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Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation.

Puleston DJ, Buck MD, Klein Geltink RI, Kyle RL, Caputa G, O'Sullivan D, Cameron AM, Castoldi A, Musa Y, Kabat AM, Zhang Y, Flachsmann LJ, Field CS, Patterson AE, Scherer S, Alfei F, Baixauli F, Austin SK, Kelly B, Matsushita M, Curtis JD, Grzes KM, Villa M, Corrado M, Sanin DE, Qiu J, Pällman N, Paz K, Maccari ME, Blazar BR, Mittler G, Buescher JM, Zehn D, Rospert S, Pearce EJ, Balabanov S, Pearce EL.

Cell Metab. 2019 Aug 6;30(2):352-363.e8. doi: 10.1016/j.cmet.2019.05.003. Epub 2019 May 23.


A dual role of the ribosome-bound chaperones RAC/Ssb in maintaining the fidelity of translation termination.

Gribling-Burrer AS, Chiabudini M, Zhang Y, Qiu Z, Scazzari M, Wölfle T, Wohlwend D, Rospert S.

Nucleic Acids Res. 2019 Jul 26;47(13):7018-7034. doi: 10.1093/nar/gkz334.


Function, evolution, and structure of J-domain proteins.

Kampinga HH, Andreasson C, Barducci A, Cheetham ME, Cyr D, Emanuelsson C, Genevaux P, Gestwicki JE, Goloubinoff P, Huerta-Cepas J, Kirstein J, Liberek K, Mayer MP, Nagata K, Nillegoda NB, Pulido P, Ramos C, De Los Rios P, Rospert S, Rosenzweig R, Sahi C, Taipale M, Tomiczek B, Ushioda R, Young JC, Zimmermann R, Zylicz A, Zylicz M, Craig EA, Marszalek J.

Cell Stress Chaperones. 2019 Jan;24(1):7-15. doi: 10.1007/s12192-018-0948-4. Epub 2018 Nov 26.


The Hsp70 homolog Ssb affects ribosome biogenesis via the TORC1-Sch9 signaling pathway.

Mudholkar K, Fitzke E, Prinz C, Mayer MP, Rospert S.

Nat Commun. 2017 Oct 16;8(1):937. doi: 10.1038/s41467-017-00635-z.


Protein glutaminylation is a yeast-specific posttranslational modification of elongation factor 1A.

Jank T, Belyi Y, Wirth C, Rospert S, Hu Z, Dengjel J, Tzivelekidis T, Andersen GR, Hunte C, Schlosser A, Aktories K.

J Biol Chem. 2017 Sep 29;292(39):16014-16023. doi: 10.1074/jbc.M117.801035. Epub 2017 Aug 11.


Two chaperones locked in an embrace: structure and function of the ribosome-associated complex RAC.

Zhang Y, Sinning I, Rospert S.

Nat Struct Mol Biol. 2017 Aug 3;24(8):611-619. doi: 10.1038/nsmb.3435. Review.


Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain.

Gumiero A, Conz C, Gesé GV, Zhang Y, Weyer FA, Lapouge K, Kappes J, von Plehwe U, Schermann G, Fitzke E, Wölfle T, Fischer T, Rospert S, Sinning I.

Nat Commun. 2016 Nov 24;7:13563. doi: 10.1038/ncomms13563.


Cotranslational Intersection between the SRP and GET Targeting Pathways to the Endoplasmic Reticulum of Saccharomyces cerevisiae.

Zhang Y, Schäffer T, Wölfle T, Fitzke E, Thiel G, Rospert S.

Mol Cell Biol. 2016 Aug 26;36(18):2374-83. doi: 10.1128/MCB.00131-16. Print 2016 Sep 15.


Ribosomal Protein Rps26 Influences 80S Ribosome Assembly in Saccharomyces cerevisiae.

Belyy A, Levanova N, Tabakova I, Rospert S, Belyi Y.

mSphere. 2016 Feb 24;1(1). pii: e00109-15. doi: 10.1128/mSphere.00109-15. eCollection 2016 Jan-Feb.


The yeast Hsp70 homolog Ssb: a chaperone for general de novo protein folding and a nanny for specific intrinsically disordered protein domains.

Hübscher V, Mudholkar K, Rospert S.

Curr Genet. 2017 Feb;63(1):9-13. doi: 10.1007/s00294-016-0610-6. Epub 2016 May 26. Review.


The Hsp70 homolog Ssb and the 14-3-3 protein Bmh1 jointly regulate transcription of glucose repressed genes in Saccharomyces cerevisiae.

Hübscher V, Mudholkar K, Chiabudini M, Fitzke E, Wölfle T, Pfeifer D, Drepper F, Warscheid B, Rospert S.

Nucleic Acids Res. 2016 Jul 8;44(12):5629-45. doi: 10.1093/nar/gkw168. Epub 2016 Mar 21.


Stress-resistant Translation of Cathepsin L mRNA in Breast Cancer Progression.

Tholen M, Wolanski J, Stolze B, Chiabudini M, Gajda M, Bronsert P, Stickeler E, Rospert S, Reinheckel T.

J Biol Chem. 2015 Jun 19;290(25):15758-69. doi: 10.1074/jbc.M114.624353. Epub 2015 May 8.


Mitochondrial heat shock protein (Hsp) 70 and Hsp10 cooperate in the formation of Hsp60 complexes.

Böttinger L, Oeljeklaus S, Guiard B, Rospert S, Warscheid B, Becker T.

J Biol Chem. 2015 May 1;290(18):11611-22. doi: 10.1074/jbc.M115.642017. Epub 2015 Mar 18.


Mgr2 functions as lateral gatekeeper for preprotein sorting in the mitochondrial inner membrane.

Ieva R, Schrempp SG, Opaliński L, Wollweber F, Höß P, Heißwolf AK, Gebert M, Zhang Y, Guiard B, Rospert S, Becker T, Chacinska A, Pfanner N, van der Laan M.

Mol Cell. 2014 Dec 4;56(5):641-52. doi: 10.1016/j.molcel.2014.10.010. Epub 2014 Nov 13.


Release factor eRF3 mediates premature translation termination on polylysine-stalled ribosomes in Saccharomyces cerevisiae.

Chiabudini M, Tais A, Zhang Y, Hayashi S, Wölfle T, Fitzke E, Rospert S.

Mol Cell Biol. 2014 Nov;34(21):4062-76. doi: 10.1128/MCB.00799-14. Epub 2014 Aug 25.


Inefficient SRP interaction with a nascent chain triggers a mRNA quality control pathway.

Karamyshev AL, Patrick AE, Karamysheva ZN, Griesemer DS, Hudson H, Tjon-Kon-Sang S, Nilsson I, Otto H, Liu Q, Rospert S, von Heijne G, Johnson AE, Thomas PJ.

Cell. 2014 Jan 16;156(1-2):146-57. doi: 10.1016/j.cell.2013.12.017.


Interaction of nascent chains with the ribosomal tunnel proteins Rpl4, Rpl17, and Rpl39 of Saccharomyces cerevisiae.

Zhang Y, Wölfle T, Rospert S.

J Biol Chem. 2013 Nov 22;288(47):33697-707. doi: 10.1074/jbc.M113.508283. Epub 2013 Sep 26.


Carbon monoxide releasing molecule-2 CORM-2 represses global protein synthesis by inhibition of eukaryotic elongation factor eEF2.

Schwer CI, Stoll P, Rospert S, Fitzke E, Schallner N, Bürkle H, Schmidt R, Humar M.

Int J Biochem Cell Biol. 2013 Feb;45(2):201-12. doi: 10.1016/j.biocel.2012.09.020. Epub 2012 Oct 4.


Ribosome-associated complex and Ssb are required for translational repression induced by polylysine segments within nascent chains.

Chiabudini M, Conz C, Reckmann F, Rospert S.

Mol Cell Biol. 2012 Dec;32(23):4769-79. doi: 10.1128/MCB.00809-12. Epub 2012 Sep 24.


NAC functions as a modulator of SRP during the early steps of protein targeting to the endoplasmic reticulum.

Zhang Y, Berndt U, Gölz H, Tais A, Oellerer S, Wölfle T, Fitzke E, Rospert S.

Mol Biol Cell. 2012 Aug;23(16):3027-40. doi: 10.1091/mbc.E12-02-0112. Epub 2012 Jun 27.


Elongation factor 1A is the target of growth inhibition in yeast caused by Legionella pneumophila glucosyltransferase Lgt1.

Belyi Y, Tartakovskaya D, Tais A, Fitzke E, Tzivelekidis T, Jank T, Rospert S, Aktories K.

J Biol Chem. 2012 Jul 27;287(31):26029-37. doi: 10.1074/jbc.M112.372672. Epub 2012 Jun 8.


Aminoacyl-tRNA-charged eukaryotic elongation factor 1A is the bona fide substrate for Legionella pneumophila effector glucosyltransferases.

Tzivelekidis T, Jank T, Pohl C, Schlosser A, Rospert S, Knudsen CR, Rodnina MV, Belyi Y, Aktories K.

PLoS One. 2011;6(12):e29525. doi: 10.1371/journal.pone.0029525. Epub 2011 Dec 22.


Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis.

von der Malsburg K, Müller JM, Bohnert M, Oeljeklaus S, Kwiatkowska P, Becker T, Loniewska-Lwowska A, Wiese S, Rao S, Milenkovic D, Hutu DP, Zerbes RM, Schulze-Specking A, Meyer HE, Martinou JC, Rospert S, Rehling P, Meisinger C, Veenhuis M, Warscheid B, van der Klei IJ, Pfanner N, Chacinska A, van der Laan M.

Dev Cell. 2011 Oct 18;21(4):694-707. doi: 10.1016/j.devcel.2011.08.026. Epub 2011 Sep 22.


The chaperone network connected to human ribosome-associated complex.

Jaiswal H, Conz C, Otto H, Wölfle T, Fitzke E, Mayer MP, Rospert S.

Mol Cell Biol. 2011 Mar;31(6):1160-73. doi: 10.1128/MCB.00986-10. Epub 2011 Jan 18.


Transcriptional activation of polycomb-repressed genes by ZRF1.

Richly H, Rocha-Viegas L, Ribeiro JD, Demajo S, Gundem G, Lopez-Bigas N, Nakagawa T, Rospert S, Ito T, Di Croce L.

Nature. 2010 Dec 23;468(7327):1124-8. doi: 10.1038/nature09574.


BiP modulates the affinity of its co-chaperone ERj1 for ribosomes.

Benedix J, Lajoie P, Jaiswal H, Burgard C, Greiner M, Zimmermann R, Rospert S, Snapp EL, Dudek J.

J Biol Chem. 2010 Nov 19;285(47):36427-33. doi: 10.1074/jbc.M110.143263. Epub 2010 Sep 23.


Molecular chaperones and intracellular protein transport.

Rehling P, Rospert S.

Biochim Biophys Acta. 2010 Jun;1803(6):639-40. doi: 10.1016/j.bbamcr.2010.04.010. No abstract available.


The ribosome-bound Hsp70 homolog Ssb of Saccharomyces cerevisiae.

Peisker K, Chiabudini M, Rospert S.

Biochim Biophys Acta. 2010 Jun;1803(6):662-72. doi: 10.1016/j.bbamcr.2010.03.005. Epub 2010 Mar 11. Review.


A targeted analysis of cellular chaperones reveals contrasting roles for heat shock protein 70 in flock house virus RNA replication.

Weeks SA, Shield WP, Sahi C, Craig EA, Rospert S, Miller DJ.

J Virol. 2010 Jan;84(1):330-9. doi: 10.1128/JVI.01808-09.


The Hsp70 homolog Ssb is essential for glucose sensing via the SNF1 kinase network.

von Plehwe U, Berndt U, Conz C, Chiabudini M, Fitzke E, Sickmann A, Petersen A, Pfeifer D, Rospert S.

Genes Dev. 2009 Sep 1;23(17):2102-15. doi: 10.1101/gad.529409.


Identification of the signal directing Tim9 and Tim10 into the intermembrane space of mitochondria.

Milenkovic D, Ramming T, Müller JM, Wenz LS, Gebert N, Schulze-Specking A, Stojanovski D, Rospert S, Chacinska A.

Mol Biol Cell. 2009 May;20(10):2530-9. doi: 10.1091/mbc.E08-11-1108. Epub 2009 Mar 18.


A signal-anchor sequence stimulates signal recognition particle binding to ribosomes from inside the exit tunnel.

Berndt U, Oellerer S, Zhang Y, Johnson AE, Rospert S.

Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1398-403. doi: 10.1073/pnas.0808584106. Epub 2009 Jan 21.


Ribosome-associated complex binds to ribosomes in close proximity of Rpl31 at the exit of the polypeptide tunnel in yeast.

Peisker K, Braun D, Wölfle T, Hentschel J, Fünfschilling U, Fischer G, Sickmann A, Rospert S.

Mol Biol Cell. 2008 Dec;19(12):5279-88. doi: 10.1091/mbc.E08-06-0661. Epub 2008 Oct 1.


Functional characterization of the atypical Hsp70 subunit of yeast ribosome-associated complex.

Conz C, Otto H, Peisker K, Gautschi M, Wölfle T, Mayer MP, Rospert S.

J Biol Chem. 2007 Nov 23;282(47):33977-84. Epub 2007 Sep 27.


Distinct yet linked: chaperone networks in the eukaryotic cytosol.

Rospert S, Chacinska A.

Genome Biol. 2006;7(3):208. Epub 2006 Mar 31. Review.


The chaperones MPP11 and Hsp70L1 form the mammalian ribosome-associated complex.

Otto H, Conz C, Maier P, Wölfle T, Suzuki CK, Jenö P, Rücknagel P, Stahl J, Rospert S.

Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10064-9. Epub 2005 Jul 7.


Polypeptide chain termination and stop codon readthrough on eukaryotic ribosomes.

Rospert S, Rakwalska M, Dubaquié Y.

Rev Physiol Biochem Pharmacol. 2005;155:1-30. Review.


The Hsp70 Ssz1 modulates the function of the ribosome-associated J-protein Zuo1.

Huang P, Gautschi M, Walter W, Rospert S, Craig EA.

Nat Struct Mol Biol. 2005 Jun;12(6):497-504. Epub 2005 May 22.


Ribosome function: governing the fate of a nascent polypeptide.

Rospert S.

Curr Biol. 2004 May 25;14(10):R386-8. Review.


The yeast N(alpha)-acetyltransferase NatA is quantitatively anchored to the ribosome and interacts with nascent polypeptides.

Gautschi M, Just S, Mun A, Ross S, Rücknagel P, Dubaquié Y, Ehrenhofer-Murray A, Rospert S.

Mol Cell Biol. 2003 Oct;23(20):7403-14.


Machinery for protein sorting and assembly in the mitochondrial outer membrane.

Wiedemann N, Kozjak V, Chacinska A, Schönfisch B, Rospert S, Ryan MT, Pfanner N, Meisinger C.

Nature. 2003 Jul 31;424(6948):565-71.


Nascent-polypeptide-associated complex.

Rospert S, Dubaquié Y, Gautschi M.

Cell Mol Life Sci. 2002 Oct;59(10):1632-9. Review.


A functional chaperone triad on the yeast ribosome.

Gautschi M, Mun A, Ross S, Rospert S.

Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4209-14.


GroEL/GroES-mediated folding of a protein too large to be encapsulated.

Chaudhuri TK, Farr GW, Fenton WA, Rospert S, Horwich AL.

Cell. 2001 Oct 19;107(2):235-46.


Purification of yeast mitochondrial Hsp60.

Dubaquié Y, Looser R, Rospert S.

Methods Mol Biol. 2000;140:139-43. No abstract available.


RAC, a stable ribosome-associated complex in yeast formed by the DnaK-DnaJ homologs Ssz1p and zuotin.

Gautschi M, Lilie H, Fünfschilling U, Mun A, Ross S, Lithgow T, Rücknagel P, Rospert S.

Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3762-7.


Prion-dependent switching between respiratory competence and deficiency in the yeast nam9-1 mutant.

Chacinska A, Boguta M, Krzewska J, Rospert S.

Mol Cell Biol. 2000 Oct;20(19):7220-9.


Nascent polypeptide-associated complex stimulates protein import into yeast mitochondria.

Fünfschilling U, Rospert S.

Mol Biol Cell. 1999 Oct;10(10):3289-99.

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