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Items: 1 to 50 of 72

1.

Treatment with levetiracetam improves cognition in a ketamine rat model of schizophrenia.

Koh MT, Shao Y, Rosenzweig-Lipson S, Gallagher M.

Schizophr Res. 2018 Mar;193:119-125. doi: 10.1016/j.schres.2017.06.027. Epub 2017 Jun 17.

2.

A 6-week randomized, double-blind, placebo-controlled, comparator referenced trial of vabicaserin in acute schizophrenia.

Shen JH, Zhao Y, Rosenzweig-Lipson S, Popp D, Williams JB, Giller E, Detke MJ, Kane JM.

J Psychiatr Res. 2014 Jun;53:14-22. doi: 10.1016/j.jpsychires.2014.02.012. Epub 2014 Feb 24.

PMID:
24613032
3.

Synergism between a serotonin 5-HT2A receptor (5-HT2AR) antagonist and 5-HT2CR agonist suggests new pharmacotherapeutics for cocaine addiction.

Cunningham KA, Anastasio NC, Fox RG, Stutz SJ, Bubar MJ, Swinford SE, Watson CS, Gilbertson SR, Rice KC, Rosenzweig-Lipson S, Moeller FG.

ACS Chem Neurosci. 2013 Jan 16;4(1):110-21. doi: 10.1021/cn300072u. Epub 2012 Aug 11.

4.

Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes.

Sukoff Rizzo SJ, Neal SJ, Hughes ZA, Beyna M, Rosenzweig-Lipson S, Moss SJ, Brandon NJ.

Transl Psychiatry. 2012 Dec 4;2:e199. doi: 10.1038/tp.2012.120.

5.

5-HT(2C) agonists as therapeutics for the treatment of schizophrenia.

Rosenzweig-Lipson S, Comery TA, Marquis KL, Gross J, Dunlop J.

Handb Exp Pharmacol. 2012;(213):147-65. doi: 10.1007/978-3-642-25758-2_6. Review.

PMID:
23027415
6.

Selective GABA(A) α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment.

Koh MT, Rosenzweig-Lipson S, Gallagher M.

Neuropharmacology. 2013 Jan;64:145-52. doi: 10.1016/j.neuropharm.2012.06.023. Epub 2012 Jun 23.

7.

Negative allosteric modulation of metabotropic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression.

Hughes ZA, Neal SJ, Smith DL, Sukoff Rizzo SJ, Pulicicchio CM, Lotarski S, Lu S, Dwyer JM, Brennan J, Olsen M, Bender CN, Kouranova E, Andree TH, Harrison JE, Whiteside GT, Springer D, O'Neil SV, Leonard SK, Schechter LE, Dunlop J, Rosenzweig-Lipson S, Ring RH.

Neuropharmacology. 2013 Mar;66:202-14. doi: 10.1016/j.neuropharm.2012.04.007. Epub 2012 Apr 21.

PMID:
22551786
8.

Selective serotonin 5-HT(2C) receptor activation suppresses the reinforcing efficacy of cocaine and sucrose but differentially affects the incentive-salience value of cocaine- vs. sucrose-associated cues.

Cunningham KA, Fox RG, Anastasio NC, Bubar MJ, Stutz SJ, Moeller FG, Gilbertson SR, Rosenzweig-Lipson S.

Neuropharmacology. 2011 Sep;61(3):513-23. doi: 10.1016/j.neuropharm.2011.04.034. Epub 2011 May 11.

9.

The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise?

Sukoff Rizzo SJ, Leonard SK, Gilbert A, Dollings P, Smith DL, Zhang MY, Di L, Platt BJ, Neal S, Dwyer JM, Bender CN, Zhang J, Lock T, Kowal D, Kramer A, Randall A, Huselton C, Vishwanathan K, Tse SY, Butera J, Ring RH, Rosenzweig-Lipson S, Hughes ZA, Dunlop J.

J Pharmacol Exp Ther. 2011 Jul;338(1):345-52. doi: 10.1124/jpet.110.177378. Epub 2011 Apr 20.

PMID:
21508084
10.

Characterization of vabicaserin (SCA-136), a selective 5-hydroxytryptamine 2C receptor agonist.

Dunlop J, Watts SW, Barrett JE, Coupet J, Harrison B, Mazandarani H, Nawoschik S, Pangalos MN, Ramamoorthy S, Schechter L, Smith D, Stack G, Zhang J, Zhang G, Rosenzweig-Lipson S.

J Pharmacol Exp Ther. 2011 Jun;337(3):673-80. doi: 10.1124/jpet.111.179572. Epub 2011 Mar 14.

PMID:
21402690
11.

3-(Pyridin-2-yl-ethynyl)benzamide metabotropic glutamate receptor 5 negative allosteric modulators: hit to lead studies.

Gilbert AM, Bursavich MG, Lombardi S, Adedoyin A, Dwyer JM, Hughes Z, Kern JC, Khawaja X, Rosenzweig-Lipson S, Moore WJ, Neal SJ, Olsen M, Rizzo SJ, Springer D.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):195-9. doi: 10.1016/j.bmcl.2010.11.038. Epub 2010 Nov 12.

PMID:
21126874
12.

New horizons for selective 5-HT2C receptor ligands in psychiatric/neurological disorders.

Rosenzweig-Lipson S.

Neuropsychopharmacology. 2011 Jan;36(1):363-4. doi: 10.1038/npp.2010.168. No abstract available.

13.

Discriminative stimulus effects of serotonin agonists, neutral antagonists, and inverse agonists in pigeons: perspectives on intrinsic efficacy measurements in vivo.

Farrell M, Rosenzweig-Lipson S, Walker E.

Psychopharmacology (Berl). 2010 Aug;211(2):149-59. doi: 10.1007/s00213-010-1893-9. Epub 2010 Jun 5.

PMID:
20526585
14.

The synthesis and biological evaluation of quinolyl-piperazinyl piperidines as potent serotonin 5-HT1A antagonists.

Childers WE Jr, Havran LM, Asselin M, Bicksler JJ, Chong DC, Grosu GT, Shen Z, Abou-Gharbia MA, Bach AC 3rd, Harrison BL, Kagan N, Kleintop T, Magolda R, Marathias V, Robichaud AJ, Sabb AL, Zhang MY, Andree TH, Aschmies SH, Beyer C, Comery TA, Day M, Grauer SM, Hughes ZA, Rosenzweig-Lipson S, Platt B, Pulicicchio C, Smith DE, Sukoff-Rizzo SJ, Sullivan KM, Adedoyin A, Huselton C, Hirst WD.

J Med Chem. 2010 May 27;53(10):4066-84. doi: 10.1021/jm1000908.

PMID:
20443629
15.

Angiotensin IV elevates oxytocin levels in the rat amygdala and produces anxiolytic-like activity through subsequent oxytocin receptor activation.

Beyer CE, Dwyer JM, Platt BJ, Neal S, Luo B, Ling HP, Lin Q, Mark RJ, Rosenzweig-Lipson S, Schechter LE.

Psychopharmacology (Berl). 2010 May;209(4):303-11. doi: 10.1007/s00213-010-1791-1. Epub 2010 Mar 12.

PMID:
20224888
16.

Preclinical characterization of BRL 44408: antidepressant- and analgesic-like activity through selective alpha2A-adrenoceptor antagonism.

Dwyer JM, Platt BJ, Rizzo SJ, Pulicicchio CM, Wantuch C, Zhang MY, Cummons T, Leventhal L, Bender CN, Zhang J, Kowal D, Lu S, Rajarao SJ, Smith DL, Shilling AD, Wang J, Butera J, Resnick L, Rosenzweig-Lipson S, Schechter LE, Beyer CE.

Int J Neuropsychopharmacol. 2010 Oct;13(9):1193-205. doi: 10.1017/S1461145709991088. Epub 2010 Jan 5.

PMID:
20047711
17.

WS-50030 [7-{4-[3-(1H-inden-3-yl)propyl]piperazin-1-yl}-1,3-benzoxazol-2(3H)-one]: a novel dopamine D2 receptor partial agonist/serotonin reuptake inhibitor with preclinical antipsychotic-like and antidepressant-like activity.

Brennan JA, Graf R, Grauer SM, Navarra RL, Pulicicchio CM, Hughes ZA, Lin Q, Wantuch C, Rosenzweig-Lipson S, Pruthi F, Lai M, Smith D, Goutier W, van de Neut M, Robichaud AJ, Rotella D, Feenstra RW, Kruse C, Broqua P, Beyer CE, McCreary AC, Pausch MH, Marquis KL.

J Pharmacol Exp Ther. 2010 Jan;332(1):190-201. doi: 10.1124/jpet.109.157388. Epub 2009 Oct 14.

PMID:
19828876
18.

The orphan GPCR, GPR88, modulates function of the striatal dopamine system: a possible therapeutic target for psychiatric disorders?

Logue SF, Grauer SM, Paulsen J, Graf R, Taylor N, Sung MA, Zhang L, Hughes Z, Pulito VL, Liu F, Rosenzweig-Lipson S, Brandon NJ, Marquis KL, Bates B, Pausch M.

Mol Cell Neurosci. 2009 Dec;42(4):438-47. doi: 10.1016/j.mcn.2009.09.007. Epub 2009 Sep 29.

PMID:
19796684
19.

Receptor and behavioral pharmacology of WAY-267464, a non-peptide oxytocin receptor agonist.

Ring RH, Schechter LE, Leonard SK, Dwyer JM, Platt BJ, Graf R, Grauer S, Pulicicchio C, Resnick L, Rahman Z, Sukoff Rizzo SJ, Luo B, Beyer CE, Logue SF, Marquis KL, Hughes ZA, Rosenzweig-Lipson S.

Neuropharmacology. 2010 Jan;58(1):69-77. doi: 10.1016/j.neuropharm.2009.07.016. Epub 2009 Jul 15.

PMID:
19615387
20.

Novel 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines are potent 5-HT(6) agonists.

Bernotas RC, Lenicek S, Antane S, Cole DC, Harrison BL, Robichaud AJ, Zhang GM, Smith D, Platt B, Lin Q, Li P, Coupet J, Rosenzweig-Lipson S, Beyer CE, Schechter LE.

Bioorg Med Chem. 2009 Jul 15;17(14):5153-63. doi: 10.1016/j.bmc.2009.05.055. Epub 2009 May 29.

PMID:
19523834
21.

5-HT(1A) receptor antagonism reverses and prevents fluoxetine-induced sexual dysfunction in rats.

Sukoff Rizzo SJ, Pulicicchio C, Malberg JE, Andree TH, Stack GP, Hughes ZA, Schechter LE, Rosenzweig-Lipson S.

Int J Neuropsychopharmacol. 2009 Sep;12(8):1045-53. doi: 10.1017/S1461145709000406. Epub 2009 May 13.

PMID:
19435548
22.

Preclinical characterization of WAY-211612: a dual 5-HT uptake inhibitor and 5-HT (1A) receptor antagonist and potential novel antidepressant.

Beyer CE, Lin Q, Platt B, Malberg J, Hornby G, Sullivan KM, Smith DL, Lock T, Mitchell PJ, Hatzenbuhler NT, Evrard DA, Harrison BL, Magolda R, Pangalos MN, Schechter LE, Rosenzweig-Lipson S, Andree TH.

Br J Pharmacol. 2009 May;157(2):307-19. doi: 10.1111/j.1476-5381.2009.00146.x. Epub 2009 Mar 26.

23.

The supra-additive hyperactivity caused by an amphetamine-chlordiazepoxide mixture exhibits an inverted-U dose response: negative implications for the use of a model in screening for mood stabilizers.

Kelly MP, Logue SF, Dwyer JM, Beyer CE, Majchrowski H, Cai Z, Liu Z, Adedoyin A, Rosenzweig-Lipson S, Comery TA.

Pharmacol Biochem Behav. 2009 Jun;92(4):649-54. doi: 10.1016/j.pbb.2009.03.003. Epub 2009 Mar 18.

PMID:
19303035
24.

Flow cytometric analysis of BrdU incorporation as a high-throughput method for measuring adult neurogenesis in the mouse.

Balu DT, Hodes GE, Hill TE, Ho N, Rahman Z, Bender CN, Ring RH, Dwyer JM, Rosenzweig-Lipson S, Hughes ZA, Schechter LE, Lucki I.

J Pharmacol Toxicol Methods. 2009 Mar-Apr;59(2):100-7. doi: 10.1016/j.vascn.2008.12.002. Epub 2008 Dec 14.

25.

WAY-163909, a 5-HT2C agonist, enhances the preclinical potency of current antipsychotics.

Grauer SM, Graf R, Navarra R, Sung A, Logue SF, Stack G, Huselton C, Liu Z, Comery TA, Marquis KL, Rosenzweig-Lipson S.

Psychopharmacology (Berl). 2009 May;204(1):37-48. doi: 10.1007/s00213-008-1433-z. Epub 2008 Dec 20.

PMID:
19107466
26.

Acid sensing ion channel (ASIC) inhibitors exhibit anxiolytic-like activity in preclinical pharmacological models.

Dwyer JM, Rizzo SJ, Neal SJ, Lin Q, Jow F, Arias RL, Rosenzweig-Lipson S, Dunlop J, Beyer CE.

Psychopharmacology (Berl). 2009 Mar;203(1):41-52. doi: 10.1007/s00213-008-1373-7. Epub 2008 Oct 24.

PMID:
18949460
27.

ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities.

Liu F, Grauer S, Kelley C, Navarra R, Graf R, Zhang G, Atkinson PJ, Popiolek M, Wantuch C, Khawaja X, Smith D, Olsen M, Kouranova E, Lai M, Pruthi F, Pulicicchio C, Day M, Gilbert A, Pausch MH, Brandon NJ, Beyer CE, Comery TA, Logue S, Rosenzweig-Lipson S, Marquis KL.

J Pharmacol Exp Ther. 2008 Dec;327(3):827-39. doi: 10.1124/jpet.108.136580. Epub 2008 Aug 27.

PMID:
18753411
28.

Antidepressant-like behavioral effects of IGF-I produced by enhanced serotonin transmission.

Hoshaw BA, Hill TI, Crowley JJ, Malberg JE, Khawaja X, Rosenzweig-Lipson S, Schechter LE, Lucki I.

Eur J Pharmacol. 2008 Oct 10;594(1-3):109-16. doi: 10.1016/j.ejphar.2008.07.023. Epub 2008 Jul 17.

29.

Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors.

Mahaney PE, Gavrin LK, Trybulski EJ, Stack GP, Vu TA, Cohn ST, Ye F, Belardi JK, Santilli AA, Sabatucci JP, Leiter J, Johnston GH, Bray JA, Burroughs KD, Cosmi SA, Leventhal L, Koury EJ, Zhang Y, Mugford CA, Ho DM, Rosenzweig-Lipson SJ, Platt B, Smith VA, Deecher DC.

J Med Chem. 2008 Jul 10;51(13):4038-49. doi: 10.1021/jm8002262. Epub 2008 Jun 17.

PMID:
18557608
30.

Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments.

Balu DT, Hoshaw BA, Malberg JE, Rosenzweig-Lipson S, Schechter LE, Lucki I.

Brain Res. 2008 May 23;1211:37-43. doi: 10.1016/j.brainres.2008.03.023. Epub 2008 Mar 21.

31.

Schedule-induced polydipsia: a rat model of obsessive-compulsive disorder.

Platt B, Beyer CE, Schechter LE, Rosenzweig-Lipson S.

Curr Protoc Neurosci. 2008 Apr;Chapter 9:Unit 9.27. doi: 10.1002/0471142301.ns0927s43.

PMID:
18428677
32.

WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent.

Hughes ZA, Liu F, Platt BJ, Dwyer JM, Pulicicchio CM, Zhang G, Schechter LE, Rosenzweig-Lipson S, Day M.

Neuropharmacology. 2008 Jun;54(7):1136-42. doi: 10.1016/j.neuropharm.2008.03.004. Epub 2008 Mar 18.

PMID:
18423777
33.

Inhibition of uptake 2 (or extraneuronal monoamine transporter) by normetanephrine potentiates the neurochemical effects of venlafaxine.

Rahman Z, Ring RH, Young K, Platt B, Lin Q, Schechter LE, Rosenzweig-Lipson S, Beyer CE.

Brain Res. 2008 Apr 8;1203:68-78. doi: 10.1016/j.brainres.2008.01.062. Epub 2008 Feb 5.

PMID:
18321472
34.

Pharmacology of neuropeptide S in mice: therapeutic relevance to anxiety disorders.

Leonard SK, Dwyer JM, Sukoff Rizzo SJ, Platt B, Logue SF, Neal SJ, Malberg JE, Beyer CE, Schechter LE, Rosenzweig-Lipson S, Ring RH.

Psychopharmacology (Berl). 2008 May;197(4):601-11. doi: 10.1007/s00213-008-1080-4. Epub 2008 Mar 3.

PMID:
18311561
35.

The 5-HT(2C) receptor agonist WAY-163909 decreases impulsivity in the 5-choice serial reaction time test.

Navarra R, Comery TA, Graf R, Rosenzweig-Lipson S, Day M.

Behav Brain Res. 2008 Apr 9;188(2):412-5. doi: 10.1016/j.bbr.2007.11.016. Epub 2007 Nov 29.

PMID:
18191235
36.

Correlating efficacy in rodent cognition models with in vivo 5-hydroxytryptamine1a receptor occupancy by a novel antagonist, (R)-N-(2-methyl-(4-indolyl-1-piperazinyl)ethyl)-N-(2-pyridinyl)-cyclohexane carboxamide (WAY-101405).

Hirst WD, Andree TH, Aschmies S, Childers WE, Comery TA, Dawson LA, Day M, Feingold IB, Grauer SM, Harrison BL, Hughes ZA, Kao J, Kelly MG, van der Lee H, Rosenzweig-Lipson S, Saab AL, Smith DL, Sullivan K, Rizzo SJ, Tio C, Zhang MY, Schechter LE.

J Pharmacol Exp Ther. 2008 Apr;325(1):134-45. doi: 10.1124/jpet.107.133082. Epub 2008 Jan 8.

PMID:
18182558
37.

5-HT2C receptor agonists as an innovative approach for psychiatric disorders.

Rosenzweig-Lipson S, Dunlop J, Marquis KL.

Drug News Perspect. 2007 Nov;20(9):565-71. doi: 10.1358/dnp.2007.20.9.1162244. Review.

PMID:
18176661
38.

Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist.

Cole DC, Stock JR, Lennox WJ, Bernotas RC, Ellingboe JW, Boikess S, Coupet J, Smith DL, Leung L, Zhang GM, Feng X, Kelly MF, Galante R, Huang P, Dawson LA, Marquis K, Rosenzweig-Lipson S, Beyer CE, Schechter LE.

J Med Chem. 2007 Nov 15;50(23):5535-8. Epub 2007 Oct 19.

PMID:
17948978
39.

A novel approach for predicting antidepressant-induced sexual dysfunction in rats.

Sukoff Rizzo SJ, Schechter LE, Rosenzweig-Lipson S.

Psychopharmacology (Berl). 2008 Jan;195(4):459-67. Epub 2007 Sep 16.

PMID:
17874315
40.

Anxiolytic-like activity of the non-selective galanin receptor agonist, galnon.

Rajarao SJ, Platt B, Sukoff SJ, Lin Q, Bender CN, Nieuwenhuijsen BW, Ring RH, Schechter LE, Rosenzweig-Lipson S, Beyer CE.

Neuropeptides. 2007 Oct;41(5):307-20. Epub 2007 Jul 16.

PMID:
17637475
41.

Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466.

Schechter LE, Lin Q, Smith DL, Zhang G, Shan Q, Platt B, Brandt MR, Dawson LA, Cole D, Bernotas R, Robichaud A, Rosenzweig-Lipson S, Beyer CE.

Neuropsychopharmacology. 2008 May;33(6):1323-35. Epub 2007 Jul 11.

42.

Increasing the levels of insulin-like growth factor-I by an IGF binding protein inhibitor produces anxiolytic and antidepressant-like effects.

Malberg JE, Platt B, Rizzo SJ, Ring RH, Lucki I, Schechter LE, Rosenzweig-Lipson S.

Neuropsychopharmacology. 2007 Nov;32(11):2360-8. Epub 2007 Mar 7.

43.

Antidepressant-like effects of the novel, selective, 5-HT2C receptor agonist WAY-163909 in rodents.

Rosenzweig-Lipson S, Sabb A, Stack G, Mitchell P, Lucki I, Malberg JE, Grauer S, Brennan J, Cryan JF, Sukoff Rizzo SJ, Dunlop J, Barrett JE, Marquis KL.

Psychopharmacology (Berl). 2007 Jun;192(2):159-70. Epub 2007 Feb 13.

PMID:
17297636
44.

Pharmacological profile of the 5-HT(2C) receptor agonist WAY-163909; therapeutic potential in multiple indications.

Dunlop J, Marquis KL, Lim HK, Leung L, Kao J, Cheesman C, Rosenzweig-Lipson S.

CNS Drug Rev. 2006 Fall-Winter;12(3-4):167-77. Review.

45.

WAY-163909 [(7bR,10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole]: A novel 5-hydroxytryptamine 2C receptor-selective agonist with preclinical antipsychotic-like activity.

Marquis KL, Sabb AL, Logue SF, Brennan JA, Piesla MJ, Comery TA, Grauer SM, Ashby CR Jr, Nguyen HQ, Dawson LA, Barrett JE, Stack G, Meltzer HY, Harrison BL, Rosenzweig-Lipson S.

J Pharmacol Exp Ther. 2007 Jan;320(1):486-96. Epub 2006 Oct 12.

PMID:
17038512
46.

Differentiating antidepressants of the future: efficacy and safety.

Rosenzweig-Lipson S, Beyer CE, Hughes ZA, Khawaja X, Rajarao SJ, Malberg JE, Rahman Z, Ring RH, Schechter LE.

Pharmacol Ther. 2007 Jan;113(1):134-53. Epub 2006 Sep 27. Review.

PMID:
17010443
47.

Alpha 2A-adrenoceptors enhance the serotonergic effects of fluoxetine.

Beyer CE, Lin Q, Rosenzweig-Lipson S, Schechter LE.

Eur J Pharmacol. 2006 Jun 13;539(3):164-7. Epub 2006 Apr 19.

PMID:
16714015
48.

Innovative approaches for the development of antidepressant drugs: current and future strategies.

Schechter LE, Ring RH, Beyer CE, Hughes ZA, Khawaja X, Malberg JE, Rosenzweig-Lipson S.

NeuroRx. 2005 Oct;2(4):590-611. Review.

49.

Antiobesity-like effects of the 5-HT2C receptor agonist WAY-161503.

Rosenzweig-Lipson S, Zhang J, Mazandarani H, Harrison BL, Sabb A, Sabalski J, Stack G, Welmaker G, Barrett JE, Dunlop J.

Brain Res. 2006 Feb 16;1073-1074:240-51. Epub 2006 Jan 20.

PMID:
16430874
50.

Anxiolytic-like activity of oxytocin in male mice: behavioral and autonomic evidence, therapeutic implications.

Ring RH, Malberg JE, Potestio L, Ping J, Boikess S, Luo B, Schechter LE, Rizzo S, Rahman Z, Rosenzweig-Lipson S.

Psychopharmacology (Berl). 2006 Apr;185(2):218-25. Epub 2006 Jan 18.

PMID:
16418825

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