassetta MI, Novelli A, Rossolini GM, Messori L.

ChemMedChem. 2018 Nov 20;13(22):2448-2454. doi: 10.1002/cmdc.201800498. Epub 2018 Nov 5.


Characterization of vB_Kpn_F48, a Newly Discovered Lytic Bacteriophage for Klebsiella pneumoniae of Sequence Type 101.

Ciacci N, D'Andrea MM, Marmo P, Demattè E, Amisano F, Di Pilato V, Fraziano M, Lupetti P, Rossolini GM, Thaller MC.

Viruses. 2018 Sep 9;10(9). pii: E482. doi: 10.3390/v10090482.


Interconnected clusters of invasive meningococcal disease due to Neisseria meningitidis serogroup C ST-11 (cc11), involving bisexuals and men who have sex with men, with discos and gay-venues hotspots of transmission, Tuscany, Italy, 2015 to 2016.

Miglietta A, Fazio C, Neri A, Pezzotti P, Innocenti F, Azzari C, Rossolini GM, Moriondo M, Nieddu F, Iannazzo S, D'Ancona F, Maraglino FP, Guerra R, Rezza G, Voller F, Stefanelli P.

Euro Surveill. 2018 Aug;23(34). doi: 10.2807/1560-7917.ES.2018.23.34.1700636.


Synergistic Activity of Colistin in Combination With Resveratrol Against Colistin-Resistant Gram-Negative Pathogens.

Cannatelli A, Principato S, Colavecchio OL, Pallecchi L, Rossolini GM.

Front Microbiol. 2018 Aug 7;9:1808. doi: 10.3389/fmicb.2018.01808. eCollection 2018.

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