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Items: 27


Mechanism of Activation of AMPK by Cordycepin.

Hawley SA, Ross FA, Russell FM, Atrih A, Lamont DJ, Hardie DG.

Cell Chem Biol. 2020 Feb 20;27(2):214-222.e4. doi: 10.1016/j.chembiol.2020.01.004. Epub 2020 Jan 27.


The LKB1-AMPK-α1 signaling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria.

Moral-Sanz J, Lewis SA, MacMillan S, Ross FA, Thomson A, Viollet B, Foretz M, Moran C, Hardie DG, Evans AM.

Sci Signal. 2018 Oct 2;11(550). pii: eaau0296. doi: 10.1126/scisignal.aau0296.


Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib.

Ross FA, Hawley SA, Auciello FR, Gowans GJ, Atrih A, Lamont DJ, Hardie DG.

Cell Chem Biol. 2017 Jul 20;24(7):813-824.e4. doi: 10.1016/j.chembiol.2017.05.021. Epub 2017 Jun 15.


AMPK Causes Cell Cycle Arrest in LKB1-Deficient Cells via Activation of CAMKK2.

Fogarty S, Ross FA, Vara Ciruelos D, Gray A, Gowans GJ, Hardie DG.

Mol Cancer Res. 2016 Aug;14(8):683-95. doi: 10.1158/1541-7786.MCR-15-0479. Epub 2016 May 2.


AMP-activated protein kinase inhibits Kv 1.5 channel currents of pulmonary arterial myocytes in response to hypoxia and inhibition of mitochondrial oxidative phosphorylation.

Moral-Sanz J, Mahmoud AD, Ross FA, Eldstrom J, Fedida D, Hardie DG, Evans AM.

J Physiol. 2016 Sep 1;594(17):4901-15. doi: 10.1113/JP272032. Epub 2016 Jun 30.


AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours.

Ross FA, MacKintosh C, Hardie DG.

FEBS J. 2016 Aug;283(16):2987-3001. doi: 10.1111/febs.13698. Epub 2016 Mar 24. Review.


Differential regulation by AMP and ADP of AMPK complexes containing different γ subunit isoforms.

Ross FA, Jensen TE, Hardie DG.

Biochem J. 2016 Jan 15;473(2):189-99. doi: 10.1042/BJ20150910. Epub 2015 Nov 5.


Bitter Melon (Momordica charantia) Extract Inhibits Tumorigenicity and Overcomes Cisplatin-Resistance in Ovarian Cancer Cells Through Targeting AMPK Signaling Cascade.

Yung MM, Ross FA, Hardie DG, Leung TH, Zhan J, Ngan HY, Chan DW.

Integr Cancer Ther. 2016 Sep;15(3):376-89. doi: 10.1177/1534735415611747. Epub 2015 Oct 19.


PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain.

Jensen TE, Ross FA, Kleinert M, Sylow L, Knudsen JR, Gowans GJ, Hardie DG, Richter EA.

Biochem J. 2015 May 1;467(3):461-72. doi: 10.1042/BJ20141142.


Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation.

Pirkmajer S, Kulkarni SS, Tom RZ, Ross FA, Hawley SA, Hardie DG, Zierath JR, Chibalin AV.

Diabetes. 2015 Feb;64(2):360-9. doi: 10.2337/db14-0508. Epub 2014 Oct 22.


Oxidative stress activates AMPK in cultured cells primarily by increasing cellular AMP and/or ADP.

Auciello FR, Ross FA, Ikematsu N, Hardie DG.

FEBS Lett. 2014 Sep 17;588(18):3361-6. doi: 10.1016/j.febslet.2014.07.025. Epub 2014 Jul 30.


Mechanism of action of compound-13: an α1-selective small molecule activator of AMPK.

Hunter RW, Foretz M, Bultot L, Fullerton MD, Deak M, Ross FA, Hawley SA, Shpiro N, Viollet B, Barron D, Kemp BE, Steinberg GR, Hardie DG, Sakamoto K.

Chem Biol. 2014 Jul 17;21(7):866-79. doi: 10.1016/j.chembiol.2014.05.014.


Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells.

Hawley SA, Ross FA, Gowans GJ, Tibarewal P, Leslie NR, Hardie DG.

Biochem J. 2014 Apr 15;459(2):275-87. doi: 10.1042/BJ20131344.


AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation.

Gowans GJ, Hawley SA, Ross FA, Hardie DG.

Cell Metab. 2013 Oct 1;18(4):556-66. doi: 10.1016/j.cmet.2013.08.019.


AMP-activated protein kinase: a target for drugs both ancient and modern.

Hardie DG, Ross FA, Hawley SA.

Chem Biol. 2012 Oct 26;19(10):1222-36. doi: 10.1016/j.chembiol.2012.08.019. Review.


The ancient drug salicylate directly activates AMP-activated protein kinase.

Hawley SA, Fullerton MD, Ross FA, Schertzer JD, Chevtzoff C, Walker KJ, Peggie MW, Zibrova D, Green KA, Mustard KJ, Kemp BE, Sakamoto K, Steinberg GR, Hardie DG.

Science. 2012 May 18;336(6083):918-22. doi: 10.1126/science.1215327. Epub 2012 Apr 19.


AMPK: a nutrient and energy sensor that maintains energy homeostasis.

Hardie DG, Ross FA, Hawley SA.

Nat Rev Mol Cell Biol. 2012 Mar 22;13(4):251-62. doi: 10.1038/nrm3311. Review.


Phosphorylation of the voltage-gated potassium channel Kv2.1 by AMP-activated protein kinase regulates membrane excitability.

Ikematsu N, Dallas ML, Ross FA, Lewis RW, Rafferty JN, David JA, Suman R, Peers C, Hardie DG, Evans AM.

Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18132-7. doi: 10.1073/pnas.1106201108. Epub 2011 Oct 17.


Selective expression in carotid body type I cells of a single splice variant of the large conductance calcium- and voltage-activated potassium channel confers regulation by AMP-activated protein kinase.

Ross FA, Rafferty JN, Dallas ML, Ogunbayo O, Ikematsu N, McClafferty H, Tian L, Widmer H, Rowe IC, Wyatt CN, Shipston MJ, Peers C, Hardie DG, Evans AM.

J Biol Chem. 2011 Apr 8;286(14):11929-36. doi: 10.1074/jbc.M110.189779. Epub 2011 Jan 5.


Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation.

Hawley SA, Ross FA, Chevtzoff C, Green KA, Evans A, Fogarty S, Towler MC, Brown LJ, Ogunbayo OA, Evans AM, Hardie DG.

Cell Metab. 2010 Jun 9;11(6):554-65. doi: 10.1016/j.cmet.2010.04.001.


Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.

Göransson O, McBride A, Hawley SA, Ross FA, Shpiro N, Foretz M, Viollet B, Hardie DG, Sakamoto K.

J Biol Chem. 2007 Nov 9;282(45):32549-60. Epub 2007 Sep 12.


Fatal infantile cardiac glycogenosis with phosphorylase kinase deficiency and a mutation in the gamma2-subunit of AMP-activated protein kinase.

Akman HO, Sampayo JN, Ross FA, Scott JW, Wilson G, Benson L, Bruno C, Shanske S, Hardie DG, Dimauro S.

Pediatr Res. 2007 Oct;62(4):499-504.


Regulation of AMP-activated protein kinase by a pseudosubstrate sequence on the gamma subunit.

Scott JW, Ross FA, Liu JK, Hardie DG.

EMBO J. 2007 Feb 7;26(3):806-15. Epub 2007 Jan 25.


Occult papillary thyroid carcinoma presenting as extrathyroidal solitary neck cyst.

Aytug S, Sievert R, Ross FA.

QJM. 2002 Mar;95(3):186-8. No abstract available.


A case of adenocarcinoma of the lung associated with a neck mass and hypercalcemia.

Benisovich VI, Rybak BJ, Ross FA.

Cancer. 1991 Sep 1;68(5):1106-8.


Typhoid fever complicated by hepatitis, nephritis, and thrombocytopenia.

Faierman D, Ross FA, Seckler SG.

JAMA. 1972 Jul 3;221(1):60-1. No abstract available.


An abdominal aortic aneurysm associated with a horseshoe kidney.

Love JW, Calhoon HW, Ross FA.

Am Surg. 1968 May;34(5):354-7. No abstract available.


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