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Items: 1 to 50 of 106

1.

Who's In and Who's Out-Compositional Control of Biomolecular Condensates.

Ditlev JA, Case LB, Rosen MK.

J Mol Biol. 2018 Nov 2;430(23):4666-4684. doi: 10.1016/j.jmb.2018.08.003. Epub 2018 Aug 9. Review.

2.

Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites.

Yoshizawa T, Ali R, Jiou J, Fung HYJ, Burke KA, Kim SJ, Lin Y, Peeples WB, Saltzberg D, Soniat M, Baumhardt JM, Oldenbourg R, Sali A, Fawzi NL, Rosen MK, Chook YM.

Cell. 2018 Apr 19;173(3):693-705.e22. doi: 10.1016/j.cell.2018.03.003.

PMID:
29677513
3.

Intrinsically Disordered Regions Can Contribute Promiscuous Interactions to RNP Granule Assembly.

Protter DSW, Rao BS, Van Treeck B, Lin Y, Mizoue L, Rosen MK, Parker R.

Cell Rep. 2018 Feb 6;22(6):1401-1412. doi: 10.1016/j.celrep.2018.01.036.

4.

Allosteric Modulation of Grb2 Recruitment to the Intrinsically Disordered Scaffold Protein, LAT, by Remote Site Phosphorylation.

Huang WYC, Ditlev JA, Chiang HK, Rosen MK, Groves JT.

J Am Chem Soc. 2017 Dec 13;139(49):18009-18015. doi: 10.1021/jacs.7b09387. Epub 2017 Nov 28.

5.

Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins.

Harmon TS, Holehouse AS, Rosen MK, Pappu RV.

Elife. 2017 Nov 1;6. pii: e30294. doi: 10.7554/eLife.30294.

6.

Rac1 GTPase activates the WAVE regulatory complex through two distinct binding sites.

Chen B, Chou HT, Brautigam CA, Xing W, Yang S, Henry L, Doolittle LK, Walz T, Rosen MK.

Elife. 2017 Sep 26;6. pii: e29795. doi: 10.7554/eLife.29795.

7.

Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs.

Lin Y, Currie SL, Rosen MK.

J Biol Chem. 2017 Nov 17;292(46):19110-19120. doi: 10.1074/jbc.M117.800466. Epub 2017 Sep 18.

8.

ATP controls the crowd.

Rice AM, Rosen MK.

Science. 2017 May 19;356(6339):701-702. doi: 10.1126/science.aan4223. No abstract available.

PMID:
28522495
9.

Reconstitution of TCR Signaling Using Supported Lipid Bilayers.

Su X, Ditlev JA, Rosen MK, Vale RD.

Methods Mol Biol. 2017;1584:65-76. doi: 10.1007/978-1-4939-6881-7_5.

10.

Biomolecular condensates: organizers of cellular biochemistry.

Banani SF, Lee HO, Hyman AA, Rosen MK.

Nat Rev Mol Cell Biol. 2017 May;18(5):285-298. doi: 10.1038/nrm.2017.7. Epub 2017 Feb 22. Review.

PMID:
28225081
11.

Actin is an evolutionarily-conserved damage-associated molecular pattern that signals tissue injury in Drosophila melanogaster.

Srinivasan N, Gordon O, Ahrens S, Franz A, Deddouche S, Chakravarty P, Phillips D, Yunus AA, Rosen MK, Valente RS, Teixeira L, Thompson B, Dionne MS, Wood W, Reis e Sousa C.

Elife. 2016 Nov 22;5. pii: e19662. doi: 10.7554/eLife.19662.

12.

Structural and mechanistic insights into regulation of the retromer coat by TBC1d5.

Jia D, Zhang JS, Li F, Wang J, Deng Z, White MA, Osborne DG, Phillips-Krawczak C, Gomez TS, Li H, Singla A, Burstein E, Billadeau DD, Rosen MK.

Nat Commun. 2016 Nov 9;7:13305. doi: 10.1038/ncomms13305.

13.

Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein.

Pak CW, Kosno M, Holehouse AS, Padrick SB, Mittal A, Ali R, Yunus AA, Liu DR, Pappu RV, Rosen MK.

Mol Cell. 2016 Jul 7;63(1):72-85. doi: 10.1016/j.molcel.2016.05.042.

14.

Compositional Control of Phase-Separated Cellular Bodies.

Banani SF, Rice AM, Peeples WB, Lin Y, Jain S, Parker R, Rosen MK.

Cell. 2016 Jul 28;166(3):651-663. doi: 10.1016/j.cell.2016.06.010. Epub 2016 Jun 30.

15.

Phase separation of signaling molecules promotes T cell receptor signal transduction.

Su X, Ditlev JA, Hui E, Xing W, Banjade S, Okrut J, King DS, Taunton J, Rosen MK, Vale RD.

Science. 2016 Apr 29;352(6285):595-9. doi: 10.1126/science.aad9964. Epub 2016 Apr 7.

16.

Correction: Fat2 acts through the WAVE regulatory complex to drive collective cell migration during tissue rotation.

Squarr AJ, Brinkmann K, Chen B, Steinbacher T, Ebnet K, Rosen MK, Bogdan S.

J Cell Biol. 2016 Mar 28;212(7):883. doi: 10.1083/jcb.20150808103082016c. Epub 2016 Mar 21. No abstract available.

17.

Data publication with the structural biology data grid supports live analysis.

Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P.

Nat Commun. 2016 Mar 7;7:10882. doi: 10.1038/ncomms10882.

18.

Fat2 acts through the WAVE regulatory complex to drive collective cell migration during tissue rotation.

Squarr AJ, Brinkmann K, Chen B, Steinbacher T, Ebnet K, Rosen MK, Bogdan S.

J Cell Biol. 2016 Feb 29;212(5):591-603. doi: 10.1083/jcb.201508081. Epub 2016 Feb 22. Erratum in: J Cell Biol. 2016 Mar 28;212(7):883.

19.

Erratum to: Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris.

Clark L, Zahm JA, Ali R, Kukula M, Bian L, Patrie SM, Gardner KH, Rosen MK, Rosenbaum DM.

J Biomol NMR. 2016 Mar;64(3):267. doi: 10.1007/s10858-016-0016-2. No abstract available.

20.

Conserved interdomain linker promotes phase separation of the multivalent adaptor protein Nck.

Banjade S, Wu Q, Mittal A, Peeples WB, Pappu RV, Rosen MK.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6426-35. doi: 10.1073/pnas.1508778112. Epub 2015 Nov 9.

21.

Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins.

Lin Y, Protter DS, Rosen MK, Parker R.

Mol Cell. 2015 Oct 15;60(2):208-19. doi: 10.1016/j.molcel.2015.08.018. Epub 2015 Sep 24.

22.

Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris.

Clark L, Zahm JA, Ali R, Kukula M, Bian L, Patrie SM, Gardner KH, Rosen MK, Rosenbaum DM.

J Biomol NMR. 2015 Jul;62(3):239-45. doi: 10.1007/s10858-015-9939-2. Epub 2015 May 30. Erratum in: J Biomol NMR. 2016 Mar;64(3):267.

23.

Phase transitions of multivalent proteins can promote clustering of membrane receptors.

Banjade S, Rosen MK.

Elife. 2014 Oct 16;3. doi: 10.7554/eLife.04123.

24.

Ena/VASP proteins cooperate with the WAVE complex to regulate the actin cytoskeleton.

Chen XJ, Squarr AJ, Stephan R, Chen B, Higgins TE, Barry DJ, Martin MC, Rosen MK, Bogdan S, Way M.

Dev Cell. 2014 Sep 8;30(5):569-84. doi: 10.1016/j.devcel.2014.08.001.

25.

Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation.

McGough IJ, Steinberg F, Jia D, Barbuti PA, McMillan KJ, Heesom KJ, Whone AL, Caldwell MA, Billadeau DD, Rosen MK, Cullen PJ.

Curr Biol. 2014 Jul 21;24(14):1678. doi: 10.1016/j.cub.2014.07.004. Epub 2014 Jul 21. No abstract available.

26.

Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation.

McGough IJ, Steinberg F, Jia D, Barbuti PA, McMillan KJ, Heesom KJ, Whone AL, Caldwell MA, Billadeau DD, Rosen MK, Cullen PJ.

Curr Biol. 2014 Jul 21;24(14):1670-1676. doi: 10.1016/j.cub.2014.06.024. Epub 2014 Jul 3. Erratum in: Curr Biol. 2014 Jul 21;24(14):1678. Whone, Alan L [added].

27.

The Haemophilus ducreyi LspA1 protein inhibits phagocytosis by using a new mechanism involving activation of C-terminal Src kinase.

Dodd DA, Worth RG, Rosen MK, Grinstein S, van Oers NS, Hansen EJ.

MBio. 2014 May 20;5(3):e01178-14. doi: 10.1128/mBio.01178-14.

28.

Biochemical reconstitution of the WAVE regulatory complex.

Chen B, Padrick SB, Henry L, Rosen MK.

Methods Enzymol. 2014;540:55-72. doi: 10.1016/B978-0-12-397924-7.00004-2.

29.

Local F-actin network links synapse formation and axon branching.

Chia PH, Chen B, Li P, Rosen MK, Shen K.

Cell. 2014 Jan 16;156(1-2):208-20. doi: 10.1016/j.cell.2013.12.009.

30.

The WAVE regulatory complex links diverse receptors to the actin cytoskeleton.

Chen B, Brinkmann K, Chen Z, Pak CW, Liao Y, Shi S, Henry L, Grishin NV, Bogdan S, Rosen MK.

Cell. 2014 Jan 16;156(1-2):195-207. doi: 10.1016/j.cell.2013.11.048.

31.

The bacterial effector VopL organizes actin into filament-like structures.

Zahm JA, Padrick SB, Chen Z, Pak CW, Yunus AA, Henry L, Tomchick DR, Chen Z, Rosen MK.

Cell. 2013 Oct 10;155(2):423-34. doi: 10.1016/j.cell.2013.09.019.

32.

Three-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation.

Smith BA, Padrick SB, Doolittle LK, Daugherty-Clarke K, Corrêa IR Jr, Xu MQ, Goode BL, Rosen MK, Gelles J.

Elife. 2013 Sep 3;2:e01008. doi: 10.7554/eLife.01008.

33.

Measurement and analysis of in vitro actin polymerization.

Doolittle LK, Rosen MK, Padrick SB.

Methods Mol Biol. 2013;1046:273-93. doi: 10.1007/978-1-62703-538-5_16.

34.

Purification of Arp2/3 complex from Saccharomyces cerevisiae.

Doolittle LK, Rosen MK, Padrick SB.

Methods Mol Biol. 2013;1046:251-71. doi: 10.1007/978-1-62703-538-5_15.

35.

Purification of native Arp2/3 complex from bovine thymus.

Doolittle LK, Rosen MK, Padrick SB.

Methods Mol Biol. 2013;1046:231-50. doi: 10.1007/978-1-62703-538-5_14.

36.

Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination.

Hao YH, Doyle JM, Ramanathan S, Gomez TS, Jia D, Xu M, Chen ZJ, Billadeau DD, Rosen MK, Potts PR.

Cell. 2013 Feb 28;152(5):1051-64. doi: 10.1016/j.cell.2013.01.051.

37.

Enlightening molecular mechanisms through study of protein interactions.

Rizo J, Rosen MK, Gardner KH.

J Mol Cell Biol. 2012 Oct;4(5):270-83. doi: 10.1093/jmcb/mjs036. Epub 2012 Jun 26. Review.

38.

Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer.

Jia D, Gomez TS, Billadeau DD, Rosen MK.

Mol Biol Cell. 2012 Jun;23(12):2352-61. doi: 10.1091/mbc.E11-12-1059. Epub 2012 Apr 18.

39.

Phase transitions in the assembly of multivalent signalling proteins.

Li P, Banjade S, Cheng HC, Kim S, Chen B, Guo L, Llaguno M, Hollingsworth JV, King DS, Banani SF, Russo PS, Jiang QX, Nixon BT, Rosen MK.

Nature. 2012 Mar 7;483(7389):336-40. doi: 10.1038/nature10879.

40.

The feasibility of parameterizing four-state equilibria using relaxation dispersion measurements.

Li P, Martins IR, Rosen MK.

J Biomol NMR. 2011 Sep;51(1-2):57-70. doi: 10.1007/s10858-011-9541-1. Epub 2011 Sep 27.

41.

Mechanism of actin filament nucleation by the bacterial effector VopL.

Yu B, Cheng HC, Brautigam CA, Tomchick DR, Rosen MK.

Nat Struct Mol Biol. 2011 Aug 28;18(9):1068-74. doi: 10.1038/nsmb.2110.

42.

Arp2/3 complex is bound and activated by two WASP proteins.

Padrick SB, Doolittle LK, Brautigam CA, King DS, Rosen MK.

Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):E472-9. doi: 10.1073/pnas.1100236108. Epub 2011 Jun 15.

43.

Structure and control of the actin regulatory WAVE complex.

Chen Z, Borek D, Padrick SB, Gomez TS, Metlagel Z, Ismail AM, Umetani J, Billadeau DD, Otwinowski Z, Rosen MK.

Nature. 2010 Nov 25;468(7323):533-8. doi: 10.1038/nature09623.

44.

Crystal structure of the Formin mDia1 in autoinhibited conformation.

Otomo T, Tomchick DR, Otomo C, Machius M, Rosen MK.

PLoS One. 2010 Sep 30;5(9). pii: e12896. doi: 10.1371/journal.pone.0012896.

45.

Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments.

Padrick SB, Deka RK, Chuang JL, Wynn RM, Chuang DT, Norgard MV, Rosen MK, Brautigam CA.

Anal Biochem. 2010 Dec 1;407(1):89-103. doi: 10.1016/j.ab.2010.07.017. Epub 2010 Jul 25.

46.

Rationally improving LOV domain-based photoswitches.

Strickland D, Yao X, Gawlak G, Rosen MK, Gardner KH, Sosnick TR.

Nat Methods. 2010 Aug;7(8):623-6. doi: 10.1038/nmeth.1473. Epub 2010 Jun 20.

47.

Physical mechanisms of signal integration by WASP family proteins.

Padrick SB, Rosen MK.

Annu Rev Biochem. 2010;79:707-35. doi: 10.1146/annurev.biochem.77.060407.135452. Review.

48.

Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes.

Westerberg LS, Meelu P, Baptista M, Eston MA, Adamovich DA, Cotta-de-Almeida V, Seed B, Rosen MK, Vandenberghe P, Thrasher AJ, Klein C, Alt FW, Snapper SB.

J Exp Med. 2010 Jun 7;207(6):1145-52. doi: 10.1084/jem.20091245. Epub 2010 May 31.

49.

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes.

Jia D, Gomez TS, Metlagel Z, Umetani J, Otwinowski Z, Rosen MK, Billadeau DD.

Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10442-7. doi: 10.1073/pnas.0913293107. Epub 2010 May 24.

50.

Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1.

Yu B, Martins IR, Li P, Amarasinghe GK, Umetani J, Fernandez-Zapico ME, Billadeau DD, Machius M, Tomchick DR, Rosen MK.

Cell. 2010 Jan 22;140(2):246-56. doi: 10.1016/j.cell.2009.12.033.

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