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Regulation of Apoptotic Cell Clearance During Resolution of Inflammation.

Arienti S, Barth ND, Dorward DA, Rossi AG, Dransfield I.

Front Pharmacol. 2019 Aug 13;10:891. doi: 10.3389/fphar.2019.00891. eCollection 2019. Review.


A Negative Feedback Loop Regulates Integrin Inactivation and Promotes Neutrophil Recruitment to Inflammatory Sites.

McCormick B, Craig HE, Chu JY, Carlin LM, Canel M, Wollweber F, Toivakka M, Michael M, Astier AL, Norton L, Lilja J, Felton JM, Sasaki T, Ivaska J, Hers I, Dransfield I, Rossi AG, Vermeren S.

J Immunol. 2019 Sep 15;203(6):1579-1588. doi: 10.4049/jimmunol.1900443. Epub 2019 Aug 19.


Enhanced monocyte recruitment and delayed alternative macrophage polarization accompanies impaired repair following myocardial infarction in C57BL/6 compared to BALB/c mice.

Toor IS, Rückerl D, Mair I, Thomson A, Rossi AG, Newby DE, Allen JE, Gray GA.

Clin Exp Immunol. 2019 Oct;198(1):83-93. doi: 10.1111/cei.13330. Epub 2019 Jun 17.


Cathelicidin is a "fire alarm", generating protective NLRP3-dependent airway epithelial cell inflammatory responses during infection with Pseudomonas aeruginosa.

McHugh BJ, Wang R, Li HN, Beaumont PE, Kells R, Stevens H, Young L, Rossi AG, Gray RD, Dorin JR, Gwyer Findlay EL, Brough D, Davidson DJ.

PLoS Pathog. 2019 Apr 12;15(4):e1007694. doi: 10.1371/journal.ppat.1007694. eCollection 2019 Apr.


Inflammation Resolution and the Induction of Granulocyte Apoptosis by Cyclin-Dependent Kinase Inhibitor Drugs.

Cartwright JA, Lucas CD, Rossi AG.

Front Pharmacol. 2019 Feb 19;10:55. doi: 10.3389/fphar.2019.00055. eCollection 2019. Review.


Neutrophils in the initiation and resolution of acute pulmonary inflammation: understanding biological function and therapeutic potential.

Potey PM, Rossi AG, Lucas CD, Dorward DA.

J Pathol. 2019 Apr;247(5):672-685. doi: 10.1002/path.5221. Epub 2019 Feb 15. Review.


Repurposing simvastatin as a therapy for preterm labor: evidence from preclinical models.

Boyle AK, Rinaldi SF, Rossi AG, Saunders PTK, Norman JE.

FASEB J. 2019 Feb;33(2):2743-2758. doi: 10.1096/fj.201801104R. Epub 2018 Oct 12.


Validation of the Incremental Shuttle Walk Test as a Clinical End Point in Bronchiectasis.

Cartlidge MK, Smith MP, Bedi P, Donaldson S, Clarke A, Mantoani LC, Rabinovich RA, Rossi AG, Hill AT.

Chest. 2018 Dec;154(6):1321-1329. doi: 10.1016/j.chest.2018.09.019. Epub 2018 Oct 6.


Early PREdiction of sepsis using leukocyte surface biomarkers: the ExPRES-sepsis cohort study.

Shankar-Hari M, Datta D, Wilson J, Assi V, Stephen J, Weir CJ, Rennie J, Antonelli J, Bateman A, Felton JM, Warner N, Judge K, Keenan J, Wang A, Burpee T, Brown AK, Lewis SM, Mare T, Roy AI, Wright J, Hulme G, Dimmick I, Gray A, Rossi AG, Simpson AJ, Conway Morris A, Walsh TS.

Intensive Care Med. 2018 Nov;44(11):1836-1848. doi: 10.1007/s00134-018-5389-0. Epub 2018 Oct 5.


Augmentation of Human Monocyte Responses to Lipopolysaccharide by the Protein S and Mer/Tyro3 Receptor Tyrosine Kinase Axis.

Barth ND, Marwick JA, Heeb MJ, Gale AJ, Rossi AG, Dransfield I.

J Immunol. 2018 Nov 1;201(9):2602-2611. doi: 10.4049/jimmunol.1800249. Epub 2018 Sep 24.


Cerebral Concussion Primes the Lungs for Subsequent Neutrophil-Mediated Injury.

Humphries DC, O'Neill S, Scholefield E, Dorward DA, Mackinnon AC, Rossi AG, Haslett C, Andrews PJD, Rhodes J, Dhaliwal K.

Crit Care Med. 2018 Sep;46(9):e937-e944. doi: 10.1097/CCM.0000000000003270.


Cell-surface signatures of immune dysfunction risk-stratify critically ill patients: INFECT study.

Conway Morris A, Datta D, Shankar-Hari M, Stephen J, Weir CJ, Rennie J, Antonelli J, Bateman A, Warner N, Judge K, Keenan J, Wang A, Burpee T, Brown KA, Lewis SM, Mare T, Roy AI, Hulme G, Dimmick I, Rossi AG, Simpson AJ, Walsh TS.

Intensive Care Med. 2018 May;44(5):627-635. doi: 10.1007/s00134-018-5247-0. Epub 2018 Jun 7.


Neutrophils induce macrophage anti-inflammatory reprogramming by suppressing NF-κB activation.

Marwick JA, Mills R, Kay O, Michail K, Stephen J, Rossi AG, Dransfield I, Hirani N.

Cell Death Dis. 2018 Jun 4;9(6):665. doi: 10.1038/s41419-018-0710-y.


Purine metabolism controls innate lymphoid cell function and protects against intestinal injury.

Crittenden S, Cheyne A, Adams A, Forster T, Robb CT, Felton J, Ho GT, Ruckerl D, Rossi AG, Anderton SM, Ghazal P, Satsangi J, Howie SE, Yao C.

Immunol Cell Biol. 2018 Nov;96(10):1049-1059. doi: 10.1111/imcb.12167. Epub 2018 Jul 10.


Immune complex-induced neutrophil functions: A focus on cell death.

Vermeren S, Karmakar U, Rossi AG.

Eur J Clin Invest. 2018 Nov;48 Suppl 2:e12948. doi: 10.1111/eci.12948. Epub 2018 May 22. Review.


Blood Neutrophils Are Reprogrammed in Bronchiectasis.

Bedi P, Davidson DJ, McHugh BJ, Rossi AG, Hill AT.

Am J Respir Crit Care Med. 2018 Oct 1;198(7):880-890. doi: 10.1164/rccm.201712-2423OC.


Mitochondrial DNA Is a Pro-Inflammatory Damage-Associated Molecular Pattern Released During Active IBD.

Boyapati RK, Dorward DA, Tamborska A, Kalla R, Ventham NT, Doherty MK, Whitfield PD, Gray M, Loane J, Rossi AG, Satsangi J, Ho GT.

Inflamm Bowel Dis. 2018 Sep 15;24(10):2113-2122. doi: 10.1093/ibd/izy095.


Facilitation of IL-22 production from innate lymphoid cells by prostaglandin E2 prevents experimental lung neutrophilic inflammation.

Felton JM, Duffin R, Robb CT, Crittenden S, Anderton SM, Howie SEM, Whyte MKB, Rossi AG, Yao C.

Thorax. 2018 Nov;73(11):1081-1084. doi: 10.1136/thoraxjnl-2017-211097. Epub 2018 Mar 24.


Mer-mediated eosinophil efferocytosis regulates resolution of allergic airway inflammation.

Felton JM, Lucas CD, Dorward DA, Duffin R, Kipari T, Vermeren S, Robb CT, MacLeod KG, Serrels B, Schwarze J, Haslett C, Dransfield I, Rossi AG.

J Allergy Clin Immunol. 2018 Dec;142(6):1884-1893.e6. doi: 10.1016/j.jaci.2018.01.029. Epub 2018 Feb 8.


The "Phagocytic Synapse" and Clearance of Apoptotic Cells.

Barth ND, Marwick JA, Vendrell M, Rossi AG, Dransfield I.

Front Immunol. 2017 Dec 4;8:1708. doi: 10.3389/fimmu.2017.01708. eCollection 2017. Review.


The BRICS (Bronchiectasis Radiologically Indexed CT Score): A Multicenter Study Score for Use in Idiopathic and Postinfective Bronchiectasis.

Bedi P, Chalmers JD, Goeminne PC, Mai C, Saravanamuthu P, Velu PP, Cartlidge MK, Loebinger MR, Jacob J, Kamal F, Schembri N, Aliberti S, Hill U, Harrison M, Johnson C, Screaton N, Haworth C, Polverino E, Rosales E, Torres A, Benegas MN, Rossi AG, Patel D, Hill AT.

Chest. 2018 May;153(5):1177-1186. doi: 10.1016/j.chest.2017.11.033. Epub 2017 Dec 13.


Adoption of in vitro systems and zebrafish embryos as alternative models for reducing rodent use in assessments of immunological and oxidative stress responses to nanomaterials.

Johnston HJ, Verdon R, Gillies S, Brown DM, Fernandes TF, Henry TB, Rossi AG, Tran L, Tucker C, Tyler CR, Stone V.

Crit Rev Toxicol. 2018 Mar;48(3):252-271. doi: 10.1080/10408444.2017.1404965. Epub 2017 Dec 14. Review.


Endometrial apoptosis and neutrophil infiltration during menstruation exhibits spatial and temporal dynamics that are recapitulated in a mouse model.

Armstrong GM, Maybin JA, Murray AA, Nicol M, Walker C, Saunders PTK, Rossi AG, Critchley HOD.

Sci Rep. 2017 Dec 12;7(1):17416. doi: 10.1038/s41598-017-17565-x.


Immune cell and transcriptomic analysis of the human decidua in term and preterm parturition.

Rinaldi SF, Makieva S, Saunders PT, Rossi AG, Norman JE.

Mol Hum Reprod. 2017 Oct 1;23(10):708-724. doi: 10.1093/molehr/gax038.


Delayed neutrophil apoptosis enhances NET formation in cystic fibrosis.

Gray RD, Hardisty G, Regan KH, Smith M, Robb CT, Duffin R, Mackellar A, Felton JM, Paemka L, McCullagh BN, Lucas CD, Dorward DA, McKone EF, Cooke G, Donnelly SC, Singh PK, Stoltz DA, Haslett C, McCray PB, Whyte MKB, Rossi AG, Davidson DJ.

Thorax. 2018 Feb;73(2):134-144. doi: 10.1136/thoraxjnl-2017-210134. Epub 2017 Sep 15.


Prostaglandin E2 stimulates adaptive IL-22 production and promotes allergic contact dermatitis.

Robb CT, McSorley HJ, Lee J, Aoki T, Yu C, Crittenden S, Astier A, Felton JM, Parkinson N, Ayele A, Breyer RM, Anderton SM, Narumiya S, Rossi AG, Howie SE, Guttman-Yassky E, Weller RB, Yao C.

J Allergy Clin Immunol. 2018 Jan;141(1):152-162. doi: 10.1016/j.jaci.2017.04.045. Epub 2017 Jun 3.


A Randomized Controlled Trial of Atorvastatin in Patients With Bronchiectasis Infected With Pseudomonas Aeruginosa: A Proof of Concept Study.

Bedi P, Chalmers JD, Graham C, Clarke A, Donaldson S, Doherty C, Govan JRW, Davidson DJ, Rossi AG, Hill AT.

Chest. 2017 Aug;152(2):368-378. doi: 10.1016/j.chest.2017.05.017. Epub 2017 May 26.


Novel role for endogenous mitochondrial formylated peptide-driven formyl peptide receptor 1 signalling in acute respiratory distress syndrome.

Dorward DA, Lucas CD, Doherty MK, Chapman GB, Scholefield EJ, Conway Morris A, Felton JM, Kipari T, Humphries DC, Robb CT, Simpson AJ, Whitfield PD, Haslett C, Dhaliwal K, Rossi AG.

Thorax. 2017 Oct;72(10):928-936. doi: 10.1136/thoraxjnl-2017-210030. Epub 2017 May 3.


MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation.

Ho GT, Aird RE, Liu B, Boyapati RK, Kennedy NA, Dorward DA, Noble CL, Shimizu T, Carter RN, Chew ETS, Morton NM, Rossi AG, Sartor RB, Iredale JP, Satsangi J.

Mucosal Immunol. 2018 Jan;11(1):120-130. doi: 10.1038/mi.2017.31. Epub 2017 Apr 12.


The cyclin-dependent kinase inhibitor AT7519 accelerates neutrophil apoptosis in sepsis-related acute respiratory distress syndrome.

Dorward DA, Felton JM, Robb CT, Craven T, Kipari T, Walsh TS, Haslett C, Kefala K, Rossi AG, Lucas CD.

Thorax. 2017 Feb;72(2):182-185. doi: 10.1136/thoraxjnl-2016-209229. Epub 2016 Oct 24.


Genetic and pharmacological inhibition of CDK9 drives neutrophil apoptosis to resolve inflammation in zebrafish in vivo.

Hoodless LJ, Lucas CD, Duffin R, Denvir MA, Haslett C, Tucker CS, Rossi AG.

Sci Rep. 2016 Nov 11;5:36980. doi: 10.1038/srep36980.


Non-canonical PI3K-Cdc42-Pak-Mek-Erk Signaling Promotes Immune-Complex-Induced Apoptosis in Human Neutrophils.

Chu JY, Dransfield I, Rossi AG, Vermeren S.

Cell Rep. 2016 Oct 4;17(2):374-386. doi: 10.1016/j.celrep.2016.09.006.


Posture and body balance of schoolchildren aged 8 to 12 years with and without oral breathing.

Roggia B, Santos VA Filha, Correa B, Rossi ÂG.

Codas. 2016 Jul-Aug;28(4):395-402. doi: 10.1590/2317-1782/20162015002. Epub 2016 Aug 18. English, Portuguese.


Early PREdiction of Severe Sepsis (ExPRES-Sepsis) study: protocol for an observational derivation study to discover potential leucocyte cell surface biomarkers.

Datta D, Conway Morris A, Antonelli J, Warner N, Brown KA, Wright J, Simpson AJ, Rennie J, Hulme G, Lewis SM, Mare TA, Cookson S, Weir CJ, Dimmick I, Keenan J, Rossi AG, Shankar-Hari M, Walsh TS; ExPRES Sepsis Investigators.

BMJ Open. 2016 Aug 1;6(8):e011335. doi: 10.1136/bmjopen-2016-011335.


Predictive value of cell-surface markers in infections in critically ill patients: protocol for an observational study (ImmuNe FailurE in Critical Therapy (INFECT) Study).

Conway Morris A, Datta D, Shankar-Hari M, Weir CJ, Rennie J, Antonelli J, Rossi AG, Warner N, Keenan J, Wang A, Brown KA, Lewis S, Mare T, Simpson AJ, Hulme G, Dimmick I, Walsh TS.

BMJ Open. 2016 Jul 18;6(7):e011326. doi: 10.1136/bmjopen-2016-011326.


11β-Hydroxysteroid Dehydrogenase Type 1 Is Expressed in Neutrophils and Restrains an Inflammatory Response in Male Mice.

Coutinho AE, Kipari TM, Zhang Z, Esteves CL, Lucas CD, Gilmour JS, Webster SP, Walker BR, Hughes J, Savill JS, Seckl JR, Rossi AG, Chapman KE.

Endocrinology. 2016 Jul;157(7):2928-36. doi: 10.1210/en.2016-1118. Epub 2016 May 4.


Systemic inflammation after critical illness: relationship with physical recovery and exploration of potential mechanisms.

Griffith DM, Lewis S, Rossi AG, Rennie J, Salisbury L, Merriweather JL, Templeton K, Walsh TS; RECOVER Investigators.

Thorax. 2016 Sep;71(9):820-9. doi: 10.1136/thoraxjnl-2015-208114. Epub 2016 Apr 26.


Key mechanisms governing resolution of lung inflammation.

Robb CT, Regan KH, Dorward DA, Rossi AG.

Semin Immunopathol. 2016 Jul;38(4):425-48. doi: 10.1007/s00281-016-0560-6. Epub 2016 Apr 27. Review.


Low-pathogenicity Mycoplasma spp. alter human monocyte and macrophage function and are highly prevalent among patients with ventilator-acquired pneumonia.

Nolan TJ, Gadsby NJ, Hellyer TP, Templeton KE, McMullan R, McKenna JP, Rennie J, Robb CT, Walsh TS, Rossi AG, Conway Morris A, Simpson AJ.

Thorax. 2016 Jul;71(7):594-600. doi: 10.1136/thoraxjnl-2015-208050. Epub 2016 Apr 12.


Neutrophil-derived alpha defensins control inflammation by inhibiting macrophage mRNA translation.

Brook M, Tomlinson GH, Miles K, Smith RW, Rossi AG, Hiemstra PS, van 't Wout EF, Dean JL, Gray NK, Lu W, Gray M.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4350-5. doi: 10.1073/pnas.1601831113. Epub 2016 Apr 4.


The role of neutrophils in inflammation resolution.

Jones HR, Robb CT, Perretti M, Rossi AG.

Semin Immunol. 2016 Apr;28(2):137-45. doi: 10.1016/j.smim.2016.03.007. Epub 2016 Mar 24. Review.


Prostaglandin E₂ constrains systemic inflammation through an innate lymphoid cell-IL-22 axis.

Duffin R, O'Connor RA, Crittenden S, Forster T, Yu C, Zheng X, Smyth D, Robb CT, Rossi F, Skouras C, Tang S, Richards J, Pellicoro A, Weller RB, Breyer RM, Mole DJ, Iredale JP, Anderton SM, Narumiya S, Maizels RM, Ghazal P, Howie SE, Rossi AG, Yao C.

Science. 2016 Mar 18;351(6279):1333-8. doi: 10.1126/science.aad9903.


Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis.

Meijer L, Nelson DJ, Riazanski V, Gabdoulkhakova AG, Hery-Arnaud G, Le Berre R, Loaëc N, Oumata N, Galons H, Nowak E, Gueganton L, Dorothée G, Prochazkova M, Hall B, Kulkarni AB, Gray RD, Rossi AG, Witko-Sarsat V, Norez C, Becq F, Ravel D, Mottier D, Rault G.

J Innate Immun. 2016;8(4):330-49. doi: 10.1159/000444256. Epub 2016 Mar 18. Review.


Gut mucosal DAMPs in IBD: from mechanisms to therapeutic implications.

Boyapati RK, Rossi AG, Satsangi J, Ho GT.

Mucosal Immunol. 2016 May;9(3):567-82. doi: 10.1038/mi.2016.14. Epub 2016 Mar 2. Review.


Models for the Study of the Cross Talk Between Inflammation and Cell Cycle.

Hoodless LJ, Robb CT, Felton JM, Tucker CS, Rossi AG.

Methods Mol Biol. 2016;1336:179-209. doi: 10.1007/978-1-4939-2926-9_15.


Optical projection tomography permits efficient assessment of infarct volume in the murine heart postmyocardial infarction.

Zhao X, Wu J, Gray CD, McGregor K, Rossi AG, Morrison H, Jansen MA, Gray GA.

Am J Physiol Heart Circ Physiol. 2015 Aug 15;309(4):H702-10. doi: 10.1152/ajpheart.00233.2015. Epub 2015 Jun 12.


Crosstalk between monocytes and myometrial smooth muscle in culture generates synergistic pro-inflammatory cytokine production and enhances myocyte contraction, with effects opposed by progesterone.

Rajagopal SP, Hutchinson JL, Dorward DA, Rossi AG, Norman JE.

Mol Hum Reprod. 2015 Aug;21(8):672-86. doi: 10.1093/molehr/gav027. Epub 2015 May 22.


Mechanism of neutrophil activation and toxicity elicited by engineered nanomaterials.

Johnston H, Brown DM, Kanase N, Euston M, Gaiser BK, Robb CT, Dyrynda E, Rossi AG, Brown ER, Stone V.

Toxicol In Vitro. 2015 Aug;29(5):1172-84. doi: 10.1016/j.tiv.2015.04.021. Epub 2015 May 8.


The role of formylated peptides and formyl peptide receptor 1 in governing neutrophil function during acute inflammation.

Dorward DA, Lucas CD, Chapman GB, Haslett C, Dhaliwal K, Rossi AG.

Am J Pathol. 2015 May;185(5):1172-84. doi: 10.1016/j.ajpath.2015.01.020. Epub 2015 Mar 17. Review.


Induction of eosinophil apoptosis by hydrogen peroxide promotes the resolution of allergic inflammation.

Reis AC, Alessandri AL, Athayde RM, Perez DA, Vago JP, Ávila TV, Ferreira TP, de Arantes AC, Coutinho Dde S, Rachid MA, Sousa LP, Martins MA, Menezes GB, Rossi AG, Teixeira MM, Pinho V.

Cell Death Dis. 2015 Feb 12;6:e1632. doi: 10.1038/cddis.2014.580.

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