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Items: 1 to 50 of 119

1.

Discovery of ML323 as a Novel Inhibitor of the USP1/UAF1 Deubiquitinase Complex.

Dexheimer TS, Rosenthal AS, Liang Q, Chen J, Villamil MA, Kerns EH, Simeonov A, Jadhav A, Zhuang Z, Maloney DJ.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Oct 23 [updated 2014 Sep 18].

2.

Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer.

Dexheimer TS, Rosenthal AS, Luci DK, Liang Q, Villamil MA, Chen J, Sun H, Kerns EH, Simeonov A, Jadhav A, Zhuang Z, Maloney DJ.

J Med Chem. 2014 Oct 9;57(19):8099-110. doi: 10.1021/jm5010495. Epub 2014 Sep 17.

3.

Biochemical assays for the discovery of TDP1 inhibitors.

Marchand C, Huang SY, Dexheimer TS, Lea WA, Mott BT, Chergui A, Naumova A, Stephen AG, Rosenthal AS, Rai G, Murai J, Gao R, Maloney DJ, Jadhav A, Jorgensen WL, Simeonov A, Pommier Y.

Mol Cancer Ther. 2014 Aug;13(8):2116-26. doi: 10.1158/1535-7163.MCT-13-0952. Epub 2014 Jul 14.

4.

A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses.

Liang Q, Dexheimer TS, Zhang P, Rosenthal AS, Villamil MA, You C, Zhang Q, Chen J, Ott CA, Sun H, Luci DK, Yuan B, Simeonov A, Jadhav A, Xiao H, Wang Y, Maloney DJ, Zhuang Z.

Nat Chem Biol. 2014 Apr;10(4):298-304. doi: 10.1038/nchembio.1455. Epub 2014 Feb 16.

5.

Discovery of ML216, a Small Molecule Inhibitor of Bloom (BLM) Helicase.

Rosenthal AS, Dexheimer TS, Nguyen G, Gileadi O, Vindigni A, Simeonov A, Jadhav A, Hickson I, Maloney DJ.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2011 Apr 15 [updated 2013 Feb 28].

6.

Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase.

Rosenthal AS, Dexheimer TS, Gileadi O, Nguyen GH, Chu WK, Hickson ID, Jadhav A, Simeonov A, Maloney DJ.

Bioorg Med Chem Lett. 2013 Oct 15;23(20):5660-6. doi: 10.1016/j.bmcl.2013.08.025. Epub 2013 Aug 13.

7.

A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.

Nguyen GH, Dexheimer TS, Rosenthal AS, Chu WK, Singh DK, Mosedale G, Bachrati CZ, Schultz L, Sakurai M, Savitsky P, Abu M, McHugh PJ, Bohr VA, Harris CC, Jadhav A, Gileadi O, Maloney DJ, Simeonov A, Hickson ID.

Chem Biol. 2013 Jan 24;20(1):55-62. doi: 10.1016/j.chembiol.2012.10.016.

8.

Capillary electrophoresis with three-color fluorescence detection for the analysis of glycosphingolipid metabolism.

Keithley RB, Rosenthal AS, Essaka DC, Tanaka H, Yoshimura Y, Palcic MM, Hindsgaul O, Dovichi NJ.

Analyst. 2013 Jan 7;138(1):164-70. doi: 10.1039/c2an36286d. Epub 2012 Nov 16.

9.

An artemisinin-derived dimer has highly potent anti-cytomegalovirus (CMV) and anti-cancer activities.

He R, Mott BT, Rosenthal AS, Genna DT, Posner GH, Arav-Boger R.

PLoS One. 2011;6(8):e24334. doi: 10.1371/journal.pone.0024334. Epub 2011 Aug 31.

10.

An inhibitor of the Cdc2-like kinase 4 (Clk4).

Rosenthal AS, Tanega C, Shen M, Mott BT, Bougie JM, Nguyen DT, Misteli T, Auld DS, Maloney DJ, Thomas CJ.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2010 Mar 29 [updated 2011 Mar 3].

11.

Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk).

Rosenthal AS, Tanega C, Shen M, Mott BT, Bougie JM, Nguyen DT, Misteli T, Auld DS, Maloney DJ, Thomas CJ.

Bioorg Med Chem Lett. 2011 May 15;21(10):3152-8. doi: 10.1016/j.bmcl.2011.02.114. Epub 2011 Mar 4.

12.

Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells.

Rosenthal AS, Chen X, Liu JO, West DC, Hergenrother PJ, Shapiro TA, Posner GH.

J Med Chem. 2009 Feb 26;52(4):1198-203. doi: 10.1021/jm801484v.

13.

Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent.

Hartwig CL, Rosenthal AS, D'Angelo J, Griffin CE, Posner GH, Cooper RA.

Biochem Pharmacol. 2009 Feb 1;77(3):322-36. doi: 10.1016/j.bcp.2008.10.015. Epub 2008 Oct 19.

14.

Malaria-infected mice are cured by oral administration of new artemisinin derivatives.

Posner GH, Chang W, Hess L, Woodard L, Sinishtaj S, Usera AR, Maio W, Rosenthal AS, Kalinda AS, D'Angelo JG, Petersen KS, Stohler R, Chollet J, Santo-Tomas J, Snyder C, Rottmann M, Wittlin S, Brun R, Shapiro TA.

J Med Chem. 2008 Feb 28;51(4):1035-42. doi: 10.1021/jm701168h. Epub 2008 Jan 31.

PMID:
18232653
15.

Malaria-infected mice are cured by a single dose of novel artemisinin derivatives.

Posner GH, Paik IH, Chang W, Borstnik K, Sinishtaj S, Rosenthal AS, Shapiro TA.

J Med Chem. 2007 May 17;50(10):2516-9. Epub 2007 Apr 17.

PMID:
17439113
16.

A novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase.

Merluzzi VJ, Rosenthal AS.

Adv Exp Med Biol. 1992;312:89-94. Review. No abstract available.

PMID:
1381140
17.

Threshold eta photoproduction.

Rosenthal AS, Forest T, Gonzales M.

Phys Rev C Nucl Phys. 1991 Dec;44(6):2765-2770. No abstract available.

PMID:
9967711
18.

BI-RG-587 is active against zidovudine-resistant human immunodeficiency virus type 1 and synergistic with zidovudine.

Richman D, Rosenthal AS, Skoog M, Eckner RJ, Chou TC, Sabo JP, Merluzzi VJ.

Antimicrob Agents Chemother. 1991 Feb;35(2):305-8.

19.

Photoproduction of eta mesons from nuclei.

Halderson D, Rosenthal AS.

Phys Rev C Nucl Phys. 1990 Dec;42(6):2584-2590. No abstract available.

PMID:
9967009
20.

Dementia and agitation in nursing home residents: how are they related?

Cohen-Mansfield J, Marx MS, Rosenthal AS.

Psychol Aging. 1990 Mar;5(1):3-8.

PMID:
2317299
21.

Medical correlates of agitation in nursing home residents.

Cohen-Mansfield J, Billig N, Lipson S, Rosenthal AS, Pawlson LG.

Gerontology. 1990;36(3):150-8.

PMID:
2227468
22.

Evaluation of zinc complexes on the replication of rhinovirus 2 in vitro.

Merluzzi VJ, Cipriano D, McNeil D, Fuchs V, Supeau C, Rosenthal AS, Skiles JW.

Res Commun Chem Pathol Pharmacol. 1989 Dec;66(3):425-40.

PMID:
2558406
23.

A description of agitation in a nursing home.

Cohen-Mansfield J, Marx MS, Rosenthal AS.

J Gerontol. 1989 May;44(3):M77-84.

PMID:
2715584
24.

Absenteeism of nursing staff in a nursing home.

Cohen-Mansfield J, Rosenthal AS.

Int J Nurs Stud. 1989;26(2):187-94.

PMID:
2744972
25.

Suppression of in vitro granulocytopoiesis by captopril and penicillamine.

Hammond WP, Miller JE, Starkebaum G, Zweerink HJ, Rosenthal AS, Dale DC.

Exp Hematol. 1988 Sep;16(8):674-80.

PMID:
2841147
26.

T-cells recognize IA conformation in the interaction with antigen presenting cells.

Tse HY, Hansen TH, Lin SC, Rosenthal AS.

Adv Exp Med Biol. 1987;225:55-63. Review. No abstract available.

PMID:
3331064
27.

Development of monoclonal antibodies against parathyroid hormone: genetic control of the immune response to human PTH.

Nussbaum SR, Lin CS, Potts JT Jr, Rosenthal AS, Rosenblatt M.

Methods Enzymol. 1985;109:625-38. No abstract available.

PMID:
3921804
28.

The development of sensitive and specific radioimmunoassays for leukotrienes.

Rokach J, Hayes EC, Girard Y, Lombardo DL, Maycock AL, Rosenthal AS, Young RN, Zamboni R, Zweerink HJ.

Prostaglandins Leukot Med. 1984 Jan;13(1):21-5.

PMID:
6324239
29.

Delineation of Ia:nominal antigen complementary determinants recognized by T cells in studies of gene complementation in response to insulin.

Lin CC, Hansen TH, Passmore HC, Rosenthal AS, Tse HY, Walsh WD, Kanamori S.

J Immunol. 1984 Jan;132(1):303-9.

PMID:
6197448
30.

Measuring leukotrienes of slow reacting substance of anaphylaxis: development of a specific radioimmunoassay.

Hayes EC, Lombardo DL, Girard Y, Maycock AL, Rokach J, Rosenthal AS, Young RN, Egan RW, Zweerink HJ.

J Immunol. 1983 Jul;131(1):429-33.

PMID:
6190920
31.

The immune response to insulin in man. Interaction of HLA alloantigens and the development of the immune response.

Kahn CR, Mann D, Rosenthal AS, Galloway JA, Johnson AH, Mendell N.

Diabetes. 1982 Aug;31(8 Pt 1):716-23. No abstract available.

PMID:
6761210
32.

Determinant selection and macrophage function.

Rosenthal AS.

Immunol Today. 1982 Feb;3(2):33-4. doi: 10.1016/0167-5699(82)90056-1. No abstract available.

PMID:
25291021
33.

Regulation of immune response by preadministration of cells briefly pulsed with antigen in vitro. I. Suppression of IgE antibody response by antigen pulsed spleen cells.

Yokomuro K, Mabuchi A, Saizawa M, Kojima N, Rosenthal AS, Kimura Y.

Int Arch Allergy Appl Immunol. 1982;69(2):98-108.

PMID:
7049962
34.

Selective loss of antigen-specific Ir gene function in IA mutant B6.C-H-2bm12 is an antigen presenting cell defect.

Lin CC, Rosenthal AS, Passmore HC, Hansen TH.

Proc Natl Acad Sci U S A. 1981 Oct;78(10):6406-10.

35.
36.

I-A mutation resulted in a selective loss of an antigen-specific Ir gene function.

Lin CS, Rosenthal AS, Hansen TH.

J Supramol Struct Cell Biochem. 1981;16(2):115-20.

PMID:
6170758
37.

Regulation of the immune response--role of the macrophage.

Rosenthal AS.

N Engl J Med. 1980 Nov 13;303(20):1153-6. Review. No abstract available.

PMID:
6775227
38.

Function of macrophages as antigen presenting cells.

Schroer J, Rosenthal AS.

Springer Semin Immunopathol. 1980 Aug;3(2):247-64. Review. No abstract available.

PMID:
6168025
41.
44.

H-2-linked Ir gene control of antibody responses to insulin. I. Anti-insulin plaque-forming cell primary responses.

Schroer JA, Inman JK, Thomas JW, Rosenthal AS.

J Immunol. 1979 Aug;123(2):670-5. No abstract available.

PMID:
110878
45.

Immune response gene control of determinant selection. II. Genetic control of the murine T lymphocyte proliferative response to insulin.

Rosenwasser LJ, Barcinski MA, Schwartz RH, Rosenthal AS.

J Immunol. 1979 Jul;123(1):471-6.

PMID:
87482
46.

Immunologic reactions to insulin: insulin allergy, insulin resistance, and the autoimmune insulin syndrome.

Kahn CR, Rosenthal AS.

Diabetes Care. 1979 May-Jun;2(3):283-95. No abstract available.

PMID:
510122
47.
48.

Macrophage-lymphocyte interaction and genetic control of immune responsiveness.

Thomas JW, Schroer J, Yokomuro K, Blake JT, Rosenthal AS.

Adv Exp Med Biol. 1979;121B:165-79. Review.

PMID:
94754
50.

Analogous functions of macrophages and Langerhans cells in the initiation in the immune response.

Stingl G, Katz SI, Shevach EM, Rosenthal AS, Green I.

J Invest Dermatol. 1978 Jul;71(1):59-64. Review.

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