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Items: 1 to 50 of 94

1.

Allosteric regulation of arylamine N-acetyltransferase 1 by adenosine triphosphate.

Minchin RF, Rosengren KJ, Burow R, Butcher NJ.

Biochem Pharmacol. 2018 Dec;158:153-160. doi: 10.1016/j.bcp.2018.10.013. Epub 2018 Oct 17.

PMID:
30342020
2.

Prediction of disulfide dihedral angles using chemical shifts.

Armstrong DA, Kaas Q, Rosengren KJ.

Chem Sci. 2018 Jul 5;9(31):6548-6556. doi: 10.1039/c8sc01423j. eCollection 2018 Aug 21.

3.

Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides.

Sousa SR, McArthur JR, Brust A, Bhola RF, Rosengren KJ, Ragnarsson L, Dutertre S, Alewood PF, Christie MJ, Adams DJ, Vetter I, Lewis RJ.

Sci Rep. 2018 Sep 7;8(1):13397. doi: 10.1038/s41598-018-31245-4.

4.

Binding conformation and determinants of a single-chain peptide antagonist at the relaxin-3 receptor RXFP3.

Haugaard-Kedström LM, Lee HS, Jones MV, Song A, Rathod V, Hossain MA, Bathgate RAD, Rosengren KJ.

J Biol Chem. 2018 Oct 12;293(41):15765-15776. doi: 10.1074/jbc.RA118.002611. Epub 2018 Aug 21.

PMID:
30131342
5.

Distinct but overlapping binding sites of agonist and antagonist at the relaxin family peptide 3 (RXFP3) receptor.

Wong LLL, Scott DJ, Hossain MA, Kaas Q, Rosengren KJ, Bathgate RAD.

J Biol Chem. 2018 Oct 12;293(41):15777-15789. doi: 10.1074/jbc.RA118.002645. Epub 2018 Aug 21.

PMID:
30131340
6.

Peptide ion channel toxins from the bootlace worm, the longest animal on Earth.

Jacobsson E, Andersson HS, Strand M, Peigneur S, Eriksson C, Lodén H, Shariatgorji M, Andrén PE, Lebbe EKM, Rosengren KJ, Tytgat J, Göransson U.

Sci Rep. 2018 Mar 22;8(1):4596. doi: 10.1038/s41598-018-22305-w.

7.

Alanine and Lysine Scans of the LL-37-Derived Peptide Fragment KR-12 Reveal Key Residues for Antimicrobial Activity.

Gunasekera S, Muhammad T, Strömstedt AA, Rosengren KJ, Göransson U.

Chembiochem. 2018 May 4;19(9):931-939. doi: 10.1002/cbic.201700599. Epub 2018 Mar 30.

PMID:
29430821
8.

Buried treasure: biosynthesis, structures and applications of cyclic peptides hidden in seed storage albumins.

Franke B, Mylne JS, Rosengren KJ.

Nat Prod Rep. 2018 Feb 21;35(2):137-146. doi: 10.1039/c7np00066a.

PMID:
29379937
9.

Cyclotide Evolution: Insights from the Analyses of Their Precursor Sequences, Structures and Distribution in Violets (Viola).

Park S, Yoo KO, Marcussen T, Backlund A, Jacobsson E, Rosengren KJ, Doo I, Göransson U.

Front Plant Sci. 2017 Dec 18;8:2058. doi: 10.3389/fpls.2017.02058. eCollection 2017.

10.

Corrigendum: Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.

Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, Christie MJ, King GF, Alewood PF, Lewis RJ, Wood JN, Vetter I.

Sci Rep. 2017 May 26;7:46816. doi: 10.1038/srep46816. No abstract available.

11.

Two proteins for the price of one: Structural studies of the dual-destiny protein preproalbumin with sunflower trypsin inhibitor-1.

Franke B, James AM, Mobli M, Colgrave ML, Mylne JS, Rosengren KJ.

J Biol Chem. 2017 Jul 28;292(30):12398-12411. doi: 10.1074/jbc.M117.776955. Epub 2017 May 23.

12.

Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.

Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, Christie MJ, King GF, Alewood PF, Lewis RJ, Wood JN, Vetter I.

Sci Rep. 2017 Jan 20;7:40883. doi: 10.1038/srep40883. Erratum in: Sci Rep. 2017 May 26;7:46816.

13.

Relaxin family peptides: structure-activity relationship studies.

Patil NA, Rosengren KJ, Separovic F, Wade JD, Bathgate RAD, Hossain MA.

Br J Pharmacol. 2017 May;174(10):950-961. doi: 10.1111/bph.13684. Epub 2017 Jan 19. Review. Erratum in: Br J Pharmacol. 2017 Dec;174(24):4836.

14.

Natural structural diversity within a conserved cyclic peptide scaffold.

Elliott AG, Franke B, Armstrong DA, Craik DJ, Mylne JS, Rosengren KJ.

Amino Acids. 2017 Jan;49(1):103-116. doi: 10.1007/s00726-016-2333-x. Epub 2016 Oct 1.

PMID:
27695949
15.

Development of a Single-Chain Peptide Agonist of the Relaxin-3 Receptor Using Hydrocarbon Stapling.

Hojo K, Hossain MA, Tailhades J, Shabanpoor F, Wong LL, Ong-Pålsson EE, Kastman HE, Ma S, Gundlach AL, Rosengren KJ, Wade JD, Bathgate RA.

J Med Chem. 2016 Aug 25;59(16):7445-56. doi: 10.1021/acs.jmedchem.6b00265. Epub 2016 Aug 8.

PMID:
27464307
16.

Diverse cyclic seed peptides in the Mexican zinnia (Zinnia haageana).

Franke B, Jayasena AS, Fisher MF, Swedberg JE, Taylor NL, Mylne JS, Rosengren KJ.

Biopolymers. 2016 Nov;106(6):806-817. doi: 10.1002/bip.22901.

PMID:
27352920
17.

A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1.

Hossain MA, Kocan M, Yao ST, Royce SG, Nair VB, Siwek C, Patil NA, Harrison IP, Rosengren KJ, Selemidis S, Summers RJ, Wade JD, Bathgate RAD, Samuel CS.

Chem Sci. 2016 Jun 1;7(6):3805-3819. doi: 10.1039/c5sc04754d. Epub 2016 Feb 26.

18.

Mature forms of the major seed storage albumins in sunflower: A mass spectrometric approach.

Franke B, Colgrave ML, Mylne JS, Rosengren KJ.

J Proteomics. 2016 Sep 16;147:177-186. doi: 10.1016/j.jprot.2016.05.004. Epub 2016 May 10.

PMID:
27185550
19.

Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide.

Kwon S, Bosmans F, Kaas Q, Cheneval O, Conibear AC, Rosengren KJ, Wang CK, Schroeder CI, Craik DJ.

Biotechnol Bioeng. 2016 Oct;113(10):2202-12. doi: 10.1002/bit.25993. Epub 2016 Aug 9.

20.

Engineering of a Novel Simplified Human Insulin-Like Peptide 5 Agonist.

Patil NA, Hughes RA, Rosengren KJ, Kocan M, Ang SY, Tailhades J, Separovic F, Summers RJ, Grosse J, Wade JD, Bathgate RA, Hossain MA.

J Med Chem. 2016 Mar 10;59(5):2118-25. doi: 10.1021/acs.jmedchem.5b01786. Epub 2016 Feb 12.

PMID:
26824523
21.

Distribution of circular proteins in plants: large-scale mapping of cyclotides in the Violaceae.

Burman R, Yeshak MY, Larsson S, Craik DJ, Rosengren KJ, Göransson U.

Front Plant Sci. 2015 Oct 27;6:855. doi: 10.3389/fpls.2015.00855. eCollection 2015.

22.

Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization.

Conibear AC, Chaousis S, Durek T, Rosengren KJ, Craik DJ, Schroeder CI.

Biopolymers. 2016 Jan;106(1):89-100. doi: 10.1002/bip.22767.

PMID:
26566734
23.

Chemically synthesized dicarba H2 relaxin analogues retain strong RXFP1 receptor activity but show an unexpected loss of in vitro serum stability.

Hossain MA, Haugaard-Kedström LM, Rosengren KJ, Bathgate RA, Wade JD.

Org Biomol Chem. 2015 Nov 28;13(44):10895-903. doi: 10.1039/c5ob01539a. Epub 2015 Sep 14.

PMID:
26368576
24.

Isolation, Characterization, and Synthesis of the Barrettides: Disulfide-Containing Peptides from the Marine Sponge Geodia barretti.

Carstens BB, Rosengren KJ, Gunasekera S, Schempp S, Bohlin L, Dahlström M, Clark RJ, Göransson U.

J Nat Prod. 2015 Aug 28;78(8):1886-93. doi: 10.1021/acs.jnatprod.5b00210. Epub 2015 Jul 29.

PMID:
26222779
25.

Identification, Characterization, and Three-Dimensional Structure of the Novel Circular Bacteriocin, Enterocin NKR-5-3B, from Enterococcus faecium.

Himeno K, Rosengren KJ, Inoue T, Perez RH, Colgrave ML, Lee HS, Chan LY, Henriques ST, Fujita K, Ishibashi N, Zendo T, Wilaipun P, Nakayama J, Leelawatcharamas V, Jikuya H, Craik DJ, Sonomoto K.

Biochemistry. 2015 Aug 11;54(31):4863-76. doi: 10.1021/acs.biochem.5b00196. Epub 2015 Jul 31.

PMID:
26174911
26.

Central relaxin-3 receptor (RXFP3) activation reduces elevated, but not basal, anxiety-like behaviour in C57BL/6J mice.

Zhang C, Chua BE, Yang A, Shabanpoor F, Hossain MA, Wade JD, Rosengren KJ, Smith CM, Gundlach AL.

Behav Brain Res. 2015 Oct 1;292:125-32. doi: 10.1016/j.bbr.2015.06.010. Epub 2015 Jun 6.

PMID:
26057358
27.

Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition.

de Veer SJ, Swedberg JE, Akcan M, Rosengren KJ, Brattsand M, Craik DJ, Harris JM.

Biochem J. 2015 Jul 15;469(2):243-53. doi: 10.1042/BJ20150412. Epub 2015 May 18.

PMID:
25981970
28.

Identification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens.

Cardoso FC, Dekan Z, Rosengren KJ, Erickson A, Vetter I, Deuis JR, Herzig V, Alewood PF, King GF, Lewis RJ.

Mol Pharmacol. 2015 Aug;88(2):291-303. doi: 10.1124/mol.115.098178. Epub 2015 May 15.

29.

A cactus-derived toxin-like cystine knot Peptide with selective antimicrobial activity.

Aboye TL, Strömstedt AA, Gunasekera S, Bruhn JG, El-Seedi H, Rosengren KJ, Göransson U.

Chembiochem. 2015 May 4;16(7):1068-77. doi: 10.1002/cbic.201402704. Epub 2015 Mar 27.

PMID:
25821084
30.

Synthesis and pharmacological characterization of a europium-labelled single-chain antagonist for binding studies of the relaxin-3 receptor RXFP3.

Haugaard-Kedström LM, Wong LL, Bathgate RA, Rosengren KJ.

Amino Acids. 2015 Jun;47(6):1267-71. doi: 10.1007/s00726-015-1961-x. Epub 2015 Mar 20.

PMID:
25792111
31.

Solution structure, aggregation behavior, and flexibility of human relaxin-2.

Haugaard-Kedström LM, Hossain MA, Daly NL, Bathgate RA, Rinderknecht E, Wade JD, Craik DJ, Rosengren KJ.

ACS Chem Biol. 2015 Mar 20;10(3):891-900. doi: 10.1021/cb500918v. Epub 2015 Jan 15.

PMID:
25547165
32.

Stabilization of the cysteine-rich conotoxin MrIA by using a 1,2,3-triazole as a disulfide bond mimetic.

Gori A, Wang CI, Harvey PJ, Rosengren KJ, Bhola RF, Gelmi ML, Longhi R, Christie MJ, Lewis RJ, Alewood PF, Brust A.

Angew Chem Int Ed Engl. 2015 Jan 19;54(4):1361-4. doi: 10.1002/anie.201409678. Epub 2014 Dec 5.

PMID:
25483297
33.

Insights into the molecular flexibility of θ-defensins by NMR relaxation analysis.

Conibear AC, Wang CK, Bi T, Rosengren KJ, Camarero JA, Craik DJ.

J Phys Chem B. 2014 Dec 11;118(49):14257-66. doi: 10.1021/jp507754c. Epub 2014 Nov 25.

34.

Understanding the molecular basis of toxin promiscuity: the analgesic sea anemone peptide APETx2 interacts with acid-sensing ion channel 3 and hERG channels via overlapping pharmacophores.

Jensen JE, Cristofori-Armstrong B, Anangi R, Rosengren KJ, Lau CH, Mobli M, Brust A, Alewood PF, King GF, Rash LD.

J Med Chem. 2014 Nov 13;57(21):9195-203. doi: 10.1021/jm501400p. Epub 2014 Nov 4.

PMID:
25337890
35.

Evolutionary origins of a bioactive peptide buried within Preproalbumin.

Elliott AG, Delay C, Liu H, Phua Z, Rosengren KJ, Benfield AH, Panero JL, Colgrave ML, Jayasena AS, Dunse KM, Anderson MA, Schilling EE, Ortiz-Barrientos D, Craik DJ, Mylne JS.

Plant Cell. 2014 Mar;26(3):981-95. doi: 10.1105/tpc.114.123620. Epub 2014 Mar 28.

36.

Central injection of relaxin-3 receptor (RXFP3) antagonist peptides reduces motivated food seeking and consumption in C57BL/6J mice.

Smith CM, Chua BE, Zhang C, Walker AW, Haidar M, Hawkes D, Shabanpoor F, Hossain MA, Wade JD, Rosengren KJ, Gundlach AL.

Behav Brain Res. 2014 Jul 15;268:117-26. doi: 10.1016/j.bbr.2014.03.037. Epub 2014 Mar 25.

PMID:
24681162
37.

Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro.

Schroeder CI, Swedberg JE, Withka JM, Rosengren KJ, Akcan M, Clayton DJ, Daly NL, Cheneval O, Borzilleri KA, Griffor M, Stock I, Colless B, Walsh P, Sunderland P, Reyes A, Dullea R, Ammirati M, Liu S, McClure KF, Tu M, Bhattacharya SK, Liras S, Price DA, Craik DJ.

Chem Biol. 2014 Feb 20;21(2):284-94. doi: 10.1016/j.chembiol.2013.11.014. Epub 2014 Jan 16.

38.

Solution structure, membrane interactions, and protein binding partners of the tetraspanin Sm-TSP-2, a vaccine antigen from the human blood fluke Schistosoma mansoni.

Jia X, Schulte L, Loukas A, Pickering D, Pearson M, Mobli M, Jones A, Rosengren KJ, Daly NL, Gobert GN, Jones MK, Craik DJ, Mulvenna J.

J Biol Chem. 2014 Mar 7;289(10):7151-63. doi: 10.1074/jbc.M113.531558. Epub 2014 Jan 15.

39.

Semienzymatic cyclization of disulfide-rich peptides using Sortase A.

Jia X, Kwon S, Wang CI, Huang YH, Chan LY, Tan CC, Rosengren KJ, Mulvenna JP, Schroeder CI, Craik DJ.

J Biol Chem. 2014 Mar 7;289(10):6627-38. doi: 10.1074/jbc.M113.539262. Epub 2014 Jan 14.

40.

The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: A proof-of-concept study using the integrin-binding RGD motif.

Conibear AC, Bochen A, Rosengren KJ, Stupar P, Wang C, Kessler H, Craik DJ.

Chembiochem. 2014 Feb 10;15(3):451-9. doi: 10.1002/cbic.201300568. Epub 2014 Jan 2.

PMID:
24382674
41.

Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2.

Schroeder CI, Rash LD, Vila-Farrés X, Rosengren KJ, Mobli M, King GF, Alewood PF, Craik DJ, Durek T.

Angew Chem Int Ed Engl. 2014 Jan 20;53(4):1017-20. doi: 10.1002/anie.201308898. Epub 2013 Dec 9.

PMID:
24323786
42.

Relaxin-3/RXFP3 system regulates alcohol-seeking.

Ryan PJ, Kastman HE, Krstew EV, Rosengren KJ, Hossain MA, Churilov L, Wade JD, Gundlach AL, Lawrence AJ.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20789-94. doi: 10.1073/pnas.1317807110. Epub 2013 Dec 2.

43.

Structural insights into the role of the cyclic backbone in a squash trypsin inhibitor.

Daly NL, Thorstholm L, Greenwood KP, King GJ, Rosengren KJ, Heras B, Martin JL, Craik DJ.

J Biol Chem. 2013 Dec 13;288(50):36141-8. doi: 10.1074/jbc.M113.528240. Epub 2013 Oct 29.

44.

The self-association of the cyclotide kalata B2 in solution is guided by hydrophobic interactions.

Rosengren KJ, Daly NL, Harvey PJ, Craik DJ.

Biopolymers. 2013 Sep;100(5):453-60. doi: 10.1002/bip.22269. Erratum in: Biopolymers. 2014 Jan;102(1):136.

PMID:
23893463
45.

Elucidation of relaxin-3 binding interactions in the extracellular loops of RXFP3.

Bathgate RA, Oh MH, Ling WJ, Kaas Q, Hossain MA, Gooley PR, Rosengren KJ.

Front Endocrinol (Lausanne). 2013 Feb 22;4:13. doi: 10.3389/fendo.2013.00013. eCollection 2013.

46.

The cyclic cystine ladder in θ-defensins is important for structure and stability, but not antibacterial activity.

Conibear AC, Rosengren KJ, Daly NL, Henriques ST, Craik DJ.

J Biol Chem. 2013 Apr 12;288(15):10830-40. doi: 10.1074/jbc.M113.451047. Epub 2013 Feb 21.

47.

Conopeptide ρ-TIA defines a new allosteric site on the extracellular surface of the α1B-adrenoceptor.

Ragnarsson L, Wang CI, Andersson Å, Fajarningsih D, Monks T, Brust A, Rosengren KJ, Lewis RJ.

J Biol Chem. 2013 Jan 18;288(3):1814-27. doi: 10.1074/jbc.M112.430785. Epub 2012 Nov 26.

48.

Structural characterization of the cyclic cystine ladder motif of θ-defensins.

Conibear AC, Rosengren KJ, Harvey PJ, Craik DJ.

Biochemistry. 2012 Dec 4;51(48):9718-26. doi: 10.1021/bi301363a. Epub 2012 Nov 20.

PMID:
23148585
49.

Identification of key residues essential for the structural fold and receptor selectivity within the A-chain of human gene-2 (H2) relaxin.

Chan LJ, Rosengren KJ, Layfield SL, Bathgate RA, Separovic F, Samuel CS, Hossain MA, Wade JD.

J Biol Chem. 2012 Nov 30;287(49):41152-64. doi: 10.1074/jbc.M112.409284. Epub 2012 Sep 28.

50.

The different ligand-binding modes of relaxin family peptide receptors RXFP1 and RXFP2.

Scott DJ, Rosengren KJ, Bathgate RA.

Mol Endocrinol. 2012 Nov;26(11):1896-906. doi: 10.1210/me.2012-1188. Epub 2012 Sep 12.

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