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Items: 1 to 50 of 147

1.

Rate-limiting step in the decarbamoylation of acetylcholinesterases with large carbamoyl groups.

Rosenberry TL, Cheung J.

Chem Biol Interact. 2019 Aug 1;308:392-395. doi: 10.1016/j.cbi.2019.06.004. Epub 2019 Jun 6. Review.

PMID:
31175846
2.

VEGF receptor-1 modulates amyloid β 1-42 oligomer-induced senescence in brain endothelial cells.

Singh Angom R, Wang Y, Wang E, Pal K, Bhattacharya S, Watzlawik JO, Rosenberry TL, Das P, Mukhopadhyay D.

FASEB J. 2019 Mar;33(3):4626-4637. doi: 10.1096/fj.201802003R. Epub 2018 Dec 21.

PMID:
30576228
3.

Decarbamoylation of acetylcholinesterases is markedly slowed as carbamoyl groups increase in size.

Venkatasubban KS, Johnson JL, Thomas JL, Fauq A, Cusack B, Rosenberry TL.

Arch Biochem Biophys. 2018 Oct 1;655:67-74. doi: 10.1016/j.abb.2018.08.006. Epub 2018 Aug 9.

4.

Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study.

Rosenberry TL, Brazzolotto X, Macdonald IR, Wandhammer M, Trovaslet-Leroy M, Darvesh S, Nachon F.

Molecules. 2017 Nov 29;22(12). pii: E2098. doi: 10.3390/molecules22122098.

5.

Distinct spatiotemporal accumulation of N-truncated and full-length amyloid-β42 in Alzheimer's disease.

Shinohara M, Koga S, Konno T, Nix J, Shinohara M, Aoki N, Das P, Parisi JE, Petersen RC, Rosenberry TL, Dickson DW, Bu G.

Brain. 2017 Dec 1;140(12):3301-3316. doi: 10.1093/brain/awx284.

6.

Blood-Based Oligomeric and Other Protein Variant Biomarkers to Facilitate Pre-Symptomatic Diagnosis and Staging of Alzheimer's Disease.

Williams SM, Schulz P, Rosenberry TL, Caselli RJ, Sierks MR.

J Alzheimers Dis. 2017;58(1):23-35. doi: 10.3233/JAD-161116.

PMID:
28372328
7.

Development of acetophenone ligands as potential neuroimaging agents for cholinesterases.

Jollymore-Hughes CT, Pottie IR, Martin E, Rosenberry TL, Darvesh S.

Bioorg Med Chem. 2016 Nov 1;24(21):5270-5279. doi: 10.1016/j.bmc.2016.08.048. Epub 2016 Aug 28.

PMID:
27637382
8.

Hopeahainol A binds reversibly at the acetylcholinesterase (AChE) peripheral site and inhibits enzyme activity with a novel higher order concentration dependence.

Rosenberry TL, Martin PK, Nix AJ, Wildman SA, Cheung J, Snyder SA, Tan RX.

Chem Biol Interact. 2016 Nov 25;259(Pt B):78-84. doi: 10.1016/j.cbi.2016.05.032. Epub 2016 Jun 11.

9.

Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation.

Zheng H, Liu CC, Atagi Y, Chen XF, Jia L, Yang L, He W, Zhang X, Kang SS, Rosenberry TL, Fryer JD, Zhang YW, Xu H, Bu G.

Neurobiol Aging. 2016 Jun;42:132-41. doi: 10.1016/j.neurobiolaging.2016.03.004. Epub 2016 Mar 16.

10.

Antiparallel β-Sheet Structure within the C-Terminal Region of 42-Residue Alzheimer's Amyloid-β Peptides When They Form 150-kDa Oligomers.

Huang D, Zimmerman MI, Martin PK, Nix AJ, Rosenberry TL, Paravastu AK.

J Mol Biol. 2015 Jul 3;427(13):2319-28. doi: 10.1016/j.jmb.2015.04.004. Epub 2015 Apr 16.

11.

Structures of human acetylcholinesterase bound to dihydrotanshinone I and territrem B show peripheral site flexibility.

Cheung J, Gary EN, Shiomi K, Rosenberry TL.

ACS Med Chem Lett. 2013 Sep 23;4(11):1091-6. doi: 10.1021/ml400304w. eCollection 2013 Nov 14.

12.

Acetylcholinesterase complexes with the natural product inhibitors dihydrotanshinone I and territrem B: binding site assignment from inhibitor competition and validation through crystal structure determination.

Cheung J, Beri V, Shiomi K, Rosenberry TL.

J Mol Neurosci. 2014 Jul;53(3):506-10. doi: 10.1007/s12031-014-0261-3. Epub 2014 Feb 27. Review.

PMID:
24573600
13.

The natural product dihydrotanshinone I provides a prototype for uncharged inhibitors that bind specifically to the acetylcholinesterase peripheral site with nanomolar affinity.

Beri V, Wildman SA, Shiomi K, Al-Rashid ZF, Cheung J, Rosenberry TL.

Biochemistry. 2013 Oct 22;52(42):7486-99. doi: 10.1021/bi401043w. Epub 2013 Oct 9.

PMID:
24040835
14.

The Alzheimer's amyloid-β(1-42) peptide forms off-pathway oligomers and fibrils that are distinguished structurally by intermolecular organization.

Tay WM, Huang D, Rosenberry TL, Paravastu AK.

J Mol Biol. 2013 Jul 24;425(14):2494-508. doi: 10.1016/j.jmb.2013.04.003. Epub 2013 Apr 11.

PMID:
23583777
15.

This special Issue of Chemico-Biological Interactions comprises 70 manuscripts from lectures and short talks given at the 11th International Meeting on Cholinesterases. Preface.

Lushchekina S, Masson P, Rosenberry TL; Guest-Editors.

Chem Biol Interact. 2013 Mar 25;203(1):1-2. doi: 10.1016/j.cbi.2013.03.002. No abstract available.

PMID:
23558087
16.

Hydrolysis of low concentrations of the acetylthiocholine analogs acetyl(homo)thiocholine and acetyl(nor)thiocholine by acetylcholinesterase may be limited by selective gating at the enzyme peripheral site.

Beri V, Auletta JT, Maharvi GM, Wood JF, Fauq AH, Rosenberry TL.

Chem Biol Interact. 2013 Mar 25;203(1):38-43. doi: 10.1016/j.cbi.2012.09.017. Epub 2012 Oct 6.

17.

Probing the peripheral site of human butyrylcholinesterase.

Macdonald IR, Martin E, Rosenberry TL, Darvesh S.

Biochemistry. 2012 Sep 11;51(36):7046-53. Epub 2012 Aug 27.

18.

A mass spectrometric approach for characterization of amyloid-β aggregates and identification of their post-translational modifications.

Tay WM, Bryant JG, Martin PK, Nix AJ, Cusack BM, Rosenberry TL.

Biochemistry. 2012 May 8;51(18):3759-66. doi: 10.1021/bi300316d. Epub 2012 Apr 25.

PMID:
22506642
19.

Drug-like leads for steric discrimination between substrate and inhibitors of human acetylcholinesterase.

Wildman SA, Zheng X, Sept D, Auletta JT, Rosenberry TL, Marshall GR.

Chem Biol Drug Des. 2011 Oct;78(4):495-504. doi: 10.1111/j.1747-0285.2011.01157.x. Epub 2011 Aug 22.

20.

Molecular basis of inhibition of substrate hydrolysis by a ligand bound to the peripheral site of acetylcholinesterase.

Auletta JT, Johnson JL, Rosenberry TL.

Chem Biol Interact. 2010 Sep 6;187(1-3):135-41. doi: 10.1016/j.cbi.2010.05.009. Epub 2010 May 21.

21.

Acetylcholinesterase: from 3D structure to function.

Dvir H, Silman I, Harel M, Rosenberry TL, Sussman JL.

Chem Biol Interact. 2010 Sep 6;187(1-3):10-22. doi: 10.1016/j.cbi.2010.01.042. Epub 2010 Feb 4.

22.

Biophysical analyses of synthetic amyloid-beta(1-42) aggregates before and after covalent cross-linking. Implications for deducing the structure of endogenous amyloid-beta oligomers.

Moore BD, Rangachari V, Tay WM, Milkovic NM, Rosenberry TL.

Biochemistry. 2009 Dec 15;48(49):11796-806. doi: 10.1021/bi901571t.

PMID:
19916493
23.

Strategies to resolve the catalytic mechanism of acetylcholinesterase.

Rosenberry TL.

J Mol Neurosci. 2010 Jan;40(1-2):32-9. doi: 10.1007/s12031-009-9250-3.

PMID:
19757206
24.

Rationally designed dehydroalanine (DeltaAla)-containing peptides inhibit amyloid-beta (Abeta) peptide aggregation.

Rangachari V, Davey ZS, Healy B, Moore BD, Sonoda LK, Cusack B, Maharvi GM, Fauq AH, Rosenberry TL.

Biopolymers. 2009 Jun;91(6):456-65. doi: 10.1002/bip.21151.

PMID:
19189374
25.

Analysis of the reaction of carbachol with acetylcholinesterase using thioflavin T as a coupled fluorescence reporter.

Rosenberry TL, Sonoda LK, Dekat SE, Cusack B, Johnson JL.

Biochemistry. 2008 Dec 9;47(49):13056-63. doi: 10.1021/bi8015197.

26.

Monitoring the reaction of carbachol with acetylcholinesterase by thioflavin T fluorescence and acetylthiocholine hydrolysis.

Rosenberry TL, Sonoda LK, Dekat SE, Cusack B, Johnson JL.

Chem Biol Interact. 2008 Sep 25;175(1-3):235-41. doi: 10.1016/j.cbi.2008.06.002. Epub 2008 Jun 17.

27.

Substrate-targeting gamma-secretase modulators.

Kukar TL, Ladd TB, Bann MA, Fraering PC, Narlawar R, Maharvi GM, Healy B, Chapman R, Welzel AT, Price RW, Moore B, Rangachari V, Cusack B, Eriksen J, Jansen-West K, Verbeeck C, Yager D, Eckman C, Ye W, Sagi S, Cottrell BA, Torpey J, Rosenberry TL, Fauq A, Wolfe MS, Schmidt B, Walsh DM, Koo EH, Golde TE.

Nature. 2008 Jun 12;453(7197):925-9. doi: 10.1038/nature07055.

28.
29.

Amyloid-beta(1-42) rapidly forms protofibrils and oligomers by distinct pathways in low concentrations of sodium dodecylsulfate.

Rangachari V, Moore BD, Reed DK, Sonoda LK, Bridges AW, Conboy E, Hartigan D, Rosenberry TL.

Biochemistry. 2007 Oct 30;46(43):12451-62. Epub 2007 Oct 2.

PMID:
17910477
30.

Accumulation of pathological tau species and memory loss in a conditional model of tauopathy.

Berger Z, Roder H, Hanna A, Carlson A, Rangachari V, Yue M, Wszolek Z, Ashe K, Knight J, Dickson D, Andorfer C, Rosenberry TL, Lewis J, Hutton M, Janus C.

J Neurosci. 2007 Apr 4;27(14):3650-62.

31.

Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models.

Levites Y, Smithson LA, Price RW, Dakin RS, Yuan B, Sierks MR, Kim J, McGowan E, Reed DK, Rosenberry TL, Das P, Golde TE.

FASEB J. 2006 Dec;20(14):2576-8. Epub 2006 Oct 26.

PMID:
17068112
32.

Secondary structure and interfacial aggregation of amyloid-beta(1-40) on sodium dodecyl sulfate micelles.

Rangachari V, Reed DK, Moore BD, Rosenberry TL.

Biochemistry. 2006 Jul 18;45(28):8639-48.

PMID:
16834338
33.

Steric effects in the decarbamoylation of carbamoylated acetylcholinesterases.

Venkatasubban KS, Johnson JL, Thomas JL, Fauq A, Cusack B, Rosenberry TL.

Chem Biol Interact. 2005 Dec 15;157-158:433-4. No abstract available.

PMID:
16429582
34.

Measuring carbamoylation and decarbamoylation rate constants by continuous assay of AChE.

Johnson JL, Thomas JL, Emani S, Cusack B, Rosenberry TL.

Chem Biol Interact. 2005 Dec 15;157-158:384-5. No abstract available.

PMID:
16429515
35.

A novel strategy for protection against organophosphate toxicity: Evolution of cyclic inhibitors with high affinity for the acetylcholinesterase peripheral site.

Cusack B, Romanovskis P, Johnson JL, Etienne G, Rosenberry TL.

Chem Biol Interact. 2005 Dec 15;157-158:370. No abstract available.

PMID:
16429491
36.

Interactions between the peripheral site and the acylation site in acetylcholinesterase.

Rosenberry TL, Johnson JL, Cusack B, Thomas JL, Emani S, Venkatasubban KS.

Chem Biol Interact. 2005 Dec 15;157-158:181-9. Epub 2005 Oct 27.

PMID:
16256966
37.

Amyloid-beta aggregates formed at polar-nonpolar interfaces differ from amyloid-beta protofibrils produced in aqueous buffers.

Nichols MR, Moss MA, Reed DK, Hoh JH, Rosenberry TL.

Microsc Res Tech. 2005 Jul;67(3-4):164-74. Review.

PMID:
16103999
38.

Rapid assembly of amyloid-beta peptide at a liquid/liquid interface produces unstable beta-sheet fibers.

Nichols MR, Moss MA, Reed DK, Hoh JH, Rosenberry TL.

Biochemistry. 2005 Jan 11;44(1):165-73.

PMID:
15628857
39.

Amyloid-beta protofibrils differ from amyloid-beta aggregates induced in dilute hexafluoroisopropanol in stability and morphology.

Nichols MR, Moss MA, Reed DK, Cratic-McDaniel S, Hoh JH, Rosenberry TL.

J Biol Chem. 2005 Jan 28;280(4):2471-80. Epub 2004 Nov 4.

40.
42.

Inhibitors tethered near the acetylcholinesterase active site serve as molecular rulers of the peripheral and acylation sites.

Johnson JL, Cusack B, Hughes TF, McCullough EH, Fauq A, Romanovskis P, Spatola AF, Rosenberry TL.

J Biol Chem. 2003 Oct 3;278(40):38948-55. Epub 2003 Jul 8.

43.

Mechanisms of altered vagal control in heart failure: influence of muscarinic receptors and acetylcholinesterase activity.

Dunlap ME, Bibevski S, Rosenberry TL, Ernsberger P.

Am J Physiol Heart Circ Physiol. 2003 Oct;285(4):H1632-40. Epub 2003 Jun 26.

44.

Unmasking tandem site interaction in human acetylcholinesterase. Substrate activation with a cationic acetanilide substrate.

Johnson JL, Cusack B, Davies MP, Fauq A, Rosenberry TL.

Biochemistry. 2003 May 13;42(18):5438-52.

PMID:
12731886
45.

Growth of beta-amyloid(1-40) protofibrils by monomer elongation and lateral association. Characterization of distinct products by light scattering and atomic force microscopy.

Nichols MR, Moss MA, Reed DK, Lin WL, Mukhopadhyay R, Hoh JH, Rosenberry TL.

Biochemistry. 2002 May 14;41(19):6115-27.

PMID:
11994007
46.

3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates.

Dvir H, Wong DM, Harel M, Barril X, Orozco M, Luque FJ, Muñoz-Torrero D, Camps P, Rosenberry TL, Silman I, Sussman JL.

Biochemistry. 2002 Mar 5;41(9):2970-81.

PMID:
11863435
48.

Properties of exogenously added GPI-anchored proteins following their incorporation into cells.

Premkumar DR, Fukuoka Y, Sevlever D, Brunschwig E, Rosenberry TL, Tykocinski ML, Medof ME.

J Cell Biochem. 2001;82(2):234-45.

PMID:
11527149
49.

Short, strong hydrogen bonds at the active site of human acetylcholinesterase: proton NMR studies.

Massiah MA, Viragh C, Reddy PM, Kovach IM, Johnson J, Rosenberry TL, Mildvan AS.

Biochemistry. 2001 May 15;40(19):5682-90.

PMID:
11341833
50.

Thioflavin T is a fluorescent probe of the acetylcholinesterase peripheral site that reveals conformational interactions between the peripheral and acylation sites.

De Ferrari GV, Mallender WD, Inestrosa NC, Rosenberry TL.

J Biol Chem. 2001 Jun 29;276(26):23282-7. Epub 2001 Apr 19.

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