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Podocalyxin is required for maintaining blood-brain barrier function during acute inflammation.

Cait J, Hughes MR, Zeglinski MR, Chan AW, Osterhof S, Scott RW, Canals Hernaez D, Cait A, Vogl AW, Bernatchez P, Underhill TM, Granville DJ, Murphy TH, Roskelley CD, McNagny KM.

Proc Natl Acad Sci U S A. 2019 Feb 20. pii: 201814766. doi: 10.1073/pnas.1814766116. [Epub ahead of print]


Loukoumasomes Are Distinct Subcellular Structures from Rods and Rings and Are Structurally Associated with MAP2 and the Nuclear Envelope in Retinal Cells.

Noble JW, Hunter DV, Roskelley CD, Chan EK, Mills J.

PLoS One. 2016 Oct 31;11(10):e0165162. doi: 10.1371/journal.pone.0165162. eCollection 2016.


Using C. elegans Forward and Reverse Genetics to Identify New Compounds with Anthelmintic Activity.

Mathew MD, Mathew ND, Miller A, Simpson M, Au V, Garland S, Gestin M, Edgley ML, Flibotte S, Balgi A, Chiang J, Giaever G, Dean P, Tung A, Roberge M, Roskelley C, Forge T, Nislow C, Moerman D.

PLoS Negl Trop Dis. 2016 Oct 18;10(10):e0005058. doi: 10.1371/journal.pntd.0005058. eCollection 2016 Oct.


Systematic identification of genes involved in metabolic acid stress resistance in yeast and their potential as cancer targets.

Shin JJ, Aftab Q, Austin P, McQueen JA, Poon T, Li SC, Young BP, Roskelley CD, Loewen CJ.

Dis Model Mech. 2016 Sep 1;9(9):1039-49. doi: 10.1242/dmm.023374. Epub 2016 Aug 12.


On-chip clearing of arrays of 3-D cell cultures and micro-tissues.

Grist SM, Nasseri SS, Poon T, Roskelley C, Cheung KC.

Biomicrofluidics. 2016 Jul 20;10(4):044107. doi: 10.1063/1.4959031. eCollection 2016 Jul.


Applied stretch initiates directional invasion through the action of Rap1 GTPase as a tension sensor.

Freeman SA, Christian S, Austin P, Iu I, Graves ML, Huang L, Tang S, Coombs D, Gold MR, Roskelley CD.

J Cell Sci. 2017 Jan 1;130(1):152-163. doi: 10.1242/jcs.180612. Epub 2016 May 19.


The cell surface mucin podocalyxin regulates collective breast tumor budding.

Graves ML, Cipollone JA, Austin P, Bell EM, Nielsen JS, Gilks CB, McNagny KM, Roskelley CD.

Breast Cancer Res. 2016 Jan 22;18(1):11. doi: 10.1186/s13058-015-0670-4.


Integrin-linked kinase regulates senescence in an Rb-dependent manner in cancer cell lines.

Duminuco R, Noble JW, Goody J, Sharma M, Ksander BR, Roskelley CD, Cox ME, Mills J.

Cell Cycle. 2015;14(18):2924-37. doi: 10.1080/15384101.2015.1064205.


Podocalyxin enhances breast tumor growth and metastasis and is a target for monoclonal antibody therapy.

Snyder KA, Hughes MR, Hedberg B, Brandon J, Hernaez DC, Bergqvist P, Cruz F, Po K, Graves ML, Turvey ME, Nielsen JS, Wilkins JA, McColl SR, Babcook JS, Roskelley CD, McNagny KM.

Breast Cancer Res. 2015 Mar 27;17:46. doi: 10.1186/s13058-015-0562-7.


Erratum: Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor.

Freeman SA, Jaumouillé V, Choi K, Hsu BE, Wong HS, Abraham L, Graves ML, Coombs D, Roskelley CD, Das R, Grinstein S, Gold MR.

Nat Commun. 2015 Apr 17;6:7015. doi: 10.1038/ncomms8015. No abstract available.


Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor.

Freeman SA, Jaumouillé V, Choi K, Hsu BE, Wong HS, Abraham L, Graves ML, Coombs D, Roskelley CD, Das R, Grinstein S, Gold MR.

Nat Commun. 2015 Feb 3;6:6168. doi: 10.1038/ncomms7168. Erratum in: Nat Commun. 2015;6:7015.


The invasion inhibitor sarasinoside A1 reverses mesenchymal tumor transformation in an E-cadherin-independent manner.

Austin P, Freeman SA, Gray CA, Gold MR, Vogl AW, Andersen RJ, Roberge M, Roskelley CD.

Mol Cancer Res. 2013 May;11(5):530-40. doi: 10.1158/1541-7786.MCR-12-0385. Epub 2013 Feb 11.


Microenvironmental regulation of BRCA1 gene expression by c-Jun and Fra2 in premalignant human ovarian surface epithelial cells.

Zhou L, Graves M, MacDonald G, Cipollone J, Mueller CR, Roskelley CD.

Mol Cancer Res. 2013 Mar;11(3):272-81. doi: 10.1158/1541-7786.MCR-12-0395. Epub 2013 Jan 21.


Synthesis and biological studies of neopetrosiamides as inhibitors of cancer cell invasion.

Towle KM, Chaytor JL, Liu H, Austin P, Roberge M, Roskelley CD, Vederas JC.

Org Biomol Chem. 2013 Mar 7;11(9):1476-81. doi: 10.1039/c3ob27238a.


The small molecule genkwanine M induces single mode, mesenchymal tumor cell motility.

Zimmerman C, Austin P, Khong A, McLeod S, Bean B, Forestieri R, Andersen RJ, Jan E, Roberge M, Roskelley CD.

Exp Cell Res. 2013 Apr 1;319(6):908-17. doi: 10.1016/j.yexcr.2013.01.005. Epub 2013 Jan 17.


A novel subcellular machine contributes to basal junction remodeling in the seminiferous epithelium.

Du M, Young J, De Asis M, Cipollone J, Roskelley C, Takai Y, Nicholls PK, Stanton PG, Deng W, Finlay BB, Vogl AW.

Biol Reprod. 2013 Mar 14;88(3):60. doi: 10.1095/biolreprod.112.104851. Print 2013 Mar.


Zinc inhibits magnesium-dependent migration of human breast cancer MDA-MB-231 cells on fibronectin.

Lymburner S, McLeod S, Purtzki M, Roskelley C, Xu Z.

J Nutr Biochem. 2013 Jun;24(6):1034-40. doi: 10.1016/j.jnutbio.2012.07.013. Epub 2012 Sep 29.


The anti-adhesive mucin podocalyxin may help initiate the transperitoneal metastasis of high grade serous ovarian carcinoma.

Cipollone JA, Graves ML, Köbel M, Kalloger SE, Poon T, Gilks CB, McNagny KM, Roskelley CD.

Clin Exp Metastasis. 2012 Mar;29(3):239-52. doi: 10.1007/s10585-011-9446-0. Epub 2012 Jan 20.


Organellar (Na+, K+)/H+ exchanger NHE7 regulates cell adhesion, invasion and anchorage-independent growth of breast cancer MDA-MB-231 cells.

Onishi I, Lin PJ, Numata Y, Austin P, Cipollone J, Roberge M, Roskelley CD, Numata M.

Oncol Rep. 2012 Feb;27(2):311-7. doi: 10.3892/or.2011.1542. Epub 2011 Nov 9.


Cofilin-mediated F-actin severing is regulated by the Rap GTPase and controls the cytoskeletal dynamics that drive lymphocyte spreading and BCR microcluster formation.

Freeman SA, Lei V, Dang-Lawson M, Mizuno K, Roskelley CD, Gold MR.

J Immunol. 2011 Dec 1;187(11):5887-900. doi: 10.4049/jimmunol.1102233. Epub 2011 Nov 7.


Microarray and proteomic analysis of breast cancer cell and osteoblast co-cultures: role of osteoblast matrix metalloproteinase (MMP)-13 in bone metastasis.

Morrison C, Mancini S, Cipollone J, Kappelhoff R, Roskelley C, Overall C.

J Biol Chem. 2011 Sep 30;286(39):34271-85. doi: 10.1074/jbc.M111.222513. Epub 2011 Jul 22.


Opposing roles for CD34 in B16 melanoma tumor growth alter early stage vasculature and late stage immune cell infiltration.

Maltby S, Freeman S, Gold MJ, Baker JH, Minchinton AI, Gold MR, Roskelley CD, McNagny KM.

PLoS One. 2011 Apr 11;6(4):e18160. doi: 10.1371/journal.pone.0018160.


Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.

Lou Y, McDonald PC, Oloumi A, Chia S, Ostlund C, Ahmadi A, Kyle A, Auf dem Keller U, Leung S, Huntsman D, Clarke B, Sutherland BW, Waterhouse D, Bally M, Roskelley C, Overall CM, Minchinton A, Pacchiano F, Carta F, Scozzafava A, Touisni N, Winum JY, Supuran CT, Dedhar S.

Cancer Res. 2011 May 1;71(9):3364-76. doi: 10.1158/0008-5472.CAN-10-4261. Epub 2011 Mar 17. Erratum in: Cancer Res. 2011 Jul 1;71(13):4733. Cancer Res. 2011 Jun 15;71(12):4325.


ETV6-NTRK3-mediated breast epithelial cell transformation is blocked by targeting the IGF1R signaling pathway.

Tognon CE, Somasiri AM, Evdokimova VE, Trigo G, Uy EE, Melnyk N, Carboni JM, Gottardis MM, Roskelley CD, Pollak M, Sorensen PH.

Cancer Res. 2011 Feb 1;71(3):1060-70. doi: 10.1158/0008-5472.CAN-10-3096. Epub 2010 Dec 9.


Release of membrane-bound vesicles and inhibition of tumor cell adhesion by the peptide Neopetrosiamide A.

Austin P, Heller M, Williams DE, McIntosh LP, Vogl AW, Foster LJ, Andersen RJ, Roberge M, Roskelley CD.

PLoS One. 2010 May 26;5(5):e10836. doi: 10.1371/journal.pone.0010836.


Preventing the activation or cycling of the Rap1 GTPase alters adhesion and cytoskeletal dynamics and blocks metastatic melanoma cell extravasation into the lungs.

Freeman SA, McLeod SJ, Dukowski J, Austin P, Lee CC, Millen-Martin B, Kubes P, McCafferty DM, Gold MR, Roskelley CD.

Cancer Res. 2010 Jun 1;70(11):4590-601. doi: 10.1158/0008-5472.CAN-09-3414. Epub 2010 May 18.


Primary ovarian mucinous carcinoma of intestinal type: significance of pattern of invasion and immunohistochemical expression profile in a series of 31 cases.

Tabrizi AD, Kalloger SE, Köbel M, Cipollone J, Roskelley CD, Mehl E, Gilks CB.

Int J Gynecol Pathol. 2010 Mar;29(2):99-107. doi: 10.1097/PGP.0b013e3181bbbcc1.


Chemical synthesis and biological activity of the neopetrosiamides and their analogues: revision of disulfide bond connectivity.

Liu H, Boudreau MA, Zheng J, Whittal RM, Austin P, Roskelley CD, Roberge M, Andersen RJ, Vederas JC.

J Am Chem Soc. 2010 Feb 10;132(5):1486-7. doi: 10.1021/ja9102925.


Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis.

Kemmer D, McHardy LM, Hoon S, Rebérioux D, Giaever G, Nislow C, Roskelley CD, Roberge M.

BMC Microbiol. 2009 Jan 14;9:9. doi: 10.1186/1471-2180-9-9.


Epithelial-mesenchymal transition (EMT) is not sufficient for spontaneous murine breast cancer metastasis.

Lou Y, Preobrazhenska O, auf dem Keller U, Sutcliffe M, Barclay L, McDonald PC, Roskelley C, Overall CM, Dedhar S.

Dev Dyn. 2008 Oct;237(10):2755-68. doi: 10.1002/dvdy.21658.


Gonadotropin releasing hormone receptor gene and protein expression and immunohistochemical localization in bovine uterus and oviducts.

Singh R, Graves ML, Roskelley CD, Giritharan G, Rajamahendran R.

Domest Anim Endocrinol. 2008 Apr;34(3):319-26. Epub 2007 Oct 24.


The morphogenic function of E-cadherin-mediated adherens junctions in epithelial ovarian carcinoma formation and progression.

Wu C, Cipollone J, Maines-Bandiera S, Tan C, Karsan A, Auersperg N, Roskelley CD.

Differentiation. 2008 Feb;76(2):193-205. Epub 2007 Jul 2.


Regulation of the BRCA1 promoter in ovarian surface epithelial cells and ovarian carcinoma cells.

Graves ML, Zhou L, MacDonald G, Mueller CR, Roskelley CD.

FEBS Lett. 2007 May 1;581(9):1825-33. Epub 2007 Apr 4.


Strongylophorine-26, an inhibitor of cancer cell Invasion: SAR revealed by synthesis of analogues.

Warabi K, Patrick BO, Austin P, Roskelley CD, Roberge M, Andersen RJ.

J Nat Prod. 2007 May;70(5):736-40. Epub 2007 Apr 4.


The CD34-related molecule podocalyxin is a potent inducer of microvillus formation.

Nielsen JS, Graves ML, Chelliah S, Vogl AW, Roskelley CD, McNagny KM.

PLoS One. 2007 Feb 21;2(2):e237.


Avinosol, a meroterpenoid-nucleoside conjugate with antiinvasion activity isolated from the marine sponge Dysidea sp.

Diaz-Marrero AR, Austin P, Van Soest R, Matainaho T, Roskelley CD, Roberge M, Andersen RJ.

Org Lett. 2006 Aug 17;8(17):3749-52.


Absence of p300 induces cellular phenotypic changes characteristic of epithelial to mesenchyme transition.

Krubasik D, Iyer NG, English WR, Ahmed AA, Vias M, Roskelley C, Brenton JD, Caldas C, Murphy G.

Br J Cancer. 2006 May 8;94(9):1326-32. Erratum in: Br J Cancer. 2006 Jul 17;95(2):245.


The anti-invasive compound motuporamine C is a robust stimulator of neuronal growth cone collapse.

To KC, Loh KT, Roskelley CD, Andersen RJ, O'Connor TP.

Neuroscience. 2006;139(4):1263-74. Epub 2006 Mar 29.


Na+/H+ exchanger regulatory factor-1 is a hematopoietic ligand for a subset of the CD34 family of stem cell surface proteins.

Tan PC, Furness SG, Merkens H, Lin S, McCoy ML, Roskelley CD, Kast J, McNagny KM.

Stem Cells. 2006 May;24(5):1150-61. Epub 2006 Jan 12.


Neopetrosiamides, peptides from the marine sponge Neopetrosia sp. that inhibit amoeboid invasion by human tumor cells.

Williams DE, Austin P, Diaz-Marrero AR, Soest RV, Matainaho T, Roskelley CD, Roberge M, Andersen RJ.

Org Lett. 2005 Sep 15;7(19):4173-6.


Podocalyxin: a marker of blasts in acute leukemia.

Kelley TW, Huntsman D, McNagny KM, Roskelley CD, Hsi ED.

Am J Clin Pathol. 2005 Jul;124(1):134-42.


Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via alpha-PIX.

Filipenko NR, Attwell S, Roskelley C, Dedhar S.

Oncogene. 2005 Sep 1;24(38):5837-49.


Strongylophorine-26, a new meroditerpenoid isolated from the marine sponge Petrosia (Strongylophora) corticata that exhibits anti-invasion activity.

Warabi K, McHardy LM, Matainaho L, Van Soest R, Roskelley CD, Roberge M, Andersen RJ.

J Nat Prod. 2004 Aug;67(8):1387-9.


Progressive changes in Met-dependent signaling in a human ovarian surface epithelial model of malignant transformation.

Wong AS, Roskelley CD, Pelech S, Miller D, Leung PC, Auersperg N.

Exp Cell Res. 2004 Sep 10;299(1):248-56.


Overexpression of the anti-adhesin podocalyxin is an independent predictor of breast cancer progression.

Somasiri A, Nielsen JS, Makretsov N, McCoy ML, Prentice L, Gilks CB, Chia SK, Gelmon KA, Kershaw DB, Huntsman DG, McNagny KM, Roskelley CD.

Cancer Res. 2004 Aug 1;64(15):5068-73.


Epithelio-mesenchymal transition in a neoplastic ovarian epithelial hybrid cell line.

Maines-Bandiera SL, Huntsman D, Lestou VS, Kuo WL, Leung PC, Horsman RD, Wong AS, Woo MM, Choi KK, Roskelley CD, Auersperg N.

Differentiation. 2004 Apr;72(4):150-61.


The tumor invasion inhibitor dihydromotuporamine C activates RHO, remodels stress fibers and focal adhesions, and stimulates sodium-proton exchange.

McHardy LM, Sinotte R, Troussard A, Sheldon C, Church J, Williams DE, Andersen RJ, Dedhar S, Roberge M, Roskelley CD.

Cancer Res. 2004 Feb 15;64(4):1468-74.


Expression of activated M-Ras in a murine mammary epithelial cell line induces epithelial-mesenchymal transition and tumorigenesis.

Ward KR, Zhang KX, Somasiri AM, Roskelley CD, Schrader JW.

Oncogene. 2004 Feb 12;23(6):1187-96. Erratum in: Oncogene. 2004 Nov 18;23(54):8858. Zhang, Kai-Xiu [corrected to Zhang, Kai-Xin].


The role of the breast cancer susceptibility gene 1 (BRCA1) in sporadic epithelial ovarian cancer.

McCoy ML, Mueller CR, Roskelley CD.

Reprod Biol Endocrinol. 2003 Oct 7;1:72. Review.

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