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Items: 32

1.

Genome-wide association analysis identifies genetic correlates of immune infiltrates in solid tumors.

Siemers NO, Holloway JL, Chang H, Chasalow SD, Ross-MacDonald PB, Voliva CF, Szustakowski JD.

PLoS One. 2017 Jul 27;12(7):e0179726. doi: 10.1371/journal.pone.0179726. eCollection 2017.

2.

Immunomodulatory Activity of Nivolumab in Metastatic Renal Cell Carcinoma.

Choueiri TK, Fishman MN, Escudier B, McDermott DF, Drake CG, Kluger H, Stadler WM, Perez-Gracia JL, McNeel DG, Curti B, Harrison MR, Plimack ER, Appleman L, Fong L, Albiges L, Cohen L, Young TC, Chasalow SD, Ross-Macdonald P, Srivastava S, Jure-Kunkel M, Kurland JF, Simon JS, Sznol M.

Clin Cancer Res. 2016 Nov 15;22(22):5461-5471. doi: 10.1158/1078-0432.CCR-15-2839. Epub 2016 May 11.

3.

A Landscape of Pharmacogenomic Interactions in Cancer.

Iorio F, Knijnenburg TA, Vis DJ, Bignell GR, Menden MP, Schubert M, Aben N, Gonçalves E, Barthorpe S, Lightfoot H, Cokelaer T, Greninger P, van Dyk E, Chang H, de Silva H, Heyn H, Deng X, Egan RK, Liu Q, Mironenko T, Mitropoulos X, Richardson L, Wang J, Zhang T, Moran S, Sayols S, Soleimani M, Tamborero D, Lopez-Bigas N, Ross-Macdonald P, Esteller M, Gray NS, Haber DA, Stratton MR, Benes CH, Wessels LFA, Saez-Rodriguez J, McDermott U, Garnett MJ.

Cell. 2016 Jul 28;166(3):740-754. doi: 10.1016/j.cell.2016.06.017. Epub 2016 Jul 7.

4.

Sensitivity of Small Cell Lung Cancer to BET Inhibition Is Mediated by Regulation of ASCL1 Gene Expression.

Lenhart R, Kirov S, Desilva H, Cao J, Lei M, Johnston K, Peterson R, Schweizer L, Purandare A, Ross-Macdonald P, Fairchild C, Wong T, Wee S.

Mol Cancer Ther. 2015 Oct;14(10):2167-74. doi: 10.1158/1535-7163.MCT-15-0037. Epub 2015 Aug 7.

5.

Impairment of type I but not type III IFN signaling by hepatitis C virus infection influences antiviral responses in primary human hepatocytes.

Friborg J, Ross-Macdonald P, Cao J, Willard R, Lin B, Eggers B, McPhee F.

PLoS One. 2015 Mar 31;10(3):e0121734. doi: 10.1371/journal.pone.0121734. eCollection 2015.

6.

Biochemical and transcriptional profiling to triage additional activities in a series of IGF-1R/IR inhibitors.

Ross-Macdonald P, de Silva H, Patel V, Truong A, He A, Neuhaus I, Tilford C, Ji R, Siemers N, Greer A, Carboni J, Gottardis M, Menard K, Lee F, Dodier M, Frennesson D, Sampognaro A, Saulnier M, Trainor G, Vyas D, Zimmermann K, Wittman M.

Bioorg Med Chem. 2012 Mar 15;20(6):1961-72. doi: 10.1016/j.bmc.2011.10.090. Epub 2011 Nov 6.

PMID:
22137930
7.

Characterization of BMS-911543, a functionally selective small-molecule inhibitor of JAK2.

Purandare AV, McDevitt TM, Wan H, You D, Penhallow B, Han X, Vuppugalla R, Zhang Y, Ruepp SU, Trainor GL, Lombardo L, Pedicord D, Gottardis MM, Ross-Macdonald P, de Silva H, Hosbach J, Emanuel SL, Blat Y, Fitzpatrick E, Taylor TL, McIntyre KW, Michaud E, Mulligan C, Lee FY, Woolfson A, Lasho TL, Pardanani A, Tefferi A, Lorenzi MV.

Leukemia. 2012 Feb;26(2):280-8. doi: 10.1038/leu.2011.292. Epub 2011 Oct 21.

PMID:
22015772
8.

Exome sequencing reveals comprehensive genomic alterations across eight cancer cell lines.

Chang H, Jackson DG, Kayne PS, Ross-Macdonald PB, Ryseck RP, Siemers NO.

PLoS One. 2011;6(6):e21097. doi: 10.1371/journal.pone.0021097. Epub 2011 Jun 20.

9.

Transcriptional profiling of the dose response: a more powerful approach for characterizing drug activities.

Ji RR, de Silva H, Jin Y, Bruccoleri RE, Cao J, He A, Huang W, Kayne PS, Neuhaus IM, Ott KH, Penhallow B, Cockett MI, Neubauer MG, Siemers NO, Ross-Macdonald P.

PLoS Comput Biol. 2009 Sep;5(9):e1000512. doi: 10.1371/journal.pcbi.1000512. Epub 2009 Sep 18.

10.

Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors.

Ross-Macdonald P, de Silva H, Guo Q, Xiao H, Hung CY, Penhallow B, Markwalder J, He L, Attar RM, Lin TA, Seitz S, Tilford C, Wardwell-Swanson J, Jackson D.

Mol Cancer Ther. 2008 Nov;7(11):3490-8. doi: 10.1158/1535-7163.MCT-08-0826.

11.

Construction of a reference gene association network from multiple profiling data: application to data analysis.

Ucar D, Neuhaus I, Ross-MacDonald P, Tilford C, Parthasarathy S, Siemers N, Ji RR.

Bioinformatics. 2007 Oct 15;23(20):2716-24. Epub 2007 Sep 10.

PMID:
17846039
12.

Drug discovery without a molecular target: the road less traveled.

Ross-Macdonald P.

Expert Rev Mol Diagn. 2007 Jan;7(1):1-4. Review. No abstract available.

PMID:
17187477
13.

Chemical genetics reveals an RGS/G-protein role in the action of a compound.

Fitzgerald K, Tertyshnikova S, Moore L, Bjerke L, Burley B, Cao J, Carroll P, Choy R, Doberstein S, Dubaquie Y, Franke Y, Kopczynski J, Korswagen H, Krystek SR, Lodge NJ, Plasterk R, Starrett J, Stouch T, Thalody G, Wayne H, van der Linden A, Zhang Y, Walker SG, Cockett M, Wardwell-Swanson J, Ross-Macdonald P, Kindt RM.

PLoS Genet. 2006 Apr;2(4):e57. Epub 2006 Apr 21.

14.

Forward in reverse: how reverse genetics complements chemical genetics.

Ross-Macdonald P.

Pharmacogenomics. 2005 Jun;6(4):429-34. Review.

PMID:
16004561
15.

Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors.

Lackner MR, Kindt RM, Carroll PM, Brown K, Cancilla MR, Chen C, de Silva H, Franke Y, Guan B, Heuer T, Hung T, Keegan K, Lee JM, Manne V, O'Brien C, Parry D, Perez-Villar JJ, Reddy RK, Xiao H, Zhan H, Cockett M, Plowman G, Fitzgerald K, Costa M, Ross-Macdonald P.

Cancer Cell. 2005 Apr;7(4):325-36.

16.

Model systems in drug discovery: chemical genetics meets genomics.

Carroll PM, Dougherty B, Ross-Macdonald P, Browman K, FitzGerald K.

Pharmacol Ther. 2003 Aug;99(2):183-220. Review.

PMID:
12888112
17.

Functional profiling of the Saccharomyces cerevisiae genome.

Giaever G, Chu AM, Ni L, Connelly C, Riles L, Véronneau S, Dow S, Lucau-Danila A, Anderson K, André B, Arkin AP, Astromoff A, El-Bakkoury M, Bangham R, Benito R, Brachat S, Campanaro S, Curtiss M, Davis K, Deutschbauer A, Entian KD, Flaherty P, Foury F, Garfinkel DJ, Gerstein M, Gotte D, Güldener U, Hegemann JH, Hempel S, Herman Z, Jaramillo DF, Kelly DE, Kelly SL, Kötter P, LaBonte D, Lamb DC, Lan N, Liang H, Liao H, Liu L, Luo C, Lussier M, Mao R, Menard P, Ooi SL, Revuelta JL, Roberts CJ, Rose M, Ross-Macdonald P, Scherens B, Schimmack G, Shafer B, Shoemaker DD, Sookhai-Mahadeo S, Storms RK, Strathern JN, Valle G, Voet M, Volckaert G, Wang CY, Ward TR, Wilhelmy J, Winzeler EA, Yang Y, Yen G, Youngman E, Yu K, Bussey H, Boeke JD, Snyder M, Philippsen P, Davis RW, Johnston M.

Nature. 2002 Jul 25;418(6896):387-91.

PMID:
12140549
18.

Functional analysis of the yeast genome.

Ross-Macdonald P.

Funct Integr Genomics. 2000 Sep;1(2):99-113. Review.

PMID:
11793226
19.
20.

Mutagenesis of murine cytomegalovirus using a Tn3-based transposon.

Zhan X, Lee M, Abenes G, Von Reis I, Kittinunvorakoon C, Ross-Macdonald P, Snyder M, Liu F.

Virology. 2000 Jan 20;266(2):264-74.

21.

TRIPLES: a database of gene function in Saccharomyces cerevisiae.

Kumar A, Cheung KH, Ross-Macdonald P, Coelho PS, Miller P, Snyder M.

Nucleic Acids Res. 2000 Jan 1;28(1):81-4.

22.

Large-scale analysis of the yeast genome by transposon tagging and gene disruption.

Ross-Macdonald P, Coelho PS, Roemer T, Agarwal S, Kumar A, Jansen R, Cheung KH, Sheehan A, Symoniatis D, Umansky L, Heidtman M, Nelson FK, Iwasaki H, Hager K, Gerstein M, Miller P, Roeder GS, Snyder M.

Nature. 1999 Nov 25;402(6760):413-8.

PMID:
10586881
23.

Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis.

Winzeler EA, Shoemaker DD, Astromoff A, Liang H, Anderson K, Andre B, Bangham R, Benito R, Boeke JD, Bussey H, Chu AM, Connelly C, Davis K, Dietrich F, Dow SW, El Bakkoury M, Foury F, Friend SH, Gentalen E, Giaever G, Hegemann JH, Jones T, Laub M, Liao H, Liebundguth N, Lockhart DJ, Lucau-Danila A, Lussier M, M'Rabet N, Menard P, Mittmann M, Pai C, Rebischung C, Revuelta JL, Riles L, Roberts CJ, Ross-MacDonald P, Scherens B, Snyder M, Sookhai-Mahadeo S, Storms RK, Véronneau S, Voet M, Volckaert G, Ward TR, Wysocki R, Yen GS, Yu K, Zimmermann K, Philippsen P, Johnston M, Davis RW.

Science. 1999 Aug 6;285(5429):901-6.

24.

Transposon mutagenesis for the analysis of protein production, function, and localization.

Ross-Macdonald P, Sheehan A, Friddle C, Roeder GS, Snyder M.

Methods Enzymol. 1999;303:512-32. No abstract available.

PMID:
10349663
25.

Malaria parasites contain two identical copies of an elongation factor 1 alpha gene.

Vinkenoog R, Sperança MA, van Breemen O, Ramesar J, Williamson DH, Ross-MacDonald PB, Thomas AW, Janse CJ, del Portillo HA, Waters AP.

Mol Biochem Parasitol. 1998 Jul 1;94(1):1-12.

PMID:
9719506
26.

A shuttle mutagenesis system for tagging genes in the yeast Yarrowia lipolytica.

Neuvéglise C, Nicauda JM, Ross-Macdonald P, Gaillardin C.

Gene. 1998 Jun 15;213(1-2):37-46.

PMID:
9630501
27.

A multipurpose transposon system for analyzing protein production, localization, and function in Saccharomyces cerevisiae.

Ross-Macdonald P, Sheehan A, Roeder GS, Snyder M.

Proc Natl Acad Sci U S A. 1997 Jan 7;94(1):190-5.

28.

Mutation of a meiosis-specific MutS homolog decreases crossing over but not mismatch correction.

Ross-Macdonald P, Roeder GS.

Cell. 1994 Dec 16;79(6):1069-80.

PMID:
8001134
29.

Large-scale analysis of gene expression, protein localization, and gene disruption in Saccharomyces cerevisiae.

Burns N, Grimwade B, Ross-Macdonald PB, Choi EY, Finberg K, Roeder GS, Snyder M.

Genes Dev. 1994 May 1;8(9):1087-105.

30.

Isolation and expression of a gene specifying a cdc2-like protein kinase from the human malaria parasite Plasmodium falciparum.

Ross-Macdonald PB, Graeser R, Kappes B, Franklin R, Williamson DH.

Eur J Biochem. 1994 Mar 15;220(3):693-701.

31.

MEI4, a meiosis-specific yeast gene required for chromosome synapsis.

Menees TM, Ross-MacDonald PB, Roeder GS.

Mol Cell Biol. 1992 Mar;12(3):1340-51.

32.

Structure and expression of a newt cardio-skeletal myosin gene. Implications for the C value paradox.

Casimir CM, Gates PB, Ross-Macdonald PB, Jackson JF, Patient RK, Brockes JP.

J Mol Biol. 1988 Jul 20;202(2):287-96.

PMID:
2459393

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