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Items: 50


Duct- and Acinar-Derived Pancreatic Ductal Adenocarcinomas Show Distinct Tumor Progression and Marker Expression.

Ferreira RMM, Sancho R, Messal HA, Nye E, Spencer-Dene B, Stone RK, Stamp G, Rosewell I, Quaglia A, Behrens A.

Cell Rep. 2017 Oct 24;21(4):966-978. doi: 10.1016/j.celrep.2017.09.093.


Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion.

Quétier I, Marshall JJT, Spencer-Dene B, Lachmann S, Casamassima A, Franco C, Escuin S, Worrall JT, Baskaran P, Rajeeve V, Howell M, Copp AJ, Stamp G, Rosewell I, Cutillas P, Gerhardt H, Parker PJ, Cameron AJM.

Cell Rep. 2016 Jan 26;14(3):440-448. doi: 10.1016/j.celrep.2015.12.049. Epub 2016 Jan 7.


Runx2 contributes to the regenerative potential of the mammary epithelium.

Ferrari N, Riggio AI, Mason S, McDonald L, King A, Higgins T, Rosewell I, Neil JC, Smalley MJ, Sansom OJ, Morris J, Cameron ER, Blyth K.

Sci Rep. 2015 Oct 22;5:15658. doi: 10.1038/srep15658.


Mouse superkiller-2-like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses.

Goubau D, van der Veen AG, Chakravarty P, Lin R, Rogers N, Rehwinkel J, Deddouche S, Rosewell I, Hiscott J, Reis e Sousa C.

Eur J Immunol. 2015 Dec;45(12):3386-403. doi: 10.1002/eji.201545794. Epub 2015 Oct 12.


Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch.

Aspalter IM, Gordon E, Dubrac A, Ragab A, Narloch J, Vizán P, Geudens I, Collins RT, Franco CA, Abrahams CL, Thurston G, Fruttiger M, Rosewell I, Eichmann A, Gerhardt H.

Nat Commun. 2015 Jun 17;6:7264. doi: 10.1038/ncomms8264.


Dendritic cells control fibroblastic reticular network tension and lymph node expansion.

Acton SE, Farrugia AJ, Astarita JL, Mourão-Sá D, Jenkins RP, Nye E, Hooper S, van Blijswijk J, Rogers NC, Snelgrove KJ, Rosewell I, Moita LF, Stamp G, Turley SJ, Sahai E, Reis e Sousa C.

Nature. 2014 Oct 23;514(7523):498-502. doi: 10.1038/nature13814.


Bicaudal-D1 regulates the intracellular sorting and signalling of neurotrophin receptors.

Terenzio M, Golding M, Russell MR, Wicher KB, Rosewell I, Spencer-Dene B, Ish-Horowicz D, Schiavo G.

EMBO J. 2014 Jul 17;33(14):1582-98. doi: 10.15252/embj.201387579. Epub 2014 Jun 11.


SRF selectively controls tip cell invasive behavior in angiogenesis.

Franco CA, Blanc J, Parlakian A, Blanco R, Aspalter IM, Kazakova N, Diguet N, Mylonas E, Gao-Li J, Vaahtokari A, Penard-Lacronique V, Fruttiger M, Rosewell I, Mericskay M, Gerhardt H, Li Z.

Development. 2013 Jun;140(11):2321-33. doi: 10.1242/dev.091074.


Murine aggregation chimeras and wholemount imaging in airway stem cell biology.

Rosewell IR, Giangreco A.

Methods Mol Biol. 2012;916:263-74. doi: 10.1007/978-1-61779-980-8_20.


Fibroblast growth factor 22 is not essential for skin development and repair but plays a role in tumorigenesis.

Jarosz M, Robbez-Masson L, Chioni AM, Cross B, Rosewell I, Grose R.

PLoS One. 2012;7(6):e39436. doi: 10.1371/journal.pone.0039436. Epub 2012 Jun 21.


Epidermal Cadm1 expression promotes autoimmune alopecia via enhanced T cell adhesion and cytotoxicity.

Giangreco A, Hoste E, Takai Y, Rosewell I, Watt FM.

J Immunol. 2012 Feb 1;188(3):1514-22. doi: 10.4049/jimmunol.1003342. Epub 2011 Dec 30.


Endothelial basement membrane limits tip cell formation by inducing Dll4/Notch signalling in vivo.

Stenzel D, Franco CA, Estrach S, Mettouchi A, Sauvaget D, Rosewell I, Schertel A, Armer H, Domogatskaya A, Rodin S, Tryggvason K, Collinson L, Sorokin L, Gerhardt H.

EMBO Rep. 2011 Oct 28;12(11):1135-43. doi: 10.1038/embor.2011.194.


PLU-1/JARID1B/KDM5B is required for embryonic survival and contributes to cell proliferation in the mammary gland and in ER+ breast cancer cells.

Catchpole S, Spencer-Dene B, Hall D, Santangelo S, Rosewell I, Guenatri M, Beatson R, Scibetta AG, Burchell JM, Taylor-Papadimitriou J.

Int J Oncol. 2011 May;38(5):1267-77. doi: 10.3892/ijo.2011.956. Epub 2011 Feb 28.


Tumor formation initiated by nondividing epidermal cells via an inflammatory infiltrate.

Arwert EN, Lal R, Quist S, Rosewell I, van Rooijen N, Watt FM.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19903-8. doi: 10.1073/pnas.1007404107. Epub 2010 Nov 1.


Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting.

Jakobsson L, Franco CA, Bentley K, Collins RT, Ponsioen B, Aspalter IM, Rosewell I, Busse M, Thurston G, Medvinsky A, Schulte-Merker S, Gerhardt H.

Nat Cell Biol. 2010 Oct;12(10):943-53. doi: 10.1038/ncb2103. Epub 2010 Sep 26.


Stem cells are dispensable for lung homeostasis but restore airways after injury.

Giangreco A, Arwert EN, Rosewell IR, Snyder J, Watt FM, Stripp BR.

Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9286-91. doi: 10.1073/pnas.0900668106. Epub 2009 May 28.


Identification of a dendritic cell receptor that couples sensing of necrosis to immunity.

Sancho D, Joffre OP, Keller AM, Rogers NC, Martínez D, Hernanz-Falcón P, Rosewell I, Reis e Sousa C.

Nature. 2009 Apr 16;458(7240):899-903. doi: 10.1038/nature07750.


Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5.

Finn RD, McLaughlin LA, Ronseaux S, Rosewell I, Houston JB, Henderson CJ, Wolf CR.

J Biol Chem. 2008 Nov 14;283(46):31385-93. doi: 10.1074/jbc.M803496200. Epub 2008 Sep 19.


Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway.

Pollard PJ, Spencer-Dene B, Shukla D, Howarth K, Nye E, El-Bahrawy M, Deheragoda M, Joannou M, McDonald S, Martin A, Igarashi P, Varsani-Brown S, Rosewell I, Poulsom R, Maxwell P, Stamp GW, Tomlinson IP.

Cancer Cell. 2007 Apr;11(4):311-9.


Targeted deletion of p97 (VCP/CDC48) in mouse results in early embryonic lethality.

Müller JM, Deinhardt K, Rosewell I, Warren G, Shima DT.

Biochem Biophys Res Commun. 2007 Mar 9;354(2):459-65. Epub 2007 Jan 8.


The dual-specificity protein phosphatase DUSP9/MKP-4 is essential for placental function but is not required for normal embryonic development.

Christie GR, Williams DJ, Macisaac F, Dickinson RJ, Rosewell I, Keyse SM.

Mol Cell Biol. 2005 Sep;25(18):8323-33.


Trefoil factor 2 (TFF2) deficiency in murine digestive tract influences the immune system.

Baus-Loncar M, Schmid J, Lalani el-N, Rosewell I, Goodlad RA, Stamp GW, Blin N, Kayademir T.

Cell Physiol Biochem. 2005;16(1-3):31-42.


Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis.

Morita M, Stamp G, Robins P, Dulic A, Rosewell I, Hrivnak G, Daly G, Lindahl T, Barnes DE.

Mol Cell Biol. 2004 Aug;24(15):6719-27.


A short region of the promoter of the breast cancer associated PLU-1 gene can regulate transcription in vitro and in vivo.

Catteau A, Rosewell I, Solomon E, Taylor-Papadimitriou J.

Int J Oncol. 2004 Jul;25(1):5-16.


Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection.

Costello PS, Nicolas RH, Watanabe Y, Rosewell I, Treisman R.

Nat Immunol. 2004 Mar;5(3):289-98. Epub 2004 Feb 8.


"Mouse locator-UK": a networking tool for academic transgenic research in the UK.

Bugeon L, Rosewell I.

Transgenic Res. 2003 Oct;12(5):637. No abstract available.


The thyroid hormone receptor-associated protein TRAP220 is required at distinct embryonic stages in placental, cardiac, and hepatic development.

Landles C, Chalk S, Steel JH, Rosewell I, Spencer-Dene B, Lalani el-N, Parker MG.

Mol Endocrinol. 2003 Dec;17(12):2418-35. Epub 2003 Sep 18.


Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

Henderson CJ, Otto DM, Carrie D, Magnuson MA, McLaren AW, Rosewell I, Wolf CR.

J Biol Chem. 2003 Apr 11;278(15):13480-6. Epub 2003 Feb 3.


Truncation of the Mll gene in exon 5 by gene targeting leads to early preimplantation lethality of homozygous embryos.

Ayton P, Sneddon SF, Palmer DB, Rosewell IR, Owen MJ, Young B, Presley R, Subramanian V.

Genesis. 2001 Aug;30(4):201-12.


The nuclear receptor co-repressor nrip1 (RIP140) is essential for female fertility.

White R, Leonardsson G, Rosewell I, Ann Jacobs M, Milligan S, Parker M.

Nat Med. 2000 Dec;6(12):1368-74.


Disruption of the developmentally regulated Rev3l gene causes embryonic lethality.

Wittschieben J, Shivji MK, Lalani E, Jacobs MA, Marini F, Gearhart PJ, Rosewell I, Stamp G, Wood RD.

Curr Biol. 2000 Oct 5;10(19):1217-20.


Fibroblast growth factor signalling and cyclin D1 function are necessary for normal mammary gland development during pregnancy. A transgenic mouse approach.

Fantl V, Creer A, Dillon C, Bresnick J, Jackson D, Edwards P, Rosewell I, Dickson C.

Adv Exp Med Biol. 2000;480:1-7. Review.


Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication.

Nilsen H, Rosewell I, Robins P, Skjelbred CF, Andersen S, Slupphaug G, Daly G, Krokan HE, Lindahl T, Barnes DE.

Mol Cell. 2000 Jun;5(6):1059-65.


The p24 family member p23 is required for early embryonic development.

Denzel A, Otto F, Girod A, Pepperkok R, Watson R, Rosewell I, Bergeron JJ, Solari RC, Owen MJ.

Curr Biol. 2000 Jan 13;10(1):55-8.


An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis.

De Moerlooze L, Spencer-Dene B, Revest JM, Hajihosseini M, Rosewell I, Dickson C.

Development. 2000 Feb;127(3):483-92.


Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage.

Klungland A, Rosewell I, Hollenbach S, Larsen E, Daly G, Epe B, Seeberg E, Lindahl T, Barnes DE.

Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13300-5.


Tumor burden and clonality in multiple intestinal neoplasia mouse/normal mouse aggregation chimeras.

Novelli MR, Wasan H, Rosewell I, Bee J, Tomlinson IP, Wright NA, Bodmer WF.

Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12553-8.


Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice.

Barnes DE, Stamp G, Rosewell I, Denzel A, Lindahl T.

Curr Biol. 1998 Dec 17-31;8(25):1395-8.


Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero.

Brandeis M, Rosewell I, Carrington M, Crompton T, Jacobs MA, Kirk J, Gannon J, Hunt T.

Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4344-9.


Fibroblast growth factor receptor signalling has a role in lobuloalveolar development of the mammary gland.

Jackson D, Bresnick J, Rosewell I, Crafton T, Poulsom R, Stamp G, Dickson C.

J Cell Sci. 1997 Jun;110 ( Pt 11):1261-8.


Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development.

Otto F, Thornell AP, Crompton T, Denzel A, Gilmour KC, Rosewell IR, Stamp GW, Beddington RS, Mundlos S, Olsen BR, Selby PB, Owen MJ.

Cell. 1997 May 30;89(5):765-71.


Raf regulates positive selection.

O'Shea CC, Crompton T, Rosewell IR, Hayday AC, Owen MJ.

Eur J Immunol. 1996 Oct;26(10):2350-5.


Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

Fantl V, Stamp G, Andrews A, Rosewell I, Dickson C.

Genes Dev. 1995 Oct 1;9(19):2364-72.


Subtle differences in antibody responses and hypermutation of lambda light chains in mice with a disrupted chi constant region.

Zou X, Xian J, Popov AV, Rosewell IR, Müller M, Brüggemann M.

Eur J Immunol. 1995 Aug;25(8):2154-62.


Creation of mice expressing human antibody light chains by introduction of a yeast artificial chromosome containing the core region of the human immunoglobulin kappa locus.

Davies NP, Rosewell IR, Richardson JC, Cook GP, Neuberger MS, Brownstein BH, Norris ML, Brüggemann M.

Biotechnology (N Y). 1993 Aug;11(8):911-4.


Designer mice: the production of human antibody repertoires in transgenic animals.

Brüggemann M, Davies NP, Rosewell IR.

Year Immunol. 1993;7:33-40. Review. No abstract available.


Targeted alterations in yeast artificial chromosomes for inter-species gene transfer.

Davies NP, Rosewell IR, Brüggemann M.

Nucleic Acids Res. 1992 Jun 11;20(11):2693-8.


Human antibody production in transgenic mice: expression from 100 kb of the human IgH locus.

Brüggemann M, Spicer C, Buluwela L, Rosewell I, Barton S, Surani MA, Rabbitts TH.

Eur J Immunol. 1991 May;21(5):1323-6.


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