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Sex differences in mineralocorticoid receptor antagonist trials: a pooled analysis of three large clinical trials.

Rossello X, Ferreira JP, Pocock SJ, McMurray JJV, Solomon SD, Lam CSP, Girerd N, Pitt B, Rossignol P, Zannad F.

Eur J Heart Fail. 2020 Feb 19. doi: 10.1002/ejhf.1740. [Epub ahead of print]


Enhanced clinical phenotyping by mechanistic bioprofiling in heart failure with preserved ejection fraction: insights from the MEDIA-DHF study (The Metabolic Road to Diastolic Heart Failure).

Stienen S, Ferreira JP, Kobayashi M, Preud'homme G, Dobre D, Machu JL, Duarte K, Bresso E, Devignes MD, López N, Girerd N, Aakhus S, Ambrosio G, Brunner-La Rocca HP, Fontes-Carvalho R, Fraser AG, van Heerebeek L, Heymans S, de Keulenaer G, Marino P, McDonald K, Mebazaa A, Papp Z, Raddino R, Tschöpe C, Paulus WJ, Zannad F, Rossignol P.

Biomarkers. 2020 Feb 16:1-11. doi: 10.1080/1354750X.2020.1727015. [Epub ahead of print]


Spironolactone for resistant hypertension in advanced chronic kidney disease-red, amber or green?

Agarwal R, Rossignol P, Williams B, White WB.

Nephrol Dial Transplant. 2020 Feb 11. pii: gfz299. doi: 10.1093/ndt/gfz299. [Epub ahead of print] No abstract available.


Longer Duration of Hypertension and MRI Microvascular Brain Alterations Are Associated with Lower Hippocampal Volumes in Older Individuals with Hypertension.

Triantafyllou A, Ferreira JP, Kobayashi M, Micard E, Xie Y, Kearney-Schwartz A, Hossu G, Rossignol P, Bracard S, Benetos A.

J Alzheimers Dis. 2020 Feb 6. doi: 10.3233/JAD-190842. [Epub ahead of print]


Association of estimated plasma volume status with hemodynamic and echocardiographic parameters.

Kobayashi M, Huttin O, Donal E, Duarte K, Hubert A, Le Breton H, Galli E, Fournet M, Mabo P, Schnell F, Leclercq C, Rossignol P, Girerd N.

Clin Res Cardiol. 2020 Jan 31. doi: 10.1007/s00392-020-01599-9. [Epub ahead of print]


Effect of Uric Acid-Lowering Agents on Cardiovascular Outcome in Patients With Heart Failure: A Systematic Review and Meta-Analysis of Clinical Studies.

Kanbay M, Afsar B, Siriopol D, Dincer N, Erden N, Yilmaz O, Sag AA, Kuwabara M, Cherney D, Rossignol P, Ortiz A, Covic A.

Angiology. 2020 Jan 31:3319719897509. doi: 10.1177/0003319719897509. [Epub ahead of print]


Clinic Versus Ambulatory Blood Pressure in Resistant Hypertension: Impact of Antihypertensive Medication Nonadherence: A Post Hoc Analysis the DENERHTN Study.

Hamdidouche I, Gosse P, Cremer A, Lorthioir A, Delsart P, Courand PY, Denolle T, Halimi JM, Girerd X, Ormezzano O, Rossignol P, Pereira H, Azizi M; DENERHTN Investigators.

Hypertension. 2019 Nov;74(5):1096-1103. doi: 10.1161/HYPERTENSIONAHA.119.13520. Epub 2019 Sep 23.


Biomarkers in patients with heart failure and central sleep apnoea: findings from the SERVE-HF trial.

Ferreira JP, Duarte K, Woehrle H, Cowie MR, Wegscheider K, Angermann C, d'Ortho MP, Erdmann E, Levy P, Simonds AK, Somers VK, Teschler H, Rossignol P, Koenig W, Zannad F.

ESC Heart Fail. 2020 Jan 17. doi: 10.1002/ehf2.12521. [Epub ahead of print]


Effects of spironolactone on serum markers of fibrosis in people at high risk of developing heart failure: rationale, design and baseline characteristics of a proof-of-concept, randomised, precision-medicine, prevention trial. The Heart OMics in AGing (HOMAGE) trial.

Pellicori P, Ferreira JP, Mariottoni B, Brunner-La Rocca HP, Ahmed FZ, Verdonschot J, Collier T, Cuthbert JJ, Petutschnigg J, Mujaj B, Girerd N, González A, Clark AL, Cosmi F, Staessen JA, Heymans S, Latini R, Rossignol P, Zannad F, Cleland JGF.

Eur J Heart Fail. 2020 Jan 16. doi: 10.1002/ejhf.1716. [Epub ahead of print]


Predictors of sudden cardiac death in high-risk patients following a myocardial infarction.

Docherty KF, Ferreira JP, Sharma A, Girerd N, Gregson J, Duarte K, Petrie MC, Jhund PS, Dickstein K, Pfeffer MA, Pitt B, Rossignol P, Zannad F, McMurray JJV.

Eur J Heart Fail. 2020 Jan 16. doi: 10.1002/ejhf.1694. [Epub ahead of print]


Mineralocorticoid Receptor Antagonists, Blood Pressure, and Outcomes in Heart Failure With Reduced Ejection Fraction.

Serenelli M, Jackson A, Dewan P, Jhund PS, Petrie MC, Rossignol P, Campo G, Pitt B, Zannad F, Ferreira JP, McMurray JJV.

JACC Heart Fail. 2020 Jan 6. pii: S2213-1779(19)30802-9. doi: 10.1016/j.jchf.2019.09.011. [Epub ahead of print]


Cardiovascular risk associated with serum potassium in the context of mineralocorticoid receptor antagonist use in patients with heart failure and left ventricular dysfunction.

Rossignol P, Duarte K, Girerd N, Karoui M, McMurray JJV, Swedberg K, van Veldhuisen DJ, Pocock S, Dickstein K, Zannad F, Pitt B.

Eur J Heart Fail. 2020 Jan 9. doi: 10.1002/ejhf.1724. [Epub ahead of print]


Inflammation is an amplifier of lung congestion by high lv filling pressure in hemodialysis patients: a longitudinal study.

Torino C, Gargani L, Sicari R, Letachowicz K, Ekart R, Fliser D, Covic A, Siamopoulos K, Stavroulopoulos A, Massy ZA, Fiaccadori E, Regolisti G, Bachelet T, Slotki I, Martinez-Castelao A, Coudert-Krier MJ, Rossignol P, Hannedouche T, Wiecek A, Sarafidis P, Battaglia Y, Prohić N, Klinger M, Hojs R, Seiler-Mußler S, Lizzi F, Siriopol D, Balafa O, Shavit L, Loutradis C, Seidowsky A, Tripepi R, Mallamaci F, Tripepi G, Picano E, London GM, Zoccali C.

J Nephrol. 2020 Jan 8. doi: 10.1007/s40620-019-00696-x. [Epub ahead of print]


Renal function, electrolytes, and congestion monitoring in heart failure.

Rossignol P, Coats AJ, Chioncel O, Spoletini I, Rosano G.

Eur Heart J Suppl. 2019 Dec;21(Suppl M):M25-M31. doi: 10.1093/eurheartj/suz220. Epub 2019 Dec 31.


Evaluation of kidney function throughout the heart failure trajectory - a position statement from the Heart Failure Association of the European Society of Cardiology.

Mullens W, Damman K, Testani JM, Martens P, Mueller C, Lassus J, Tang WHW, Skouri H, Verbrugge FH, Orso F, Hill L, Dilek U, Lainscak M, Rossignol P, Metra M, Mebazaa A, Seferovic P, Ruschitzka F, Coats A.

Eur J Heart Fail. 2020 Jan 7. doi: 10.1002/ejhf.1697. [Epub ahead of print]


Heritability of a resting heart rate in a 20-year follow-up family cohort with GWAS data: Insights from the STANISLAS cohort.

Xhaard C, Dandine-Roulland C, Villemereuil P, Floch EL, Bacq-Daian D, Machu JL, Ferreira JP, Deleuze JF, Zannad F, Rossignol P, Girerd N.

Eur J Prev Cardiol. 2019 Dec 2:2047487319890763. doi: 10.1177/2047487319890763. [Epub ahead of print]


Bioprofiles and mechanistic pathways associated with Cheyne-Stokes respiration: insights from the SERVE-HF trial.

Ferreira JP, Duarte K, Woehrle H, Cowie MR, Angermann C, d'Ortho MP, Erdmann E, Levy P, Simonds AK, Somers VK, Teschler H, Wegscheider K, Bresso E, Dominique-Devignes M, Rossignol P, Koenig W, Zannad F.

Clin Res Cardiol. 2019 Nov 29. doi: 10.1007/s00392-019-01578-9. [Epub ahead of print]


MRAs in Elderly HF Patients: Individual Patient-Data Meta-Analysis of RALES, EMPAHSIS-HF, and TOPCAT.

Ferreira JP, Rossello X, Eschalier R, McMurray JJV, Pocock S, Girerd N, Rossignol P, Pitt B, Zannad F.

JACC Heart Fail. 2019 Dec;7(12):1012-1021. doi: 10.1016/j.jchf.2019.08.017.


Insulin-like growth factor binding protein 2: A prognostic biomarker for heart failure hardly redundant with natriuretic peptides.

Girerd N, Bresso E, Devignes MD, Rossignol P.

Int J Cardiol. 2020 Feb 1;300:252-254. doi: 10.1016/j.ijcard.2019.11.100. Epub 2019 Nov 13. No abstract available.


Renin-angiotensin-aldosterone system and kidney interactions in heart failure.

Ferreira JP, Rossignol P, Zannad F.

J Renin Angiotensin Aldosterone Syst. 2019 Oct-Dec;20(4):1470320319889415. doi: 10.1177/1470320319889415. No abstract available.


Heart failure etiologies and clinical factors precipitating for worsening heart failure: Findings from BIOSTAT-CHF.

Kobayashi M, Voors AA, Girerd N, Billotte M, Anker SD, Cleland JG, Lang CC, Ng LL, van Veldhuisen DJ, Dickstein K, Metra M, Duarte K, Rossignol P, Zannad F, Ferreira JP.

Eur J Intern Med. 2020 Jan;71:62-69. doi: 10.1016/j.ejim.2019.10.017. Epub 2019 Nov 8.


Income level and inequality as complement to geographical differences in cardiovascular trials.

Ferreira JP, Rossignol P, Dewan P, Lamiral Z, White WB, Pitt B, McMurray JJV, Zannad F.

Am Heart J. 2019 Dec;218:66-74. doi: 10.1016/j.ahj.2019.08.019. Epub 2019 Sep 1.


Telomere length tracking in children and their parents: implications for adult onset diseases.

Benetos A, Verhulst S, Labat C, Lai TP, Girerd N, Toupance S, Zannad F, Rossignol P, Aviv A.

FASEB J. 2019 Dec;33(12):14248-14253. doi: 10.1096/fj.201901275R. Epub 2019 Oct 25.


Visit-to-visit blood pressure variation and outcomes in heart failure with reduced ejection fraction: findings from the Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms trial.

Monzo L, Ferreira JP, Abreu P, Szumski A, Böhm M, McMurray JJV, Pitt B, Swedberg K, van Veldhuisen DJ, Girerd N, Vincent J, Zannad F, Rossignol P.

J Hypertens. 2020 Mar;38(3):420-425. doi: 10.1097/HJH.0000000000002275.


Beta-blockers in heart failure patients with severe chronic kidney disease-time for a randomized controlled trial?

Agarwal R, Rossignol P.

Nephrol Dial Transplant. 2019 Oct 3. pii: gfz187. doi: 10.1093/ndt/gfz187. [Epub ahead of print] No abstract available.


Patiromer versus placebo to enable spironolactone use in patients with resistant hypertension and chronic kidney disease (AMBER): a phase 2, randomised, double-blind, placebo-controlled trial.

Agarwal R, Rossignol P, Romero A, Garza D, Mayo MR, Warren S, Ma J, White WB, Williams B.

Lancet. 2019 Oct 26;394(10208):1540-1550. doi: 10.1016/S0140-6736(19)32135-X. Epub 2019 Sep 15.


Arterial Remodeling and Dysfunction in the ZSF1 Rat Model of Heart Failure With Preserved Ejection Fraction.

Leite S, Cerqueira RJ, Ibarrola J, Fontoura D, Fernández-Celis A, Zannad F, Falcão-Pires I, Paulus WJ, Leite-Moreira AF, Rossignol P, López-Andrés N, Lourenço AP.

Circ Heart Fail. 2019 Jul;12(7):e005596. doi: 10.1161/CIRCHEARTFAILURE.118.005596. Epub 2019 Jul 1.


Emerging Drug Classes and Their Potential Use in Hypertension.

Azizi M, Rossignol P, Hulot JS.

Hypertension. 2019 Nov;74(5):1075-1083. doi: 10.1161/HYPERTENSIONAHA.119.12676. Epub 2019 Sep 9. Review.


Eplerenone in patients with myocardial infarction and "mid-range" ejection fraction: An analysis from the EPHESUS trial.

Ferreira JP, Rossello X, Pitt B, Rossignol P, Zannad F.

Clin Cardiol. 2019 Nov;42(11):1106-1112. doi: 10.1002/clc.23261. Epub 2019 Sep 3.


Association of diabetes and kidney function according to age and systolic function with the incidence of sudden cardiac death and non-sudden cardiac death in myocardial infarction survivors with heart failure.

Coiro S, Girerd N, Sharma A, Rossignol P, Tritto I, Pitt B, Pfeffer MA, McMurray JJV, Ambrosio G, Dickstein K, Moss A, Zannad F.

Eur J Heart Fail. 2019 Oct;21(10):1248-1258. doi: 10.1002/ejhf.1541. Epub 2019 Sep 2.


Correlation of Quantitated Intravascular Volume with Blood Pressure in Patients with Systemic Hypertension.

Fudim M, Blumer VL, Lopes RD, Rossignol P, Feldschuh M, Miller WL, Sobotka PA.

J Cardiovasc Transl Res. 2019 Aug 28. doi: 10.1007/s12265-019-09910-4. [Epub ahead of print]


Accuracy of Several Lung Ultrasound Methods for the Diagnosis of Acute Heart Failure in the ED: A Multicenter Prospective Study.

Buessler A, Chouihed T, Duarte K, Bassand A, Huot-Marchand M, Gottwalles Y, Pénine A, André E, Nace L, Jaeger D, Kobayashi M, Coiro S, Rossignol P, Girerd N.

Chest. 2020 Jan;157(1):99-110. doi: 10.1016/j.chest.2019.07.017. Epub 2019 Aug 2.


Adherence to ESC guideline-recommended medications over a 36-month follow-up period after hospitalization for heart failure: Results from the EPICAL2 cohort study.

Bitar S, Agrinier N, Alla F, Rossignol P, Mebazaa A, Thilly N.

Pharmacoepidemiol Drug Saf. 2019 Nov;28(11):1489-1500. doi: 10.1002/pds.4868. Epub 2019 Jul 24.


Hyperkalemia in the Emergency Department: Urgent Need for a Rigorous Evaluation of the First-Line Treatments.

Lemoine L, Chouihed T, Legrand M, Rossignol P, Potel G, Montassier E.

J Emerg Med. 2019 Jul;57(1):102-103. doi: 10.1016/j.jemermed.2018.11.024. No abstract available.


Is blood pressure measured correctly in dialysis centres? Physicians' and patients' views.

Pappaccogli M, Labriola L, Van der Niepen P, Pruijm M, Vogt L, Halimi JM, Ferro CJ, Halabi G, Phan O, Bullani R, Saudan P, Avdelidou A, Panou E, Papoulidou F, London G, Rossignol P, Sarafidis P, Persu A, Wuerzner G.

Nephrol Dial Transplant. 2019 Sep 1;34(9):1612-1615. doi: 10.1093/ndt/gfz125. No abstract available.


Left ventricular ejection fraction and adjudicated, cause-specific hospitalizations after myocardial infarction complicated by heart failure or left ventricular dysfunction.

Hall TS, von Lueder TG, Zannad F, Rossignol P, Duarte K, Chouihed T, Solomon SD, Dickstein K, Atar D, Agewall S, Girerd N; High-Risk Myocardial Infarction Database Initiative investigators.

Am Heart J. 2019 Sep;215:83-90. doi: 10.1016/j.ahj.2019.06.004. Epub 2019 Jun 12.


Soluble ST2 promotes oxidative stress and inflammation in cardiac fibroblasts: an in vitro and in vivo study in aortic stenosis.

Matilla L, Ibarrola J, Arrieta V, Garcia-Peña A, Martinez-Martinez E, Sádaba R, Alvarez V, Navarro A, Fernández-Celis A, Gainza A, Santamaría E, Fernández-Irigoyen J, Bayes-Genis A, Rossignol P, López-Andrés N.

Clin Sci (Lond). 2019 Jul 17;133(14):1537-1548. doi: 10.1042/CS20190475. Print 2019 Jul 31.


Chest X-ray quantification of admission lung congestion as a prognostic factor in patients admitted for worsening heart failure from the ICALOR cohort study.

Kobayashi M, Bercker M, Huttin O, Pierre S, Sadoul N, Bozec E, Chouihed T, Ferreira JP, Zannad F, Rossignol P, Girerd N.

Int J Cardiol. 2020 Jan 15;299:192-198. doi: 10.1016/j.ijcard.2019.06.062. Epub 2019 Jun 26.


Effect of the mineralocorticoid receptor antagonist eplerenone on liver fat and metabolism in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial (MIRAD trial).

Johansen ML, Schou M, Rossignol P, Holm MR, Rasmussen J, Brandt N, Frandsen M, Chabanova E, Dela F, Faber J, Kistorp C.

Diabetes Obes Metab. 2019 Oct;21(10):2305-2314. doi: 10.1111/dom.13809. Epub 2019 Jul 5.


Association Between Layer-Specific Longitudinal Strain and Risk Factors of Heart Failure and Dyspnea: A Population-Based Study.

Huttin O, Girerd N, Coiro S, Bozec E, Selton-Suty C, Lamiral Z, Frikha Z, Kobayashi M, Argulian E, Narula J, Fraser AG, Rossignol P, Zannad F.

J Am Soc Echocardiogr. 2019 Jul;32(7):854-865.e8. doi: 10.1016/j.echo.2019.03.011. Epub 2019 May 16.


Proteomic Bioprofiles and Mechanistic Pathways of Progression to Heart Failure.

Ferreira JP, Verdonschot J, Collier T, Wang P, Pizard A, Bär C, Björkman J, Boccanelli A, Butler J, Clark A, Cleland JG, Delles C, Diez J, Girerd N, González A, Hazebroek M, Huby AC, Jukema W, Latini R, Leenders J, Levy D, Mebazaa A, Mischak H, Pinet F, Rossignol P, Sattar N, Sever P, Staessen JA, Thum T, Vodovar N, Zhang ZY, Heymans S, Zannad F.

Circ Heart Fail. 2019 May;12(5):e005897. doi: 10.1161/CIRCHEARTFAILURE.118.005897.


Estimated Long-Term Survival With Eplerenone.

Stienen S, Ferreira JP, Vincent J, Busselen M, Li B, McMurray JJV, Pitt B, Girerd N, Rossignol P, Zannad F.

J Am Coll Cardiol. 2019 May 14;73(18):2357-2359. doi: 10.1016/j.jacc.2019.02.043. No abstract available.


Plasma protein biomarkers and their association with mutually exclusive cardiovascular phenotypes: the FIBRO-TARGETS case-control analyses.

Ferreira JP, Pizard A, Machu JL, Bresso E, Rocca HB, Girerd N, Leroy C, González A, Diez J, Heymans S, Devignes MD, Rossignol P, Zannad F; FIBRO-TARGETS investigators.

Clin Res Cardiol. 2020 Jan;109(1):22-33. doi: 10.1007/s00392-019-01480-4. Epub 2019 May 6.


Low fibrosis biomarker levels predict cardiac resynchronization therapy response.

Massoullié G, Sapin V, Ploux S, Rossignol P, Mulliez A, Jean F, Marie PY, Merlin C, Pereira B, Andronache M, Motreff P, Chabin X, Sellal JM, Citron B, Lusson JR, Vorilhon C, Clerfond G, Bordachar P, Zannad F, Eschalier R.

Sci Rep. 2019 Apr 15;9(1):6103. doi: 10.1038/s41598-019-42468-4.


Mean BMI, visit-to-visit BMI variability and BMI changes during follow-up in patients with acute myocardial infarction with systolic dysfunction and/or heart failure: insights from the High-Risk Myocardial Infarction Initiative.

Stienen S, Ferreira JP, Girerd N, Duarte K, Lamiral Z, McMurray JJV, Pitt B, Dickstein K, Zannad F, Rossignol P; High-Risk Myocardial Infarction Database Initiative.

Clin Res Cardiol. 2019 Nov;108(11):1215-1225. doi: 10.1007/s00392-019-01453-7. Epub 2019 Apr 5.


Extracting Meaning of Tubular Injury Molecules: Implications for Cardiorenal Health.

Rossignol P, Ferreira JP.

Am J Nephrol. 2019;49(5):343-345. doi: 10.1159/000499533. Epub 2019 Apr 2. No abstract available.


The safety of mineralocorticoid antagonists in maintenance hemodialysis patients: two steps forward.

Rossignol P, Frimat L, Zannad F.

Kidney Int. 2019 Apr;95(4):747-749. doi: 10.1016/j.kint.2018.12.006.


Heart failure drug treatment.

Rossignol P, Hernandez AF, Solomon SD, Zannad F.

Lancet. 2019 Mar 9;393(10175):1034-1044. doi: 10.1016/S0140-6736(18)31808-7. Review.


A new area for the management of hyperkalaemia with potassium binders: clinical use in nephrology.

Rossignol P.

Eur Heart J Suppl. 2019 Feb;21(Suppl A):A48-A54. doi: 10.1093/eurheartj/suy032. Epub 2019 Feb 26.

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