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Items: 1 to 50 of 151


Bone health issues in breast cancer survivors: a Medicare Current Beneficiary Survey (MCBS) study.

Peppone LJ, Mustian KM, Rosier RN, Carroll JK, Purnell JQ, Janelsins MC, Morrow GR, Mohile SG.

Support Care Cancer. 2014 Jan;22(1):245-51. doi: 10.1007/s00520-013-1967-4. Epub 2013 Sep 17.


Lead induces an osteoarthritis-like phenotype in articular chondrocytes through disruption of TGF-β signaling.

Holz JD, Beier E, Sheu TJ, Ubayawardena R, Wang M, Sampson ER, Rosier RN, Zuscik M, Puzas JE.

J Orthop Res. 2012 Nov;30(11):1760-6. doi: 10.1002/jor.22117. Epub 2012 Apr 19.


Ski inhibits TGF-β/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes.

Kim KO, Sampson ER, Maynard RD, O'Keefe RJ, Chen D, Drissi H, Rosier RN, Hilton MJ, Zuscik MJ.

J Cell Biochem. 2012 Jun;113(6):2156-66. doi: 10.1002/jcb.24089.


High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injury.

Mooney RA, Sampson ER, Lerea J, Rosier RN, Zuscik MJ.

Arthritis Res Ther. 2011;13(6):R198. doi: 10.1186/ar3529. Epub 2011 Dec 7.


Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis.

Sampson ER, Hilton MJ, Tian Y, Chen D, Schwarz EM, Mooney RA, Bukata SV, O'Keefe RJ, Awad H, Puzas JE, Rosier RN, Zuscik MJ.

Sci Transl Med. 2011 Sep 21;3(101):101ra93. doi: 10.1126/scitranslmed.3002214.


The effect of various vitamin D supplementation regimens in breast cancer patients.

Peppone LJ, Huston AJ, Reid ME, Rosier RN, Zakharia Y, Trump DL, Mustian KM, Janelsins MC, Purnell JQ, Morrow GR.

Breast Cancer Res Treat. 2011 May;127(1):171-7. doi: 10.1007/s10549-011-1415-4. Epub 2011 Mar 8.


Establishment of an index with increased sensitivity for assessing murine arthritis.

Sampson ER, Beck CA, Ketz J, Canary KL, Hilton MJ, Awad H, Schwarz EM, Chen D, O'Keefe RJ, Rosier RN, Zuscik MJ.

J Orthop Res. 2011 Aug;29(8):1145-51. doi: 10.1002/jor.21368. Epub 2011 Mar 3.


The orally bioavailable met inhibitor PF-2341066 inhibits osteosarcoma growth and osteolysis/matrix production in a xenograft model.

Sampson ER, Martin BA, Morris AE, Xie C, Schwarz EM, O'Keefe RJ, Rosier RN.

J Bone Miner Res. 2011 Jun;26(6):1283-94. doi: 10.1002/jbmr.336.


The histone deacetylase inhibitor vorinostat selectively sensitizes fibrosarcoma cells to chemotherapy.

Sampson ER, Amin V, Schwarz EM, O'Keefe RJ, Rosier RN.

J Orthop Res. 2011 Apr;29(4):623-32. doi: 10.1002/jor.21274. Epub 2010 Oct 18.


Effects of a structured weight-bearing exercise program on bone metabolism among breast cancer survivors: a feasibility trial.

Peppone LJ, Mustian KM, Janelsins MC, Palesh OG, Rosier RN, Piazza KM, Purnell JQ, Darling TV, Morrow GR.

Clin Breast Cancer. 2010 Jun;10(3):224-9. doi: 10.3816/CBC.2010.n.030.


Beta-catenin, cartilage, and osteoarthritis.

Wu Q, Zhu M, Rosier RN, Zuscik MJ, O'Keefe RJ, Chen D.

Ann N Y Acad Sci. 2010 Mar;1192:344-50. doi: 10.1111/j.1749-6632.2009.05212.x. Review.


The efficacy of calcitriol therapy in the management of bone loss and fractures: a qualitative review.

Peppone LJ, Hebl S, Purnell JQ, Reid ME, Rosier RN, Mustian KM, Palesh OG, Huston AJ, Ling MN, Morrow GR.

Osteoporos Int. 2010 Jul;21(7):1133-49. doi: 10.1007/s00198-009-1136-2. Epub 2009 Dec 4. Review.


Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage.

Wu Q, Huang JH, Sampson ER, Kim KO, Zuscik MJ, O'Keefe RJ, Chen D, Rosier RN.

Exp Cell Res. 2009 Aug 15;315(14):2386-98. doi: 10.1016/j.yexcr.2009.05.019. Epub 2009 May 27.


Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice.

Wu Q, Kim KO, Sampson ER, Chen D, Awad H, O'Brien T, Puzas JE, Drissi H, Schwarz EM, O'Keefe RJ, Zuscik MJ, Rosier RN.

Arthritis Rheum. 2008 Oct;58(10):3132-44. doi: 10.1002/art.23946.


Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice.

Zhu M, Tang D, Wu Q, Hao S, Chen M, Xie C, Rosier RN, O'Keefe RJ, Zuscik M, Chen D.

J Bone Miner Res. 2009 Jan;24(1):12-21. doi: 10.1359/jbmr.080901.


Erythropoietin accelerates functional recovery after peripheral nerve injury.

Elfar JC, Jacobson JA, Puzas JE, Rosier RN, Zuscik MJ.

J Bone Joint Surg Am. 2008 Aug;90(8):1644-53. doi: 10.2106/JBJS.G.00557.


Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction.

Zhu M, Chen M, Zuscik M, Wu Q, Wang YJ, Rosier RN, O'Keefe RJ, Chen D.

Arthritis Rheum. 2008 Jul;58(7):2053-64. doi: 10.1002/art.23614.


Quantification of massive allograft healing with dynamic contrast enhanced-MRI and cone beam-CT: a pilot study.

Ehrhart N, Kraft S, Conover D, Rosier RN, Schwarz EM.

Clin Orthop Relat Res. 2008 Aug;466(8):1897-904. doi: 10.1007/s11999-008-0293-5. Epub 2008 Jun 10.


Teriparatide (1-34 human PTH) regulation of osterix during fracture repair.

Kaback LA, Soung do Y, Naik A, Geneau G, Schwarz EM, Rosier RN, O'Keefe RJ, Drissi H.

J Cell Biochem. 2008 Sep 1;105(1):219-26. doi: 10.1002/jcb.21816.


Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis.

Eliseev RA, Dong YF, Sampson E, Zuscik MJ, Schwarz EM, O'Keefe RJ, Rosier RN, Drissi MH.

Oncogene. 2008 Jun 5;27(25):3605-14. doi: 10.1038/sj.onc.1211020. Epub 2008 Jan 28.


Regulation of embryonic endochondral ossification by Smurf2.

Wu Q, Wang M, Zuscik MJ, Chen D, O'Keefe RJ, Rosier RN.

J Orthop Res. 2008 May;26(5):704-12. doi: 10.1002/jor.20563.


Overexpression of Smurf2 stimulates endochondral ossification through upregulation of beta-catenin.

Wu Q, Chen D, Zuscik MJ, O'Keefe RJ, Rosier RN.

J Bone Miner Res. 2008 Apr;23(4):552-63.


Institutional barriers to the orthopaedic clinician-scientist.

Rosier RN.

Clin Orthop Relat Res. 2006 Aug;449:159-64. Review.


Continuing competency in orthopaedics: the future of recertification.

Rosier RN.

Clin Orthop Relat Res. 2006 Aug;449:72-5. Review.


Role of cyclophilin D in the resistance of brain mitochondria to the permeability transition.

Eliseev RA, Filippov G, Velos J, VanWinkle B, Goldman A, Rosier RN, Gunter TE.

Neurobiol Aging. 2007 Oct;28(10):1532-42. Epub 2006 Jul 31.


American Board of Orthopaedic Surgery Practice of the Orthopaedic Surgeon: Part-II, certification examination case mix.

Garrett WE Jr, Swiontkowski MF, Weinstein JN, Callaghan J, Rosier RN, Berry DJ, Harrast J, Derosa GP.

J Bone Joint Surg Am. 2006 Mar;88(3):660-7. No abstract available.


Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation.

Li TF, Darowish M, Zuscik MJ, Chen D, Schwarz EM, Rosier RN, Drissi H, O'Keefe RJ.

J Bone Miner Res. 2006 Jan;21(1):4-16. Epub 2005 Sep 19.


A genome-wide expression profile and system-level integration of nuclear factor kappa B regulated genes reveals fundamental metabolic adaptations during cell growth and survival.

Andela VB, Schwarz EM, O'Keefe RJ, Puzas EJ, Rosenblatt JD, Rosier RN.

FEBS Lett. 2005 Dec 19;579(30):6814-20. Epub 2005 Nov 28.


Molecular biology in orthopaedics: the advent of molecular orthopaedics.

Evans CH, Rosier RN.

J Bone Joint Surg Am. 2005 Nov;87(11):2550-64.


Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB.

Eliseev RA, Schwarz EM, Zuscik MJ, O'Keefe RJ, Drissi H, Rosier RN.

Exp Cell Res. 2006 Jan 1;312(1):40-50. Epub 2005 Nov 2.


Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase.

Eliseev RA, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H, Rosier RN.

J Cell Biochem. 2005 Dec 15;96(6):1262-73.


Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency.

Carmouche JJ, Puzas JE, Zhang X, Tiyapatanaputi P, Cory-Slechta DA, Gelein R, Zuscik M, Rosier RN, Boyce BF, O'Keefe RJ, Schwarz EM.

Environ Health Perspect. 2005 Jun;113(6):749-55.


Case report: Bone metastases from fallopian tube carcinoma.

Courville XF, Cortés Z, Katzman PJ, Rosier RN.

Clin Orthop Relat Res. 2005 May;(434):278-81.


Nuclear factor-kappaB-dependent mechanisms in breast cancer cells regulate tumor burden and osteolysis in bone.

Gordon AH, O'Keefe RJ, Schwarz EM, Rosier RN, Puzas JE.

Cancer Res. 2005 Apr 15;65(8):3209-17.


PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling.

Li TF, Zuscik MJ, Ionescu AM, Zhang X, Rosier RN, Schwarz EM, Drissi H, O'Keefe RJ.

Exp Cell Res. 2004 Oct 15;300(1):159-69.


Diazoxide-mediated preconditioning against apoptosis involves activation of cAMP-response element-binding protein (CREB) and NFkappaB.

Eliseev RA, Vanwinkle B, Rosier RN, Gunter TE.

J Biol Chem. 2004 Nov 5;279(45):46748-54. Epub 2004 Aug 23.


Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway.

Li TF, Dong Y, Ionescu AM, Rosier RN, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H.

Exp Cell Res. 2004 Sep 10;299(1):128-36.


The association between environmental lead exposure and bone density in children.

Campbell JR, Rosier RN, Novotny L, Puzas JE.

Environ Health Perspect. 2004 Aug;112(11):1200-3.


Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation.

Zhang X, Ziran N, Goater JJ, Schwarz EM, Puzas JE, Rosier RN, Zuscik M, Drissi H, O'Keefe RJ.

Bone. 2004 May;34(5):809-17.


5-azacytidine alters TGF-beta and BMP signaling and induces maturation in articular chondrocytes.

Zuscik MJ, Baden JF, Wu Q, Sheu TJ, Schwarz EM, Drissi H, O'Keefe RJ, Puzas JE, Rosier RN.

J Cell Biochem. 2004 May 15;92(2):316-31.


CREB Cooperates with BMP-stimulated Smad signaling to enhance transcription of the Smad6 promoter.

Ionescu AM, Drissi H, Schwarz EM, Kato M, Puzas JE, McCance DJ, Rosier RN, Zuscik MJ, O'Keefe RJ.

J Cell Physiol. 2004 Mar;198(3):428-40.


PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox-2 dependent pathway.

Bukata SV, Gelinas J, Wei X, Rosier RN, Puzas JE, Zhang X, Schwarz EM, Song XY, Griswold DE, O'Keefe RJ.

J Orthop Res. 2004 Jan;22(1):6-12.


Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes.

Drissi MH, Li X, Sheu TJ, Zuscik MJ, Schwarz EM, Puzas JE, Rosier RN, O'Keefe RJ.

J Cell Biochem. 2003 Dec 15;90(6):1287-98.


NFkappaB: a pivotal transcription factor in prostate cancer metastasis to bone.

Andela VB, Gordon AH, Zotalis G, Rosier RN, Goater JJ, Lewis GD, Schwarz EM, Puzas JE, O'Keefe RJ.

Clin Orthop Relat Res. 2003 Oct;(415 Suppl):S75-85. Review.


The mevalonate synthesis pathway as a therapeutic target in cancer.

Andela VB, Pirri M, Schwarz EM, Puzas EJ, O'Keefe RJ, Rosenblatt JD, Rosier RN.

Clin Orthop Relat Res. 2003 Oct;(415 Suppl):S59-66. Review.


ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development.

Zhang D, Schwarz EM, Rosier RN, Zuscik MJ, Puzas JE, O'Keefe RJ.

J Bone Miner Res. 2003 Sep;18(9):1593-604.


Smad6 is induced by BMP-2 and modulates chondrocyte differentiation.

Li X, Ionescu AM, Schwarz EM, Zhang X, Drissi H, Puzas JE, Rosier RN, Zuscik MJ, O'Keefe RJ.

J Orthop Res. 2003 Sep;21(5):908-13.

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