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Items: 40

1.

The Novel Phosphodiesterase 9A Inhibitor BI 409306 Increases Cyclic Guanosine Monophosphate Levels in the Brain, Promotes Synaptic Plasticity, and Enhances Memory Function in Rodents.

Rosenbrock H, Giovannini R, Schänzle G, Koros E, Runge F, Fuchs H, Marti A, Reymann KG, Schröder UH, Fedele E, Dorner-Ciossek C.

J Pharmacol Exp Ther. 2019 Dec;371(3):633-641. doi: 10.1124/jpet.119.260059. Epub 2019 Oct 2.

PMID:
31578258
2.
3.

Evaluation of Pharmacokinetics and Pharmacodynamics of BI 425809, a Novel GlyT1 Inhibitor: Translational Studies.

Rosenbrock H, Desch M, Kleiner O, Dorner-Ciossek C, Schmid B, Keller S, Schlecker C, Moschetti V, Goetz S, Liesenfeld KH, Fillon G, Giovannini R, Ramael S, Wunderlich G, Wind S.

Clin Transl Sci. 2018 Nov;11(6):616-623. doi: 10.1111/cts.12578. Epub 2018 Aug 23.

4.

Targeting the dopamine D1 receptor or its downstream signalling by inhibiting phosphodiesterase-1 improves cognitive performance.

Pekcec A, Schülert N, Stierstorfer B, Deiana S, Dorner-Ciossek C, Rosenbrock H.

Br J Pharmacol. 2018 Jul;175(14):3021-3033. doi: 10.1111/bph.14350. Epub 2018 Jun 3.

5.

The safety, tolerability and pharmacokinetics of BI 409306, a novel and potent PDE9 inhibitor: Overview of three Phase I randomised trials in healthy volunteers.

Moschetti V, Kim M, Sand M, Wunderlich G, Andersen G, Feifel U, Jang IJ, Timmer W, Rosenbrock H, Boland K.

Eur Neuropsychopharmacol. 2018 May;28(5):643-655. doi: 10.1016/j.euroneuro.2018.01.003. Epub 2018 Mar 19.

6.

sAPPβ and sAPPα increase structural complexity and E/I input ratio in primary hippocampal neurons and alter Ca2+ homeostasis and CREB1-signaling.

Hesse R, von Einem B, Wagner F, Bott P, Schwanzar D, Jackson RJ, Föhr KJ, Lausser L, Kroker KS, Proepper C, Walther P, Kestler HA, Spires-Jones TL, Boeckers T, Rosenbrock H, von Arnim CAF.

Exp Neurol. 2018 Jun;304:1-13. doi: 10.1016/j.expneurol.2018.02.010. Epub 2018 Feb 18.

PMID:
29466703
7.

Safety, Tolerability and Pharmacokinetics of Oral BI 425809, a Glycine Transporter 1 Inhibitor, in Healthy Male Volunteers: A Partially Randomised, Single-Blind, Placebo-Controlled, First-in-Human Study.

Moschetti V, Desch M, Goetz S, Liesenfeld KH, Rosenbrock H, Kammerer KP, Wunderlich G, Wind S.

Eur J Drug Metab Pharmacokinet. 2018 Apr;43(2):239-249. doi: 10.1007/s13318-017-0440-z.

8.

Role of PDE9 in Cognition.

Dorner-Ciossek C, Kroker KS, Rosenbrock H.

Adv Neurobiol. 2017;17:231-254. doi: 10.1007/978-3-319-58811-7_9. Review.

PMID:
28956335
9.

Pharmaceutical Characterization of Tropomyosin Receptor Kinase B-Agonistic Antibodies on Human Induced Pluripotent Stem (hiPS) Cell-Derived Neurons.

Traub S, Stahl H, Rosenbrock H, Simon E, Florin L, Hospach L, Hörer S, Heilker R.

J Pharmacol Exp Ther. 2017 Jun;361(3):355-365. doi: 10.1124/jpet.117.240184. Epub 2017 Mar 28.

PMID:
28351853
10.

Reduced cGMP levels in CSF of AD patients correlate with severity of dementia and current depression.

Hesse R, Lausser L, Gummert P, Schmid F, Wahler A, Schnack C, Kroker KS, Otto M, Tumani H, Kestler HA, Rosenbrock H, von Arnim CA.

Alzheimers Res Ther. 2017 Mar 9;9(1):17. doi: 10.1186/s13195-017-0245-y.

11.

Upscaling of hiPS Cell-Derived Neurons for High-Throughput Screening.

Traub S, Stahl H, Rosenbrock H, Simon E, Heilker R.

SLAS Discov. 2017 Mar;22(3):274-286. doi: 10.1177/1087057116678161. Epub 2016 Nov 16.

PMID:
28231034
12.

Overexpression of Protein Kinase Mζ in the Hippocampus Enhances Long-Term Potentiation and Long-Term Contextual But Not Cued Fear Memory in Rats.

Schuette SR, Fernández-Fernández D, Lamla T, Rosenbrock H, Hobson S.

J Neurosci. 2016 Apr 13;36(15):4313-24. doi: 10.1523/JNEUROSCI.3600-15.2016.

13.

Age-related synaptic dysfunction in Tg2576 mice starts as a failure in early long-term potentiation which develops into a full abolishment of late long-term potentiation.

Fernández-Fernández D, Dorner-Ciossek C, Kroker KS, Rosenbrock H.

J Neurosci Res. 2016 Mar;94(3):266-81. doi: 10.1002/jnr.23701. Epub 2015 Dec 2.

PMID:
26629777
14.

Inhibition of PDE2A, but not PDE9A, modulates presynaptic short-term plasticity measured by paired-pulse facilitation in the CA1 region of the hippocampus.

Fernández-Fernández D, Rosenbrock H, Kroker KS.

Synapse. 2015 Oct;69(10):484-96. doi: 10.1002/syn.21840. Epub 2015 Jul 29.

PMID:
26178667
15.

Touchscreen tasks in mice to demonstrate differences between hippocampal and striatal functions.

Delotterie DF, Mathis C, Cassel JC, Rosenbrock H, Dorner-Ciossek C, Marti A.

Neurobiol Learn Mem. 2015 Apr;120:16-27. doi: 10.1016/j.nlm.2015.02.007. Epub 2015 Feb 14.

PMID:
25687692
16.

PDE9A inhibition rescues amyloid beta-induced deficits in synaptic plasticity and cognition.

Kroker KS, Mathis C, Marti A, Cassel JC, Rosenbrock H, Dorner-Ciossek C.

Neurobiol Aging. 2014 Sep;35(9):2072-8. doi: 10.1016/j.neurobiolaging.2014.03.023. Epub 2014 Mar 26.

PMID:
24746365
17.

Restoring long-term potentiation impaired by amyloid-beta oligomers: comparison of an acetylcholinesterase inhibitior and selective neuronal nicotinic receptor agonists.

Kroker KS, Moreth J, Kussmaul L, Rast G, Rosenbrock H.

Brain Res Bull. 2013 Jul;96:28-38. doi: 10.1016/j.brainresbull.2013.04.006. Epub 2013 Apr 29.

PMID:
23639920
18.

Globular and protofibrillar aβ aggregates impair neurotransmission by different mechanisms.

Moreth J, Kroker KS, Schwanzar D, Schnack C, von Arnim CA, Hengerer B, Rosenbrock H, Kussmaul L.

Biochemistry. 2013 Feb 26;52(8):1466-76. doi: 10.1021/bi3016444. Epub 2013 Feb 14.

PMID:
23374097
19.

Inhibition of acetylcholinesterase and phosphodiesterase-9A has differential effects on hippocampal early and late LTP.

Kroker KS, Rast G, Giovannini R, Marti A, Dorner-Ciossek C, Rosenbrock H.

Neuropharmacology. 2012 Apr;62(5-6):1964-74. doi: 10.1016/j.neuropharm.2011.12.021. Epub 2012 Jan 4.

PMID:
22245562
20.

Differential effects of subtype-specific nicotinic acetylcholine receptor agonists on early and late hippocampal LTP.

Kroker KS, Rast G, Rosenbrock H.

Eur J Pharmacol. 2011 Dec 5;671(1-3):26-32. doi: 10.1016/j.ejphar.2011.09.167. Epub 2011 Sep 24.

PMID:
21968142
21.

Differential effect of the mGlu5 receptor positive allosteric modulator ADX-47273 on early and late hippocampal LTP.

Kroker KS, Rast G, Rosenbrock H.

Neuropharmacology. 2011 Sep;61(4):707-14. doi: 10.1016/j.neuropharm.2011.05.014. Epub 2011 May 27.

PMID:
21640734
22.

A multi-slice recording system for stable late phase hippocampal long-term potentiation experiments.

Kroker KS, Rosenbrock H, Rast G.

J Neurosci Methods. 2011 Jan 15;194(2):394-401. doi: 10.1016/j.jneumeth.2010.11.006. Epub 2010 Nov 16.

PMID:
21087635
23.

Functional interaction of metabotropic glutamate receptor 5 and NMDA-receptor by a metabotropic glutamate receptor 5 positive allosteric modulator.

Rosenbrock H, Kramer G, Hobson S, Koros E, Grundl M, Grauert M, Reymann KG, Schröder UH.

Eur J Pharmacol. 2010 Aug 10;639(1-3):40-6. doi: 10.1016/j.ejphar.2010.02.057. Epub 2010 Apr 2.

PMID:
20371241
24.

Sub-chronic rolipram treatment leads to a persistent improvement in long-term object memory in rats.

Rutten K, Prickaerts J, Schaenzle G, Rosenbrock H, Blokland A.

Neurobiol Learn Mem. 2008 Oct;90(3):569-75. doi: 10.1016/j.nlm.2008.04.016. Epub 2008 Jun 16.

PMID:
18558503
25.

Automated classification of the behavior of rats in the forced swimming test with support vector machines.

Fröhlich H, Hoenselaar A, Eichner J, Rosenbrock H, Birk G, Zell A.

Neural Netw. 2008 Jan;21(1):92-101. Epub 2007 Nov 29.

PMID:
18158234
27.

The selective mGlu5 receptor antagonist MTEP, similar to NMDA receptor antagonists, induces social isolation in rats.

Koros E, Rosenbrock H, Birk G, Weiss C, Sams-Dodd F.

Neuropsychopharmacology. 2007 Mar;32(3):562-76. Epub 2006 Jun 14.

28.

Prophylaxis of contrast material-induced nephropathy in patients in intensive care: acetylcysteine, theophylline, or both? A randomized study.

Huber W, Eckel F, Hennig M, Rosenbrock H, Wacker A, Saur D, Sennefelder A, Hennico R, Schenk C, Meining A, Schmelz R, Fritsch R, Weiss W, Hamar P, Heemann U, Schmid RM.

Radiology. 2006 Jun;239(3):793-804.

PMID:
16714461
29.
30.
31.

Identification, induction and localization of cytochrome P450s of the 3A-subfamily in mouse brain.

Rosenbrock H, Hagemeyer CE, Ditter M, Knoth R, Volk B.

Neurotox Res. 2001 Aug;3(4):339-49.

PMID:
14715464
32.

Targeting of hematopoietic progenitor cells with MR contrast agents.

Daldrup-Link HE, Rudelius M, Oostendorp RA, Settles M, Piontek G, Metz S, Rosenbrock H, Keller U, Heinzmann U, Rummeny EJ, Schlegel J, Link TM.

Radiology. 2003 Sep;228(3):760-7. Epub 2003 Jul 24.

PMID:
12881578
33.

Predominantly neuronal expression of cytochrome P450 isoforms CYP3A11 and CYP3A13 in mouse brain.

Hagemeyer CE, Rosenbrock H, Ditter M, Knoth R, Volk B.

Neuroscience. 2003;117(3):521-9.

PMID:
12617959
34.

Systemic inflammation leads to resistance to atracurium without increasing membrane expression of acetylcholine receptors.

Fink H, Luppa P, Mayer B, Rosenbrock H, Metzger J, Martyn JA, Blobner M.

Anesthesiology. 2003 Jan;98(1):82-8.

PMID:
12502983
35.

Synaptic vesicle protein synaptoporin is differently expressed by subpopulations of mouse hippocampal neurons.

Singec I, Knoth R, Ditter M, Hagemeyer CE, Rosenbrock H, Frotscher M, Volk B.

J Comp Neurol. 2002 Oct 14;452(2):139-53.

PMID:
12271488
36.

Changes of biochemical bone markers during the menopausal transition.

Rosenbrock H, Seifert-Klauss V, Kaspar S, Busch R, Luppa PB.

Clin Chem Lab Med. 2002 Feb;40(2):143-51.

PMID:
11939487
37.

Expression and localization of the CYP2B subfamily predominantly in neurones of rat brain.

Rosenbrock H, Hagemeyer CE, Ditter M, Knoth R, Volk B.

J Neurochem. 2001 Jan;76(2):332-40.

38.

Different testosterone metabolism by immortalized embryonic and postnatal hippocampal neurons from C57BL/6 mice: a crucial role for androstenedione.

Hagemeyer CE, Rosenbrock H, Singec I, Knoth R, Volk B.

J Neurosci Res. 2000 Apr 1;60(1):106-15.

PMID:
10723073
39.

Testosterone metabolism in rat brain is differentially enhanced by phenytoin-inducible cytochrome P450 isoforms.

Rosenbrock H, Hagemeyer CE, Singeç I, Knoth R, Volk B.

J Neuroendocrinol. 1999 Aug;11(8):597-604.

PMID:
10447797
40.

DNA isolation from recalcitrant materials such as tree roots, bark, and forest soil for the detection of fungal pathogens by polymerase chain reaction.

Bahnweg G, Schulze S, Möller EM, Rosenbrock H, Langebartels C, Sandermann H Jr.

Anal Biochem. 1998 Aug 15;262(1):79-82. No abstract available.

PMID:
9735151

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