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Tranexamic Acid Administration is Associated With an Increased Risk of Post-Traumatic Venous Thromboembolism.

Myers SP, Kutcher ME, Rosengart MR, Sperry JL, Peitzman AB, Brown JB, Neal MD.

J Trauma Acute Care Surg. 2018 Sep 19. doi: 10.1097/TA.0000000000002061. [Epub ahead of print]


Serious games may improve physician heuristics in trauma triage.

Mohan D, Fischhoff B, Angus DC, Rosengart MR, Wallace DJ, Yealy DM, Farris C, Chang CH, Kerti S, Barnato AE.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9204-9209. doi: 10.1073/pnas.1805450115. Epub 2018 Aug 27.


Calcium/calmodulin-dependent protein kinase IV (CaMKIV) activation contributes to the pathogenesis of experimental colitis via inhibition of intestinal epithelial cell proliferation.

Cunningham KE, Novak EA, Vincent G, Siow VS, Griffith BD, Ranganathan S, Rosengart MR, Piganelli JD, Mollen KP.

FASEB J. 2018 Aug 16:fj201800535R. doi: 10.1096/fj.201800535R. [Epub ahead of print]


Translational Sepsis Research: Spanning the Divide.

Lewis AJ, Lee JS, Rosengart MR.

Crit Care Med. 2018 Sep;46(9):1497-1505. doi: 10.1097/CCM.0000000000003271.


Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock.

Sperry JL, Guyette FX, Brown JB, Yazer MH, Triulzi DJ, Early-Young BJ, Adams PW, Daley BJ, Miller RS, Harbrecht BG, Claridge JA, Phelan HA, Witham WR, Putnam AT, Duane TM, Alarcon LH, Callaway CW, Zuckerbraun BS, Neal MD, Rosengart MR, Forsythe RM, Billiar TR, Yealy DM, Peitzman AB, Zenati MS; PAMPer Study Group.

N Engl J Med. 2018 Jul 26;379(4):315-326. doi: 10.1056/NEJMoa1802345.


A qualitative study of gender differences in the experiences of general surgery trainees.

Myers SP, Hill KA, Nicholson KJ, Neal MD, Hamm ME, Switzer GE, Hausmann LRM, Hamad GG, Rosengart MR, Littleton EB.

J Surg Res. 2018 Aug;228:127-134. doi: 10.1016/j.jss.2018.02.043. Epub 2018 Apr 7.


Heme Oxygenase-2 Localizes to Mitochondria and Regulates Hypoxic Responses in Hepatocytes.

Waltz PK, Kautza B, Luciano J, Dyer M, Stolz DB, Loughran P, Neal MD, Sperry JL, Rosengart MR, Zuckerbraun BS.

Oxid Med Cell Longev. 2018 Apr 12;2018:2021645. doi: 10.1155/2018/2021645. eCollection 2018.


Logistics of air medical transport: When and where does helicopter transport reduce prehospital time for trauma?

Chen X, Gestring ML, Rosengart MR, Peitzman AB, Billiar TR, Sperry JL, Brown JB.

J Trauma Acute Care Surg. 2018 Jul;85(1):174-181. doi: 10.1097/TA.0000000000001935.


Blue Light Enhances Bacterial Clearance and Reduces Organ Injury During Sepsis.

Lewis AJ, Zhang X, Griepentrog JE, Yuan D, Collage RD, Waltz PK, Angus DC, Zuckerbraun BS, Rosengart MR.

Crit Care Med. 2018 Aug;46(8):e779-e787. doi: 10.1097/CCM.0000000000003190.


Bench-to-Bedside: A Translational Perspective on Murine Models of Sepsis.

Lewis AJ, Rosengart MR.

Surg Infect (Larchmt). 2018 Feb/Mar;19(2):137-141. doi: 10.1089/sur.2017.308. Epub 2018 Feb 2. Review.


Prompt Administration of Antibiotics and Fluids in the Treatment of Sepsis: A Murine Trial.

Lewis AJ, Griepentrog JE, Zhang X, Angus DC, Seymour CW, Rosengart MR.

Crit Care Med. 2018 May;46(5):e426-e434. doi: 10.1097/CCM.0000000000003004.


Using incentives to recruit physicians into behavioral trials: lessons learned from four studies.

Mohan D, Rosengart MR, Fischhoff B, Angus DC, Wallace DJ, Farris C, Yealy DM, Barnato AE.

BMC Res Notes. 2017 Dec 28;10(1):776. doi: 10.1186/s13104-017-3101-z.


Speed is not everything: Identifying patients who may benefit from helicopter transport despite faster ground transport.

Chen X, Gestring ML, Rosengart MR, Billiar TR, Peitzman AB, Sperry JL, Brown JB.

J Trauma Acute Care Surg. 2018 Apr;84(4):549-557. doi: 10.1097/TA.0000000000001769.


Efficacy of educational video game versus traditional educational apps at improving physician decision making in trauma triage: randomized controlled trial.

Mohan D, Farris C, Fischhoff B, Rosengart MR, Angus DC, Yealy DM, Wallace DJ, Barnato AE.

BMJ. 2017 Dec 12;359:j5416. doi: 10.1136/bmj.j5416.


Comparing the Air Medical Prehospital Triage Score With Current Practice for Triage of Injured Patients to Helicopter Emergency Medical Services: A Cost-effectiveness Analysis.

Brown JB, Smith KJ, Gestring ML, Rosengart MR, Billiar TR, Peitzman AB, Sperry JL, Weissman JS.

JAMA Surg. 2018 Mar 1;153(3):261-268. doi: 10.1001/jamasurg.2017.4485. No abstract available.


Calcium/calmodulin-dependent protein kinase regulates the PINK1/Parkin and DJ-1 pathways of mitophagy during sepsis.

Zhang X, Yuan D, Sun Q, Xu L, Lee E, Lewis AJ, Zuckerbraun BS, Rosengart MR.

FASEB J. 2017 Oct;31(10):4382-4395. doi: 10.1096/fj.201601096RRR. Epub 2017 Jun 14.


Should All Massively Transfused Patients Be Treated Equally? An Analysis of Massive Transfusion Ratios in the Nontrauma Setting.

Etchill EW, Myers SP, McDaniel LM, Rosengart MR, Raval JS, Triulzi DJ, Peitzman AB, Sperry JL, Neal MD.

Crit Care Med. 2017 Aug;45(8):1311-1316. doi: 10.1097/CCM.0000000000002498.


Distance matters: Effect of geographic trauma system resource organization on fatal motor vehicle collisions.

Brown JB, Rosengart MR, Billiar TR, Peitzman AB, Sperry JL.

J Trauma Acute Care Surg. 2017 Jul;83(1):111-118. doi: 10.1097/TA.0000000000001508.


Management and Novel Adjuncts of Necrotizing Soft Tissue Infections.

Cocanour CS, Chang P, Huston JM, Adams CA Jr, Diaz JJ, Wessel CB, Falcione BA, Bauza GM, Forsythe RA, Rosengart MR.

Surg Infect (Larchmt). 2017 Apr;18(3):250-272. doi: 10.1089/sur.2016.200. Epub 2017 Apr 4. Review.


The Surgical Infection Society Revised Guidelines on the Management of Intra-Abdominal Infection.

Mazuski JE, Tessier JM, May AK, Sawyer RG, Nadler EP, Rosengart MR, Chang PK, O'Neill PJ, Mollen KP, Huston JM, Diaz JJ Jr, Prince JM.

Surg Infect (Larchmt). 2017 Jan;18(1):1-76. doi: 10.1089/sur.2016.261.


Factors Associated With Nontransfer in Trauma Patients Meeting American College of Surgeons' Criteria for Transfer at Nontertiary Centers.

Zhou Q, Rosengart MR, Billiar TR, Peitzman AB, Sperry JL, Brown JB.

JAMA Surg. 2017 Apr 1;152(4):369-376. doi: 10.1001/jamasurg.2016.4976.


External validation of the Air Medical Prehospital Triage score for identifying trauma patients likely to benefit from scene helicopter transport.

Brown JB, Gestring ML, Guyette FX, Rosengart MR, Stassen NA, Forsythe RM, Billiar TR, Peitzman AB, Sperry JL.

J Trauma Acute Care Surg. 2017 Feb;82(2):270-279. doi: 10.1097/TA.0000000000001326.


Surgical rescue: The next pillar of acute care surgery.

Kutcher ME, Sperry JL, Rosengart MR, Mohan D, Hoffman MK, Neal MD, Alarcon LH, Watson GA, Puyana JC, Bauzá GM, Schuchert VD, Fombona A, Zhou T, Zolin SJ, Becher RD, Billiar TR, Forsythe RM, Zuckerbraun BS, Peitzman AB.

J Trauma Acute Care Surg. 2017 Feb;82(2):280-286. doi: 10.1097/TA.0000000000001312.


Testing a videogame intervention to recalibrate physician heuristics in trauma triage: study protocol for a randomized controlled trial.

Mohan D, Rosengart MR, Fischhoff B, Angus DC, Farris C, Yealy DM, Wallace DJ, Barnato AE.

BMC Emerg Med. 2016 Nov 11;16(1):44.


Surgical Infection Society Curriculum Development Symposium: An Overview.

Chipman JG, Rosengart MR, Issa N, O'Neill PJ, Upperman JS.

Surg Infect (Larchmt). 2016 Dec;17(6):665-674. Epub 2016 Sep 16. Review.


Impact of Volume Change Over Time on Trauma Mortality in the United States.

Brown JB, Rosengart MR, Kahn JM, Mohan D, Zuckerbraun BS, Billiar TR, Peitzman AB, Angus DC, Sperry JL.

Ann Surg. 2017 Jul;266(1):173-178. doi: 10.1097/SLA.0000000000001838.


Current Murine Models of Sepsis.

Lewis AJ, Seymour CW, Rosengart MR.

Surg Infect (Larchmt). 2016 Aug;17(4):385-93. doi: 10.1089/sur.2016.021. Epub 2016 Jun 15. Review. No abstract available.


Blue light reduces organ injury from ischemia and reperfusion.

Yuan D, Collage RD, Huang H, Zhang X, Kautza BC, Lewis AJ, Zuckerbraun BS, Tsung A, Angus DC, Rosengart MR.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):5239-44. doi: 10.1073/pnas.1515296113. Epub 2016 Apr 25.


Biology and Metabolism of Sepsis: Innate Immunity, Bioenergetics, and Autophagy.

Lewis AJ, Billiar TR, Rosengart MR.

Surg Infect (Larchmt). 2016 Jun;17(3):286-93. doi: 10.1089/sur.2015.262. Epub 2016 Apr 19. Review.


Not all prehospital time is equal: Influence of scene time on mortality.

Brown JB, Rosengart MR, Forsythe RM, Reynolds BR, Gestring ML, Hallinan WM, Peitzman AB, Billiar TR, Sperry JL.

J Trauma Acute Care Surg. 2016 Jul;81(1):93-100. doi: 10.1097/TA.0000000000000999.


Use of Biotelemetry to Define Physiology-Based Deterioration Thresholds in a Murine Cecal Ligation and Puncture Model of Sepsis.

Lewis AJ, Yuan D, Zhang X, Angus DC, Rosengart MR, Seymour CW.

Crit Care Med. 2016 Jun;44(6):e420-31. doi: 10.1097/CCM.0000000000001615.


Bedside Ultrasonography for Diagnosis of Septic Shock--Reply.

Seymour CW, Rosengart MR.

JAMA. 2016 Jan 5;315(1):89-90. doi: 10.1001/jama.2015.15073. No abstract available.


Helicopter transport improves survival following injury in the absence of a time-saving advantage.

Brown JB, Gestring ML, Guyette FX, Rosengart MR, Stassen NA, Forsythe RM, Billiar TR, Peitzman AB, Sperry JL.

Surgery. 2016 Mar;159(3):947-59. doi: 10.1016/j.surg.2015.09.015. Epub 2015 Oct 23.


Geographic distribution of trauma centers and injury-related mortality in the United States.

Brown JB, Rosengart MR, Billiar TR, Peitzman AB, Sperry JL.

J Trauma Acute Care Surg. 2016 Jan;80(1):42-9; discussion 49-50. doi: 10.1097/TA.0000000000000902.


Development and Validation of the Air Medical Prehospital Triage Score for Helicopter Transport of Trauma Patients.

Brown JB, Gestring ML, Guyette FX, Rosengart MR, Stassen NA, Forsythe RM, Billiar TR, Peitzman AB, Sperry JL.

Ann Surg. 2016 Aug;264(2):378-85. doi: 10.1097/SLA.0000000000001496.


Redefining acute care surgery: Surgical rescue.

Peitzman AB, Sperry JL, Kutcher ME, Zuckerbraun BS, Forsythe RM, Billiar TR, Alarcon L, Rosengart MR, Mohan D, Watson G, Puyana JC, Bauza G, Schuchert VD, Neal MD.

J Trauma Acute Care Surg. 2015 Aug;79(2):327. No abstract available.


Inhaled Carbon Monoxide Protects against the Development of Shock and Mitochondrial Injury following Hemorrhage and Resuscitation.

Gomez H, Kautza B, Escobar D, Nassour I, Luciano J, Botero AM, Gordon L, Martinez S, Holder A, Ogundele O, Loughran P, Rosengart MR, Pinsky M, Shiva S, Zuckerbraun BS.

PLoS One. 2015 Sep 14;10(9):e0135032. doi: 10.1371/journal.pone.0135032. eCollection 2015.


Prior inpatient admission increases the risk of post-operative infection in hepatobiliary and pancreatic surgery.

Dong ZM, Chidi AP, Goswami J, Han K, Simmons RL, Rosengart MR, Tsung A.

HPB (Oxford). 2015 Dec;17(12):1105-12. doi: 10.1111/hpb.12499. Epub 2015 Sep 3.


Surgical Rescue: An Essential Component of Acute Care Surgery.

Peitzman AB, Leppäniemi A, Kutcher ME, Forsythe RM, Rosengart MR, Sperry JL, Zuckerbraun BS.

Scand J Surg. 2015 Sep;104(3):135-6. doi: 10.1177/1457496915600955. No abstract available.


Septic Shock: Advances in Diagnosis and Treatment.

Seymour CW, Rosengart MR.

JAMA. 2015 Aug 18;314(7):708-17. doi: 10.1001/jama.2015.7885. Review. Erratum in: JAMA. 2015 Oct 6;314(13):1404.


The early evolving sex hormone environment is associated with significant outcome and inflammatory response differences after injury.

Zolin SJ, Vodovotz Y, Forsythe RM, Rosengart MR, Namas R, Brown JB, Peitzman AP, Billiar TR, Sperry JL.

J Trauma Acute Care Surg. 2015 Mar;78(3):451-7; discussion 457-8. doi: 10.1097/TA.0000000000000550.


Adenosine monophosphate-activated protein kinase activation protects against sepsis-induced organ injury and inflammation.

Escobar DA, Botero-Quintero AM, Kautza BC, Luciano J, Loughran P, Darwiche S, Rosengart MR, Zuckerbraun BS, Gomez H.

J Surg Res. 2015 Mar;194(1):262-72. doi: 10.1016/j.jss.2014.10.009. Epub 2014 Oct 8.


X chromosome-linked IRAK-1 polymorphism is a strong predictor of multiple organ failure and mortality postinjury.

Sperry JL, Zolin S, Zuckerbraun BS, Vodovotz Y, Namas R, Neal MD, Ferrell RE, Rosengart MR, Peitzman AB, Billiar TR.

Ann Surg. 2014 Oct;260(4):698-703; discussion 703-5. doi: 10.1097/SLA.0000000000000918.


Evaluating for acute mesenteric ischemia in critically ill patients: diagnostic peritoneal lavage is associated with reduced operative intervention and mortality.

Lee MJ, Sperry JL, Rosengart MR.

J Trauma Acute Care Surg. 2014 Sep;77(3):441-7. doi: 10.1097/TA.0000000000000381.


Assessing the validity of using serious game technology to analyze physician decision making.

Mohan D, Angus DC, Ricketts D, Farris C, Fischhoff B, Rosengart MR, Yealy DM, Barnato AE.

PLoS One. 2014 Aug 25;9(8):e105445. doi: 10.1371/journal.pone.0105445. eCollection 2014.


CaMKIV-dependent preservation of mTOR expression is required for autophagy during lipopolysaccharide-induced inflammation and acute kidney injury.

Zhang X, Howell GM, Guo L, Collage RD, Loughran PA, Zuckerbraun BS, Rosengart MR.

J Immunol. 2014 Sep 1;193(5):2405-15. doi: 10.4049/jimmunol.1302798. Epub 2014 Jul 28.


Triage patterns for medicare patients presenting to nontrauma hospitals with moderate or severe injuries.

Mohan D, Barnato AE, Rosengart MR, Angus DC, Wallace DJ, Kahn JM.

Ann Surg. 2015 Feb;261(2):383-9. doi: 10.1097/SLA.0000000000000603.


Determining a core curriculum in surgical infections for fellowship training in acute care surgery using the Delphi technique.

May AK, Cuschieri J, Johnson JL, Duane TM, Cherry-Bukowiec JR, Rosengart MR.

Surg Infect (Larchmt). 2013 Dec;14(6):547-53. doi: 10.1089/sur.2012.202.


Validating a vignette-based instrument to study physician decision making in trauma triage.

Mohan D, Fischhoff B, Farris C, Switzer GE, Rosengart MR, Yealy DM, Saul M, Angus DC, Barnato AE.

Med Decis Making. 2014 Feb;34(2):242-52. doi: 10.1177/0272989X13508007. Epub 2013 Oct 14.


Thrombospondin-1 triggers macrophage IL-10 production and promotes resolution of experimental lung injury.

Zhao Y, Xiong Z, Lechner EJ, Klenotic PA, Hamburg BJ, Hulver M, Khare A, Oriss T, Mangalmurti N, Chan Y, Zhang Y, Ross MA, Stolz DB, Rosengart MR, Pilewski J, Ray P, Ray A, Silverstein RL, Lee JS.

Mucosal Immunol. 2014 Mar;7(2):440-8. doi: 10.1038/mi.2013.63. Epub 2013 Sep 18.

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