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Items: 1 to 50 of 122

1.

Physical, ecological and human dimensions of environmental change in Brazil's Pantanal wetland: Synthesis and research agenda.

Schulz C, Whitney BS, Rossetto OC, Neves DM, Crabb L, de Oliveira EC, Terra Lima PL, Afzal M, Laing AF, de Souza Fernandes LC, da Silva CA, Steinke VA, Torres Steinke E, Saito CH.

Sci Total Environ. 2019 Oct 15;687:1011-1027. doi: 10.1016/j.scitotenv.2019.06.023. Epub 2019 Jun 5. Review.

2.

The role of the single interchains disulfide bond in tetanus and botulinum neurotoxins and the development of antitetanus and antibotulism drugs.

Rossetto O, Pirazzini M, Lista F, Montecucco C.

Cell Microbiol. 2019 May 3:e13037. doi: 10.1111/cmi.13037. [Epub ahead of print] Review.

PMID:
31050145
3.

Transynaptic Action of Botulinum Neurotoxin Type A at Central Cholinergic Boutons.

Caleo M, Spinelli M, Colosimo F, Matak I, Rossetto O, Lackovic Z, Restani L.

J Neurosci. 2018 Nov 28;38(48):10329-10337. doi: 10.1523/JNEUROSCI.0294-18.2018. Epub 2018 Oct 12.

4.

Primary resistance of human patients to botulinum neurotoxins A and B.

Pirazzini M, Carle S, Barth H, Rossetto O, Montecucco C.

Ann Clin Transl Neurol. 2018 Jul 17;5(8):971-975. doi: 10.1002/acn3.586. eCollection 2018 Aug.

5.

Variability in venom composition of European viper subspecies limits the cross-effectiveness of antivenoms.

Zanetti G, Duregotti E, Locatelli CA, Giampreti A, Lonati D, Rossetto O, Pirazzini M.

Sci Rep. 2018 Jun 29;8(1):9818. doi: 10.1038/s41598-018-28135-0.

6.

High Conservation of Tetanus and Botulinum Neurotoxins Cleavage Sites on Human SNARE Proteins Suggests That These Pathogens Exerted Little or No Evolutionary Pressure on Humans.

Carle S, Pirazzini M, Rossetto O, Barth H, Montecucco C.

Toxins (Basel). 2017 Dec 19;9(12). pii: E404. doi: 10.3390/toxins9120404.

7.

Hsp90 and Thioredoxin-Thioredoxin Reductase enable the catalytic activity of Clostridial neurotoxins inside nerve terminals.

Pirazzini M, Azarnia Tehran D, Zanetti G, Rossetto O, Montecucco C.

Toxicon. 2018 Jun 1;147:32-37. doi: 10.1016/j.toxicon.2017.10.028. Epub 2017 Oct 28. Review.

PMID:
29111118
8.

The binding of botulinum neurotoxins to different peripheral neurons.

Rossetto O.

Toxicon. 2018 Jun 1;147:27-31. doi: 10.1016/j.toxicon.2017.10.010. Epub 2017 Oct 16.

PMID:
29042309
9.

Botulinum neurotoxin C mutants reveal different effects of syntaxin or SNAP-25 proteolysis on neuromuscular transmission.

Zanetti G, Sikorra S, Rummel A, Krez N, Duregotti E, Negro S, Henke T, Rossetto O, Binz T, Pirazzini M.

PLoS Pathog. 2017 Aug 11;13(8):e1006567. doi: 10.1371/journal.ppat.1006567. eCollection 2017 Aug.

10.

Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology.

Pirazzini M, Rossetto O, Eleopra R, Montecucco C.

Pharmacol Rev. 2017 Apr;69(2):200-235. doi: 10.1124/pr.116.012658. Review.

11.

Challenges in searching for therapeutics against Botulinum Neurotoxins.

Pirazzini M, Rossetto O.

Expert Opin Drug Discov. 2017 May;12(5):497-510. doi: 10.1080/17460441.2017.1303476. Epub 2017 Mar 17. Review.

PMID:
28271909
12.

Electrophysiological Characterization of the Antarease Metalloprotease from Tityus serrulatus Venom.

Zornetta I, Scorzeto M, Mendes Dos Reis PV, De Lima ME, Montecucco C, Megighian A, Rossetto O.

Toxins (Basel). 2017 Feb 27;9(3). pii: E81. doi: 10.3390/toxins9030081.

13.

Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature.

Peck MW, Smith TJ, Anniballi F, Austin JW, Bano L, Bradshaw M, Cuervo P, Cheng LW, Derman Y, Dorner BG, Fisher A, Hill KK, Kalb SR, Korkeala H, Lindström M, Lista F, Lúquez C, Mazuet C, Pirazzini M, Popoff MR, Rossetto O, Rummel A, Sesardic D, Singh BR, Stringer SC.

Toxins (Basel). 2017 Jan 18;9(1). pii: E38. doi: 10.3390/toxins9010038. Review.

14.

Erratum to "Inhibition of botulinum neurotoxins interchain disulfide bond reduction prevents the peripheral neuroparalysis of botulism" [Biochem. Pharmacol. 98 (2015) 522-530].

Zanetti G, Azarnia Tehran D, Pirazzini M, Binz T, Shone CC, Fillo S, Lista F, Rossetto O, Montecucco C.

Biochem Pharmacol. 2016 Sep 1;115:152. doi: 10.1016/j.bcp.2016.07.006. Epub 2016 Jul 12. No abstract available.

PMID:
27498956
15.

Hsp90 is involved in the entry of clostridial neurotoxins into the cytosol of nerve terminals.

Azarnia Tehran D, Pirazzini M, Leka O, Mattarei A, Lista F, Binz T, Rossetto O, Montecucco C.

Cell Microbiol. 2017 Feb;19(2). doi: 10.1111/cmi.12647. Epub 2016 Aug 4.

PMID:
27404998
16.

A Novel Inhibitor Prevents the Peripheral Neuroparalysis of Botulinum Neurotoxins.

Azarnia Tehran D, Zanetti G, Leka O, Lista F, Fillo S, Binz T, Shone CC, Rossetto O, Montecucco C, Paradisi C, Mattarei A, Pirazzini M.

Sci Rep. 2015 Dec 16;5:17513. doi: 10.1038/srep17513.

17.

Inhibition of botulinum neurotoxins interchain disulfide bond reduction prevents the peripheral neuroparalysis of botulism.

Zanetti G, Azarnia Tehran D, Pirazzini M, Binz T, Shone CC, Fillo S, Lista F, Rossetto O, Montecucco C.

Biochem Pharmacol. 2015 Dec 1;98(3):522-30. doi: 10.1016/j.bcp.2015.09.023. Epub 2015 Oct 9.

PMID:
26449594
18.

On the translocation of botulinum and tetanus neurotoxins across the membrane of acidic intracellular compartments.

Pirazzini M, Azarnia Tehran D, Leka O, Zanetti G, Rossetto O, Montecucco C.

Biochim Biophys Acta. 2016 Mar;1858(3):467-74. doi: 10.1016/j.bbamem.2015.08.014. Epub 2015 Aug 22. Review.

19.

Altered sensory processing and dendritic remodeling in hyperexcitable visual cortical networks.

Vannini E, Restani L, Pietrasanta M, Panarese A, Mazzoni A, Rossetto O, Middei S, Micera S, Caleo M.

Brain Struct Funct. 2016 Jul;221(6):2919-36. doi: 10.1007/s00429-015-1080-1. Epub 2015 Jul 12.

PMID:
26163822
20.

Current gaps in basic science knowledge of botulinum neurotoxin biological actions.

Rossetto O, Pirazzini M, Montecucco C.

Toxicon. 2015 Dec 1;107(Pt A):59-63. doi: 10.1016/j.toxicon.2015.07.002. Epub 2015 Jul 7.

PMID:
26163315
21.

The thioredoxin reductase--Thioredoxin redox system cleaves the interchain disulphide bond of botulinum neurotoxins on the cytosolic surface of synaptic vesicles.

Pirazzini M, Azarnia Tehran D, Zanetti G, Lista F, Binz T, Shone CC, Rossetto O, Montecucco C.

Toxicon. 2015 Dec 1;107(Pt A):32-6. doi: 10.1016/j.toxicon.2015.06.019. Epub 2015 Jun 27.

PMID:
26130523
22.

Thioredoxin and its reductase are present on synaptic vesicles, and their inhibition prevents the paralysis induced by botulinum neurotoxins.

Pirazzini M, Azarnia Tehran D, Zanetti G, Megighian A, Scorzeto M, Fillo S, Shone CC, Binz T, Rossetto O, Lista F, Montecucco C.

Cell Rep. 2014 Sep 25;8(6):1870-1878. doi: 10.1016/j.celrep.2014.08.017. Epub 2014 Sep 15.

23.

Botulinum neurotoxins: genetic, structural and mechanistic insights.

Rossetto O, Pirazzini M, Montecucco C.

Nat Rev Microbiol. 2014 Aug;12(8):535-49. doi: 10.1038/nrmicro3295. Epub 2014 Jun 30. Review.

PMID:
24975322
24.

Botulinum toxin type A selectivity for certain types of pain is associated with capsaicin-sensitive neurons.

Matak I, Rossetto O, Lacković Z.

Pain. 2014 Aug;155(8):1516-26. doi: 10.1016/j.pain.2014.04.027. Epub 2014 May 2.

PMID:
24793910
25.

Intrathecal administration of botulinum toxin type A improves urinary bladder function and reduces pain in rats with cystitis.

Coelho A, Oliveira R, Rossetto O, Cruz CD, Cruz F, Avelino A.

Eur J Pain. 2014 Nov;18(10):1480-9. doi: 10.1002/ejp.513. Epub 2014 Apr 23.

PMID:
24756904
26.

Neurotoxicity of European viperids in Italy: Pavia Poison Control Centre case series 2001-2011.

Lonati D, Giampreti A, Rossetto O, Petrolini VM, Vecchio S, Buscaglia E, Mazzoleni M, Chiara F, Aloise M, Gentilli A, Montecucco C, Coccini T, Locatelli CA.

Clin Toxicol (Phila). 2014 Apr;52(4):269-76. doi: 10.3109/15563650.2014.904046. Epub 2014 Apr 7.

PMID:
24708390
27.

Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain.

Pirazzini M, Henke T, Rossetto O, Mahrhold S, Krez N, Rummel A, Montecucco C, Binz T.

FEBS Lett. 2013 Nov 29;587(23):3831-6. doi: 10.1016/j.febslet.2013.10.010. Epub 2013 Oct 21.

28.

Evidence for a radial SNARE super-complex mediating neurotransmitter release at the Drosophila neuromuscular junction.

Megighian A, Zordan M, Pantano S, Scorzeto M, Rigoni M, Zanini D, Rossetto O, Montecucco C.

J Cell Sci. 2013 Jul 15;126(Pt 14):3134-40. doi: 10.1242/jcs.123802. Epub 2013 May 17.

29.

Botulinum neurotoxin type A is internalized and translocated from small synaptic vesicles at the neuromuscular junction.

Colasante C, Rossetto O, Morbiato L, Pirazzini M, Molgó J, Montecucco C.

Mol Neurobiol. 2013 Aug;48(1):120-7. doi: 10.1007/s12035-013-8423-9. Epub 2013 Mar 8.

PMID:
23471747
30.

Botulinum neurotoxins.

Rossetto O, Megighian A, Scorzeto M, Montecucco C.

Toxicon. 2013 Jun 1;67:31-6. doi: 10.1016/j.toxicon.2013.01.017. Epub 2013 Feb 19. Review. No abstract available.

PMID:
23435262
31.

Tetanus neurotoxin.

Rossetto O, Scorzeto M, Megighian A, Montecucco C.

Toxicon. 2013 May;66:59-63. doi: 10.1016/j.toxicon.2012.12.027. Epub 2013 Feb 16. Review. No abstract available.

PMID:
23419592
32.

Botulinum neurotoxins A and E undergo retrograde axonal transport in primary motor neurons.

Restani L, Giribaldi F, Manich M, Bercsenyi K, Menendez G, Rossetto O, Caleo M, Schiavo G.

PLoS Pathog. 2012 Dec;8(12):e1003087. doi: 10.1371/journal.ppat.1003087. Epub 2012 Dec 27.

33.

Botulinum neurotoxin serotype D is poorly effective in humans: an in vivo electrophysiological study.

Eleopra R, Montecucco C, Devigili G, Lettieri C, Rinaldo S, Verriello L, Pirazzini M, Caccin P, Rossetto O.

Clin Neurophysiol. 2013 May;124(5):999-1004. doi: 10.1016/j.clinph.2012.11.004. Epub 2012 Dec 13.

PMID:
23245668
34.

Time course and temperature dependence of the membrane translocation of tetanus and botulinum neurotoxins C and D in neurons.

Pirazzini M, Rossetto O, Bertasio C, Bordin F, Shone CC, Binz T, Montecucco C.

Biochem Biophys Res Commun. 2013 Jan 4;430(1):38-42. doi: 10.1016/j.bbrc.2012.11.048. Epub 2012 Nov 27.

PMID:
23200837
35.

The thioredoxin reductase-thioredoxin system is involved in the entry of tetanus and botulinum neurotoxins in the cytosol of nerve terminals.

Pirazzini M, Bordin F, Rossetto O, Shone CC, Binz T, Montecucco C.

FEBS Lett. 2013 Jan 16;587(2):150-5. doi: 10.1016/j.febslet.2012.11.007. Epub 2012 Nov 21.

36.

Tetanus neurotoxin-induced epilepsy in mouse visual cortex.

Mainardi M, Pietrasanta M, Vannini E, Rossetto O, Caleo M.

Epilepsia. 2012 Jul;53(7):e132-6. doi: 10.1111/j.1528-1167.2012.03510.x. Epub 2012 May 11.

37.

An update on the mechanism of action of tetanus and botulinum neurotoxins.

Rossetto O, Pirazzini M, Bolognese P, Rigoni M, Montecucco C.

Acta Chim Slov. 2011 Dec;58(4):702-7. Review.

PMID:
24061118
38.

Re-assembled botulinum neurotoxin inhibits CNS functions without systemic toxicity.

Ferrari E, Maywood ES, Restani L, Caleo M, Pirazzini M, Rossetto O, Hastings MH, Niranjan D, Schiavo G, Davletov B.

Toxins (Basel). 2011 Apr;3(4):345-55. doi: 10.3390/toxins3040345. Epub 2011 Mar 24.

39.

Evidence for anterograde transport and transcytosis of botulinum neurotoxin A (BoNT/A).

Restani L, Antonucci F, Gianfranceschi L, Rossi C, Rossetto O, Caleo M.

J Neurosci. 2011 Nov 2;31(44):15650-9. doi: 10.1523/JNEUROSCI.2618-11.2011.

40.

Double anchorage to the membrane and intact inter-chain disulfide bond are required for the low pH induced entry of tetanus and botulinum neurotoxins into neurons.

Pirazzini M, Rossetto O, Bolognese P, Shone CC, Montecucco C.

Cell Microbiol. 2011 Nov;13(11):1731-43. doi: 10.1111/j.1462-5822.2011.01654.x. Epub 2011 Aug 25.

PMID:
21790947
41.

Alternative splicing of the human gene SYBL1 modulates protein domain architecture of Longin VAMP7/TI-VAMP, showing both non-SNARE and synaptobrevin-like isoforms.

Vacca M, Albania L, Della Ragione F, Carpi A, Rossi V, Strazzullo M, De Franceschi N, Rossetto O, Filippini F, D'Esposito M.

BMC Mol Biol. 2011 May 24;12:26. doi: 10.1186/1471-2199-12-26.

42.

Arg206 of SNAP-25 is essential for neuroexocytosis at the Drosophila melanogaster neuromuscular junction.

Megighian A, Scorzeto M, Zanini D, Pantano S, Rigoni M, Benna C, Rossetto O, Montecucco C, Zordan M.

J Cell Sci. 2010 Oct 1;123(Pt 19):3276-83. doi: 10.1242/jcs.071316. Epub 2010 Sep 7.

43.

Mass spectrometry analysis of the phospholipase A(2) activity of snake pre-synaptic neurotoxins in cultured neurons.

Paoli M, Rigoni M, Koster G, Rossetto O, Montecucco C, Postle AD.

J Neurochem. 2009 Nov;111(3):737-44. doi: 10.1111/j.1471-4159.2009.06365.x. Epub 2009 Aug 27.

44.

Assay of diffusion of different botulinum neurotoxin type a formulations injected in the mouse leg.

Carli L, Montecucco C, Rossetto O.

Muscle Nerve. 2009 Sep;40(3):374-80. doi: 10.1002/mus.21343.

PMID:
19618426
45.

Calcium imaging of muscle cells treated with snake myotoxins reveals toxin synergism and presence of acceptors.

Cintra-Francischinelli M, Pizzo P, Rodrigues-Simioni L, Ponce-Soto LA, Rossetto O, Lomonte B, Gutiérrez JM, Pozzan T, Montecucco C.

Cell Mol Life Sci. 2009 May;66(10):1718-28. doi: 10.1007/s00018-009-9053-2.

PMID:
19370311
46.

Calcium overload in nerve terminals of cultured neurons intoxicated by alpha-latrotoxin and snake PLA2 neurotoxins.

Tedesco E, Rigoni M, Caccin P, Grishin E, Rossetto O, Montecucco C.

Toxicon. 2009 Aug;54(2):138-44. doi: 10.1016/j.toxicon.2009.03.025. Epub 2009 Mar 31.

PMID:
19341756
47.

The N-terminal half of the receptor domain of botulinum neurotoxin A binds to microdomains of the plasma membrane.

Muraro L, Tosatto S, Motterlini L, Rossetto O, Montecucco C.

Biochem Biophys Res Commun. 2009 Feb 27;380(1):76-80. doi: 10.1016/j.bbrc.2009.01.037. Epub 2009 Jan 20.

PMID:
19161982
48.

Neurotoxicity of inverted-cone shaped lipids.

Caccin P, Rossetto O, Montecucco C.

Neurotoxicology. 2009 Mar;30(2):174-81. doi: 10.1016/j.neuro.2008.11.013. Epub 2008 Dec 9.

PMID:
19114055
49.

Different mechanisms of inhibition of nerve terminals by botulinum and snake presynaptic neurotoxins.

Montecucco C, Rossetto O, Caccin P, Rigoni M, Carli L, Morbiato L, Muraro L, Paoli M.

Toxicon. 2009 Oct;54(5):561-4. doi: 10.1016/j.toxicon.2008.12.012. Epub 2008 Dec 14. Review.

PMID:
19111566
50.

On the quaternary structure of taipoxin and textilotoxin: the advantage of being multiple.

Montecucco C, Rossetto O.

Toxicon. 2008 Jun 15;51(8):1560-2. doi: 10.1016/j.toxicon.2008.03.020. Epub 2008 Mar 25. No abstract available.

PMID:
18471843

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