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Items: 42

1.

Rho GTPase Transcriptome Analysis Reveals Oncogenic Roles for Rho GTPase-Activating Proteins in Basal-like Breast Cancers.

Lawson CD, Fan C, Mitin N, Baker NM, George SD, Graham DM, Perou CM, Burridge K, Der CJ, Rossman KL.

Cancer Res. 2016 Jul 1;76(13):3826-37. doi: 10.1158/0008-5472.CAN-15-2923. Epub 2016 May 23.

2.

RAS isoforms and mutations in cancer at a glance.

Hobbs GA, Der CJ, Rossman KL.

J Cell Sci. 2016 Apr 1;129(7):1287-92. doi: 10.1242/jcs.182873. Epub 2016 Mar 16. Review.

3.

Substrate trapping proteomics reveals targets of the ╬▓TrCP2/FBXW11 ubiquitin ligase.

Kim TY, Siesser PF, Rossman KL, Goldfarb D, Mackinnon K, Yan F, Yi X, MacCoss MJ, Moon RT, Der CJ, Major MB.

Mol Cell Biol. 2015 Jan;35(1):167-81. doi: 10.1128/MCB.00857-14. Epub 2014 Oct 20.

4.

P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils.

Damoulakis G, Gambardella L, Rossman KL, Lawson CD, Anderson KE, Fukui Y, Welch HC, Der CJ, Stephens LR, Hawkins PT.

J Cell Sci. 2014 Jun 1;127(Pt 11):2589-600. doi: 10.1242/jcs.153049. Epub 2014 Mar 21.

5.

Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease.

Cook DR, Rossman KL, Der CJ.

Oncogene. 2014 Jul 31;33(31):4021-35. doi: 10.1038/onc.2013.362. Epub 2013 Sep 16. Review.

6.

The RhoGEF TEM4 Regulates Endothelial Cell Migration by Suppressing Actomyosin Contractility.

Mitin N, Rossman KL, Currin R, Anne S, Marshall TW, Bear JE, Bautch VL, Der CJ.

PLoS One. 2013 Jun 18;8(6):e66260. doi: 10.1371/journal.pone.0066260. Print 2013.

7.

Identification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4.

Mitin N, Rossman KL, Der CJ.

PLoS One. 2012;7(7):e41876. doi: 10.1371/journal.pone.0041876. Epub 2012 Jul 24.

8.

The RalB small GTPase mediates formation of invadopodia through a GTPase-activating protein-independent function of the RalBP1/RLIP76 effector.

Neel NF, Rossman KL, Martin TD, Hayes TK, Yeh JJ, Der CJ.

Mol Cell Biol. 2012 Apr;32(8):1374-86. doi: 10.1128/MCB.06291-11. Epub 2012 Feb 13.

9.

Oncogenic activity of Ect2 is regulated through protein kinase C iota-mediated phosphorylation.

Justilien V, Jameison L, Der CJ, Rossman KL, Fields AP.

J Biol Chem. 2011 Mar 11;286(10):8149-57. doi: 10.1074/jbc.M110.196113. Epub 2010 Dec 28.

10.

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

Vigil D, Cherfils J, Rossman KL, Der CJ.

Nat Rev Cancer. 2010 Dec;10(12):842-57. doi: 10.1038/nrc2960. Epub 2010 Nov 24. Review.

11.

Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression.

Mitin N, Betts L, Yohe ME, Der CJ, Sondek J, Rossman KL.

Nat Struct Mol Biol. 2007 Sep;14(9):814-23. Epub 2007 Aug 19.

12.

Auto-inhibition of the Dbl family protein Tim by an N-terminal helical motif.

Yohe ME, Rossman KL, Gardner OS, Karnoub AE, Snyder JT, Gershburg S, Graves LM, Der CJ, Sondek J.

J Biol Chem. 2007 May 4;282(18):13813-23. Epub 2007 Mar 2.

13.
14.

Signaling interplay in Ras superfamily function.

Mitin N, Rossman KL, Der CJ.

Curr Biol. 2005 Jul 26;15(14):R563-74. Review.

15.

Larger than Dbl: new structural insights into RhoA activation.

Rossman KL, Sondek J.

Trends Biochem Sci. 2005 Apr;30(4):163-5. Review.

PMID:
15817389
16.

The Ras superfamily at a glance.

Wennerberg K, Rossman KL, Der CJ.

J Cell Sci. 2005 Mar 1;118(Pt 5):843-6. Review. No abstract available.

17.

A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs.

Lu M, Kinchen JM, Rossman KL, Grimsley C, Hall M, Sondek J, Hengartner MO, Yajnik V, Ravichandran KS.

Curr Biol. 2005 Feb 22;15(4):371-7.

18.

GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors.

Rossman KL, Der CJ, Sondek J.

Nat Rev Mol Cell Biol. 2005 Feb;6(2):167-80. Review.

PMID:
15688002
19.

Crystal structure of the DH/PH fragment of Dbs without bound GTPase.

Worthylake DK, Rossman KL, Sondek J.

Structure. 2004 Jun;12(6):1078-86.

20.

PH domain of ELMO functions in trans to regulate Rac activation via Dock180.

Lu M, Kinchen JM, Rossman KL, Grimsley C, deBakker C, Brugnera E, Tosello-Trampont AC, Haney LB, Klingele D, Sondek J, Hengartner MO, Ravichandran KS.

Nat Struct Mol Biol. 2004 Aug;11(8):756-62. Epub 2004 Jul 11.

PMID:
15247908
21.

Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation.

Solski PA, Wilder RS, Rossman KL, Sondek J, Cox AD, Campbell SL, Der CJ.

J Biol Chem. 2004 Jun 11;279(24):25226-33. Epub 2004 Apr 8.

22.

Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton.

Salazar MA, Kwiatkowski AV, Pellegrini L, Cestra G, Butler MH, Rossman KL, Serna DM, Sondek J, Gertler FB, De Camilli P.

J Biol Chem. 2003 Dec 5;278(49):49031-43. Epub 2003 Sep 22.

23.

Established and emerging fluorescence-based assays for G-protein function: Ras-superfamily GTPases.

Rojas RJ, Kimple RJ, Rossman KL, Siderovski DP, Sondek J.

Comb Chem High Throughput Screen. 2003 Jun;6(4):409-18. Review.

PMID:
12769685
24.

Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation.

Rossman KL, Cheng L, Mahon GM, Rojas RJ, Snyder JT, Whitehead IP, Sondek J.

J Biol Chem. 2003 May 16;278(20):18393-400. Epub 2003 Mar 13.

25.

Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting.

Baumeister MA, Martinu L, Rossman KL, Sondek J, Lemmon MA, Chou MM.

J Biol Chem. 2003 Mar 28;278(13):11457-64. Epub 2003 Jan 13.

26.

Functional analysis of cdc42 residues required for Guanine nucleotide exchange.

Rossman KL, Worthylake DK, Snyder JT, Cheng L, Whitehead IP, Sondek J.

J Biol Chem. 2002 Dec 27;277(52):50893-8. Epub 2002 Oct 24.

27.

RhoGEF specificity mutants implicate RhoA as a target for Dbs transforming activity.

Cheng L, Rossman KL, Mahon GM, Worthylake DK, Korus M, Sondek J, Whitehead IP.

Mol Cell Biol. 2002 Oct;22(19):6895-905.

28.

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.

Snyder JT, Worthylake DK, Rossman KL, Betts L, Pruitt WM, Siderovski DP, Der CJ, Sondek J.

Nat Struct Biol. 2002 Jun;9(6):468-75.

PMID:
12006984
29.

A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.

Rossman KL, Worthylake DK, Snyder JT, Siderovski DP, Campbell SL, Sondek J.

EMBO J. 2002 Mar 15;21(6):1315-26.

30.

Molecular basis for Rac1 recognition by guanine nucleotide exchange factors.

Karnoub AE, Worthylake DK, Rossman KL, Pruitt WM, Campbell SL, Sondek J, Der CJ.

Nat Struct Biol. 2001 Dec;8(12):1037-41.

PMID:
11685227
31.

Quantitative analysis of the effect of phosphoinositide interactions on the function of Dbl family proteins.

Snyder JT, Rossman KL, Baumeister MA, Pruitt WM, Siderovski DP, Der CJ, Lemmon MA, Sondek J.

J Biol Chem. 2001 Dec 7;276(49):45868-75. Epub 2001 Sep 27.

32.

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1.

Worthylake DK, Rossman KL, Sondek J.

Nature. 2000 Dec 7;408(6813):682-8.

PMID:
11130063
33.

Bacterial expressed DH and DH/PH domains.

Rossman KL, Campbell SL.

Methods Enzymol. 2000;325:25-38. No abstract available.

PMID:
11036589
34.

Vav2 is an activator of Cdc42, Rac1, and RhoA.

Abe K, Rossman KL, Liu B, Ritola KD, Chiang D, Campbell SL, Burridge K, Der CJ.

J Biol Chem. 2000 Apr 7;275(14):10141-9.

35.

Dependence of Dbl and Dbs transformation on MEK and NF-kappaB activation.

Whitehead IP, Lambert QT, Glaven JA, Abe K, Rossman KL, Mahon GM, Trzaskos JM, Kay R, Campbell SL, Der CJ.

Mol Cell Biol. 1999 Nov;19(11):7759-70.

36.

Rho family proteins and Ras transformation: the RHOad less traveled gets congested.

Zohn IM, Campbell SL, Khosravi-Far R, Rossman KL, Der CJ.

Oncogene. 1998 Sep 17;17(11 Reviews):1415-38. Review.

37.

Increasing complexity of Ras signaling.

Campbell SL, Khosravi-Far R, Rossman KL, Clark GJ, Der CJ.

Oncogene. 1998 Sep 17;17(11 Reviews):1395-413. Review.

38.

Increasing complexity of Ras signal transduction: involvement of Rho family proteins.

Khosravi-Far R, Campbell S, Rossman KL, Der CJ.

Adv Cancer Res. 1998;72:57-107. Review. No abstract available.

PMID:
9338074
39.

14-3-3 zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domain.

Clark GJ, Drugan JK, Rossman KL, Carpenter JW, Rogers-Graham K, Fu H, Der CJ, Campbell SL.

J Biol Chem. 1997 Aug 22;272(34):20990-3.

40.

Dbl family proteins.

Whitehead IP, Campbell S, Rossman KL, Der CJ.

Biochim Biophys Acta. 1997 Feb 22;1332(1):F1-23. Review. No abstract available.

PMID:
9061011
41.

Differential effects of ibogaine pretreatment on brain levels of morphine and (+)-amphetamine.

Glick SD, Gallagher CA, Hough LB, Rossman KL, Maisonneuve IM.

Brain Res. 1992 Aug 14;588(1):173-6.

PMID:
1393568
42.

Acute and prolonged effects of ibogaine on brain dopamine metabolism and morphine-induced locomotor activity in rats.

Maisonneuve IM, Rossman KL, Keller RW Jr, Glick SD.

Brain Res. 1992 Mar 13;575(1):69-73.

PMID:
1504783

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