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Items: 1 to 50 of 283

1.

Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes.

Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa FR.

Cell Metab. 2017 May 2;25(5):1207. doi: 10.1016/j.cmet.2017.04.026. No abstract available.

2.

Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes.

Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa FR.

Cell Metab. 2017 Apr 4;25(4):883-897.e8. doi: 10.1016/j.cmet.2017.03.018. Erratum in: Cell Metab. 2017 May 2;25(5):1207.

3.

The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation.

DuPage M, Chopra G, Quiros J, Rosenthal WL, Morar MM, Holohan D, Zhang R, Turka L, Marson A, Bluestone JA.

Immunity. 2015 Feb 17;42(2):227-238. doi: 10.1016/j.immuni.2015.01.007. Epub 2015 Feb 10.

4.

Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy.

Villalta SA, Rosenthal W, Martinez L, Kaur A, Sparwasser T, Tidball JG, Margeta M, Spencer MJ, Bluestone JA.

Sci Transl Med. 2014 Oct 15;6(258):258ra142. doi: 10.1126/scitranslmed.3009925.

5.

Self-antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response.

Bailey-Bucktrout SL, Martinez-Llordella M, Zhou X, Anthony B, Rosenthal W, Luche H, Fehling HJ, Bluestone JA.

Immunity. 2013 Nov 14;39(5):949-62. doi: 10.1016/j.immuni.2013.10.016.

6.

Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions.

Schäfer G, Milić J, Eldahshan A, Götz F, Zühlke K, Schillinger C, Kreuchwig A, Elkins JM, Abdul Azeez KR, Oder A, Moutty MC, Masada N, Beerbaum M, Schlegel B, Niquet S, Schmieder P, Krause G, von Kries JP, Cooper DM, Knapp S, Rademann J, Rosenthal W, Klussmann E.

Angew Chem Int Ed Engl. 2013 Nov 11;52(46):12187-91. doi: 10.1002/anie.201304686. Epub 2013 Sep 23. No abstract available.

7.

microRNA-17-92 regulates IL-10 production by regulatory T cells and control of experimental autoimmune encephalomyelitis.

de Kouchkovsky D, Esensten JH, Rosenthal WL, Morar MM, Bluestone JA, Jeker LT.

J Immunol. 2013 Aug 15;191(4):1594-605. doi: 10.4049/jimmunol.1203567. Epub 2013 Jul 15.

8.

Culturing primary rat inner medullary collecting duct cells.

Faust D, Geelhaar A, Eisermann B, Eichhorst J, Wiesner B, Rosenthal W, Klussmann E.

J Vis Exp. 2013 Jun 21;(76). doi: 10.3791/50366. Erratum in: J Vis Exp. 2013;(76):e5115. Klussman, Enno [corrected to Klussmann, Enno].

9.

Distinct genetic control of autoimmune neuropathy and diabetes in the non-obese diabetic background.

Bour-Jordan H, Thompson HL, Giampaolo JR, Davini D, Rosenthal W, Bluestone JA.

J Autoimmun. 2013 Sep;45:58-67. doi: 10.1016/j.jaut.2013.06.005. Epub 2013 Jul 12.

10.

Small-molecule screening identifies modulators of aquaporin-2 trafficking.

Bogum J, Faust D, Zühlke K, Eichhorst J, Moutty MC, Furkert J, Eldahshan A, Neuenschwander M, von Kries JP, Wiesner B, Trimpert C, Deen PM, Valenti G, Rosenthal W, Klussmann E.

J Am Soc Nephrol. 2013 Apr;24(5):744-58. doi: 10.1681/ASN.2012030295. Epub 2013 Apr 4.

11.

Inhibition of biosynthesis of human endothelin B receptor by the cyclodepsipeptide cotransin.

Westendorf C, Schmidt A, Coin I, Furkert J, Ridelis I, Zampatis D, Rutz C, Wiesner B, Rosenthal W, Beyermann M, Schülein R.

J Biol Chem. 2011 Oct 14;286(41):35588-600. doi: 10.1074/jbc.M111.239244. Epub 2011 Jul 30.

12.

Functional significance of cleavable signal peptides of G protein-coupled receptors.

Schülein R, Westendorf C, Krause G, Rosenthal W.

Eur J Cell Biol. 2012 Apr;91(4):294-9. doi: 10.1016/j.ejcb.2011.02.006. Epub 2011 May 4. Review.

PMID:
21543132
13.
14.

Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes.

Christian F, Szaszák M, Friedl S, Drewianka S, Lorenz D, Goncalves A, Furkert J, Vargas C, Schmieder P, Götz F, Zühlke K, Moutty M, Göttert H, Joshi M, Reif B, Haase H, Morano I, Grossmann S, Klukovits A, Verli J, Gáspár R, Noack C, Bergmann M, Kass R, Hampel K, Kashin D, Genieser HG, Herberg FW, Willoughby D, Cooper DM, Baillie GS, Houslay MD, von Kries JP, Zimmermann B, Rosenthal W, Klussmann E.

J Biol Chem. 2011 Mar 18;286(11):9079-96. doi: 10.1074/jbc.M110.160614. Epub 2010 Dec 22.

15.

Mechanisms of protein kinase A anchoring.

Skroblin P, Grossmann S, Schäfer G, Rosenthal W, Klussmann E.

Int Rev Cell Mol Biol. 2010;283:235-330. doi: 10.1016/S1937-6448(10)83005-9. Review.

PMID:
20801421
16.

Reciprocal regulation of aquaporin-2 abundance and degradation by protein kinase A and p38-MAP kinase.

Nedvetsky PI, Tabor V, Tamma G, Beulshausen S, Skroblin P, Kirschner A, Mutig K, Boltzen M, Petrucci O, Vossenkämper A, Wiesner B, Bachmann S, Rosenthal W, Klussmann E.

J Am Soc Nephrol. 2010 Oct;21(10):1645-56. doi: 10.1681/ASN.2009111190. Epub 2010 Aug 19.

17.

Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein.

Hundsrucker C, Skroblin P, Christian F, Zenn HM, Popara V, Joshi M, Eichhorst J, Wiesner B, Herberg FW, Reif B, Rosenthal W, Klussmann E.

J Biol Chem. 2010 Feb 19;285(8):5507-21. doi: 10.1074/jbc.M109.047944. Epub 2009 Dec 11.

18.

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo.

Zhou X, Bailey-Bucktrout SL, Jeker LT, Penaranda C, Martínez-Llordella M, Ashby M, Nakayama M, Rosenthal W, Bluestone JA.

Nat Immunol. 2009 Sep;10(9):1000-7. doi: 10.1038/ni.1774. Epub 2009 Jul 26.

19.

Structural determinants for selective recognition of peptide ligands for endothelin receptor subtypes ETA and ETB.

Lättig J, Oksche A, Beyermann M, Rosenthal W, Krause G.

J Pept Sci. 2009 Jul;15(7):479-91. doi: 10.1002/psc.1146.

PMID:
19466696
20.

A novel myelin P0-specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy.

Louvet C, Kabre BG, Davini DW, Martinier N, Su MA, DeVoss JJ, Rosenthal WL, Anderson MS, Bour-Jordan H, Bluestone JA.

J Exp Med. 2009 Mar 16;206(3):507-14. doi: 10.1084/jem.20082113. Epub 2009 Feb 16.

21.

The sequence after the signal peptide of the G protein-coupled endothelin B receptor is required for efficient translocon gating at the endoplasmic reticulum membrane.

Alken M, Schmidt A, Rutz C, Furkert J, Kleinau G, Rosenthal W, Schülein R.

Mol Pharmacol. 2009 Apr;75(4):801-11. doi: 10.1124/mol.108.051581. Epub 2009 Jan 9.

22.

Regulation of aquaporin-2 trafficking.

Nedvetsky PI, Tamma G, Beulshausen S, Valenti G, Rosenthal W, Klussmann E.

Handb Exp Pharmacol. 2009;(190):133-57. doi: 10.1007/978-3-540-79885-9_6. Review.

PMID:
19096775
23.

Use of Kaede fusions to visualize recycling of G protein-coupled receptors.

Schmidt A, Wiesner B, Weisshart K, Schulz K, Furkert J, Lamprecht B, Rosenthal W, Schülein R.

Traffic. 2009 Jan;10(1):2-15. doi: 10.1111/j.1600-0854.2008.00843.x. Epub 2008 Oct 14.

24.

Protein-protein interactions as new drug targets. Preface.

Klussmann E, Rosenthal W.

Handb Exp Pharmacol. 2008;(186):v-vi. No abstract available.

PMID:
18634198
25.

Compartmentalized cAMP signalling in regulated exocytic processes in non-neuronal cells.

Szaszák M, Christian F, Rosenthal W, Klussmann E.

Cell Signal. 2008 Apr;20(4):590-601. Epub 2007 Oct 26. Review.

PMID:
18061403
26.

Derlin-1 and p97/valosin-containing protein mediate the endoplasmic reticulum-associated degradation of human V2 vasopressin receptors.

Schwieger I, Lautz K, Krause E, Rosenthal W, Wiesner B, Hermosilla R.

Mol Pharmacol. 2008 Mar;73(3):697-708. Epub 2007 Nov 29.

27.

AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum.

Lygren B, Carlson CR, Santamaria K, Lissandron V, McSorley T, Litzenberg J, Lorenz D, Wiesner B, Rosenthal W, Zaccolo M, Taskén K, Klussmann E.

EMBO Rep. 2007 Nov;8(11):1061-7. Epub 2007 Sep 28.

28.

Microtubules are needed for the perinuclear positioning of aquaporin-2 after its endocytic retrieval in renal principal cells.

Vossenkämper A, Nedvetsky PI, Wiesner B, Furkert J, Rosenthal W, Klussmann E.

Am J Physiol Cell Physiol. 2007 Sep;293(3):C1129-38. Epub 2007 Jul 11.

29.

Rescue of a nephrogenic diabetes insipidus-causing vasopressin V2 receptor mutant by cell-penetrating peptides.

Oueslati M, Hermosilla R, Schönenberger E, Oorschot V, Beyermann M, Wiesner B, Schmidt A, Klumperman J, Rosenthal W, Schülein R.

J Biol Chem. 2007 Jul 13;282(28):20676-85. Epub 2007 May 8.

30.

A Role of myosin Vb and Rab11-FIP2 in the aquaporin-2 shuttle.

Nedvetsky PI, Stefan E, Frische S, Santamaria K, Wiesner B, Valenti G, Hammer JA 3rd, Nielsen S, Goldenring JR, Rosenthal W, Klussmann E.

Traffic. 2007 Feb;8(2):110-23. Epub 2006 Dec 6.

31.

Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells.

Stefan E, Wiesner B, Baillie GS, Mollajew R, Henn V, Lorenz D, Furkert J, Santamaria K, Nedvetsky P, Hundsrucker C, Beyermann M, Krause E, Pohl P, Gall I, MacIntyre AN, Bachmann S, Houslay MD, Rosenthal W, Klussmann E.

J Am Soc Nephrol. 2007 Jan;18(1):199-212. Epub 2006 Nov 29.

32.

Peptides for disruption of PKA anchoring.

Hundsrucker C, Rosenthal W, Klussmann E.

Biochem Soc Trans. 2006 Aug;34(Pt 4):472-3.

PMID:
16856835
33.

The corticotropin-releasing factor receptor type 2a contains an N-terminal pseudo signal peptide.

Rutz C, Renner A, Alken M, Schulz K, Beyermann M, Wiesner B, Rosenthal W, Schülein R.

J Biol Chem. 2006 Aug 25;281(34):24910-21. Epub 2006 Jun 8.

34.

Endothelin A and endothelin B receptors differ in their ability to stimulate ERK1/2 activation.

Grantcharova E, Reusch HP, Beyermann M, Rosenthal W, Oksche A.

Exp Biol Med (Maywood). 2006 Jun;231(6):757-60.

PMID:
16740994
35.

N-terminal proteolysis of the endothelin B receptor abolishes its ability to induce EGF receptor transactivation and contractile protein expression in vascular smooth muscle cells.

Grantcharova E, Reusch HP, Grossmann S, Eichhorst J, Krell HW, Beyermann M, Rosenthal W, Oksche A.

Arterioscler Thromb Vasc Biol. 2006 Jun;26(6):1288-96. Epub 2006 Apr 6.

36.

Spatial organisation of AKAP18 and PDE4 isoforms in renal collecting duct principal cells.

McSorley T, Stefan E, Henn V, Wiesner B, Baillie GS, Houslay MD, Rosenthal W, Klussmann E.

Eur J Cell Biol. 2006 Jul;85(7):673-8. Epub 2006 Feb 28. Review.

PMID:
16500722
37.

High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides.

Hundsrucker C, Krause G, Beyermann M, Prinz A, Zimmermann B, Diekmann O, Lorenz D, Stefan E, Nedvetsky P, Dathe M, Christian F, McSorley T, Krause E, McConnachie G, Herberg FW, Scott JD, Rosenthal W, Klussmann E.

Biochem J. 2006 Jun 1;396(2):297-306.

38.

Compartmentalized cAMP signalling regulates vasopressin-mediated water reabsorption by controlling aquaporin-2.

Henn V, Stefan E, Baillie GS, Houslay MD, Rosenthal W, Klussmann E.

Biochem Soc Trans. 2005 Dec;33(Pt 6):1316-8. Review.

PMID:
16246107
39.

The hydrophobic amino acid residues in the membrane-proximal C tail of the G protein-coupled vasopressin V2 receptor are necessary for transport-competent receptor folding.

Thielen A, Oueslati M, Hermosilla R, Krause G, Oksche A, Rosenthal W, Schülein R.

FEBS Lett. 2005 Sep 26;579(23):5227-35.

40.

Arrestin-independent internalization and recycling of the urotensin receptor contribute to long-lasting urotensin II-mediated vasoconstriction.

Giebing G, Tölle M, Jürgensen J, Eichhorst J, Furkert J, Beyermann M, Neuschäfer-Rube F, Rosenthal W, Zidek W, van der Giet M, Oksche A.

Circ Res. 2005 Sep 30;97(7):707-15. Epub 2005 Sep 1.

41.

Actin remodeling requires ERM function to facilitate AQP2 apical targeting.

Tamma G, Klussmann E, Oehlke J, Krause E, Rosenthal W, Svelto M, Valenti G.

J Cell Sci. 2005 Aug 15;118(Pt 16):3623-30. Epub 2005 Jul 26.

42.

The signal peptide of the rat corticotropin-releasing factor receptor 1 promotes receptor expression but is not essential for establishing a functional receptor.

Alken M, Rutz C, Köchl R, Donalies U, Oueslati M, Furkert J, Wietfeld D, Hermosilla R, Scholz A, Beyermann M, Rosenthal W, Schülein R.

Biochem J. 2005 Sep 1;390(Pt 2):455-64.

43.

Fluorescence resonance energy transfer analysis reveals the existence of endothelin-A and endothelin-B receptor homodimers.

Gregan B, Schaefer M, Rosenthal W, Oksche A.

J Cardiovasc Pharmacol. 2004 Nov;44 Suppl 1:S30-3.

PMID:
15838305
44.

Disease-causing V(2) vasopressin receptors are retained in different compartments of the early secretory pathway.

Hermosilla R, Oueslati M, Donalies U, Schönenberger E, Krause E, Oksche A, Rosenthal W, Schülein R.

Traffic. 2004 Dec;5(12):993-1005.

45.

Waiting for a liver--hidden costs of the organ shortage.

Brand DA, Viola D, Rampersaud P, Patrick PA, Rosenthal WS, Wolf DC.

Liver Transpl. 2004 Aug;10(8):1001-10.

46.

Pharmacochaperones post-translationally enhance cell surface expression by increasing conformational stability of wild-type and mutant vasopressin V2 receptors.

Wüller S, Wiesner B, Löffler A, Furkert J, Krause G, Hermosilla R, Schaefer M, Schülein R, Rosenthal W, Oksche A.

J Biol Chem. 2004 Nov 5;279(45):47254-63. Epub 2004 Aug 19.

47.

Ligand-dependent differences in the internalization of endothelin A and endothelin B receptor heterodimers.

Gregan B, Jürgensen J, Papsdorf G, Furkert J, Schaefer M, Beyermann M, Rosenthal W, Oksche A.

J Biol Chem. 2004 Jun 25;279(26):27679-87. Epub 2004 Apr 9.

48.

Identification of a novel A-kinase anchoring protein 18 isoform and evidence for its role in the vasopressin-induced aquaporin-2 shuttle in renal principal cells.

Henn V, Edemir B, Stefan E, Wiesner B, Lorenz D, Theilig F, Schmitt R, Vossebein L, Tamma G, Beyermann M, Krause E, Herberg FW, Valenti G, Bachmann S, Rosenthal W, Klussmann E.

J Biol Chem. 2004 Jun 18;279(25):26654-65. Epub 2004 Mar 22.

49.

Aquaporin-1, nothing but a water channel.

Tsunoda SP, Wiesner B, Lorenz D, Rosenthal W, Pohl P.

J Biol Chem. 2004 Mar 19;279(12):11364-7. Epub 2003 Dec 30.

50.

The prostaglandin E2 analogue sulprostone antagonizes vasopressin-induced antidiuresis through activation of Rho.

Tamma G, Wiesner B, Furkert J, Hahm D, Oksche A, Schaefer M, Valenti G, Rosenthal W, Klussmann E.

J Cell Sci. 2003 Aug 15;116(Pt 16):3285-94. Epub 2003 Jun 26.

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