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Large septic pulmonary embolus complicating streptococcus mutans pulmonary valve endocarditis.

Inchaustegui CA, Wang KY, Teniola O, De Rosen VL.

J Radiol Case Rep. 2018 Feb 28;12(2):18-27. doi: 10.3941/jrcr.v12i2.3240. eCollection 2018 Feb.


The Role of Bmp2 in the Maturation and Maintenance of the Murine Knee Joint.

Gamer LW, Pregizer S, Gamer J, Feigenson M, Ionescu A, Li Q, Han L, Rosen V.

J Bone Miner Res. 2018 Apr 17. doi: 10.1002/jbmr.3441. [Epub ahead of print]


Comprehensive immunoproteogenomic analyses of malignant pleural mesothelioma.

Lee HS, Jang HJ, Choi JM, Zhang J, de Rosen VL, Wheeler TM, Lee JS, Tu T, Jindra PT, Kerman RH, Jung SY, Kheradmand F, Sugarbaker DJ, Burt BM.

JCI Insight. 2018 Apr 5;3(7). pii: 98575. doi: 10.1172/jci.insight.98575. [Epub ahead of print]


BMP3 expression by osteoblast lineage cells is regulated by canonical Wnt signaling.

Kokabu S, Rosen V.

FEBS Open Bio. 2017 Dec 16;8(2):168-176. doi: 10.1002/2211-5463.12347. eCollection 2018 Feb.


Impact of broad regulatory regions on Gdf5 expression and function in knee development and susceptibility to osteoarthritis.

Pregizer SK, Kiapour AM, Young M, Chen H, Schoor M, Liu Z, Cao J, Rosen V, Capellini TD.

Ann Rheum Dis. 2018 Mar;77(3):450. doi: 10.1136/annrheumdis-2017-212475. Epub 2018 Jan 8.


The transcriptional co-repressor TLE3 regulates myogenic differentiation by repressing the activity of the MyoD transcription factor.

Kokabu S, Nakatomi C, Matsubara T, Ono Y, Addison WN, Lowery JW, Urata M, Hudnall AM, Hitomi S, Nakatomi M, Sato T, Osawa K, Yoda T, Rosen V, Jimi E.

J Biol Chem. 2017 Aug 4;292(31):12885-12894. doi: 10.1074/jbc.M116.774570. Epub 2017 Jun 12.


Systematic Review and Network Meta-Analysis of Bevacizumab Plus First-Line Topotecan-Paclitaxel or Cisplatin-Paclitaxel Versus Non-Bevacizumab-Containing Therapies in Persistent, Recurrent, or Metastatic Cervical Cancer.

Rosen VM, Guerra I, McCormack M, Nogueira-Rodrigues A, Sasse A, Munk VC, Shang A.

Int J Gynecol Cancer. 2017 Jul;27(6):1237-1246. doi: 10.1097/IGC.0000000000001000. Review.


Bone Morphogenetic Protein-Based Therapeutic Approaches.

Lowery JW, Rosen V.

Cold Spring Harb Perspect Biol. 2018 Apr 2;10(4). pii: a022327. doi: 10.1101/cshperspect.a022327. Review.


R-SCAN: CT Angiographic Imaging for Pulmonary Embolism.

Frigini LA, Hoxhaj S, Wintermark M, Gibby C, De Rosen VL, Willis MH.

J Am Coll Radiol. 2017 May;14(5):637-640. doi: 10.1016/j.jacr.2017.01.013. Epub 2017 Mar 8. No abstract available.


Identification and characterization of adult mouse meniscus stem/progenitor cells.

Gamer LW, Shi RR, Gendelman A, Mathewson D, Gamer J, Rosen V.

Connect Tissue Res. 2017 May - Jul;58(3-4):238-245. doi: 10.1080/03008207.2016.1271797. Epub 2016 Dec 22.


Corrigendum: NPNT is Expressed by Osteoblasts and Mediates Angiogenesis via the Activation of Extracellular Signal-regulated Kinase.

Kuek V, Yang Z, Chim SM, Zhu S, Xu H, Chow ST, Tickner J, Rosen V, Erber W, Li X, Qin A, Qian Y, Xu J.

Sci Rep. 2016 Nov 21;6:37482. doi: 10.1038/srep37482. No abstract available.


Specification of osteoblast cell fate by canonical Wnt signaling requires Bmp2.

Salazar VS, Ohte S, Capelo LP, Gamer L, Rosen V.

Development. 2016 Dec 1;143(23):4352-4367. Epub 2016 Oct 17.


NPNT is Expressed by Osteoblasts and Mediates Angiogenesis via the Activation of Extracellular Signal-regulated Kinase.

Kuek V, Yang Z, Chim SM, Zhu S, Xu H, Chow ST, Tickner J, Rosen V, Erber W, Li X, Qin A, Qian Y, Xu J.

Sci Rep. 2016 Oct 26;6:36210. doi: 10.1038/srep36210. Erratum in: Sci Rep. 2016 Nov 21;6:37482.


Formation and maturation of the murine meniscus.

Gamer LW, Xiang L, Rosen V.

J Orthop Res. 2017 Aug;35(8):1683-1689. doi: 10.1002/jor.23446. Epub 2016 Oct 6.


A Survey of Strategies to Modulate the Bone Morphogenetic Protein Signaling Pathway: Current and Future Perspectives.

Lowery JW, Brookshire B, Rosen V.

Stem Cells Int. 2016;2016:7290686. doi: 10.1155/2016/7290686. Epub 2016 Jun 28. Review.


Inflammation in arthritis induces expression of BMP3, an inhibitor of bone formation.

Matzelle MM, Shaw AT, Baum R, Maeda Y, Li J, Karmakar S, Manning CA, Walsh NC, Rosen V, Gravallese EM.

Scand J Rheumatol. 2016 Oct;45(5):379-83. doi: 10.3109/03009742.2015.1126347. Epub 2016 Mar 16.


BMP signalling in skeletal development, disease and repair.

Salazar VS, Gamer LW, Rosen V.

Nat Rev Endocrinol. 2016 Apr;12(4):203-21. doi: 10.1038/nrendo.2016.12. Epub 2016 Feb 19. Review.


Neurotrophin-3 Induces BMP-2 and VEGF Activities and Promotes the Bony Repair of Injured Growth Plate Cartilage and Bone in Rats.

Su YW, Chung R, Ruan CS, Chim SM, Kuek V, Dwivedi PP, Hassanshahi M, Chen KM, Xie Y, Chen L, Foster BK, Rosen V, Zhou XF, Xu J, Xian CJ.

J Bone Miner Res. 2016 Jun;31(6):1258-74. doi: 10.1002/jbmr.2786. Epub 2016 Feb 16.


A New Subtype of Multiple Synostoses Syndrome Is Caused by a Mutation in GDF6 That Decreases Its Sensitivity to Noggin and Enhances Its Potency as a BMP Signal.

Wang J, Yu T, Wang Z, Ohte S, Yao RE, Zheng Z, Geng J, Cai H, Ge Y, Li Y, Xu Y, Zhang Q, Gusella JF, Fu Q, Pregizer S, Rosen V, Shen Y.

J Bone Miner Res. 2016 Apr;31(4):882-9. doi: 10.1002/jbmr.2761. Epub 2015 Dec 28.


Meta-analysis of studies examining medication adherence, persistence, and discontinuation of oral antihyperglycemic agents in type 2 diabetes.

Iglay K, Cartier SE, Rosen VM, Zarotsky V, Rajpathak SN, Radican L, Tunceli K.

Curr Med Res Opin. 2015;31(7):1283-96. doi: 10.1185/03007995.2015.1053048. Epub 2015 Jun 18.


Elimination of BMP7 from the developing limb mesenchyme leads to articular cartilage degeneration and synovial inflammation with increased age.

Abula K, Muneta T, Miyatake K, Yamada J, Matsukura Y, Inoue M, Sekiya I, Graf D, Economides AN, Rosen V, Tsuji K.

FEBS Lett. 2015 May 8;589(11):1240-8. doi: 10.1016/j.febslet.2015.04.004. Epub 2015 Apr 15.


Biomechanical properties of murine meniscus surface via AFM-based nanoindentation.

Li Q, Doyran B, Gamer LW, Lu XL, Qin L, Ortiz C, Grodzinsky AJ, Rosen V, Han L.

J Biomech. 2015 Jun 1;48(8):1364-70. doi: 10.1016/j.jbiomech.2015.02.064. Epub 2015 Mar 11.


Relationship between treatment effects on progression-free survival and overall survival in multiple myeloma: a systematic review and meta-analysis of published clinical trial data.

Cartier S, Zhang B, Rosen VM, Zarotsky V, Bartlett JB, Mukhopadhyay P, Wagner S, Davis C.

Oncol Res Treat. 2015;38(3):88-94. doi: 10.1159/000375392. Epub 2015 Feb 20. Review.


Loss of BMPR2 leads to high bone mass due to increased osteoblast activity.

Lowery JW, Intini G, Gamer L, Lotinun S, Salazar VS, Ote S, Cox K, Baron R, Rosen V.

J Cell Sci. 2015 Apr 1;128(7):1308-15. doi: 10.1242/jcs.156737. Epub 2015 Feb 6.


Human migratory meniscus progenitor cells are controlled via the TGF-β pathway.

Muhammad H, Schminke B, Bode C, Roth M, Albert J, von der Heyde S, Rosen V, Miosge N.

Stem Cell Reports. 2014 Nov 11;3(5):789-803. doi: 10.1016/j.stemcr.2014.08.010. Epub 2014 Sep 25.


EGFL7 is expressed in bone microenvironment and promotes angiogenesis via ERK, STAT3, and integrin signaling cascades.

Chim SM, Kuek V, Chow ST, Lim BS, Tickner J, Zhao J, Chung R, Su YW, Zhang G, Erber W, Xian CJ, Rosen V, Xu J.

J Cell Physiol. 2015 Jan;230(1):82-94. doi: 10.1002/jcp.24684.


Long bone structure and strength depend on BMP2 from osteoblasts and osteocytes, but not vascular endothelial cells.

McBride SH, McKenzie JA, Bedrick BS, Kuhlmann P, Pasteris JD, Rosen V, Silva MJ.

PLoS One. 2014 May 16;9(5):e96862. doi: 10.1371/journal.pone.0096862. eCollection 2014.


Expression of TLE3 by bone marrow stromal cells is regulated by canonical Wnt signaling.

Kokabu S, Sato T, Ohte S, Enoki Y, Okubo M, Hayashi N, Nojima J, Tsukamoto S, Fukushima Y, Sakata Y, Katagiri T, Rosen V, Yoda T.

FEBS Lett. 2014 Feb 14;588(4):614-9. doi: 10.1016/j.febslet.2013.12.031. Epub 2014 Jan 17.


N-linked glycosylation of the bone morphogenetic protein receptor type 2 (BMPR2) enhances ligand binding.

Lowery JW, Amich JM, Andonian A, Rosen V.

Cell Mol Life Sci. 2014 Aug;71(16):3165-72. doi: 10.1007/s00018-013-1541-8. Epub 2013 Dec 15.


HtrA1 is upregulated during RANKL-induced osteoclastogenesis, and negatively regulates osteoblast differentiation and BMP2-induced Smad1/5/8, ERK and p38 phosphorylation.

Wu X, Chim SM, Kuek V, Lim BS, Chow ST, Zhao J, Yang S, Rosen V, Tickner J, Xu J.

FEBS Lett. 2014 Jan 3;588(1):143-50. doi: 10.1016/j.febslet.2013.11.022. Epub 2013 Nov 21.


Gene signature of the embryonic meniscus.

Pazin DE, Gamer LW, Capelo LP, Cox KA, Rosen V.

J Orthop Res. 2014 Jan;32(1):46-53. doi: 10.1002/jor.22490. Epub 2013 Sep 21.


A discoidin domain receptor 1 knock-out mouse as a novel model for osteoarthritis of the temporomandibular joint.

Schminke B, Muhammad H, Bode C, Sadowski B, Gerter R, Gersdorff N, Bürgers R, Monsonego-Ornan E, Rosen V, Miosge N.

Cell Mol Life Sci. 2014 Mar;71(6):1081-96. doi: 10.1007/s00018-013-1436-8. Epub 2013 Aug 4.


TLE3, transducing-like enhancer of split 3, suppresses osteoblast differentiation of bone marrow stromal cells.

Kokabu S, Nguyen T, Ohte S, Sato T, Katagiri T, Yoda T, Rosen V.

Biochem Biophys Res Commun. 2013 Aug 16;438(1):205-10. doi: 10.1016/j.bbrc.2013.07.054. Epub 2013 Jul 20.


Health care utilization and risk of infection and bleeding among patients with myelodysplastic syndromes with/without transfusions, and with/without active therapy.

Smith BD, Mahmoud D, Dacosta-Byfield S, Rosen VM.

Leuk Lymphoma. 2014 May;55(5):1119-25. doi: 10.3109/10428194.2013.820286. Epub 2013 Aug 28.


Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3.

Whitman M, Rosen V, Brivanlou AH, Groppe JC, Sebald W, Mueller T.

Nat Med. 2013 Jul;19(7):809-10. doi: 10.1038/nm.3080. No abstract available.


Angiogenic factors in bone local environment.

Chim SM, Tickner J, Chow ST, Kuek V, Guo B, Zhang G, Rosen V, Erber W, Xu J.

Cytokine Growth Factor Rev. 2013 Jun;24(3):297-310. doi: 10.1016/j.cytogfr.2013.03.008. Epub 2013 Apr 20. Review.


Comparative genomics identifies the mouse Bmp3 promoter and an upstream evolutionary conserved region (ECR) in mammals.

Lowery JW, Lavigne AW, Kokabu S, Rosen V.

PLoS One. 2013;8(2):e57840. doi: 10.1371/journal.pone.0057840. Epub 2013 Feb 22.


Molecular profiling of synovial joints: use of microarray analysis to identify factors that direct the development of the knee and elbow.

Pazin DE, Gamer LW, Cox KA, Rosen V.

Dev Dyn. 2012 Nov;241(11):1816-26. doi: 10.1002/dvdy.23861. Epub 2012 Sep 25.


Periosteal BMP2 activity drives bone graft healing.

Chappuis V, Gamer L, Cox K, Lowery JW, Bosshardt DD, Rosen V.

Bone. 2012 Oct;51(4):800-9. doi: 10.1016/j.bone.2012.07.017. Epub 2012 Jul 28.


Allele-specific RNA interference in FOP silencing the FOP gene.

Lowery JW, Rosen V.

Gene Ther. 2012 Jul;19(7):701-2. doi: 10.1038/gt.2011.190. Epub 2011 Dec 1. No abstract available.


The role of BMP2 signaling in the skeleton.

Lowery JW, Pazin D, Intini G, Kokabu S, Chappuis V, Capelo LP, Rosen V.

Crit Rev Eukaryot Gene Expr. 2011;21(2):177-85.


BMP3 suppresses osteoblast differentiation of bone marrow stromal cells via interaction with Acvr2b.

Kokabu S, Gamer L, Cox K, Lowery J, Tsuji K, Raz R, Economides A, Katagiri T, Rosen V.

Mol Endocrinol. 2012 Jan;26(1):87-94. doi: 10.1210/me.2011-1168. Epub 2011 Nov 10.


Harnessing the parathyroid hormone, Wnt, and bone morphogenetic protein signaling cascades for successful bone tissue engineering.

Rosen V.

Tissue Eng Part B Rev. 2011 Dec;17(6):475-9. doi: 10.1089/ten.TEB.2011.0265. Epub 2011 Oct 6. Review.


BMPR-II is dispensable for formation of the limb skeleton.

Gamer LW, Tsuji K, Cox K, Capelo LP, Lowery J, Beppu H, Rosen V.

Genesis. 2011 Sep;49(9):719-24. doi: 10.1002/dvg.20761. Epub 2011 Aug 19.


Differences in gene expression between the otic capsule and other bones.

Stankovic KM, Adachi O, Tsuji K, Kristiansen AG, Adams JC, Rosen V, McKenna MJ.

Hear Res. 2010 Jun 14;265(1-2):83-9. doi: 10.1016/j.heares.2010.02.006. Epub 2010 Feb 8.


Cost effectiveness of intensive lipid-lowering treatment for patients with congestive heart failure and coronary heart disease in the US.

Rosen VM, Taylor DC, Parekh H, Pandya A, Thompson D, Kuznik A, Waters DD, Drummond M, Weinstein MC.

Pharmacoeconomics. 2010;28(1):47-60. doi: 10.2165/11531440-000000000-00000.


BMP2 signaling in bone development and repair.

Rosen V.

Cytokine Growth Factor Rev. 2009 Oct-Dec;20(5-6):475-80. doi: 10.1016/j.cytogfr.2009.10.018. Epub 2009 Nov 4. Review.


Conditional deletion of BMP7 from the limb skeleton does not affect bone formation or fracture repair.

Tsuji K, Cox K, Gamer L, Graf D, Economides A, Rosen V.

J Orthop Res. 2010 Mar;28(3):384-9. doi: 10.1002/jor.20996.


Are endogenous BMPs necessary for bone healing during distraction osteogenesis?

Alam N, St-Arnaud R, Lauzier D, Rosen V, Hamdy RC.

Clin Orthop Relat Res. 2009 Dec;467(12):3190-8. doi: 10.1007/s11999-009-1065-6.


Overexpression of BMP3 in the developing skeleton alters endochondral bone formation resulting in spontaneous rib fractures.

Gamer LW, Cox K, Carlo JM, Rosen V.

Dev Dyn. 2009 Sep;238(9):2374-81. doi: 10.1002/dvdy.22048.

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