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The increased protection and pathology in Mycobacterium tuberculosis-infected IL-27R-alpha-deficient mice is supported by IL-17A and is associated with the IL-17A-induced expansion of multifunctional T cells.

Erdmann H, Behrends J, Ritter K, Hölscher A, Volz J, Rosenkrands I, Hölscher C.

Mucosal Immunol. 2018 Jul;11(4):1168-1180. doi: 10.1038/s41385-018-0026-3. Epub 2018 May 4.


A flow cytometry-based assay to determine the phagocytic activity of both clinical and nonclinical antibody samples against Chlamydia trachomatis.

Grasse M, Rosenkrands I, Olsen A, Follmann F, Dietrich J.

Cytometry A. 2018 May;93(5):525-532. doi: 10.1002/cyto.a.23353. Epub 2018 Mar 7.


Africa-wide evaluation of host biomarkers in QuantiFERON supernatants for the diagnosis of pulmonary tuberculosis.

Chegou NN, Sutherland JS, Namuganga AR, Corstjens PL, Geluk A, Gebremichael G, Mendy J, Malherbe S, Stanley K, van der Spuy GD, Kriel M, Loxton AG, Kriel B, Simukonda F, Bekele Y, Sheehama JA, Nelongo J, van der Vyver M, Gebrexabher A, Hailu H, Esterhuyse MM, Rosenkrands I, Aagard C, Kidd M, Kassa D, Mihret A, Howe R, Cliff JM, Crampin AC, Mayanja-Kizza H, Kaufmann SHE, Dockrell HM, Ottenhoff THM, Walzl G; AE-TBC consortium.

Sci Rep. 2018 Feb 8;8(1):2675. doi: 10.1038/s41598-018-20855-7.


Protective Effect of Vaccine Promoted Neutralizing Antibodies against the Intracellular Pathogen Chlamydia trachomatis.

Olsen AW, Lorenzen EK, Rosenkrands I, Follmann F, Andersen P.

Front Immunol. 2017 Dec 11;8:1652. doi: 10.3389/fimmu.2017.01652. eCollection 2017.


The dynamics of immune responses to Mycobacterium tuberculosis during different stages of natural infection: A longitudinal study among Greenlanders.

Michelsen SW, Soborg B, Diaz LJ, Hoff ST, Agger EM, Koch A, Rosenkrands I, Wohlfahrt J, Melbye M.

PLoS One. 2017 Jun 1;12(6):e0177906. doi: 10.1371/journal.pone.0177906. eCollection 2017.


An attenuated Mycobacterium tuberculosis clinical strain with a defect in ESX-1 secretion induces minimal host immune responses and pathology.

Clemmensen HS, Knudsen NPH, Rasmussen EM, Winkler J, Rosenkrands I, Ahmad A, Lillebaek T, Sherman DR, Andersen PL, Aagaard C.

Sci Rep. 2017 Apr 24;7:46666. doi: 10.1038/srep46666.


Introducing the ESAT-6 free IGRA, a companion diagnostic for TB vaccines based on ESAT-6.

Ruhwald M, de Thurah L, Kuchaka D, Zaher MR, Salman AM, Abdel-Ghaffar AR, Shoukry FA, Michelsen SW, Soborg B, Blauenfeldt T, Mpagama S, Hoff ST, Agger EM, Rosenkrands I, Aagard C, Kibiki G, El-Sheikh N, Andersen P.

Sci Rep. 2017 Apr 7;7:45969. doi: 10.1038/srep45969.


Diagnostic Performance of Tuberculosis-Specific IgG Antibody Profiles in Patients with Presumptive Tuberculosis from Two Continents.

Broger T, Basu Roy R, Filomena A, Greef CH, Rimmele S, Havumaki J, Danks D, Schneiderhan-Marra N, Gray CM, Singh M, Rosenkrands I, Andersen P, Husar GM, Joos TO, Gennaro ML, Lochhead MJ, Denkinger CM, Perkins MD.

Clin Infect Dis. 2017 Apr 1;64(7):947-955. doi: 10.1093/cid/cix023.


Quantitative Protein Profiling of Chlamydia trachomatis Growth Forms Reveals Defense Strategies Against Tryptophan Starvation.

Østergaard O, Follmann F, Olsen AW, Heegaard NH, Andersen P, Rosenkrands I.

Mol Cell Proteomics. 2016 Dec;15(12):3540-3550. Epub 2016 Oct 26.


Evaluation of cytokine responses against novel Mtb antigens as diagnostic markers for TB disease.

Awoniyi DO, Teuchert A, Sutherland JS, Mayanja-Kizza H, Howe R, Mihret A, Loxton AG, Sheehama J, Kassa D, Crampin AC, Dockrell HM, Kidd M, Rosenkrands I, Geluk A, Ottenhoff TH, Corstjens PL, Chegou NN, Walzl G; AE-TBC Consortium.

J Infect. 2016 Sep;73(3):219-30. doi: 10.1016/j.jinf.2016.04.036. Epub 2016 Jun 14.


Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB.

Chegou NN, Sutherland JS, Malherbe S, Crampin AC, Corstjens PL, Geluk A, Mayanja-Kizza H, Loxton AG, van der Spuy G, Stanley K, Kotzé LA, van der Vyver M, Rosenkrands I, Kidd M, van Helden PD, Dockrell HM, Ottenhoff TH, Kaufmann SH, Walzl G; AE-TBC consortium.

Thorax. 2016 Sep;71(9):785-94. doi: 10.1136/thoraxjnl-2015-207999. Epub 2016 May 4.


Vaccine-induced Th17 cells are established as resident memory cells in the lung and promote local IgA responses.

Christensen D, Mortensen R, Rosenkrands I, Dietrich J, Andersen P.

Mucosal Immunol. 2017 Jan;10(1):260-270. doi: 10.1038/mi.2016.28. Epub 2016 Apr 6.


Identifying protective Streptococcus pyogenes vaccine antigens recognized by both B and T cells in human adults and children.

Mortensen R, Nissen TN, Fredslund S, Rosenkrands I, Christensen JP, Andersen P, Dietrich J.

Sci Rep. 2016 Feb 25;6:22030. doi: 10.1038/srep22030.


Correction for Dietrich et al., Differential Influence of Nutrient-Starved Mycobacterium tuberculosis on Adaptive Immunity Results in Progressive Tuberculosis Disease and Pathology.

Dietrich J, Roy S, Rosenkrands I, Lindenstrøm T, Filskov J, Rasmussen EM, Cassidy J, Andersen P.

Infect Immun. 2016 Jan 25;84(2):608. doi: 10.1128/IAI.01427-15. Print 2016 Feb. No abstract available.


Screening and Characterization of Linear B-Cell Epitopes by Biotinylated Peptide Libraries.

Rosenkrands I, Olsen A.

Methods Mol Biol. 2015;1348:241-50. doi: 10.1007/978-1-4939-2999-3_21.


Differential influence of nutrient-starved Mycobacterium tuberculosis on adaptive immunity results in progressive tuberculosis disease and pathology.

Dietrich J, Roy S, Rosenkrands I, Lindenstrøm T, Filskov J, Rasmussen EM, Cassidy J, Andersen P.

Infect Immun. 2015 Dec;83(12):4731-9. doi: 10.1128/IAI.01055-15. Epub 2015 Sep 28. Erratum in: Infect Immun. 2016 Feb;84(2):608.


Protection Against Chlamydia trachomatis Infection and Upper Genital Tract Pathological Changes by Vaccine-Promoted Neutralizing Antibodies Directed to the VD4 of the Major Outer Membrane Protein.

Olsen AW, Follmann F, Erneholm K, Rosenkrands I, Andersen P.

J Infect Dis. 2015 Sep 15;212(6):978-89. doi: 10.1093/infdis/jiv137. Epub 2015 Mar 6.


Potassium availability triggers Mycobacterium tuberculosis transition to, and resuscitation from, non-culturable (dormant) states.

Salina EG, Waddell SJ, Hoffmann N, Rosenkrands I, Butcher PD, Kaprelyants AS.

Open Biol. 2014 Oct;4(10). pii: 140106. doi: 10.1098/rsob.140106.


Analysis of protein species differentiation among mycobacterial low-Mr-secreted proteins by narrow pH range Immobiline gel 2-DE-MALDI-MS.

Lange S, Rosenkrands I, Stein R, Andersen P, Kaufmann SH, Jungblut PR.

J Proteomics. 2014 Jan 31;97:235-44. doi: 10.1016/j.jprot.2013.06.036. Epub 2013 Jul 13.


Development of a proof of concept immunochromatographic lateral flow assay for point of care diagnosis of Mycobacterium tuberculosis.

Wassie L, Abebe M, Aseffa A, Bobosha K, Zewdie M, Chanyalew M, Yamuah LK, Cortés A, González JR, Delgado JM, Ceyhan I, Rosenkrands I, Weldingh K, Andersen P, Doherty TM.

BMC Res Notes. 2013 May 21;6:202. doi: 10.1186/1756-0500-6-202.


Proteomic profiling of Mycobacterium tuberculosis identifies nutrient-starvation-responsive toxin-antitoxin systems.

Albrethsen J, Agner J, Piersma SR, Højrup P, Pham TV, Weldingh K, Jimenez CR, Andersen P, Rosenkrands I.

Mol Cell Proteomics. 2013 May;12(5):1180-91. doi: 10.1074/mcp.M112.018846. Epub 2013 Jan 23.


Mycobacterium tuberculosis antigen 85B and ESAT-6 expressed as a recombinant fusion protein in Mycobacterium smegmatis elicits cell-mediated immune response in a murine vaccination model.

Tsolaki AG, Nagy J, Leiva S, Kishore U, Rosenkrands I, Robertson BD.

Mol Immunol. 2013 Jul;54(3-4):278-83. doi: 10.1016/j.molimm.2012.11.014. Epub 2013 Jan 16.


Lipid-labeling facilitates a novel magnetic isolation procedure to characterize pathogen-containing phagosomes.

Steinhäuser C, Heigl U, Tchikov V, Schwarz J, Gutsmann T, Seeger K, Brandenburg J, Fritsch J, Schroeder J, Wiesmüller KH, Rosenkrands I, Walther P, Pott J, Krause E, Ehlers S, Schneider-Brachert W, Schütze S, Reiling N.

Traffic. 2013 Mar;14(3):321-36. doi: 10.1111/tra.12031. Epub 2012 Dec 28.


Immune responses to ESAT-6 and CFP-10 by FASCIA and multiplex technology for diagnosis of M. tuberculosis infection; IP-10 is a promising marker.

Borgström E, Andersen P, Atterfelt F, Julander I, Källenius G, Maeurer M, Rosenkrands I, Widfeldt M, Bruchfeld J, Gaines H.

PLoS One. 2012;7(11):e43438. doi: 10.1371/journal.pone.0043438. Epub 2012 Nov 8.


Deciphering the proteome of the in vivo diagnostic reagent "purified protein derivative" from Mycobacterium tuberculosis.

Cho YS, Dobos KM, Prenni J, Yang H, Hess A, Rosenkrands I, Andersen P, Ryoo SW, Bai GH, Brennan MJ, Izzo A, Bielefeldt-Ohmann H, Belisle JT.

Proteomics. 2012 Apr;12(7):979-91. doi: 10.1002/pmic.201100544.


EspD is critical for the virulence-mediating ESX-1 secretion system in Mycobacterium tuberculosis.

Chen JM, Boy-Röttger S, Dhar N, Sweeney N, Buxton RS, Pojer F, Rosenkrands I, Cole ST.

J Bacteriol. 2012 Feb;194(4):884-93. doi: 10.1128/JB.06417-11. Epub 2011 Dec 9.


Enhanced humoral and cell-mediated immune responses after immunization with trivalent influenza vaccine adjuvanted with cationic liposomes.

Rosenkrands I, Vingsbo-Lundberg C, Bundgaard TJ, Lindenstrøm T, Enouf V, van der Werf S, Andersen P, Agger EM.

Vaccine. 2011 Aug 26;29(37):6283-91. doi: 10.1016/j.vaccine.2011.06.040. Epub 2011 Jun 29.


Detection of proliferative responses to ESAT-6 and CFP-10 by FASCIA assay for diagnosis of Mycobacterium tuberculosis infection.

Borgström E, Andersen P, Andersson L, Julander I, Källenius G, Maeurer M, Norrby M, Rosenkrands I, Tecleab T, Bruchfeld J, Gaines H.

J Immunol Methods. 2011 Jul 29;370(1-2):55-64. doi: 10.1016/j.jim.2011.05.008. Epub 2011 May 30.


Subunit vaccines: distearoylphosphatidylcholine-based liposomes entrapping antigen offer a neutral alternative to dimethyldioctadecylammonium-based cationic liposomes as an adjuvant delivery system.

McNeil SE, Rosenkrands I, Agger EM, Andersen P, Perrie Y.

J Pharm Sci. 2011 May;100(5):1856-65. doi: 10.1002/jps.22427. Epub 2010 Dec 10.


Ag85B-ESAT-6 adjuvanted with IC31® promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in volunteers with previous BCG vaccination or tuberculosis infection.

van Dissel JT, Soonawala D, Joosten SA, Prins C, Arend SM, Bang P, Tingskov PN, Lingnau K, Nouta J, Hoff ST, Rosenkrands I, Kromann I, Ottenhoff TH, Doherty TM, Andersen P.

Vaccine. 2011 Mar 3;29(11):2100-9. doi: 10.1016/j.vaccine.2010.12.135. Epub 2011 Jan 20.


ESAT-6 secretion-independent impact of ESX-1 genes espF and espG1 on virulence of Mycobacterium tuberculosis.

Bottai D, Majlessi L, Simeone R, Frigui W, Laurent C, Lenormand P, Chen J, Rosenkrands I, Huerre M, Leclerc C, Cole ST, Brosch R.

J Infect Dis. 2011 Apr 15;203(8):1155-64. doi: 10.1093/infdis/jiq089. Epub 2010 Dec 31.


Higher human CD4 T cell response to novel Mycobacterium tuberculosis latency associated antigens Rv2660 and Rv2659 in latent infection compared with tuberculosis disease.

Govender L, Abel B, Hughes EJ, Scriba TJ, Kagina BM, de Kock M, Walzl G, Black G, Rosenkrands I, Hussey GD, Mahomed H, Andersen P, Hanekom WA.

Vaccine. 2010 Dec 10;29(1):51-7. doi: 10.1016/j.vaccine.2010.10.022. Epub 2010 Oct 23.


Ag85B-ESAT-6 adjuvanted with IC31 promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in naïve human volunteers.

van Dissel JT, Arend SM, Prins C, Bang P, Tingskov PN, Lingnau K, Nouta J, Klein MR, Rosenkrands I, Ottenhoff TH, Kromann I, Doherty TM, Andersen P.

Vaccine. 2010 Apr 30;28(20):3571-81. doi: 10.1016/j.vaccine.2010.02.094. Epub 2010 Mar 11.


CAF01 liposomes as a mucosal vaccine adjuvant: In vitro and in vivo investigations.

Christensen D, Foged C, Rosenkrands I, Lundberg CV, Andersen P, Agger EM, Nielsen HM.

Int J Pharm. 2010 May 5;390(1):19-24. doi: 10.1016/j.ijpharm.2009.10.043. Epub 2009 Oct 29.


Adjuvants induce distinct immunological phenotypes in a bovine tuberculosis vaccine model.

Vordermeier HM, Dean GS, Rosenkrands I, Agger EM, Andersen P, Kaveh DA, Hewinson RG, Hogarth PJ.

Clin Vaccine Immunol. 2009 Oct;16(10):1443-8. doi: 10.1128/CVI.00229-09. Epub 2009 Jul 29.


Novel generation mycobacterial adjuvant based on liposome-encapsulated monomycoloyl glycerol from Mycobacterium bovis bacillus Calmette-Guérin.

Andersen CA, Rosenkrands I, Olsen AW, Nordly P, Christensen D, Lang R, Kirschning C, Gomes JM, Bhowruth V, Minnikin DE, Besra GS, Follmann F, Andersen P, Agger EM.

J Immunol. 2009 Aug 15;183(4):2294-302. doi: 10.4049/jimmunol.0804091. Epub 2009 Jul 20.


Protein adsorption and displacement at lipid layers determined by total internal reflection fluorescence (TIRF).

Jorgensen L, Wood GK, Rosenkrands I, Petersen C, Christensen D.

J Liposome Res. 2009;19(2):99-104. doi: 10.1080/08982100902805475.


Tuberculosis subunit vaccination provides long-term protective immunity characterized by multifunctional CD4 memory T cells.

Lindenstrøm T, Agger EM, Korsholm KS, Darrah PA, Aagaard C, Seder RA, Rosenkrands I, Andersen P.

J Immunol. 2009 Jun 15;182(12):8047-55. doi: 10.4049/jimmunol.0801592.


Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis.

Makarov V, Manina G, Mikusova K, Möllmann U, Ryabova O, Saint-Joanis B, Dhar N, Pasca MR, Buroni S, Lucarelli AP, Milano A, De Rossi E, Belanova M, Bobovska A, Dianiskova P, Kordulakova J, Sala C, Fullam E, Schneider P, McKinney JD, Brodin P, Christophe T, Waddell S, Butcher P, Albrethsen J, Rosenkrands I, Brosch R, Nandi V, Bharath S, Gaonkar S, Shandil RK, Balasubramanian V, Balganesh T, Tyagi S, Grosset J, Riccardi G, Cole ST.

Science. 2009 May 8;324(5928):801-4. doi: 10.1126/science.1171583. Epub 2009 Mar 19.


Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosis.

Sala C, Haouz A, Saul FA, Miras I, Rosenkrands I, Alzari PM, Cole ST.

Mol Microbiol. 2009 Mar;71(5):1102-16. doi: 10.1111/j.1365-2958.2008.06583.x. Epub 2009 Jan 16.


A simple mycobacterial monomycolated glycerol lipid has potent immunostimulatory activity.

Andersen CS, Agger EM, Rosenkrands I, Gomes JM, Bhowruth V, Gibson KJ, Petersen RV, Minnikin DE, Besra GS, Andersen P.

J Immunol. 2009 Jan 1;182(1):424-32.


Characterization of active site structure in CYP121. A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv.

McLean KJ, Carroll P, Lewis DG, Dunford AJ, Seward HE, Neeli R, Cheesman MR, Marsollier L, Douglas P, Smith WE, Rosenkrands I, Cole ST, Leys D, Parish T, Munro AW.

J Biol Chem. 2008 Nov 28;283(48):33406-16. doi: 10.1074/jbc.M802115200. Epub 2008 Sep 24.


Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): a versatile adjuvant for vaccines with different immunological requirements.

Agger EM, Rosenkrands I, Hansen J, Brahimi K, Vandahl BS, Aagaard C, Werninghaus K, Kirschning C, Lang R, Christensen D, Theisen M, Follmann F, Andersen P.

PLoS One. 2008 Sep 8;3(9):e3116. doi: 10.1371/journal.pone.0003116.


NIR transmission spectroscopy for rapid determination of lipid and lyoprotector content in liposomal vaccine adjuvant system CAF01.

Christensen D, Allesø M, Rosenkrands I, Rantanen J, Foged C, Agger EM, Andersen P, Nielsen HM.

Eur J Pharm Biopharm. 2008 Nov;70(3):914-20. doi: 10.1016/j.ejpb.2008.07.007. Epub 2008 Jul 23.


Liposomes act as stronger sub-unit vaccine adjuvants when compared to microspheres.

Kirby DJ, Rosenkrands I, Agger EM, Andersen P, Coombes AG, Perrie Y.

J Drug Target. 2008 Aug;16(7):543-54. doi: 10.1080/10611860802228558.


PLGA microspheres for the delivery of a novel subunit TB vaccine.

Kirby DJ, Rosenkrands I, Agger EM, Andersen P, Coombes AG, Perrie Y.

J Drug Target. 2008 May;16(4):282-93. doi: 10.1080/10611860801900462 .


Identification of Rv0222 from RD4 as a novel serodiagnostic target for tuberculosis.

Rosenkrands I, Aagaard C, Weldingh K, Brock I, Dziegiel MH, Singh M, Hoff S, Ravn P, Andersen P.

Tuberculosis (Edinb). 2008 Jul;88(4):335-43. doi: 10.1016/ Epub 2008 Feb 19.


Cationic liposomes as vaccine adjuvants.

Christensen D, Korsholm KS, Rosenkrands I, Lindenstrøm T, Andersen P, Agger EM.

Expert Rev Vaccines. 2007 Oct;6(5):785-96. Review.


Trehalose preserves DDA/TDB liposomes and their adjuvant effect during freeze-drying.

Christensen D, Foged C, Rosenkrands I, Nielsen HM, Andersen P, Agger EM.

Biochim Biophys Acta. 2007 Sep;1768(9):2120-9. Epub 2007 May 13.

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