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GIP's effect on bone metabolism is reduced by the selective GIP receptor antagonist GIP(3-30)NH2.

Gasbjerg LS, Hartmann B, Christensen MB, Lanng AR, Vilsbøll T, Jørgensen NR, Holst JJ, Rosenkilde MM, Knop FK.

Bone. 2019 Oct 14:115079. doi: 10.1016/j.bone.2019.115079. [Epub ahead of print]


Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7.

Jørgensen AS, Larsen O, Uetz-von Allmen E, Lückmann M, Legler DF, Frimurer TM, Veldkamp CT, Hjortø GM, Rosenkilde MM.

Front Immunol. 2019 Sep 13;10:2156. doi: 10.3389/fimmu.2019.02156. eCollection 2019.


Development of highly efficient protocols for extraction and amplification of cytomegalovirus DNA from dried blood spots for detection and genotyping of polymorphic immunomodulatory genes.

Berg C, Friis MB, Rosenkilde MM, Benfield T, Nielsen L, Lüttichau HR, Sundelin T.

PLoS One. 2019 Sep 12;14(9):e0222053. doi: 10.1371/journal.pone.0222053. eCollection 2019.


Paracrine Crosstalk between Intestinal L- and D-cells Controls Secretion of Glucagon-Like Peptide-1 in mice.

Jepsen SL, Grunddal KV, Wewer Albrechtsen NJ, Engelstoft MS, Gabe MBN, Jensen EP, Ørskov C, Poulsen SS, Rosenkilde MM, Pedersen J, Gribble FM, Reimann F, Deacon CF, Schwartz TW, Christ AD, Martin RE, Holst JJ.

Am J Physiol Endocrinol Metab. 2019 Sep 10. doi: 10.1152/ajpendo.00239.2019. [Epub ahead of print]


Structure-function guided modeling of chemokine-GPCR specificity for the chemokine XCL1 and its receptor XCR1.

Fox JC, Thomas MA, Dishman AF, Larsen O, Nakayama T, Yoshie O, Rosenkilde MM, Volkman BF.

Sci Signal. 2019 Sep 3;12(597). pii: eaat4128. doi: 10.1126/scisignal.aat4128.


Increased Body Weight and Fat Mass After Subchronic GIP Receptor Antagonist, but Not GLP-2 Receptor Antagonist, Administration in Rats.

Baldassano S, Gasbjerg LS, Kizilkaya HS, Rosenkilde MM, Holst JJ, Hartmann B.

Front Endocrinol (Lausanne). 2019 Aug 6;10:492. doi: 10.3389/fendo.2019.00492. eCollection 2019.


G protein-coupled receptor pharmacology-The next generation.

Bräuner-Osborne H, Rosenkilde MM, Gether U, Gloriam DE.

Basic Clin Pharmacol Toxicol. 2019 Jul 13. doi: 10.1111/bcpt.13291. [Epub ahead of print] No abstract available.


Enhanced agonist residence time, internalization rate and signalling of the GIP receptor variant [E354Q] facilitate receptor desensitization and long-term impairment of the GIP system.

Gabe MBN, van der Velden WJC, Gadgaard S, Smit FX, Hartmann B, Bräuner-Osborne H, Rosenkilde MM.

Basic Clin Pharmacol Toxicol. 2019 Jul 12. doi: 10.1111/bcpt.13289. [Epub ahead of print]


GLP-2 and GIP exert separate effects on bone turnover: A randomized, placebo-controlled, crossover study in healthy young men.

Skov-Jeppesen K, Svane MS, Martinussen C, Gabe MBN, Gasbjerg LS, Veedfald S, Bojsen-Møller KN, Madsbad S, Holst JJ, Rosenkilde MM, Hartmann B.

Bone. 2019 Aug;125:178-185. doi: 10.1016/j.bone.2019.05.014. Epub 2019 May 15.


Gut Hormones and Their Effect on Bone Metabolism. Potential Drug Therapies in Future Osteoporosis Treatment.

Schiellerup SP, Skov-Jeppesen K, Windeløv JA, Svane MS, Holst JJ, Hartmann B, Rosenkilde MM.

Front Endocrinol (Lausanne). 2019 Feb 26;10:75. doi: 10.3389/fendo.2019.00075. eCollection 2019. Review.


Glucose and amino acid metabolism in mice depend mutually on glucagon and insulin receptor signaling.

Galsgaard KD, Winther-Sørensen M, Pedersen J, Kjeldsen SAS, Rosenkilde MM, Wewer Albrechtsen NJ, Holst JJ.

Am J Physiol Endocrinol Metab. 2019 Apr 1;316(4):E660-E673. doi: 10.1152/ajpendo.00410.2018. Epub 2019 Feb 26.


Distinct Roles of Extracellular Domains in the Epstein-Barr Virus-Encoded BILF1 Receptor for Signaling and Major Histocompatibility Complex Class I Downregulation.

Fares S, Spiess K, Olesen ETB, Zuo J, Jackson S, Kledal TN, Wills MR, Rosenkilde MM.

MBio. 2019 Jan 15;10(1). pii: e01707-18. doi: 10.1128/mBio.01707-18.


Separate and Combined Glucometabolic Effects of Endogenous Glucose-Dependent Insulinotropic Polypeptide and Glucagon-like Peptide 1 in Healthy Individuals.

Gasbjerg LS, Helsted MM, Hartmann B, Jensen MH, Gabe MBN, Sparre-Ulrich AH, Veedfald S, Stensen S, Lanng AR, Bergmann NC, Christensen MB, Vilsbøll T, Holst JJ, Rosenkilde MM, Knop FK.

Diabetes. 2019 May;68(5):906-917. doi: 10.2337/db18-1123. Epub 2019 Jan 9.


Neuromedin U Does Not Act as a Decretin in Rats.

Kuhre RE, Christiansen CB, Ghiasi SM, Gabe MBN, Skat-Rørdam PA, Modvig IM, Mandrup-Poulsen T, Albrechtsen R, Rosenkilde MM, Hartmann B, Wewer Albrechtsen NJ, Holst JJ.

Cell Metab. 2019 Mar 5;29(3):719-726.e5. doi: 10.1016/j.cmet.2018.10.008. Epub 2018 Nov 15.


Insulin Secretion Depends on Intra-islet Glucagon Signaling.

Svendsen B, Larsen O, Gabe MBN, Christiansen CB, Rosenkilde MM, Drucker DJ, Holst JJ.

Cell Rep. 2018 Oct 30;25(5):1127-1134.e2. doi: 10.1016/j.celrep.2018.10.018.


Peroxynitrite Exposure of CXCL12 Impairs Monocyte, Lymphocyte and Endothelial Cell Chemotaxis, Lymphocyte Extravasation in vivo and Anti-HIV-1 Activity.

Janssens R, Boff D, Ruytinx P, Mortier A, Vanheule V, Larsen O, Daugvilaite V, Rosenkilde MM, Noppen S, Liekens S, Schols D, De Meester I, Opdenakker G, Struyf S, Teixeira MM, Amaral FA, Proost P.

Front Immunol. 2018 Aug 28;9:1933. doi: 10.3389/fimmu.2018.01933. eCollection 2018.


Mutational analysis of CCL20 reveals flexibility of N-terminal amino acid composition and length.

Riutta SJ, Larsen O, Getschman AE, Rosenkilde MM, Hwang ST, Volkman BF.

J Leukoc Biol. 2018 Aug;104(2):423-434. doi: 10.1002/JLB.1VMA0218-049R.


Ligand-selective small molecule modulators of the constitutively active vGPCR US28.

Amărandi RM, Lückmann M, Melynis M, Jakobsen MH, Fallah Z, Spiess K, Hjortø GM, Pui A, Frimurer TM, Rosenkilde MM.

Eur J Med Chem. 2018 Jul 15;155:244-254. doi: 10.1016/j.ejmech.2018.05.053. Epub 2018 May 31.


Oleoyl-lysophosphatidylinositol enhances glucagon-like peptide-1 secretion from enteroendocrine L-cells through GPR119.

Arifin SA, Paternoster S, Carlessi R, Casari I, Ekberg JH, Maffucci T, Newsholme P, Rosenkilde MM, Falasca M.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Sep;1863(9):1132-1141. doi: 10.1016/j.bbalip.2018.06.007. Epub 2018 Jun 5.


Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy.

Miles TF, Spiess K, Jude KM, Tsutsumi N, Burg JS, Ingram JR, Waghray D, Hjorto GM, Larsen O, Ploegh HL, Rosenkilde MM, Garcia KC.

Elife. 2018 Jun 8;7. pii: e35850. doi: 10.7554/eLife.35850.


Synthesis and in Vitro Evaluation of Stabilized and Selective Neuromedin U-1 Receptor Agonists.

De Prins A, Martin C, Van Wanseele Y, Tömböly C, Tourwé D, Caveliers V, Holst B, Van Eeckhaut A, Rosenkilde MM, Smolders I, Ballet S.

ACS Med Chem Lett. 2018 Apr 23;9(5):496-501. doi: 10.1021/acsmedchemlett.8b00105. eCollection 2018 May 10.


CCL19 with CCL21-tail displays enhanced glycosaminoglycan binding with retained chemotactic potency in dendritic cells.

Jørgensen AS, Adogamhe PE, Laufer JM, Legler DF, Veldkamp CT, Rosenkilde MM, Hjortø GM.

J Leukoc Biol. 2018 Aug;104(2):401-411. doi: 10.1002/JLB.2VMA0118-008R. Epub 2018 May 16.


EBI2 in splenic and local immune responses and in autoimmunity.

Barington L, Wanke F, Niss Arfelt K, Holst PJ, Kurschus FC, Rosenkilde MM.

J Leukoc Biol. 2018 Aug;104(2):313-322. doi: 10.1002/JLB.2VMR1217-510R. Epub 2018 May 9. Review.


Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.

Kuhre RE, Wewer Albrechtsen NJ, Larsen O, Jepsen SL, Balk-Møller E, Andersen DB, Deacon CF, Schoonjans K, Reimann F, Gribble FM, Albrechtsen R, Hartmann B, Rosenkilde MM, Holst JJ.

Mol Metab. 2018 May;11:84-95. doi: 10.1016/j.molmet.2018.03.007. Epub 2018 Mar 17.


Dual treatment with a fixed ratio of glucagon and insulin increases the therapeutic window of insulin in diabetic rats.

Pedersen C, Bouman SD, Porsgaard T, Rosenkilde MM, Roed NK.

Physiol Rep. 2018 Mar;6(6):e13657. doi: 10.14814/phy2.13657.


Sustained effect of glucagon on body weight and blood glucose: Assessed by continuous glucose monitoring in diabetic rats.

Pedersen C, Porsgaard T, Thomsen M, Rosenkilde MM, Roed NK.

PLoS One. 2018 Mar 20;13(3):e0194468. doi: 10.1371/journal.pone.0194468. eCollection 2018.


The impact of short-chain fatty acids on GLP-1 and PYY secretion from the isolated perfused rat colon.

Christiansen CB, Gabe MBN, Svendsen B, Dragsted LO, Rosenkilde MM, Holst JJ.

Am J Physiol Gastrointest Liver Physiol. 2018 Jul 1;315(1):G53-G65. doi: 10.1152/ajpgi.00346.2017. Epub 2018 Mar 1.


Inhibition of HIV Fusion by Small Molecule Agonists through Efficacy-Engineering of CXCR4.

Berg C, Daugvilaite V, Steen A, Jørgensen AS, Våbenø J, Rosenkilde MM.

ACS Chem Biol. 2018 Apr 20;13(4):881-886. doi: 10.1021/acschembio.8b00061. Epub 2018 Feb 27.


Oxyntomodulin: Actions and role in diabetes.

Holst JJ, Albrechtsen NJW, Gabe MBN, Rosenkilde MM.

Peptides. 2018 Feb;100:48-53. doi: 10.1016/j.peptides.2017.09.018. Review.


Glucose-dependent insulinotropic polypeptide (GIP) receptor antagonists as anti-diabetic agents.

Gasbjerg LS, Gabe MBN, Hartmann B, Christensen MB, Knop FK, Holst JJ, Rosenkilde MM.

Peptides. 2018 Feb;100:173-181. doi: 10.1016/j.peptides.2017.11.021. Review.


Human GIP(3-30)NH2 inhibits G protein-dependent as well as G protein-independent signaling and is selective for the GIP receptor with high-affinity binding to primate but not rodent GIP receptors.

Gabe MBN, Sparre-Ulrich AH, Pedersen MF, Gasbjerg LS, Inoue A, Bräuner-Osborne H, Hartmann B, Rosenkilde MM.

Biochem Pharmacol. 2018 Apr;150:97-107. doi: 10.1016/j.bcp.2018.01.040. Epub 2018 Feb 3.


Comparing olive oil and C4-dietary oil, a prodrug for the GPR119 agonist, 2-oleoyl glycerol, less energy intake of the latter is needed to stimulate incretin hormone secretion in overweight subjects with type 2 diabetes.

Mandøe MJ, Hansen KB, Windeløv JA, Knop FK, Rehfeld JF, Rosenkilde MM, Holst JJ, Hansen HS.

Nutr Diabetes. 2018 Jan 12;8(1):2. doi: 10.1038/s41387-017-0011-z.


Development of potent and proteolytically stable human neuromedin U receptor agonists.

De Prins A, Martin C, Van Wanseele Y, Skov LJ, Tömböly C, Tourwé D, Caveliers V, Van Eeckhaut A, Holst B, Rosenkilde MM, Smolders I, Ballet S.

Eur J Med Chem. 2018 Jan 20;144:887-897. doi: 10.1016/j.ejmech.2017.12.035. Epub 2017 Dec 14.


Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production.

Wewer Albrechtsen NJ, Kuhre RE, Hornburg D, Jensen CZ, Hornum M, Dirksen C, Svane M, Gasbjerg LS, Jørgensen NB, Gabe MN, Balk-Møller E, Albrechtsen R, Winther-Sørensen M, Galsgaard KD, Meissner F, Jorsal T, Lund A, Vilsbøll T, Eliasen R, Bojsen-Møller KN, Idorn T, Deacon CF, Knop FK, Rosenkilde MM, Hartmann B, Feldt-Rasmussen B, Mann M, Madsbad S, Holst JJ.

Cell Rep. 2017 Nov 7;21(6):1452-1460. doi: 10.1016/j.celrep.2017.10.034.


Protein engineering of the chemokine CCL20 prevents psoriasiform dermatitis in an IL-23-dependent murine model.

Getschman AE, Imai Y, Larsen O, Peterson FC, Wu X, Rosenkilde MM, Hwang ST, Volkman BF.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12460-12465. doi: 10.1073/pnas.1704958114. Epub 2017 Nov 6.


Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction: a Randomized Placebo Controlled Trial.

Ekeloef S, Halladin N, Fonnes S, Jensen SE, Zaremba T, Rosenberg J, Jonsson G, Aarøe J, Gasbjerg LS, Rosenkilde MM, Gögenur I.

J Cardiovasc Transl Res. 2017 Dec;10(5-6):470-479. doi: 10.1007/s12265-017-9768-7. Epub 2017 Oct 12.


GIP(3-30)NH2 is an efficacious GIP receptor antagonist in humans: a randomised, double-blinded, placebo-controlled, crossover study.

Gasbjerg LS, Christensen MB, Hartmann B, Lanng AR, Sparre-Ulrich AH, Gabe MBN, Dela F, Vilsbøll T, Holst JJ, Rosenkilde MM, Knop FK.

Diabetologia. 2018 Feb;61(2):413-423. doi: 10.1007/s00125-017-4447-4. Epub 2017 Sep 25.


Biased signaling of G protein-coupled receptors - From a chemokine receptor CCR7 perspective.

Jørgensen AS, Rosenkilde MM, Hjortø GM.

Gen Comp Endocrinol. 2018 Mar 1;258:4-14. doi: 10.1016/j.ygcen.2017.07.004. Epub 2017 Jul 8. Review.


The Gluco- and Liporegulatory and Vasodilatory Effects of Glucose-Dependent Insulinotropic Polypeptide (GIP) Are Abolished by an Antagonist of the Human GIP Receptor.

Asmar M, Asmar A, Simonsen L, Gasbjerg LS, Sparre-Ulrich AH, Rosenkilde MM, Hartmann B, Dela F, Holst JJ, Bülow J.

Diabetes. 2017 Sep;66(9):2363-2371. doi: 10.2337/db17-0480. Epub 2017 Jun 30.


Varicella zoster virus glycoprotein C increases chemokine-mediated leukocyte migration.

González-Motos V, Jürgens C, Ritter B, Kropp KA, Durán V, Larsen O, Binz A, Ouwendijk WJD, Lenac Rovis T, Jonjic S, Verjans GMGM, Sodeik B, Krey T, Bauerfeind R, Schulz TF, Kaufer BB, Kalinke U, Proudfoot AEI, Rosenkilde MM, Viejo-Borbolla A.

PLoS Pathog. 2017 May 25;13(5):e1006346. doi: 10.1371/journal.ppat.1006346. eCollection 2017 May.


Sweet Taste Receptor Activation in the Gut Is of Limited Importance for Glucose-Stimulated GLP-1 and GIP Secretion.

Saltiel MY, Kuhre RE, Christiansen CB, Eliasen R, Conde-Frieboes KW, Rosenkilde MM, Holst JJ.

Nutrients. 2017 Apr 22;9(4). pii: E418. doi: 10.3390/nu9040418.


Biased agonism and allosteric modulation of G protein-coupled receptor 183 - a 7TM receptor also known as Epstein-Barr virus-induced gene 2.

Daugvilaite V, Madsen CM, Lückmann M, Echeverria CC, Sailer AW, Frimurer TM, Rosenkilde MM, Benned-Jensen T.

Br J Pharmacol. 2017 Jul;174(13):2031-2042. doi: 10.1111/bph.13801. Epub 2017 May 4.


Truncation of CXCL12 by CD26 reduces its CXC chemokine receptor 4- and atypical chemokine receptor 3-dependent activity on endothelial cells and lymphocytes.

Janssens R, Mortier A, Boff D, Ruytinx P, Gouwy M, Vantilt B, Larsen O, Daugvilaite V, Rosenkilde MM, Parmentier M, Noppen S, Liekens S, Van Damme J, Struyf S, Teixeira MM, Amaral FA, Proost P.

Biochem Pharmacol. 2017 May 15;132:92-101. doi: 10.1016/j.bcp.2017.03.009. Epub 2017 Mar 18.


Novel Chemokine-Based Immunotoxins for Potent and Selective Targeting of Cytomegalovirus Infected Cells.

Spiess K, Jeppesen MG, Malmgaard-Clausen M, Krzywkowski K, Kledal TN, Rosenkilde MM.

J Immunol Res. 2017;2017:4069260. doi: 10.1155/2017/4069260. Epub 2017 Jan 30.


GIP(3-30)NH2 is a potent competitive antagonist of the GIP receptor and effectively inhibits GIP-mediated insulin, glucagon, and somatostatin release.

Sparre-Ulrich AH, Gabe MN, Gasbjerg LS, Christiansen CB, Svendsen B, Hartmann B, Holst JJ, Rosenkilde MM.

Biochem Pharmacol. 2017 May 1;131:78-88. doi: 10.1016/j.bcp.2017.02.012. Epub 2017 Feb 22.


Corrigendum: Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines.

Hjortø GM, Larsen O, Steen A, Daugvilaite V, Berg C, Fares S, Hansen M, Ali S, Rosenkilde MM.

Front Immunol. 2017 Feb 8;8:89. doi: 10.3389/fimmu.2017.00089. eCollection 2017.


Targeting the latent cytomegalovirus reservoir with an antiviral fusion toxin protein.

Krishna BA, Spiess K, Poole EL, Lau B, Voigt S, Kledal TN, Rosenkilde MM, Sinclair JH.

Nat Commun. 2017 Feb 2;8:14321. doi: 10.1038/ncomms14321.


Biased small-molecule ligands for selective inhibition of HIV-1 cell entry via CCR5.

Berg C, Spiess K, Lüttichau HR, Rosenkilde MM.

Pharmacol Res Perspect. 2016 Oct 18;4(6):e00262. doi: 10.1002/prp2.262. eCollection 2016 Dec.


Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines.

Hjortø GM, Larsen O, Steen A, Daugvilaite V, Berg C, Fares S, Hansen M, Ali S, Rosenkilde MM.

Front Immunol. 2016 Dec 9;7:568. doi: 10.3389/fimmu.2016.00568. eCollection 2016. Erratum in: Front Immunol. 2017 Feb 08;8:89.


EBI2 overexpression in mice leads to B1 B-cell expansion and chronic lymphocytic leukemia-like B-cell malignancies.

Niss Arfelt K, Barington L, Benned-Jensen T, Kubale V, Kovalchuk AL, Daugvilaite V, Christensen JP, Thomsen AR, Egerod KL, Bassi MR, Spiess K, Schwartz TW, Wang H, Morse HC 3rd, Holst PJ, Rosenkilde MM.

Blood. 2017 Feb 16;129(7):866-878. doi: 10.1182/blood-2016-02-697185. Epub 2016 Dec 21.

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