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Items: 1 to 50 of 95

1.

Structure of an allosteric modulator bound to the CB1 cannabinoid receptor.

Shao Z, Yan W, Chapman K, Ramesh K, Ferrell AJ, Yin J, Wang X, Xu Q, Rosenbaum DM.

Nat Chem Biol. 2019 Dec;15(12):1199-1205. doi: 10.1038/s41589-019-0387-2. Epub 2019 Oct 28.

PMID:
31659318
2.

Improved strategy for isoleucine 1H/13C methyl labeling in Pichia pastoris.

Ali R, Clark LD, Zahm JA, Lemoff A, Ramesh K, Rosenbaum DM, Rosen MK.

J Biomol NMR. 2019 Dec;73(12):687-697. doi: 10.1007/s10858-019-00281-1. Epub 2019 Sep 20.

3.

An improved yeast surface display platform for the screening of nanobody immune libraries.

Uchański T, Zögg T, Yin J, Yuan D, Wohlkönig A, Fischer B, Rosenbaum DM, Kobilka BK, Pardon E, Steyaert J.

Sci Rep. 2019 Jan 23;9(1):382. doi: 10.1038/s41598-018-37212-3.

4.

Isotopic Labeling of Eukaryotic Membrane Proteins for NMR Studies of Interactions and Dynamics.

Dikiy I, Clark LD, Gardner KH, Rosenbaum DM.

Methods Enzymol. 2019;614:37-65. doi: 10.1016/bs.mie.2018.08.030. Epub 2018 Dec 18.

PMID:
30611431
5.

Crystal structure of the human NK1 tachykinin receptor.

Yin J, Chapman K, Clark LD, Shao Z, Borek D, Xu Q, Wang J, Rosenbaum DM.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13264-13269. doi: 10.1073/pnas.1812717115. Epub 2018 Dec 11.

6.

On the use of Pichia pastoris for isotopic labeling of human GPCRs for NMR studies.

Clark L, Dikiy I, Rosenbaum DM, Gardner KH.

J Biomol NMR. 2018 Aug;71(4):203-211. doi: 10.1007/s10858-018-0204-3. Epub 2018 Aug 18. Review.

PMID:
30121871
7.

Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA.

Suno R, Kimura KT, Nakane T, Yamashita K, Wang J, Fujiwara T, Yamanaka Y, Im D, Horita S, Tsujimoto H, Tawaramoto MS, Hirokawa T, Nango E, Tono K, Kameshima T, Hatsui T, Joti Y, Yabashi M, Shimamoto K, Yamamoto M, Rosenbaum DM, Iwata S, Shimamura T, Kobayashi T.

Structure. 2018 Jan 2;26(1):7-19.e5. doi: 10.1016/j.str.2017.11.005. Epub 2017 Dec 7.

8.

Ligand modulation of sidechain dynamics in a wild-type human GPCR.

Clark LD, Dikiy I, Chapman K, Rödström KE, Aramini J, LeVine MV, Khelashvili G, Rasmussen SG, Gardner KH, Rosenbaum DM.

Elife. 2017 Oct 6;6. pii: e28505. doi: 10.7554/eLife.28505.

9.

The prolyl 4-hydroxylase inhibitor GSK360A decreases post-stroke brain injury and sensory, motor, and cognitive behavioral deficits.

Zhou J, Li J, Rosenbaum DM, Zhuang J, Poon C, Qin P, Rivera K, Lepore J, Willette RN, Hu E, Barone FC.

PLoS One. 2017 Sep 7;12(9):e0184049. doi: 10.1371/journal.pone.0184049. eCollection 2017.

10.

Transporters Revealed.

Lee JY, Rosenbaum DM.

Cell. 2017 Mar 9;168(6):951-953. doi: 10.1016/j.cell.2017.02.033.

11.

The Human Orexin/Hypocretin Receptor Crystal Structures.

Yin J, Rosenbaum DM.

Curr Top Behav Neurosci. 2017;33:1-15. doi: 10.1007/7854_2016_52. Review.

PMID:
28025809
12.

High-resolution crystal structure of the human CB1 cannabinoid receptor.

Shao Z, Yin J, Chapman K, Grzemska M, Clark L, Wang J, Rosenbaum DM.

Nature. 2016 Dec 22;540(7634):602-606. doi: 10.1038/nature20613. Epub 2016 Nov 16.

13.

Crystal structure of the human sterol transporter ABCG5/ABCG8.

Lee JY, Kinch LN, Borek DM, Wang J, Wang J, Urbatsch IL, Xie XS, Grishin NV, Cohen JC, Otwinowski Z, Hobbs HH, Rosenbaum DM.

Nature. 2016 May 26;533(7604):561-4. doi: 10.1038/nature17666. Epub 2016 May 4.

14.

Direct Demonstration That Loop1 of Scap Binds to Loop7: A CRUCIAL EVENT IN CHOLESTEROL HOMEOSTASIS.

Zhang Y, Lee KM, Kinch LN, Clark L, Grishin NV, Rosenbaum DM, Brown MS, Goldstein JL, Radhakrishnan A.

J Biol Chem. 2016 Jun 10;291(24):12888-96. doi: 10.1074/jbc.M116.729798. Epub 2016 Apr 11.

15.

Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.

Yin J, Babaoglu K, Brautigam CA, Clark L, Shao Z, Scheuermann TH, Harrell CM, Gotter AL, Roecker AJ, Winrow CJ, Renger JJ, Coleman PJ, Rosenbaum DM.

Nat Struct Mol Biol. 2016 Apr;23(4):293-9. doi: 10.1038/nsmb.3183. Epub 2016 Mar 7.

PMID:
26950369
16.

Erratum to: Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris.

Clark L, Zahm JA, Ali R, Kukula M, Bian L, Patrie SM, Gardner KH, Rosen MK, Rosenbaum DM.

J Biomol NMR. 2016 Mar;64(3):267. doi: 10.1007/s10858-016-0016-2. No abstract available.

17.

Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris.

Clark L, Zahm JA, Ali R, Kukula M, Bian L, Patrie SM, Gardner KH, Rosen MK, Rosenbaum DM.

J Biomol NMR. 2015 Jul;62(3):239-45. doi: 10.1007/s10858-015-9939-2. Epub 2015 May 30. Erratum in: J Biomol NMR. 2016 Mar;64(3):267.

18.

Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant.

Yin J, Mobarec JC, Kolb P, Rosenbaum DM.

Nature. 2015 Mar 12;519(7542):247-50. doi: 10.1038/nature14035. Epub 2014 Dec 22.

PMID:
25533960
19.

The Arabidopsis calmodulin-like protein, CML39, functions during early seedling establishment.

Bender KW, Rosenbaum DM, Vanderbeld B, Ubaid M, Snedden WA.

Plant J. 2013 Nov;76(4):634-47. doi: 10.1111/tpj.12323. Epub 2013 Oct 17.

20.

Long-term post-stroke changes include myelin loss, specific deficits in sensory and motor behaviors and complex cognitive impairment detected using active place avoidance.

Zhou J, Zhuang J, Li J, Ooi E, Bloom J, Poon C, Lax D, Rosenbaum DM, Barone FC.

PLoS One. 2013;8(3):e57503. doi: 10.1371/journal.pone.0057503. Epub 2013 Mar 7.

21.

Structure and dynamics of the M3 muscarinic acetylcholine receptor.

Kruse AC, Hu J, Pan AC, Arlow DH, Rosenbaum DM, Rosemond E, Green HF, Liu T, Chae PS, Dror RO, Shaw DE, Weis WI, Wess J, Kobilka BK.

Nature. 2012 Feb 22;482(7386):552-6. doi: 10.1038/nature10867.

22.

Lipid and lipoprotein biomarkers and the risk of ischemic stroke in postmenopausal women.

Berger JS, McGinn AP, Howard BV, Kuller L, Manson JE, Otvos J, Curb JD, Eaton CB, Kaplan RC, Lynch JK, Rosenbaum DM, Wassertheil-Smoller S.

Stroke. 2012 Apr;43(4):958-66. doi: 10.1161/STROKEAHA.111.641324. Epub 2012 Feb 2.

23.

A novel calpain inhibitor for treatment of transient retinal ischemia in the rat.

David J, Melamud A, Kesner L, Roth S, Rosenbaum PS, Barone FC, Popp S, Hassen GW, Stracher A, Rosenbaum DM.

Neuroreport. 2011 Sep 14;22(13):633-6. doi: 10.1097/WNR.0b013e32834959c5.

24.

Neurogenic pathway mediated remote preconditioning protects the brain from transient focal ischemic injury.

Malhotra S, Naggar I, Stewart M, Rosenbaum DM.

Brain Res. 2011 Apr 22;1386:184-90. doi: 10.1016/j.brainres.2011.02.032. Epub 2011 Feb 19.

PMID:
21338588
25.

Structure and function of an irreversible agonist-β(2) adrenoceptor complex.

Rosenbaum DM, Zhang C, Lyons JA, Holl R, Aragao D, Arlow DH, Rasmussen SG, Choi HJ, Devree BT, Sunahara RK, Chae PS, Gellman SH, Dror RO, Shaw DE, Weis WI, Caffrey M, Gmeiner P, Kobilka BK.

Nature. 2011 Jan 13;469(7329):236-40. doi: 10.1038/nature09665.

26.

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor.

Rasmussen SG, Choi HJ, Fung JJ, Pardon E, Casarosa P, Chae PS, Devree BT, Rosenbaum DM, Thian FS, Kobilka TS, Schnapp A, Konetzki I, Sunahara RK, Gellman SH, Pautsch A, Steyaert J, Weis WI, Kobilka BK.

Nature. 2011 Jan 13;469(7329):175-80. doi: 10.1038/nature09648.

27.

Thrombopoietin protects the brain and improves sensorimotor functions: reduction of stroke-induced MMP-9 upregulation and blood-brain barrier injury.

Zhou J, Li J, Rosenbaum DM, Barone FC.

J Cereb Blood Flow Metab. 2011 Mar;31(3):924-33. doi: 10.1038/jcbfm.2010.171. Epub 2010 Sep 29.

28.

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor.

Bokoch MP, Zou Y, Rasmussen SG, Liu CW, Nygaard R, Rosenbaum DM, Fung JJ, Choi HJ, Thian FS, Kobilka TS, Puglisi JD, Weis WI, Pardo L, Prosser RS, Mueller L, Kobilka BK.

Nature. 2010 Jan 7;463(7277):108-12. doi: 10.1038/nature08650.

29.

Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model.

Rosenbaum DM, Degterev A, David J, Rosenbaum PS, Roth S, Grotta JC, Cuny GD, Yuan J, Savitz SI.

J Neurosci Res. 2010 May 15;88(7):1569-76. doi: 10.1002/jnr.22314.

PMID:
20025059
30.

Harmful effect of kainic acid on brain ischemic damage is not related to duration of status epilepticus.

Hasson H, Malhotra S, Giorgi FS, Rosenbaum DM, Moshé SL.

Neurol Sci. 2010 Feb;31(1):103-5. doi: 10.1007/s10072-009-0115-x. Epub 2009 Sep 25.

31.

Vascular cognitive impairment: dementia biology and translational animal models.

Barone FC, Rosenbaum DM, Zhou J, Crystal H.

Curr Opin Investig Drugs. 2009 Jul;10(7):624-37. Review.

PMID:
19579168
32.

The structure and function of G-protein-coupled receptors.

Rosenbaum DM, Rasmussen SG, Kobilka BK.

Nature. 2009 May 21;459(7245):356-63. doi: 10.1038/nature08144. Review.

33.

Structure-based discovery of beta2-adrenergic receptor ligands.

Kolb P, Rosenbaum DM, Irwin JJ, Fung JJ, Kobilka BK, Shoichet BK.

Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6843-8. doi: 10.1073/pnas.0812657106. Epub 2009 Apr 2.

34.

Involvement of erythropoietin in retinal ischemic preconditioning.

Dreixler JC, Hagevik S, Hemmert JW, Shaikh AR, Rosenbaum DM, Roth S.

Anesthesiology. 2009 Apr;110(4):774-80. doi: 10.1097/ALN.0b013e31819c4601.

35.

The role of Akt/protein kinase B subtypes in retinal ischemic preconditioning.

Dreixler JC, Hemmert JW, Shenoy SK, Shen Y, Lee HT, Shaikh AR, Rosenbaum DM, Roth S.

Exp Eye Res. 2009 Mar;88(3):512-21. doi: 10.1016/j.exer.2008.11.013. Epub 2008 Dec 3.

36.

Inflammation and hemostasis biomarkers for predicting stroke in postmenopausal women: the Women's Health Initiative Observational Study.

Kaplan RC, McGinn AP, Baird AE, Hendrix SL, Kooperberg C, Lynch J, Rosenbaum DM, Johnson KC, Strickler HD, Wassertheil-Smoller S.

J Stroke Cerebrovasc Dis. 2008 Nov-Dec;17(6):344-55. doi: 10.1016/j.jstrokecerebrovasdis.2008.04.006.

37.

Deleterious role of TNF-alpha in retinal ischemia-reperfusion injury.

Berger S, Savitz SI, Nijhawan S, Singh M, David J, Rosenbaum PS, Rosenbaum DM.

Invest Ophthalmol Vis Sci. 2008 Aug;49(8):3605-10. doi: 10.1167/iovs.07-0817.

PMID:
18660426
38.

Antithrombotic and thrombolytic therapy for ischemic stroke.

Cornett O, Ocava LC, Singh M, Malhotra S, Rosenbaum DM.

Cardiol Clin. 2008 May;26(2):251-65, vii. doi: 10.1016/j.ccl.2007.12.014. Review.

PMID:
18406998
39.

Walking speed and risk of incident ischemic stroke among postmenopausal women.

McGinn AP, Kaplan RC, Verghese J, Rosenbaum DM, Psaty BM, Baird AE, Lynch JK, Wolf PA, Kooperberg C, Larson JC, Wassertheil-Smoller S.

Stroke. 2008 Apr;39(4):1233-9. doi: 10.1161/STROKEAHA.107.500850. Epub 2008 Feb 21.

PMID:
18292379
40.

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.

Cherezov V, Rosenbaum DM, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Kuhn P, Weis WI, Kobilka BK, Stevens RC.

Science. 2007 Nov 23;318(5854):1258-65. Epub 2007 Oct 25.

41.

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function.

Rosenbaum DM, Cherezov V, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Yao XJ, Weis WI, Stevens RC, Kobilka BK.

Science. 2007 Nov 23;318(5854):1266-73. Epub 2007 Oct 25.

42.

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.

Rasmussen SG, Choi HJ, Rosenbaum DM, Kobilka TS, Thian FS, Edwards PC, Burghammer M, Ratnala VR, Sanishvili R, Fischetti RF, Schertler GF, Weis WI, Kobilka BK.

Nature. 2007 Nov 15;450(7168):383-7. Epub 2007 Oct 21.

PMID:
17952055
43.

Caveolin-1 deficiency increases cerebral ischemic injury.

Jasmin JF, Malhotra S, Singh Dhallu M, Mercier I, Rosenbaum DM, Lisanti MP.

Circ Res. 2007 Mar 16;100(5):721-9. Epub 2007 Feb 9.

PMID:
17293479
44.

EDG receptors as a potential therapeutic target in retinal ischemia-reperfusion injury.

Savitz SI, Dhallu MS, Malhotra S, Mammis A, Ocava LC, Rosenbaum PS, Rosenbaum DM.

Brain Res. 2006 Nov 6;1118(1):168-75. Epub 2006 Oct 5.

PMID:
17026968
45.
46.

Antithrombotic and thrombolytic therapy for ischemic stroke.

Ocava LC, Singh M, Malhotra S, Rosenbaum DM.

Clin Geriatr Med. 2006 Feb;22(1):135-54, ix-x. Review.

PMID:
16377471
47.
48.

Effects of status epilepticus early in life on susceptibility to ischemic injury in adulthood.

Giorgi FS, Malhotra S, Hasson H, Velísková J, Rosenbaum DM, Moshé SL.

Epilepsia. 2005 Apr;46(4):490-8.

49.

Cell therapy for stroke.

Savitz SI, Dinsmore JH, Wechsler LR, Rosenbaum DM, Caplan LR.

NeuroRx. 2004 Oct;1(4):406-14. Review.

50.

Erythropoietin (epoetin) as a protective factor for the brain.

Malhotra S, Nijhawan S, Rosenbaum DM.

Curr Atheroscler Rep. 2004 Jul;6(4):301-6. Review.

PMID:
15191705

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