Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 122

1.

Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity.

Kazak L, Rahbani JF, Samborska B, Lu GZ, Jedrychowski MP, Lajoie M, Zhang S, Ramsay LC, Dou FY, Tenen D, Chouchani ET, Dzeja P, Watson IR, Tsai L, Rosen ED, Spiegelman BM.

Nat Metab. 2019;1(3):360-370. doi: 10.1038/s42255-019-0035-x. Epub 2019 Feb 25. No abstract available.

2.

Discovering metabolic disease gene interactions by correlated effects on cellular morphology.

Jiao Y, Ahmed U, Sim MFM, Bejar A, Zhang X, Talukder MMU, Rice R, Flannick J, Podgornaia AI, Reilly DF, Engreitz JM, Kost-Alimova M, Hartland K, Mercader JM, Georges S, Wagh V, Tadin-Strapps M, Doench JG, Edwardson JM, Rochford JJ, Rosen ED, Majithia AR.

Mol Metab. 2019 Jun;24:108-119. doi: 10.1016/j.molmet.2019.03.001. Epub 2019 Mar 13.

3.

Epigenetics and Epigenomics: Implications for Diabetes and Obesity.

Rosen ED, Kaestner KH, Natarajan R, Patti ME, Sallari R, Sander M, Susztak K.

Diabetes. 2018 Oct;67(10):1923-1931. doi: 10.2337/db18-0537.

4.

Exposure of adipocytes to bisphenol-A in vitro interferes with insulin action without enhancing adipogenesis.

De Filippis E, Li T, Rosen ED.

PLoS One. 2018 Aug 22;13(8):e0201122. doi: 10.1371/journal.pone.0201122. eCollection 2018.

5.

Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin.

Kong X, Yao T, Zhou P, Kazak L, Tenen D, Lyubetskaya A, Dawes BA, Tsai L, Kahn BB, Spiegelman BM, Liu T, Rosen ED.

Cell Metab. 2018 Oct 2;28(4):631-643.e3. doi: 10.1016/j.cmet.2018.07.004. Epub 2018 Aug 2.

6.

Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity.

Roh HC, Tsai LTY, Shao M, Tenen D, Shen Y, Kumari M, Lyubetskaya A, Jacobs C, Dawes B, Gupta RK, Rosen ED.

Cell Metab. 2018 May 1;27(5):1121-1137.e5. doi: 10.1016/j.cmet.2018.03.005. Epub 2018 Apr 12.

7.

The Synergy between Palmitate and TNF-α for CCL2 Production Is Dependent on the TRIF/IRF3 Pathway: Implications for Metabolic Inflammation.

Ahmad R, Al-Roub A, Kochumon S, Akther N, Thomas R, Kumari M, Koshy MS, Tiss A, Hannun YA, Tuomilehto J, Sindhu S, Rosen ED.

J Immunol. 2018 May 15;200(10):3599-3611. doi: 10.4049/jimmunol.1701552. Epub 2018 Apr 9.

8.

Dnmt3a is an epigenetic mediator of adipose insulin resistance.

You D, Nilsson E, Tenen DE, Lyubetskaya A, Lo JC, Jiang R, Deng J, Dawes BA, Vaag A, Ling C, Rosen ED, Kang S.

Elife. 2017 Nov 1;6. pii: e30766. doi: 10.7554/eLife.30766.

9.

Adipocyte glucocorticoid receptor is important in lipolysis and insulin resistance due to exogenous steroids, but not insulin resistance caused by high fat feeding.

Shen Y, Roh HC, Kumari M, Rosen ED.

Mol Metab. 2017 Oct;6(10):1150-1160. doi: 10.1016/j.molmet.2017.06.013. Epub 2017 Jun 29.

10.

Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity.

Kazak L, Chouchani ET, Lu GZ, Jedrychowski MP, Bare CJ, Mina AI, Kumari M, Zhang S, Vuckovic I, Laznik-Bogoslavski D, Dzeja P, Banks AS, Rosen ED, Spiegelman BM.

Cell Metab. 2017 Oct 3;26(4):693. doi: 10.1016/j.cmet.2017.09.007. No abstract available.

11.

Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity.

Kazak L, Chouchani ET, Lu GZ, Jedrychowski MP, Bare CJ, Mina AI, Kumari M, Zhang S, Vuckovic I, Laznik-Bogoslavski D, Dzeja P, Banks AS, Rosen ED, Spiegelman BM.

Cell Metab. 2017 Oct 3;26(4):660-671.e3. doi: 10.1016/j.cmet.2017.08.009. Epub 2017 Aug 24. Erratum in: Cell Metab. 2017 Oct 3;26(4):693.

12.

UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction.

Kazak L, Chouchani ET, Stavrovskaya IG, Lu GZ, Jedrychowski MP, Egan DF, Kumari M, Kong X, Erickson BK, Szpyt J, Rosen ED, Murphy MP, Kristal BS, Gygi SP, Spiegelman BM.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):7981-7986. doi: 10.1073/pnas.1705406114. Epub 2017 Jun 19.

13.

Imaging mass spectrometry demonstrates age-related decline in human adipose plasticity.

Guillermier C, Fazeli PK, Kim S, Lun M, Zuflacht JP, Milian J, Lee H, Francois-Saint-Cyr H, Horreard F, Larson D, Rosen ED, Lee RT, Lechene CP, Steinhauser ML.

JCI Insight. 2017 Mar 9;2(5):e90349. doi: 10.1172/jci.insight.90349.

14.

A molecular census of arcuate hypothalamus and median eminence cell types.

Campbell JN, Macosko EZ, Fenselau H, Pers TH, Lyubetskaya A, Tenen D, Goldman M, Verstegen AM, Resch JM, McCarroll SA, Rosen ED, Lowell BB, Tsai LT.

Nat Neurosci. 2017 Mar;20(3):484-496. doi: 10.1038/nn.4495. Epub 2017 Feb 6.

15.

Simultaneous Transcriptional and Epigenomic Profiling from Specific Cell Types within Heterogeneous Tissues In Vivo.

Roh HC, Tsai LT, Lyubetskaya A, Tenen D, Kumari M, Rosen ED.

Cell Rep. 2017 Jan 24;18(4):1048-1061. doi: 10.1016/j.celrep.2016.12.087.

16.

Prospective functional classification of all possible missense variants in PPARG.

Majithia AR, Tsuda B, Agostini M, Gnanapradeepan K, Rice R, Peloso G, Patel KA, Zhang X, Broekema MF, Patterson N, Duby M, Sharpe T, Kalkhoven E, Rosen ED, Barroso I, Ellard S; UK Monogenic Diabetes Consortium, Kathiresan S; Myocardial Infarction Genetics Consortium, O'Rahilly S; UK Congenital Lipodystrophy Consortium, Chatterjee K, Florez JC, Mikkelsen T, Savage DB, Altshuler D.

Nat Genet. 2016 Dec;48(12):1570-1575. doi: 10.1038/ng.3700. Epub 2016 Oct 17.

17.

Epigenomic and transcriptional control of insulin resistance.

Rosen ED.

J Intern Med. 2016 Nov;280(5):443-456. doi: 10.1111/joim.12547. Epub 2016 Oct 14. Review.

18.

IRF3 promotes adipose inflammation and insulin resistance and represses browning.

Kumari M, Wang X, Lantier L, Lyubetskaya A, Eguchi J, Kang S, Tenen D, Roh HC, Kong X, Kazak L, Ahmad R, Rosen ED.

J Clin Invest. 2016 Aug 1;126(8):2839-54. doi: 10.1172/JCI86080. Epub 2016 Jul 11.

19.

Burning Fat by Bugging the System.

Rosen ED.

N Engl J Med. 2016 Mar 3;374(9):885-7. doi: 10.1056/NEJMcibr1515457. No abstract available.

PMID:
26962910
20.

Nuclear Mechanisms of Insulin Resistance.

Kang S, Tsai LT, Rosen ED.

Trends Cell Biol. 2016 May;26(5):341-351. doi: 10.1016/j.tcb.2016.01.002. Epub 2016 Jan 25. Review.

21.

Making Biological Sense of GWAS Data: Lessons from the FTO Locus.

Herman MA, Rosen ED.

Cell Metab. 2015 Oct 6;22(4):538-9. doi: 10.1016/j.cmet.2015.09.018.

22.

Two paths to fat.

Rosen ED.

Nat Cell Biol. 2015 Apr;17(4):360-1. doi: 10.1038/ncb3133.

PMID:
25812519
23.

Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis.

Kang S, Tsai LT, Zhou Y, Evertts A, Xu S, Griffin MJ, Issner R, Whitton HJ, Garcia BA, Epstein CB, Mikkelsen TS, Rosen ED.

Nat Cell Biol. 2015 Jan;17(1):44-56. doi: 10.1038/ncb3080. Epub 2014 Dec 15.

24.

Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes.

Majithia AR, Flannick J, Shahinian P, Guo M, Bray MA, Fontanillas P, Gabriel SB; GoT2D Consortium; NHGRI JHS/FHS Allelic Spectrum Project; SIGMA T2D Consortium; T2D-GENES Consortium, Rosen ED, Altshuler D.

Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13127-32. doi: 10.1073/pnas.1410428111. Epub 2014 Aug 25. Erratum in: Proc Natl Acad Sci U S A. 2014 Nov;11;111(45):16225. Estrada, Karol [added]; Mercader, Josep [added]; MacArthur, Daniel [added].

25.

Characterization of Cre recombinase models for the study of adipose tissue.

Jeffery E, Berry R, Church CD, Yu S, Shook BA, Horsley V, Rosen ED, Rodeheffer MS.

Adipocyte. 2014 Jul 1;3(3):206-11. doi: 10.4161/adip.29674. Epub 2014 Jun 27.

26.

IRF4 is a key thermogenic transcriptional partner of PGC-1α.

Kong X, Banks A, Liu T, Kazak L, Rao RR, Cohen P, Wang X, Yu S, Lo JC, Tseng YH, Cypess AM, Xue R, Kleiner S, Kang S, Spiegelman BM, Rosen ED.

Cell. 2014 Jul 3;158(1):69-83. doi: 10.1016/j.cell.2014.04.049.

27.

A smooth muscle-like origin for beige adipocytes.

Long JZ, Svensson KJ, Tsai L, Zeng X, Roh HC, Kong X, Rao RR, Lou J, Lokurkar I, Baur W, Castellot JJ Jr, Rosen ED, Spiegelman BM.

Cell Metab. 2014 May 6;19(5):810-20. doi: 10.1016/j.cmet.2014.03.025. Epub 2014 Apr 4.

28.

Adipocyte-specific transgenic and knockout models.

Kang S, Kong X, Rosen ED.

Methods Enzymol. 2014;537:1-16. doi: 10.1016/B978-0-12-411619-1.00001-X. Review.

PMID:
24480338
29.

What we talk about when we talk about fat.

Rosen ED, Spiegelman BM.

Cell. 2014 Jan 16;156(1-2):20-44. doi: 10.1016/j.cell.2013.12.012. Review.

30.

Early B-cell factor-1 (EBF1) is a key regulator of metabolic and inflammatory signaling pathways in mature adipocytes.

Griffin MJ, Zhou Y, Kang S, Zhang X, Mikkelsen TS, Rosen ED.

J Biol Chem. 2013 Dec 13;288(50):35925-39. doi: 10.1074/jbc.M113.491936. Epub 2013 Oct 30.

31.

Osteoblast-specific expression of Fra-2/AP-1 controls adiponectin and osteocalcin expression and affects metabolism.

Bozec A, Bakiri L, Jimenez M, Rosen ED, Catalá-Lehnen P, Schinke T, Schett G, Amling M, Wagner EF.

J Cell Sci. 2013 Dec 1;126(Pt 23):5432-40. doi: 10.1242/jcs.134510. Epub 2013 Sep 17.

32.

Charting a dynamic DNA methylation landscape of the human genome.

Ziller MJ, Gu H, Müller F, Donaghey J, Tsai LT, Kohlbacher O, De Jager PL, Rosen ED, Bennett DA, Bernstein BE, Gnirke A, Meissner A.

Nature. 2013 Aug 22;500(7463):477-81. doi: 10.1038/nature12433. Epub 2013 Aug 7.

33.

Interferon regulatory factor 4 regulates obesity-induced inflammation through regulation of adipose tissue macrophage polarization.

Eguchi J, Kong X, Tenta M, Wang X, Kang S, Rosen ED.

Diabetes. 2013 Oct;62(10):3394-403. doi: 10.2337/db12-1327. Epub 2013 Jul 8.

34.

Fibrin networks regulate protein transport during thrombus development.

Kim OV, Xu Z, Rosen ED, Alber MS.

PLoS Comput Biol. 2013;9(6):e1003095. doi: 10.1371/journal.pcbi.1003095. Epub 2013 Jun 13.

35.

New insights into adipocyte-specific leptin gene expression.

Wrann CD, Rosen ED.

Adipocyte. 2012 Jul 1;1(3):168-172.

36.

Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages.

Kiviranta R, Yamana K, Saito H, Ho DK, Laine J, Tarkkonen K, Nieminen-Pihala V, Hesse E, Correa D, Määttä J, Tessarollo L, Rosen ED, Horne WC, Jenkins NA, Copeland NG, Warming S, Baron R.

J Exp Med. 2013 May 6;210(5):969-85. doi: 10.1084/jem.20121187. Epub 2013 Apr 8.

37.

Lessons on conditional gene targeting in mouse adipose tissue.

Lee KY, Russell SJ, Ussar S, Boucher J, Vernochet C, Mori MA, Smyth G, Rourk M, Cederquist C, Rosen ED, Kahn BB, Kahn CR.

Diabetes. 2013 Mar;62(3):864-74. doi: 10.2337/db12-1089. Epub 2013 Jan 15.

38.

Regulation of early adipose commitment by Zfp521.

Kang S, Akerblad P, Kiviranta R, Gupta RK, Kajimura S, Griffin MJ, Min J, Baron R, Rosen ED.

PLoS Biol. 2012;10(11):e1001433. doi: 10.1371/journal.pbio.1001433. Epub 2012 Nov 27.

39.

Mechano-rheological properties of the murine thrombus determined via nanoindentation and finite element modeling.

Slaboch CL, Alber MS, Rosen ED, Ovaert TC.

J Mech Behav Biomed Mater. 2012 Jun;10:75-86. doi: 10.1016/j.jmbbm.2012.02.012. Epub 2012 Feb 27.

PMID:
22520420
40.

Multiscale model of fibrin accumulation on the blood clot surface and platelet dynamics.

Xu Z, Christley S, Lioi J, Kim O, Harvey C, Sun W, Rosen ED, Alber M.

Methods Cell Biol. 2012;110:367-88. doi: 10.1016/B978-0-12-388403-9.00014-X.

PMID:
22482956
41.

FOSL2 promotes leptin gene expression in human and mouse adipocytes.

Wrann CD, Eguchi J, Bozec A, Xu Z, Mikkelsen T, Gimble J, Nave H, Wagner EF, Ong SE, Rosen ED.

J Clin Invest. 2012 Mar;122(3):1010-21. doi: 10.1172/JCI58431. Epub 2012 Feb 13.

42.

Multiscale models of thrombogenesis.

Xu Z, Kim O, Kamocka M, Rosen ED, Alber M.

Wiley Interdiscip Rev Syst Biol Med. 2012 May-Jun;4(3):237-46. doi: 10.1002/wsbm.1160. Epub 2012 Jan 13. Review.

PMID:
22246734
43.

Identifying novel transcriptional components controlling energy metabolism.

Gupta RK, Rosen ED, Spiegelman BM.

Cell Metab. 2011 Dec 7;14(6):739-45. doi: 10.1016/j.cmet.2011.11.007. Review.

44.

A minor role for lipocalin 2 in high-fat diet-induced glucose intolerance.

Jun LS, Siddall CP, Rosen ED.

Am J Physiol Endocrinol Metab. 2011 Nov;301(5):E825-35. doi: 10.1152/ajpendo.00147.2011. Epub 2011 Jul 19.

45.

Modelling platelet-blood flow interaction using the subcellular element Langevin method.

Sweet CR, Chatterjee S, Xu Z, Bisordi K, Rosen ED, Alber M.

J R Soc Interface. 2011 Dec 7;8(65):1760-71. doi: 10.1098/rsif.2011.0180. Epub 2011 May 18.

46.

Transcriptional control of adipose lipid handling by IRF4.

Eguchi J, Wang X, Yu S, Kershaw EE, Chiu PC, Dushay J, Estall JL, Klein U, Maratos-Flier E, Rosen ED.

Cell Metab. 2011 Mar 2;13(3):249-59. doi: 10.1016/j.cmet.2011.02.005.

47.

Computational approaches to studying thrombus development.

Xu Z, Kamocka M, Alber M, Rosen ED.

Arterioscler Thromb Vasc Biol. 2011 Mar;31(3):500-5. doi: 10.1161/ATVBAHA.110.213397. Review.

PMID:
21325672
48.

Mammalian stem cells reprogramming in response to terahertz radiation.

Bock J, Fukuyo Y, Kang S, Phipps ML, Alexandrov LB, Rasmussen KØ, Bishop AR, Rosen ED, Martinez JS, Chen HT, Rodriguez G, Alexandrov BS, Usheva A.

PLoS One. 2010 Dec 31;5(12):e15806. doi: 10.1371/journal.pone.0015806.

49.

Comparative epigenomic analysis of murine and human adipogenesis.

Mikkelsen TS, Xu Z, Zhang X, Wang L, Gimble JM, Lander ES, Rosen ED.

Cell. 2010 Oct 1;143(1):156-69. doi: 10.1016/j.cell.2010.09.006.

50.

A multiscale model of venous thrombus formation with surface-mediated control of blood coagulation cascade.

Xu Z, Lioi J, Mu J, Kamocka MM, Liu X, Chen DZ, Rosen ED, Alber M.

Biophys J. 2010 May 19;98(9):1723-32. doi: 10.1016/j.bpj.2009.12.4331. Erratum in: Biophys J. 2010 Oct 6;99(7):2384-5.

Supplemental Content

Loading ...
Support Center