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Items: 23


Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy.

Lee JK, Liu Z, Sa JK, Shin S, Wang J, Bordyuh M, Cho HJ, Elliott O, Chu T, Choi SW, Rosenbloom DIS, Lee IH, Shin YJ, Kang HJ, Kim D, Kim SY, Sim MH, Kim J, Lee T, Seo YJ, Shin H, Lee M, Kim SH, Kwon YJ, Oh JW, Song M, Kim M, Kong DS, Choi JW, Seol HJ, Lee JI, Kim ST, Park JO, Kim KM, Song SY, Lee JW, Kim HC, Lee JE, Choi MG, Seo SW, Shim YM, Zo JI, Jeong BC, Yoon Y, Ryu GH, Kim NKD, Bae JS, Park WY, Lee J, Verhaak RGW, Iavarone A, Lee J, Rabadan R, Nam DH.

Nat Genet. 2018 Oct;50(10):1399-1411. doi: 10.1038/s41588-018-0209-6. Epub 2018 Sep 27.


Insight into treatment of HIV infection from viral dynamics models.

Hill AL, Rosenbloom DIS, Nowak MA, Siliciano RF.

Immunol Rev. 2018 Sep;285(1):9-25. doi: 10.1111/imr.12698.


Life cycle synchronization is a viral drug resistance mechanism.

Neagu IA, Olejarz J, Freeman M, Rosenbloom DIS, Nowak MA, Hill AL.

PLoS Comput Biol. 2018 Feb 15;14(2):e1005947. doi: 10.1371/journal.pcbi.1005947. eCollection 2018 Feb.


Re-evaluating evolution in the HIV reservoir.

Rosenbloom DIS, Hill AL, Laskey SB, Siliciano RF.

Nature. 2017 Nov 22;551(7681):E6-E9. doi: 10.1038/nature24634. No abstract available.


Correction: Real-Time Predictions of Reservoir Size and Rebound Time during Antiretroviral Therapy Interruption Trials for HIV.

Hill AL, Rosenbloom DIS, Goldstein E, Hanhauser E, Kuritzkes DR, Siliciano RF, Henrich TJ.

PLoS Pathog. 2017 Jul 6;13(7):e1006488. doi: 10.1371/journal.ppat.1006488. eCollection 2017 Jul.


Proliferation of latently infected CD4+ T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics.

Hosmane NN, Kwon KJ, Bruner KM, Capoferri AA, Beg S, Rosenbloom DI, Keele BF, Ho YC, Siliciano JD, Siliciano RF.

J Exp Med. 2017 Apr 3;214(4):959-972. doi: 10.1084/jem.20170193. Epub 2017 Mar 24.


Evolutionary scalpels for dissecting tumor ecosystems.

Rosenbloom DIS, Camara PG, Chu T, Rabadan R.

Biochim Biophys Acta Rev Cancer. 2017 Apr;1867(2):69-83. doi: 10.1016/j.bbcan.2016.11.005. Epub 2016 Dec 5. Review.


Insufficient Evidence for Rare Activation of Latent HIV in the Absence of Reservoir-Reducing Interventions.

Hill AL, Rosenbloom DI, Siliciano JD, Siliciano RF.

PLoS Pathog. 2016 Aug 25;12(8):e1005679. doi: 10.1371/journal.ppat.1005679. eCollection 2016 Aug. No abstract available.


Topological Data Analysis Generates High-Resolution, Genome-wide Maps of Human Recombination.

Camara PG, Rosenbloom DI, Emmett KJ, Levine AJ, Rabadan R.

Cell Syst. 2016 Jul;3(1):83-94. doi: 10.1016/j.cels.2016.05.008. Epub 2016 Jun 23.


Clonal evolution of glioblastoma under therapy.

Wang J, Cazzato E, Ladewig E, Frattini V, Rosenbloom DI, Zairis S, Abate F, Liu Z, Elliott O, Shin YJ, Lee JK, Lee IH, Park WY, Eoli M, Blumberg AJ, Lasorella A, Nam DH, Finocchiaro G, Iavarone A, Rabadan R.

Nat Genet. 2016 Jul;48(7):768-76. doi: 10.1038/ng.3590. Epub 2016 Jun 6.


Real-Time Predictions of Reservoir Size and Rebound Time during Antiretroviral Therapy Interruption Trials for HIV.

Hill AL, Rosenbloom DI, Goldstein E, Hanhauser E, Kuritzkes DR, Siliciano RF, Henrich TJ.

PLoS Pathog. 2016 Apr 27;12(4):e1005535. doi: 10.1371/journal.ppat.1005535. eCollection 2016 Apr. Erratum in: PLoS Pathog. 2017 Jul 6;13(7):e1006488. PLoS Pathog. 2016 Jul;12(7):e1005778.


Measuring the Frequency of Latent HIV-1 in Resting CD4⁺ T Cells Using a Limiting Dilution Coculture Assay.

Laird GM, Rosenbloom DI, Lai J, Siliciano RF, Siliciano JD.

Methods Mol Biol. 2016;1354:239-53. doi: 10.1007/978-1-4939-3046-3_16.


Designing and Interpreting Limiting Dilution Assays: General Principles and Applications to the Latent Reservoir for Human Immunodeficiency Virus-1.

Rosenbloom DI, Elliott O, Hill AL, Henrich TJ, Siliciano JM, Siliciano RF.

Open Forum Infect Dis. 2015 Aug 26;2(4):ofv123. doi: 10.1093/ofid/ofv123. eCollection 2015 Dec. Review.


Imperfect drug penetration leads to spatial monotherapy and rapid evolution of multidrug resistance.

Moreno-Gamez S, Hill AL, Rosenbloom DI, Petrov DA, Nowak MA, Pennings PS.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):E2874-83. doi: 10.1073/pnas.1424184112. Epub 2015 May 18.


Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations.

Laird GM, Bullen CK, Rosenbloom DI, Martin AR, Hill AL, Durand CM, Siliciano JD, Siliciano RF.

J Clin Invest. 2015 May;125(5):1901-12. doi: 10.1172/JCI80142. Epub 2015 Mar 30.


Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1.

Hill AL, Rosenbloom DI, Fu F, Nowak MA, Siliciano RF.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13475-80. doi: 10.1073/pnas.1406663111. Epub 2014 Aug 5. Erratum in: Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15598.


Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys.

Whitney JB, Hill AL, Sanisetty S, Penaloza-MacMaster P, Liu J, Shetty M, Parenteau L, Cabral C, Shields J, Blackmore S, Smith JY, Brinkman AL, Peter LE, Mathew SI, Smith KM, Borducchi EN, Rosenbloom DI, Lewis MG, Hattersley J, Li B, Hesselgesser J, Geleziunas R, Robb ML, Kim JH, Michael NL, Barouch DH.

Nature. 2014 Aug 7;512(7512):74-7. doi: 10.1038/nature13594. Epub 2014 Jul 20.


Frequency-dependent selection can lead to evolution of high mutation rates.

Rosenbloom DI, Allen B.

Am Nat. 2014 May;183(5):E131-53. doi: 10.1086/675505. Epub 2014 Apr 7.


Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure.

Ho YC, Shan L, Hosmane NN, Wang J, Laskey SB, Rosenbloom DI, Lai J, Blankson JN, Siliciano JD, Siliciano RF.

Cell. 2013 Oct 24;155(3):540-51. doi: 10.1016/j.cell.2013.09.020. Epub 2013 Oct 24.


Antiretroviral dynamics determines HIV evolution and predicts therapy outcome.

Rosenbloom DI, Hill AL, Rabi SA, Siliciano RF, Nowak MA.

Nat Med. 2012 Sep;18(9):1378-85.


Mutation rate evolution in replicator dynamics.

Allen B, Rosenbloom DI.

Bull Math Biol. 2012 Nov;74(11):2650-75. doi: 10.1007/s11538-012-9771-8. Epub 2012 Sep 1.


Evolutionary dynamics of HIV at multiple spatial and temporal scales.

Hill AL, Rosenbloom DI, Nowak MA.

J Mol Med (Berl). 2012 May;90(5):543-61. doi: 10.1007/s00109-012-0892-1. Epub 2012 May 3. Review.


Imitation dynamics of vaccination behaviour on social networks.

Fu F, Rosenbloom DI, Wang L, Nowak MA.

Proc Biol Sci. 2011 Jan 7;278(1702):42-9. doi: 10.1098/rspb.2010.1107. Epub 2010 Jul 28.

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