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Randomized clinical trial of prophylactic transanal irrigation versus supportive therapy to prevent symptoms of low anterior resection syndrome after rectal resection.

Rosen HR, Kneist W, Fürst A, Krämer G, Hebenstreit J, Schiemer JF.

BJS Open. 2019 Mar 18;3(4):461-465. doi: 10.1002/bjs5.50160. eCollection 2019 Aug.


Chronic Liver Disease in Humans Causes Expansion and Differentiation of Liver Lymphatic Endothelial Cells.

Tamburini BAJ, Finlon JM, Gillen AE, Kriss MS, Riemondy KA, Fu R, Schuyler RP, Hesselberth JR, Rosen HR, Burchill MA.

Front Immunol. 2019 May 15;10:1036. doi: 10.3389/fimmu.2019.01036. eCollection 2019.


Multi-Ancestry Genome-Wide Association Study of Spontaneous Clearance of Hepatitis C Virus.

Vergara C, Thio CL, Johnson E, Kral AH, O'Brien TR, Goedert JJ, Mangia A, Piazzolla V, Mehta SH, Kirk GD, Kim AY, Lauer GM, Chung RT, Cox AL, Peters MG, Khakoo SI, Alric L, Cramp ME, Donfield SM, Edlin BR, Busch MP, Alexander G, Rosen HR, Murphy EL, Latanich R, Wojcik GL, Taub MA, Valencia A, Thomas DL, Duggal P.

Gastroenterology. 2019 Apr;156(5):1496-1507.e7. doi: 10.1053/j.gastro.2018.12.014. Epub 2018 Dec 26.


Functional Microbiomics in Liver Transplantation: Identifying Novel Targets for Improving Allograft Outcomes.

Kriss M, Verna EC, Rosen HR, Lozupone CA.

Transplantation. 2019 Apr;103(4):668-678. doi: 10.1097/TP.0000000000002568.


Dietary Lipids Differentially Shape Nonalcoholic Steatohepatitis Progression and the Transcriptome of Kupffer Cells and Infiltrating Macrophages.

McGettigan B, McMahan R, Orlicky D, Burchill M, Danhorn T, Francis P, Cheng LL, Golden-Mason L, Jakubzick CV, Rosen HR.

Hepatology. 2019 Jul;70(1):67-83. doi: 10.1002/hep.30401. Epub 2019 Feb 27.


Revisiting the Paradox of Interferon-Stimulated Gene Expression as a Predictor of Hepatitis C Virus Treatment Response, a Decade Later.

Golden-Mason L, Rosen HR.

Hepatology. 2018 Dec;68(6):2053-2055. doi: 10.1002/hep.30195. Epub 2018 Nov 13. No abstract available.


Early and late changes in natural killer cells in response to ledipasvir/sofosbuvir treatment.

Golden-Mason L, McMahan RH, Kriss MS, Kilgore AL, Cheng L, Dran RJ, Wieland A, Rosen HR.

Hepatol Commun. 2018 Mar 1;2(4):364-375. doi: 10.1002/hep4.1166. eCollection 2018 Apr.


Fructose and sugar: A major mediator of non-alcoholic fatty liver disease.

Jensen T, Abdelmalek MF, Sullivan S, Nadeau KJ, Green M, Roncal C, Nakagawa T, Kuwabara M, Sato Y, Kang DH, Tolan DR, Sanchez-Lozada LG, Rosen HR, Lanaspa MA, Diehl AM, Johnson RJ.

J Hepatol. 2018 May;68(5):1063-1075. doi: 10.1016/j.jhep.2018.01.019. Epub 2018 Feb 2. Review.


Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection.

Huang H, Duggal P, Thio CL, Latanich R, Goedert JJ, Mangia A, Cox AL, Kirk GD, Mehta S, Aneja J, Alric L, Donfield SM, Cramp ME, Khakoo SI, Tobler LH, Busch M, Alexander GJ, Rosen HR, Edlin BR, Segal FP, Lauer GM, Thomas DL, Daly MJ, Chung RT, Kim AY.

Sci Rep. 2017 Nov 20;7(1):15843. doi: 10.1038/s41598-017-16011-2.


Rapid reversal of innate immune dysregulation in blood of patients and livers of humanized mice with HCV following DAA therapy.

Burchill MA, Roby JA, Crochet N, Wind-Rotolo M, Stone AE, Edwards MG, Dran RJ, Kriss MS, Gale M Jr, Rosen HR.

PLoS One. 2017 Oct 17;12(10):e0186213. doi: 10.1371/journal.pone.0186213. eCollection 2017.


Hepatic Complications of Anorexia Nervosa.

Rosen E, Bakshi N, Watters A, Rosen HR, Mehler PS.

Dig Dis Sci. 2017 Nov;62(11):2977-2981. doi: 10.1007/s10620-017-4766-9. Epub 2017 Sep 20. Review.


Hepatocyte-derived exosomes promote T follicular regulatory cell expansion during hepatitis C virus infection.

Cobb DA, Kim OK, Golden-Mason L, Rosen HR, Hahn YS.

Hepatology. 2018 Jan;67(1):71-85. doi: 10.1002/hep.29409. Epub 2017 Nov 15.


NAM 2017 report: A national plan to eliminate hepatitis B and C in the United States by 2030 and the AASLD's response.

Rosen HR, Ghany MG, Chung RT, Lok ASF.

Hepatology. 2017 Oct;66(4):1020-1022. doi: 10.1002/hep.29361. Epub 2017 Aug 30. No abstract available.


How an alloreactive T-cell receptor achieves peptide and MHC specificity.

Wang Y, Singh NK, Spear TT, Hellman LM, Piepenbrink KH, McMahan RH, Rosen HR, Vander Kooi CW, Nishimura MI, Baker BM.

Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4792-E4801. doi: 10.1073/pnas.1700459114. Epub 2017 Jun 1.


Galectin-9: Diverse roles in hepatic immune homeostasis and inflammation.

Golden-Mason L, Rosen HR.

Hepatology. 2017 Jul;66(1):271-279. doi: 10.1002/hep.29106. Epub 2017 May 27. Review.


Correction: Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission.

Giugliano S, Petroff MG, Warren BD, Jasti S, Linscheid C, Ward A, Kramer A, Dobrinskikh E, Sheiko MA, Gale M Jr, Golden-Mason L, Winn VD, Rosen HR.

J Immunol. 2017 Jan 15;198(2):972. doi: 10.4049/jimmunol.1601926. No abstract available.


Neutrophil-to-lymphocyte ratio correlates with proinflammatory neutrophils and predicts death in low model for end-stage liver disease patients with cirrhosis.

Kalra A, Wedd JP, Bambha KM, Gralla J, Golden-Mason L, Collins C, Rosen HR, Biggins SW.

Liver Transpl. 2017 Feb;23(2):155-165. doi: 10.1002/lt.24702.


Correction: Free Fatty Acids Differentially Downregulate Chemokines in Liver Sinusoidal Endothelial Cells: Insights into Non-Alcoholic Fatty Liver Disease.

McMahan RH, Porsche CE, Edwards MG, Rosen HR.

PLoS One. 2016 Dec 8;11(12):e0168301. doi: 10.1371/journal.pone.0168301. eCollection 2016.


Sevelamer Improves Steatohepatitis, Inhibits Liver and Intestinal Farnesoid X Receptor (FXR), and Reverses Innate Immune Dysregulation in a Mouse Model of Non-alcoholic Fatty Liver Disease.

McGettigan BM, McMahan RH, Luo Y, Wang XX, Orlicky DJ, Porsche C, Levi M, Rosen HR.

J Biol Chem. 2016 Oct 28;291(44):23058-23067. Epub 2016 Sep 7.


"Hep C, where art thou": What are the remaining (fundable) questions in hepatitis C virus research?

Rosen HR.

Hepatology. 2017 Jan;65(1):341-349. doi: 10.1002/hep.28848. Epub 2016 Nov 15.


Free Fatty Acids Differentially Downregulate Chemokines in Liver Sinusoidal Endothelial Cells: Insights into Non-Alcoholic Fatty Liver Disease.

McMahan RH, Porsche CE, Edwards MG, Rosen HR.

PLoS One. 2016 Jul 25;11(7):e0159217. doi: 10.1371/journal.pone.0159217. eCollection 2016. Erratum in: PLoS One. 2016 Dec 8;11(12 ):e0168301.


Predicting renal recovery after liver transplant with severe pretransplant subacute kidney injury: The impact of warm ischemia time.

Laskey HL, Schomaker N, Hung KW, Asrani SK, Jennings L, Nydam TL, Gralla J, Wiseman A, Rosen HR, Biggins SW.

Liver Transpl. 2016 Aug;22(8):1085-91. doi: 10.1002/lt.24488. Epub 2016 Jul 12.


Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner.

White JT, Cross EW, Burchill MA, Danhorn T, McCarter MD, Rosen HR, O'Connor B, Kedl RM.

Nat Commun. 2016 Apr 21;7:11291. doi: 10.1038/ncomms11291.


Hepatitis C virus-cross-reactive TCR gene-modified T cells: a model for immunotherapy against diseases with genomic instability.

Spear TT, Riley TP, Lyons GE, Callender GG, Roszkowski JJ, Wang Y, Simms PE, Scurti GM, Foley KC, Murray DC, Hellman LM, McMahan RH, Iwashima M, Garrett-Mayer E, Rosen HR, Baker BM, Nishimura MI.

J Leukoc Biol. 2016 Sep;100(3):545-57. doi: 10.1189/jlb.2A1215-561R. Epub 2016 Feb 26.


Hepatitis C Virus-Induced Myeloid-Derived Suppressor Cells Suppress NK Cell IFN-γ Production by Altering Cellular Metabolism via Arginase-1.

Goh CC, Roggerson KM, Lee HC, Golden-Mason L, Rosen HR, Hahn YS.

J Immunol. 2016 Mar 1;196(5):2283-92. doi: 10.4049/jimmunol.1501881. Epub 2016 Jan 29.


CD4+ and CD8+ T Cell Activation in Children with Hepatitis C.

Sheiko MA, Golden-Mason L, Giugliano S, Hurtado CW, Mack CL, Narkewicz MR, Rosen HR.

J Pediatr. 2016 Mar;170:142-8.e1. doi: 10.1016/j.jpeds.2015.11.055. Epub 2015 Dec 30.


Consensus Interferon for Recurrent Hepatitis C Infection in Nonresponders to Peginterferon and Ribavirin After Liver Transplant.

Nordstrom EM, Biggins SW, Gralla J, Rosen HR, Everson GT, Burton JR Jr.

Exp Clin Transplant. 2015 Dec;13(6):543-9.


Variants in the LGALS9 Gene Are Associated With Development of Liver Disease in Heavy Consumers of Alcohol.

Rosen HR, Golden-Mason L, Daly AK, Yang I, Day CP.

Clin Gastroenterol Hepatol. 2016 May;14(5):762-8.e1. doi: 10.1016/j.cgh.2015.11.005. Epub 2015 Nov 18.


Association Between Plasma Level of Galectin-9 and Survival of Patients With Drug-Induced Acute Liver Failure.

Rosen HR, Biggins SW, Niki T, Gralla J, Hillman H, Hirashima M, Schilsky M, Lee WM; Acute Liver Failure Study Group.

Clin Gastroenterol Hepatol. 2016 Apr;14(4):606-612.e3. doi: 10.1016/j.cgh.2015.09.040. Epub 2015 Oct 20.


Memory re-differentiation and reduced lymphocyte activation in chronic HCV-infected patients receiving direct-acting antivirals.

Burchill MA, Golden-Mason L, Wind-Rotolo M, Rosen HR.

J Viral Hepat. 2015 Dec;22(12):983-91. doi: 10.1111/jvh.12465. Epub 2015 Oct 7.


HCV-infected cells and differentiation increase monocyte immunoregulatory galectin-9 production.

Harwood NM, Golden-Mason L, Cheng L, Rosen HR, Mengshol JA.

J Leukoc Biol. 2016 Mar;99(3):495-503. doi: 10.1189/jlb.5A1214-582R. Epub 2015 Oct 16.


Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission.

Giugliano S, Petroff MG, Warren BD, Jasti S, Linscheid C, Ward A, Kramer A, Dobrinskikh E, Sheiko MA, Gale M Jr, Golden-Mason L, Winn VD, Rosen HR.

J Immunol. 2015 Oct 15;195(8):3737-47. doi: 10.4049/jimmunol.1500409. Epub 2015 Sep 4. Erratum in: J Immunol. 2017 Jan 15;198(2):972.


The corrected donor age for hepatitis C virus-infected liver transplant recipients.

Dirchwolf M, Dodge JL, Gralla J, Bambha KM, Nydam T, Hung KW, Rosen HR, Feng S, Terrault NA, Biggins SW.

Liver Transpl. 2015 Aug;21(8):1022-30. doi: 10.1002/lt.24194.


Optimizing repeat liver transplant graft utility through strategic matching of donor and recipient characteristics.

Hung K, Gralla J, Dodge JL, Bambha KM, Dirchwolf M, Rosen HR, Biggins SW.

Liver Transpl. 2015 Nov;21(11):1365-73. doi: 10.1002/lt.24138.


Hepatitis C viral infection is associated with activated cytolytic natural killer cells expressing high levels of T cell immunoglobulin- and mucin-domain-containing molecule-3.

Golden-Mason L, Waasdorp Hurtado CE, Cheng L, Rosen HR.

Clin Immunol. 2015 May;158(1):114-25. doi: 10.1016/j.clim.2015.03.008. Epub 2015 Mar 19.


Transmitted/founder hepatitis C viruses induce cell-type- and genotype-specific differences in innate signaling within the liver.

Mitchell AM, Stone AE, Cheng L, Ballinger K, Edwards MG, Stoddard M, Li H, Golden-Mason L, Shaw GM, Khetani S, Rosen HR.

MBio. 2015 Feb 24;6(2):e02510. doi: 10.1128/mBio.02510-14.


Hepatitis C virus infection induces autocrine interferon signaling by human liver endothelial cells and release of exosomes, which inhibits viral replication.

Giugliano S, Kriss M, Golden-Mason L, Dobrinskikh E, Stone AE, Soto-Gutierrez A, Mitchell A, Khetani SR, Yamane D, Stoddard M, Li H, Shaw GM, Edwards MG, Lemon SM, Gale M Jr, Shah VH, Rosen HR.

Gastroenterology. 2015 Feb;148(2):392-402.e13. doi: 10.1053/j.gastro.2014.10.040. Epub 2014 Nov 4.


Survival benefit of repeat liver transplantation in the United States: a serial MELD analysis by hepatitis C status and donor risk index.

Biggins SW, Gralla J, Dodge JL, Bambha KM, Tong S, Barón AE, Inadomi J, Terrault N, Rosen HR.

Am J Transplant. 2014 Nov;14(11):2588-94. doi: 10.1111/ajt.12867. Epub 2014 Sep 19.


Extracellular HCV-core protein induces an immature regulatory phenotype in NK cells: implications for outcome of acute infection.

Golden-Mason L, Hahn YS, Strong M, Cheng L, Rosen HR.

PLoS One. 2014 Jul 30;9(7):e103219. doi: 10.1371/journal.pone.0103219. eCollection 2014.


Hepatitis C virus core protein inhibits interferon production by a human plasmacytoid dendritic cell line and dysregulates interferon regulatory factor-7 and signal transducer and activator of transcription (STAT) 1 protein expression.

Stone AE, Mitchell A, Brownell J, Miklin DJ, Golden-Mason L, Polyak SJ, Gale MJ Jr, Rosen HR.

PLoS One. 2014 May 1;9(5):e95627. doi: 10.1371/journal.pone.0095627. eCollection 2014.


Prediction models of prevalent radiographic vertebral fractures among older women.

Schousboe JT, Rosen HR, Vokes TJ, Cauley JA, Cummings SR, Nevitt M, Black DM, Orwoll ES, Kado DM, Ensrud KE; Study of Osteoporotic Fractures Research Group.

J Clin Densitom. 2014 Jul-Sep;17(3):378-85. doi: 10.1016/j.jocd.2013.09.021. Epub 2014 Feb 25.


Simplified criteria for selecting patients for vertebral fracture assessment.

Chou SH, Vokes TJ, Ma SL, Costello M, Rosen HR, Schousboe JT.

J Clin Densitom. 2014 Jul-Sep;17(3):386-91. doi: 10.1016/j.jocd.2013.11.003. Epub 2014 Feb 25.


Prediction models of prevalent radiographic vertebral fractures among older men.

Schousboe JT, Rosen HR, Vokes TJ, Cauley JA, Cummings SR, Nevitt MC, Black DM, Orwoll ES, Kado DM, Ensrud KE; Osteoporotic Fractures in Men (MrOS) Study Research Group.

J Clin Densitom. 2014 Oct-Dec;17(4):449-57. doi: 10.1016/j.jocd.2013.09.020. Epub 2013 Nov 27.


Emerging concepts in immunity to hepatitis C virus infection.

Rosen HR.

J Clin Invest. 2013 Oct;123(10):4121-30. doi: 10.1172/JCI67714. Epub 2013 Oct 1. Review.


Natural killer cells: multifaceted players with key roles in hepatitis C immunity.

Golden-Mason L, Rosen HR.

Immunol Rev. 2013 Sep;255(1):68-81. doi: 10.1111/imr.12090. Review.


High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase.

Ishimoto T, Lanaspa MA, Rivard CJ, Roncal-Jimenez CA, Orlicky DJ, Cicerchi C, McMahan RH, Abdelmalek MF, Rosen HR, Jackman MR, MacLean PS, Diggle CP, Asipu A, Inaba S, Kosugi T, Sato W, Maruyama S, Sánchez-Lozada LG, Sautin YY, Hill JO, Bonthron DT, Johnson RJ.

Hepatology. 2013 Nov;58(5):1632-43. doi: 10.1002/hep.26594. Epub 2013 Oct 8.


Ex vivo analysis of resident hepatic pro-inflammatory CD1d-reactive T cells and hepatocyte surface CD1d expression in hepatitis C.

Yanagisawa K, Yue S, van der Vliet HJ, Wang R, Alatrakchi N, Golden-Mason L, Schuppan D, Koziel MJ, Rosen HR, Exley MA.

J Viral Hepat. 2013 Aug;20(8):556-65. doi: 10.1111/jvh.12081. Epub 2013 Mar 11.


Independent, parallel pathways to CXCL10 induction in HCV-infected hepatocytes.

Brownell J, Wagoner J, Lovelace ES, Thirstrup D, Mohar I, Smith W, Giugliano S, Li K, Crispe IN, Rosen HR, Polyak SJ.

J Hepatol. 2013 Oct;59(4):701-8. doi: 10.1016/j.jhep.2013.06.001. Epub 2013 Jun 12.


Hepatitis C virus pathogen associated molecular pattern (PAMP) triggers production of lambda-interferons by human plasmacytoid dendritic cells.

Stone AE, Giugliano S, Schnell G, Cheng L, Leahy KF, Golden-Mason L, Gale M Jr, Rosen HR.

PLoS Pathog. 2013;9(4):e1003316. doi: 10.1371/journal.ppat.1003316. Epub 2013 Apr 18. Erratum in: PLoS Pathog. 2013 Jun;9(6). doi:10.1371/annotation/6382d059-925d-4af7-b6f2-3669fc68ddfa.


Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease.

McMahan RH, Wang XX, Cheng LL, Krisko T, Smith M, El Kasmi K, Pruzanski M, Adorini L, Golden-Mason L, Levi M, Rosen HR.

J Biol Chem. 2013 Apr 26;288(17):11761-70. doi: 10.1074/jbc.M112.446575. Epub 2013 Mar 4.

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