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Items: 1 to 50 of 431

1.

Antimalarial drug resistance in Africa: the calm before the storm?

Conrad MD, Rosenthal PJ.

Lancet Infect Dis. 2019 Jul 30. pii: S1473-3099(19)30261-0. doi: 10.1016/S1473-3099(19)30261-0. [Epub ahead of print] Review.

PMID:
31375467
2.

The diversity of the Plasmodium falciparum K13 propeller domain did not increase after implementation of artemisinin-based combination therapy in Uganda.

Conrad MD, Nsobya SL, Rosenthal PJ.

Antimicrob Agents Chemother. 2019 Jul 29. pii: AAC.01234-19. doi: 10.1128/AAC.01234-19. [Epub ahead of print]

PMID:
31358588
3.

A shorter course for anti-relapse therapy against vivax malaria.

Rosenthal PJ.

Lancet. 2019 Jul 18. pii: S0140-6736(19)31605-8. doi: 10.1016/S0140-6736(19)31605-8. [Epub ahead of print] No abstract available.

4.

Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis.

Lunde CS, Stebbins EE, Jumani RS, Hasan MM, Miller P, Barlow J, Freund YR, Berry P, Stefanakis R, Gut J, Rosenthal PJ, Love MS, McNamara CW, Easom E, Plattner JJ, Jacobs RT, Huston CD.

Nat Commun. 2019 Jun 27;10(1):2816. doi: 10.1038/s41467-019-10687-y.

5.

Biannual mass azithromycin distributions and malaria parasitemia in pre-school children in Niger: A cluster-randomized, placebo-controlled trial.

Arzika AM, Maliki R, Boubacar N, Kane S, Cotter SY, Lebas E, Cook C, Bailey RL, West SK, Rosenthal PJ, Porco TC, Lietman TM, Keenan JD; MORDOR Study Group.

PLoS Med. 2019 Jun 25;16(6):e1002835. doi: 10.1371/journal.pmed.1002835. eCollection 2019 Jun.

6.

Metagenomic next-generation sequencing of samples from pediatric febrile illness in Tororo, Uganda.

Ramesh A, Nakielny S, Hsu J, Kyohere M, Byaruhanga O, de Bourcy C, Egger R, Dimitrov B, Juan YF, Sheu J, Wang J, Kalantar K, Langelier C, Ruel T, Mpimbaza A, Wilson MR, Rosenthal PJ, DeRisi JL.

PLoS One. 2019 Jun 20;14(6):e0218318. doi: 10.1371/journal.pone.0218318. eCollection 2019.

7.

Improvement of Asparagine Ethylenediamines as Anti-malarial Plasmodium-Selective Proteasome Inhibitors.

Zhan W, Visone J, Ouellette T, Harris JC, Wang R, Zhang H, Singh PK, Ginn J, Sukenick G, Wong TT, Okoro JI, Scales RM, Tumwebaze PK, Rosenthal PJ, Kafsack BFC, Cooper RA, Meinke PT, Kirkman LA, Lin G.

J Med Chem. 2019 Jul 11;62(13):6137-6145. doi: 10.1021/acs.jmedchem.9b00363. Epub 2019 Jun 20.

PMID:
31177777
8.

Reduced Exposure to Piperaquine, Compared to Adults, in Young Children Receiving Dihydroartemisinin-Piperaquine as Malaria Chemoprevention.

Whalen ME, Kajubi R, Chamankhah N, Huang L, Orukan F, Wallender E, Kamya MR, Dorsey G, Jagannathan P, Rosenthal PJ, Mwebaza N, Aweeka FT.

Clin Pharmacol Ther. 2019 Jun 7. doi: 10.1002/cpt.1534. [Epub ahead of print]

PMID:
31173649
9.

Understanding the context of delays in seeking appropriate care for children with symptoms of severe malaria in Uganda.

Mpimbaza A, Nayiga S, Ndeezi G, Rosenthal PJ, Karamagi C, Katahoire A.

PLoS One. 2019 Jun 5;14(6):e0217262. doi: 10.1371/journal.pone.0217262. eCollection 2019.

10.

Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials.

Stoye A, Juillard A, Tang AH, Legac J, Gut J, White KL, Charman SA, Rosenthal PJ, Grau GER, Hunt NH, Payne RJ.

J Med Chem. 2019 Jun 13;62(11):5562-5578. doi: 10.1021/acs.jmedchem.9b00504. Epub 2019 May 22.

PMID:
31062592
11.

Substituted 1,3-dioxoisoindoline-4-aminoquinolines coupled via amide linkers: Synthesis, antiplasmodial and cytotoxic evaluation.

Rani A, Legac J, Rosenthal PJ, Kumar V.

Bioorg Chem. 2019 Jul;88:102912. doi: 10.1016/j.bioorg.2019.04.006. Epub 2019 Apr 11.

PMID:
30991190
12.

Expanded Availability of Intravenous Artesunate for the Treatment of Severe Malaria in the United States.

Rosenthal PJ, Tan KR.

Am J Trop Med Hyg. 2019 Jun;100(6):1295-1296. doi: 10.4269/ajtmh.19-0230. No abstract available.

13.

Optimal dosing of dihydroartemisinin-piperaquine for seasonal malaria chemoprevention in young children.

Chotsiri P, Zongo I, Milligan P, Compaore YD, Somé AF, Chandramohan D, Hanpithakpong W, Nosten F, Greenwood B, Rosenthal PJ, White NJ, Ouédraogo JB, Tarning J.

Nat Commun. 2019 Jan 29;10(1):480. doi: 10.1038/s41467-019-08297-9.

14.

Volume 100 of the American Journal of Tropical Medicine and Hygiene.

Rosenthal PJ, Vinetz JM, Siegel C, Kazura JW.

Am J Trop Med Hyg. 2019 Jan;100(1):3-4. doi: 10.4269/ajtmh.18-0848. No abstract available.

15.

Malaria: How Are We Doing and How Can We Do Better?

Rosenthal PJ, John CC, Rabinovich NR.

Am J Trop Med Hyg. 2019 Feb;100(2):239-241. doi: 10.4269/ajtmh.18-0997. No abstract available.

16.

Caregiver responses and association with delayed care-seeking in children with uncomplicated and severe malaria.

Mpimbaza A, Katahoire A, Rosenthal PJ, Karamagi C, Ndeezi G.

Malar J. 2018 Dec 18;17(1):476. doi: 10.1186/s12936-018-2630-9.

17.

Changing Molecular Markers of Antimalarial Drug Sensitivity across Uganda.

Asua V, Vinden J, Conrad MD, Legac J, Kigozi SP, Kamya MR, Dorsey G, Nsobya SL, Rosenthal PJ.

Antimicrob Agents Chemother. 2019 Feb 26;63(3). pii: e01818-18. doi: 10.1128/AAC.01818-18. Print 2019 Mar.

PMID:
30559133
18.

Artemisinin Resistance in Eastern India.

Rosenthal PJ.

Clin Infect Dis. 2018 Dec 9. doi: 10.1093/cid/ciy1043. [Epub ahead of print] No abstract available.

PMID:
30541018
19.

Modeling Prevention of Malaria and Selection of Drug Resistance with Different Dosing Schedules of Dihydroartemisinin-Piperaquine Preventive Therapy during Pregnancy in Uganda.

Wallender E, Zhang N, Conrad M, Kakuru A, Muhindo M, Tumwebaze P, Kajubi R, Mota D, Legac J, Jagannathan P, Havlir D, Kamya M, Dorsey G, Aweeka F, Rosenthal PJ, Savic RM.

Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01393-18. doi: 10.1128/AAC.01393-18. Print 2019 Feb.

20.

Artemisinin Resistance Outside of Southeast Asia.

Rosenthal PJ.

Am J Trop Med Hyg. 2018 Dec;99(6):1357-1359. doi: 10.4269/ajtmh.18-0845. No abstract available.

21.

Comparative Efficacy of Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine for the Treatment of Uncomplicated Malaria in Ugandan Children.

Yeka A, Wallender E, Mulebeke R, Kibuuka A, Kigozi R, Bosco A, Kyambadde P, Opigo J, Kalyesubula S, Senzoga J, Vinden J, Conrad M, Rosenthal PJ.

J Infect Dis. 2019 Mar 15;219(7):1112-1120. doi: 10.1093/infdis/jiy637.

PMID:
30418593
22.

Persistent Parasitemia Despite Dramatic Reduction in Malaria Incidence After 3 Rounds of Indoor Residual Spraying in Tororo, Uganda.

Nankabirwa JI, Briggs J, Rek J, Arinaitwe E, Nayebare P, Katrak S, Staedke SG, Rosenthal PJ, Rodriguez-Barraquer I, Kamya MR, Dorsey G, Greenhouse B.

J Infect Dis. 2019 Mar 15;219(7):1104-1111. doi: 10.1093/infdis/jiy628.

PMID:
30383230
23.

Mass Drug Administration to Control and Eliminate Malaria in Africa: How Do We Best Utilize the Tools at Hand?

Guler JL, Rosenthal PJ.

Clin Infect Dis. 2019 Jul 2;69(2):287-289. doi: 10.1093/cid/ciy871. No abstract available.

PMID:
30304408
24.

Molecular assays for antimalarial drug resistance surveillance: A target product profile.

Nsanzabana C, Ariey F, Beck HP, Ding XC, Kamau E, Krishna S, Legrand E, Lucchi N, Miotto O, Nag S, Noedl H, Roper C, Rosenthal PJ, Schallig HDFH, Taylor SM, Volkman SK, Gonzalez IJ.

PLoS One. 2018 Sep 20;13(9):e0204347. doi: 10.1371/journal.pone.0204347. eCollection 2018.

25.

Associations between erythrocyte polymorphisms and risks of uncomplicated and severe malaria in Ugandan children: A case control study.

Mpimbaza A, Walakira A, Ndeezi G, Katahoire A, Karamagi C, Nsobya SL, Tukwasibwe S, Asua V, Rosenthal PJ.

PLoS One. 2018 Sep 17;13(9):e0203229. doi: 10.1371/journal.pone.0203229. eCollection 2018.

26.

Cysteine proteases in protozoan parasites.

Siqueira-Neto JL, Debnath A, McCall LI, Bernatchez JA, Ndao M, Reed SL, Rosenthal PJ.

PLoS Negl Trop Dis. 2018 Aug 23;12(8):e0006512. doi: 10.1371/journal.pntd.0006512. eCollection 2018 Aug. Review.

27.

Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposure.

Rodriguez-Barraquer I, Arinaitwe E, Jagannathan P, Kamya MR, Rosenthal PJ, Rek J, Dorsey G, Nankabirwa J, Staedke SG, Kilama M, Drakeley C, Ssewanyana I, Smith DL, Greenhouse B.

Elife. 2018 Jul 25;7. pii: e35832. doi: 10.7554/eLife.35832.

28.

Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance.

Kirkman LA, Zhan W, Visone J, Dziedziech A, Singh PK, Fan H, Tong X, Bruzual I, Hara R, Kawasaki M, Imaeda T, Okamoto R, Sato K, Michino M, Alvaro EF, Guiang LF, Sanz L, Mota DJ, Govindasamy K, Wang R, Ling Y, Tumwebaze PK, Sukenick G, Shi L, Vendome J, Bhanot P, Rosenthal PJ, Aso K, Foley MA, Cooper RA, Kafsack B, Doggett JS, Nathan CF, Lin G.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6863-E6870. doi: 10.1073/pnas.1806109115. Epub 2018 Jul 2.

29.

Association Between Recent Overnight Travel and Risk of Malaria: A Prospective Cohort Study at 3 Sites in Uganda.

Arinaitwe E, Dorsey G, Nankabirwa JI, Kigozi SP, Katureebe A, Kakande E, Rek J, Rosenthal PJ, Drakeley C, Kamya MR, Staedke SG.

Clin Infect Dis. 2019 Jan 7;68(2):313-320. doi: 10.1093/cid/ciy478.

30.

Reconciling Conflicting Results From Pediatric Sepsis Studies: The Need for Context-Specific Sepsis Bundles.

Kortz T, Rosenthal PJ.

Pediatr Crit Care Med. 2018 Jun;19(6):594-595. doi: 10.1097/PCC.0000000000001568. No abstract available.

PMID:
29863649
31.

Plasmodium falciparum Falcipain-2a Polymorphisms in Southeast Asia and Their Association With Artemisinin Resistance.

Siddiqui FA, Cabrera M, Wang M, Brashear A, Kemirembe K, Wang Z, Miao J, Chookajorn T, Yang Z, Cao Y, Dong G, Rosenthal PJ, Cui L.

J Infect Dis. 2018 Jul 2;218(3):434-442. doi: 10.1093/infdis/jiy188.

32.

Intermittent Preventive Treatment for Malaria in Pregnancy: Optimization of Target Concentrations of Dihydroartemisinin-Piperaquine.

Savic RM, Jagannathan P, Kajubi R, Huang L, Zhang N, Were M, Kakuru A, Muhindo MK, Mwebaza N, Wallender E, Clark TD, Opira B, Kamya M, Havlir DV, Rosenthal PJ, Dorsey G, Aweeka FT.

Clin Infect Dis. 2018 Sep 14;67(7):1079-1088. doi: 10.1093/cid/ciy218.

PMID:
29547881
33.

Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability.

Capela R, Magalhães J, Miranda D, Machado M, Sanches-Vaz M, Albuquerque IS, Sharma M, Gut J, Rosenthal PJ, Frade R, Perry MJ, Moreira R, Prudêncio M, Lopes F.

Eur J Med Chem. 2018 Apr 10;149:69-78. doi: 10.1016/j.ejmech.2018.02.048. Epub 2018 Feb 19.

PMID:
29499488
34.

Clinical consequences of submicroscopic malaria parasitaemia in Uganda.

Katrak S, Nayebare P, Rek J, Arinaitwe E, Nankabirwa JI, Kamya M, Dorsey G, Rosenthal PJ, Greenhouse B.

Malar J. 2018 Feb 5;17(1):67. doi: 10.1186/s12936-018-2221-9.

35.

Predicting Optimal Dihydroartemisinin-Piperaquine Regimens to Prevent Malaria During Pregnancy for Human Immunodeficiency Virus-Infected Women Receiving Efavirenz.

Wallender E, Vucicevic K, Jagannathan P, Huang L, Natureeba P, Kakuru A, Muhindo M, Nakalembe M, Havlir D, Kamya M, Aweeka F, Dorsey G, Rosenthal PJ, Savic RM.

J Infect Dis. 2018 Mar 5;217(6):964-972. doi: 10.1093/infdis/jix660.

36.

"The Way We Were" Ken Warren's Legacy and Modern Investments in Global Health.

Dunavan CP, Rosenthal PJ.

Am J Trop Med Hyg. 2017 Dec;97(6):1955-1957. doi: 10.4269/ajtmh.17-0829. No abstract available.

37.

Microwave-promoted facile access to 4-aminoquinoline-phthalimides: Synthesis and anti-plasmodial evaluation.

Rani A, Singh A, Gut J, Rosenthal PJ, Kumar V.

Eur J Med Chem. 2018 Jan 1;143:150-156. doi: 10.1016/j.ejmech.2017.11.033. Epub 2017 Nov 16.

PMID:
29174811
38.

Performance of Loop-Mediated Isothermal Amplification for the Identification of Submicroscopic Plasmodium falciparum Infection in Uganda.

Katrak S, Murphy M, Nayebare P, Rek J, Smith M, Arinaitwe E, Nankabirwa JI, Kamya M, Dorsey G, Rosenthal PJ, Greenhouse B.

Am J Trop Med Hyg. 2017 Dec;97(6):1777-1781. doi: 10.4269/ajtmh.17-0225. Epub 2017 Oct 5.

39.

Demographic, Socioeconomic, and Geographic Factors Leading to Severe Malaria and Delayed Care Seeking in Ugandan Children: A Case-Control Study.

Mpimbaza A, Ndeezi G, Katahoire A, Rosenthal PJ, Karamagi C.

Am J Trop Med Hyg. 2017 Nov;97(5):1513-1523. doi: 10.4269/ajtmh.17-0056. Epub 2017 Oct 10.

40.

Comparative Prevalence of Plasmodium falciparum Resistance-Associated Genetic Polymorphisms in Parasites Infecting Humans and Mosquitoes in Uganda.

Conrad MD, Mota D, Musiime A, Kilama M, Rek J, Kamya M, Dorsey G, Rosenthal PJ.

Am J Trop Med Hyg. 2017 Nov;97(5):1576-1580. doi: 10.4269/ajtmh.17-0351. Epub 2017 Oct 10.

41.

Plasmodium Species Infecting Children Presenting with Malaria in Uganda.

Asua V, Tukwasibwe S, Conrad M, Walakira A, Nankabirwa JI, Mugenyi L, Kamya MR, Nsobya SL, Rosenthal PJ.

Am J Trop Med Hyg. 2017 Sep;97(3):753-757. doi: 10.4269/ajtmh.17-0345.

42.

Let's Eliminate Diseases, Not Institutes: The Case for the Fogarty International Center.

Rosenthal PJ, Goraleski KA, Rabinovich NR, Walker PF.

Am J Trop Med Hyg. 2017 Sep;97(3):629-630. doi: 10.4269/ajtmh.17-0601. No abstract available.

43.

Impact of Intermittent Preventive Treatment During Pregnancy on Plasmodium falciparum Drug Resistance-Mediating Polymorphisms in Uganda.

Conrad MD, Mota D, Foster M, Tukwasibwe S, Legac J, Tumwebaze P, Whalen M, Kakuru A, Nayebare P, Wallender E, Havlir DV, Jagannathan P, Huang L, Aweeka F, Kamya MR, Dorsey G, Rosenthal PJ.

J Infect Dis. 2017 Nov 15;216(8):1008-1017. doi: 10.1093/infdis/jix421.

44.

Marked variation in prevalence of malaria-protective human genetic polymorphisms across Uganda.

Walakira A, Tukwasibwe S, Kiggundu M, Verra F, Kakeeto P, Ruhamyankaka E, Drakeley C, Dorsey G, Kamya MR, Nsobya SL, Rosenthal PJ.

Infect Genet Evol. 2017 Nov;55:281-287. doi: 10.1016/j.meegid.2017.09.021. Epub 2017 Sep 19.

45.

Changing Antimalarial Drug Sensitivities in Uganda.

Rasmussen SA, Ceja FG, Conrad MD, Tumwebaze PK, Byaruhanga O, Katairo T, Nsobya SL, Rosenthal PJ, Cooper RA.

Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e01516-17. doi: 10.1128/AAC.01516-17. Print 2017 Dec.

46.

Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs).

Previti S, Ettari R, Cosconati S, Amendola G, Chouchene K, Wagner A, Hellmich UA, Ulrich K, Krauth-Siegel RL, Wich PR, Schmid I, Schirmeister T, Gut J, Rosenthal PJ, Grasso S, Zappalà M.

J Med Chem. 2017 Aug 24;60(16):6911-6923. doi: 10.1021/acs.jmedchem.7b00405. Epub 2017 Aug 11.

PMID:
28763614
47.

4-Aminoquinoline-chalcone/-N-acetylpyrazoline conjugates: Synthesis and antiplasmodial evaluation.

Kumar S, Saini A, Gut J, Rosenthal PJ, Raj R, Kumar V.

Eur J Med Chem. 2017 Sep 29;138:993-1001. doi: 10.1016/j.ejmech.2017.07.041. Epub 2017 Jul 22.

PMID:
28756265
48.

Mass Azithromycin and Malaria Parasitemia in Niger: Results from a Community-Randomized Trial.

O'Brien KS, Cotter SY, Amza A, Kadri B, Nassirou B, Stoller NE, Zhou Z, Cotter C, West SK, Bailey RL, Rosenthal PJ, Gaynor BD, Porco TC, Lietman TM.

Am J Trop Med Hyg. 2017 Sep;97(3):696-701. doi: 10.4269/ajtmh.16-0487. Epub 2017 Jul 19.

49.

Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane.

Blank BR, Gut J, Rosenthal PJ, Renslo AR.

J Med Chem. 2017 Jul 27;60(14):6400-6407. doi: 10.1021/acs.jmedchem.7b00699. Epub 2017 Jul 10.

50.

Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate.

Zhang YK, Plattner JJ, Easom EE, Jacobs RT, Guo D, Freund YR, Berry P, Ciaravino V, Erve JCL, Rosenthal PJ, Campo B, Gamo FJ, Sanz LM, Cao J.

J Med Chem. 2017 Jul 13;60(13):5889-5908. doi: 10.1021/acs.jmedchem.7b00621. Epub 2017 Jun 29.

PMID:
28635296

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