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Recent advances in heme biocatalysis engineering.

Schmitz LM, Rosenthal K, Lütz S.

Biotechnol Bioeng. 2019 Sep 4. doi: 10.1002/bit.27156. [Epub ahead of print] Review.


Thinking like a futurist could help the veterinary profession.

Harris DL, Rosenthal K, Hines A.

J Am Vet Med Assoc. 2019 Sep 1;255(5):523-524. doi: 10.2460/javma.255.5.523. No abstract available.


Breath selection methods for compact mass spectrometry breath analysis.

Rosenthal K, Ruszkiewicz DM, Allen H, Lindley MR, Turner MA, Hunsicker E.

J Breath Res. 2019 Sep 30;13(4):046013. doi: 10.1088/1752-7163/ab34d4.


Why Don't We Have a Vaccine Against Autoimmune Diseases? - A Review.

Rosenthal KS, Carambula R, Zimmerman DH.

J Clin Cell Immunol. 2019;10(1). pii: 574. doi: 10.4172/2155-9899.1000574. Epub 2019 Jan 31.


Lessons from next generation influenza vaccines for inflammatory disease therapies.

Zimmerman DH, Carambula RE, Ciemielewski J, Rosenthal KS.

Int Immunopharmacol. 2019 Sep;74:105729. doi: 10.1016/j.intimp.2019.105729. Epub 2019 Jul 4. Review.


Experimentally guided computational antibody affinity maturation with de novo docking, modelling and rational design.

Cannon DA, Shan L, Du Q, Shirinian L, Rickert KW, Rosenthal KL, Korade M 3rd, van Vlerken-Ysla LE, Buchanan A, Vaughan TJ, Damschroder MM, Popovic B.

PLoS Comput Biol. 2019 May 1;15(5):e1006980. doi: 10.1371/journal.pcbi.1006980. eCollection 2019 May.


TLR10 Senses HIV-1 Proteins and Significantly Enhances HIV-1 Infection.

Henrick BM, Yao XD, Zahoor MA, Abimiku A, Osawe S, Rosenthal KL.

Front Immunol. 2019 Mar 15;10:482. doi: 10.3389/fimmu.2019.00482. eCollection 2019.


Clinical impact of Internet-based tools to guide therapeutic decisions for mantle cell lymphoma.

Gopalsamy SN, Rosenthal KM, Ayers AA, Goy A, Leonard JP, Vose JM, Obholz KL, Armitage JO, Flowers CR.

Leuk Lymphoma. 2019 Sep;60(9):2255-2263. doi: 10.1080/10428194.2019.1574006. Epub 2019 Mar 8.


Design and characterization of homogenous antibody-drug conjugates with a drug-to-antibody ratio of one prepared using an engineered antibody and a dual-maleimide pyrrolobenzodiazepine dimer.

White JB, Fleming R, Masterson L, Ruddle BT, Zhong H, Fazenbaker C, Strout P, Rosenthal K, Reed M, Muniz-Medina V, Howard P, Dixit R, Wu H, Hinrichs MJ, Gao C, Dimasi N.

MAbs. 2019 Apr;11(3):500-515. doi: 10.1080/19420862.2019.1578611. Epub 2019 Mar 5.


Discovery and characterization of potent IL-21 neutralizing antibodies via a novel alternating antigen immunization and humanization strategy.

Varkey R, Du Q, Karnell JL, Xiao X, Casey KA, Woods R, Rosenthal K, Wilson S, Dall'Acqua WF, Wu H, Herbst R, Ettinger R, Damschroder M.

PLoS One. 2019 Jan 25;14(1):e0211236. doi: 10.1371/journal.pone.0211236. eCollection 2019.


Developability Assessment of Engineered Monoclonal Antibody Variants with a Complex Self-Association Behavior Using Complementary Analytical and in Silico Tools.

Shan L, Mody N, Sormani P, Rosenthal KL, Damschroder MM, Esfandiary R.

Mol Pharm. 2018 Dec 3;15(12):5697-5710. doi: 10.1021/acs.molpharmaceut.8b00867. Epub 2018 Nov 15.


Adaptation of the Roseman 6-Point Mastery Learning Model to the College of Medicine Program.

Lazerson J, Rosenthal J, Glaubensklee C, Hunt T, Morgenstern B, Pamidimukkala J, Penn DM, Rosenthal K, Sarsekeyeva M, Wragg S.

J Med Educ Curric Dev. 2018 Oct 4;5:2382120518803111. doi: 10.1177/2382120518803111. eCollection 2018 Jan-Dec.


Evaluation of alpha-II-spectrin breakdown products as potential biomarkers for early recognition and severity of aneurysmal subarachnoid hemorrhage.

Papa L, Rosenthal K, Silvestri F, Axley JC, Kelly JM, Lewis SB.

Sci Rep. 2018 Sep 6;8(1):13308. doi: 10.1038/s41598-018-31631-y.


Alanine Scanning Mutagenesis of the MEDI4893 (Suvratoxumab) Epitope Reduces Alpha Toxin Lytic Activity In Vitro and Staphylococcus aureus Fitness in Infection Models.

Tkaczyk C, Semenova E, Shi YY, Rosenthal K, Oganesyan V, Warrener P, Stover CK, Sellman BR.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01033-18. doi: 10.1128/AAC.01033-18. Print 2018 Nov.


Breastfeeding mitigates the effects of maternal HIV on infant infectious morbidity in the Option B+ era.

Tchakoute CT, Sainani KL, Osawe S, Datong P, Kiravu A, Rosenthal KL, Gray CM, Cameron DW, Abimiku A, Jaspan HB; INFANT study team.

AIDS. 2018 Oct 23;32(16):2383-2391. doi: 10.1097/QAD.0000000000001974.


Pseudomonas aeruginosa PcrV and Psl, the Molecular Targets of Bispecific Antibody MEDI3902, Are Conserved Among Diverse Global Clinical Isolates.

Tabor DE, Oganesyan V, Keller AE, Yu L, McLaughlin RE, Song E, Warrener P, Rosenthal K, Esser M, Qi Y, Ruzin A, Stover CK, DiGiandomenico A.

J Infect Dis. 2018 Nov 5;218(12):1983-1994. doi: 10.1093/infdis/jiy438.


Structural insights into the mechanism of action of a biparatopic anti-HER2 antibody.

Oganesyan V, Peng L, Bee JS, Li J, Perry SR, Comer F, Xu L, Cook K, Senthil K, Clarke L, Rosenthal K, Gao C, Damschroder M, Wu H, Dall'Acqua W.

J Biol Chem. 2018 Jun 1;293(22):8439-8448. doi: 10.1074/jbc.M117.818013. Epub 2018 Apr 18.


Tumor uptake of pegylated diabodies: Balancing systemic clearance and vascular transport.

Li Q, White JB, Peterson NC, Rickert KW, Lloyd CO, Allen KL, Rosenthal K, Gao X, Wu H, Dall'Acqua WF, Borrok MJ, Tsui P.

J Control Release. 2018 Jun 10;279:126-135. doi: 10.1016/j.jconrel.2018.04.013. Epub 2018 Apr 11.


Characterisation of anifrolumab, a fully human anti-interferon receptor antagonist antibody for the treatment of systemic lupus erythematosus.

Riggs JM, Hanna RN, Rajan B, Zerrouki K, Karnell JL, Sagar D, Vainshtein I, Farmer E, Rosenthal K, Morehouse C, de Los Reyes M, Schifferli K, Liang M, Sanjuan MA, Sims GP, Kolbeck R.

Lupus Sci Med. 2018 Apr 5;5(1):e000261. doi: 10.1136/lupus-2018-000261. eCollection 2018.


Evaluation of SNAP cPL, Spec cPL, VetScan cPL Rapid Test, and Precision PSL Assays for the Diagnosis of Clinical Pancreatitis in Dogs.

Cridge H, MacLeod AG, Pachtinger GE, Mackin AJ, Sullivant AM, Thomason JM, Archer TM, Lunsford KV, Rosenthal K, Wills RW.

J Vet Intern Med. 2018 Mar;32(2):658-664. doi: 10.1111/jvim.15039. Epub 2018 Feb 9.


Interactive Journal Club: Teaching an Old Dog New Tricks.

Rosenthal J, Rosenthal KS.

J Med Educ Curric Dev. 2017 Jul 21;4:2382120517719710. doi: 10.1177/2382120517719710. eCollection 2017 Jan-Dec.


Breastfeeding Behaviors and the Innate Immune System of Human Milk: Working Together to Protect Infants against Inflammation, HIV-1, and Other Infections.

Henrick BM, Yao XD, Nasser L, Roozrogousheh A, Rosenthal KL.

Front Immunol. 2017 Nov 29;8:1631. doi: 10.3389/fimmu.2017.01631. eCollection 2017. Review.


A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells.

Kroh HK, Chandrasekaran R, Zhang Z, Rosenthal K, Woods R, Jin X, Nyborg AC, Rainey GJ, Warrener P, Melnyk RA, Spiller BW, Lacy DB.

J Biol Chem. 2018 Jan 19;293(3):941-952. doi: 10.1074/jbc.M117.813428. Epub 2017 Nov 27.


Enzyme-Based Electrobiotechnological Synthesis.

Schmitz LM, Rosenthal K, Lütz S.

Adv Biochem Eng Biotechnol. 2019;167:87-134. doi: 10.1007/10_2017_33. Review.


Beyond the bulk: disclosing the life of single microbial cells.

Rosenthal K, Oehling V, Dusny C, Schmid A.

FEMS Microbiol Rev. 2017 Nov 1;41(6):751-780. doi: 10.1093/femsre/fux044. Review.


Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface.

Kroh HK, Chandrasekaran R, Rosenthal K, Woods R, Jin X, Ohi MD, Nyborg AC, Rainey GJ, Warrener P, Spiller BW, Lacy DB.

J Biol Chem. 2017 Sep 1;292(35):14401-14412. doi: 10.1074/jbc.M117.781112. Epub 2017 Jul 13.


Multimechanistic Monoclonal Antibodies (MAbs) Targeting Staphylococcus aureus Alpha-Toxin and Clumping Factor A: Activity and Efficacy Comparisons of a MAb Combination and an Engineered Bispecific Antibody Approach.

Tkaczyk C, Kasturirangan S, Minola A, Jones-Nelson O, Gunter V, Shi YY, Rosenthal K, Aleti V, Semenova E, Warrener P, Tabor D, Stover CK, Corti D, Rainey G, Sellman BR.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00629-17. doi: 10.1128/AAC.00629-17. Print 2017 Aug.


An epitope-specific DerG-PG70 LEAPS vaccine modulates T cell responses and suppresses arthritis progression in two related murine models of rheumatoid arthritis.

Mikecz K, Glant TT, Markovics A, Rosenthal KS, Kurko J, Carambula RE, Cress S, Steiner HL Rd, Zimmerman DH.

Vaccine. 2017 Jul 13;35(32):4048-4056. doi: 10.1016/j.vaccine.2017.05.009. Epub 2017 Jun 3.


Technique to avoid cortical entrapment in early insertion of capsular tension rings.

Rosenthal KJ.

J Cataract Refract Surg. 2017 Apr;43(4):577. doi: 10.1016/j.jcrs.2017.01.019. No abstract available.


LEAPS Vaccine Incorporating HER-2/neu Epitope Elicits Protection That Prevents and Limits Tumor Growth and Spread of Breast Cancer in a Mouse Model.

Rosenthal KS, Stone S, Koski G, Zimmerman DH.

J Immunol Res. 2017;2017:3613505. doi: 10.1155/2017/3613505. Epub 2017 Mar 26.


Insights into Soluble Toll-Like Receptor 2 as a Downregulator of Virally Induced Inflammation.

Henrick BM, Yao XD, Taha AY, German JB, Rosenthal KL.

Front Immunol. 2016 Aug 2;7:291. doi: 10.3389/fimmu.2016.00291. eCollection 2016. Review.


Accessory renal arteries: Prevalence in resistant hypertension and an important role in nonresponse to radiofrequency renal denervation.

VonAchen P, Hamann J, Houghland T, Lesser JR, Wang Y, Caye D, Rosenthal K, Garberich RF, Daniels M, Schwartz RS.

Cardiovasc Revasc Med. 2016 Oct - Nov;17(7):470-473. doi: 10.1016/j.carrev.2016.07.009. Epub 2016 Jul 21.


Generation and Characterization of an IgG4 Monomeric Fc Platform.

Shan L, Colazet M, Rosenthal KL, Yu XQ, Bee JS, Ferguson A, Damschroder MM, Wu H, Dall'Acqua WF, Tsui P, Oganesyan V.

PLoS One. 2016 Aug 1;11(8):e0160345. doi: 10.1371/journal.pone.0160345. eCollection 2016.


Collateral circulation in ferrets (Mustela putorius) during temporary occlusion of the caudal vena cava.

Calicchio KW, Bennett RA, Laraio LC, Weisse C, Zwingenberger AL, Rosenthal KL, Johnston MS, Campbell VL, Solomon JA.

Am J Vet Res. 2016 May;77(5):540-7. doi: 10.2460/ajvr.77.5.540.


Inhibition of CD73 AMP hydrolysis by a therapeutic antibody with a dual, non-competitive mechanism of action.

Geoghegan JC, Diedrich G, Lu X, Rosenthal K, Sachsenmeier KF, Wu H, Dall'Acqua WF, Damschroder MM.

MAbs. 2016;8(3):454-67. doi: 10.1080/19420862.2016.1143182. Epub 2016 Feb 8.


Intestinal Leiomyositis: A Cause of Chronic Intestinal Pseudo-Obstruction in 6 Dogs.

Zacuto AC, Pesavento PA, Hill S, McAlister A, Rosenthal K, Cherbinsky O, Marks SL.

J Vet Intern Med. 2016 Jan-Feb;30(1):132-40. doi: 10.1111/jvim.13652. Epub 2015 Nov 26.


HIV-1 Structural Proteins Serve as PAMPs for TLR2 Heterodimers Significantly Increasing Infection and Innate Immune Activation.

Henrick BM, Yao XD, Rosenthal KL; INFANT study team.

Front Immunol. 2015 Aug 19;6:426. doi: 10.3389/fimmu.2015.00426. eCollection 2015.


Anterior Chamber Iris Claw Lens for the Treatment of Aphakia in a Patient with Megalocornea.

Saffra N, Rakhamimov A, Masini R, Rosenthal KJ.

Case Rep Ophthalmol. 2015 Jun 2;6(2):164-9. doi: 10.1159/000431251. eCollection 2015 May-Aug.


Novel chimpanzee adenovirus-vectored respiratory mucosal tuberculosis vaccine: overcoming local anti-human adenovirus immunity for potent TB protection.

Jeyanathan M, Thanthrige-Don N, Afkhami S, Lai R, Damjanovic D, Zganiacz A, Feng X, Yao XD, Rosenthal KL, Medina MF, Gauldie J, Ertl HC, Xing Z.

Mucosal Immunol. 2015 Nov;8(6):1373-87. doi: 10.1038/mi.2015.29. Epub 2015 Apr 15.


Rheumatoid arthritis vaccine therapies: perspectives and lessons from therapeutic ligand epitope antigen presentation system vaccines for models of rheumatoid arthritis.

Rosenthal KS, Mikecz K, Steiner HL 3rd, Glant TT, Finnegan A, Carambula RE, Zimmerman DH.

Expert Rev Vaccines. 2015 Jun;14(6):891-908. doi: 10.1586/14760584.2015.1026330. Epub 2015 Mar 18. Review.


S100A9 induced inflammatory responses are mediated by distinct damage associated molecular patterns (DAMP) receptors in vitro and in vivo.

Chen B, Miller AL, Rebelatto M, Brewah Y, Rowe DC, Clarke L, Czapiga M, Rosenthal K, Imamichi T, Chen Y, Chang CS, Chowdhury PS, Naiman B, Wang Y, Yang D, Humbles AA, Herbst R, Sims GP.

PLoS One. 2015 Feb 23;10(2):e0115828. doi: 10.1371/journal.pone.0115828. eCollection 2015.


Reply: To PMID 25135548.

Dewey S, Beiko G, Braga-Mela R, Nixon DR, Raviv T, Rosenthal K.

J Cataract Refract Surg. 2015 Feb;41(2):480. doi: 10.1016/j.jcrs.2014.12.037. No abstract available.


Coronary computed tomographic angiographic findings in patients with Kawasaki disease.

Han BK, Lesser A, Rosenthal K, Dummer K, Grant K, Newell M.

Am J Cardiol. 2014 Dec 1;114(11):1676-81. doi: 10.1016/j.amjcard.2014.09.004. Epub 2014 Sep 16.


Soluble toll-like receptor 2 is significantly elevated in HIV-1 infected breast milk and inhibits HIV-1 induced cellular activation, inflammation and infection.

Henrick BM, Yao XD, Drannik AG, Abimiku A, Rosenthal KL; INFANT Study Team.

AIDS. 2014 Sep 10;28(14):2023-32. doi: 10.1097/QAD.0000000000000381.


Microincisions in cataract surgery.

Dewey S, Beiko G, Braga-Mele R, Nixon DR, Raviv T, Rosenthal K; ASCRS Cataract Clinical Committee, Instrumentation and IOLs Subcommittee.

J Cataract Refract Surg. 2014 Sep;40(9):1549-57. doi: 10.1016/j.jcrs.2014.07.006. Review.


BRAF-Targeted Therapy to Treat Superior Vena Cava Syndrome in a Patient With Metastatic Cancer.

Mesko SM, Rosenthal KJ, Boasberg PD, Hamid O.

J Clin Oncol. 2015 Sep 1;33(25):e101-3. doi: 10.1200/JCO.2013.49.5622. Epub 2014 Apr 7. No abstract available.


Cardiovascular imaging trends in congenital heart disease: a single center experience.

Han BK, Lesser AM, Vezmar M, Rosenthal K, Rutten-Ramos S, Lindberg J, Caye D, Lesser JR.

J Cardiovasc Comput Tomogr. 2013 Nov-Dec;7(6):361-6. doi: 10.1016/j.jcct.2013.11.002. Epub 2013 Nov 8.


Non-sedated, free breathing cardiac CT for evaluation of complex congenital heart disease in neonates.

Han BK, Overman DM, Grant K, Rosenthal K, Rutten-Ramos S, Cook D, Lesser JR.

J Cardiovasc Comput Tomogr. 2013 Nov-Dec;7(6):354-60. doi: 10.1016/j.jcct.2013.11.006. Epub 2013 Nov 7.


November consultation #8.

Rosenthal KJ.

J Cataract Refract Surg. 2013 Nov;39(11):1786-7. doi: 10.1016/j.jcrs.2013.08.029. No abstract available.


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