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The role of tumor-associated macrophages in gastric cancer development and their potential as a therapeutic target.

Gambardella V, Castillo J, Tarazona N, Gimeno-Valiente F, Martínez-Ciarpaglini C, Cabeza-Segura M, Roselló S, Roda D, Huerta M, Cervantes A, Fleitas T.

Cancer Treat Rev. 2020 Mar 23;86:102015. doi: 10.1016/j.ctrv.2020.102015. [Epub ahead of print] Review.


EPDR1 up-regulation in human colorectal cancer is related to staging and favours cell proliferation and invasiveness.

Gimeno-Valiente F, Riffo-Campos ÁL, Ayala G, Tarazona N, Gambardella V, Rodríguez FM, Huerta M, Martínez-Ciarpaglini C, Montón-Bueno J, Roselló S, Roda D, Cervantes A, Franco L, López-Rodas G, Castillo J.

Sci Rep. 2020 Feb 28;10(1):3723. doi: 10.1038/s41598-020-60476-7.


Programmed colorectal cancer screening decreases incidence and mortality.

Roselló S, Simón S, Cervantes A.

Transl Gastroenterol Hepatol. 2019 Dec 26;4:84. doi: 10.21037/tgh.2019.12.13. eCollection 2019. No abstract available.


Impact of perioperative transfusions and sepsis on long-term oncologic outcomes after curative colon cancer resection. A retrospective analysis of a prospective database.

Baguena G, Pellino G, Frasson M, Escrig J, Marinello F, Espí A, García-Granero A, Roselló S, Cervantes A, García-Granero E.

Gastroenterol Hepatol. 2020 Feb;43(2):63-72. doi: 10.1016/j.gastrohep.2019.07.005. Epub 2020 Jan 7. English, Spanish.


Targeted next-generation sequencing of circulating-tumor DNA for tracking minimal residual disease in localized colon cancer.

Tarazona N, Gimeno-Valiente F, Gambardella V, Zuñiga S, Rentero-Garrido P, Huerta M, Roselló S, Martinez-Ciarpaglini C, Carbonell-Asins JA, Carrasco F, Ferrer-Martínez A, Bruixola G, Fleitas T, Martín J, Tébar-Martínez R, Moro D, Castillo J, Espí A, Roda D, Cervantes A.

Ann Oncol. 2019 Nov 1;30(11):1804-1812. doi: 10.1093/annonc/mdz390.


High throughput FT-MIR indirect analysis of sugars and acids in watermelon.

Martí R, Sánchez G, Valcárcel M, Roselló S, Cebolla-Cornejo J.

Food Chem. 2019 Dec 1;300:125227. doi: 10.1016/j.foodchem.2019.125227. Epub 2019 Jul 23.


Understanding the clinical behavior of relapsed colon cancers with microsatellite instability relative to BRAF mutations.

Roda D, Roselló S, Cervantes A.

Ann Oncol. 2019 Sep 1;30(9):1409-1410. doi: 10.1093/annonc/mdz229. No abstract available.


Assessing molecular subtypes of gastric cancer: microsatellite unstable and Epstein-Barr virus subtypes. Methods for detection and clinical and pathological implications.

Martinez-Ciarpaglini C, Fleitas-Kanonnikoff T, Gambardella V, Llorca M, Mongort C, Mengual R, Nieto G, Navarro L, Huerta M, Rosello S, Roda D, Tarazona N, Navarro S, Ribas G, Cervantes A.

ESMO Open. 2019 May 27;4(3):e000470. doi: 10.1136/esmoopen-2018-000470. eCollection 2019.


Analysis of KRAS, NRAS, BRAF, PIK3CA and TP53 mutations in a large prospective series of locally advanced rectal cancer patients.

Sclafani F, Wilson SH, Cunningham D, Gonzalez De Castro D, Kalaitzaki E, Begum R, Wotherspoon A, Capdevila J, Glimelius B, Roselló S, Thomas J, Tait D, Brown G, Oates J, Chau I.

Int J Cancer. 2020 Jan 1;146(1):94-102. doi: 10.1002/ijc.32507. Epub 2019 Jul 5.


Improving tumour budding evaluation in colon cancer by extending the assessment area in colectomy specimens.

Martinez-Ciarpaglini C, Fernandez-Sellers C, Tarazona N, Roselló S, Huerta M, Roda D, Mongort C, Ferrández A, Navarro S, Cervantes A.

Histopathology. 2019 Oct;75(4):517-525. doi: 10.1111/his.13900. Epub 2019 Aug 7.


Towards precision oncology for HER2 blockade in gastroesophageal adenocarcinoma.

Gambardella V, Fleitas T, Tarazona N, Cejalvo JM, Gimeno-Valiente F, Martinez-Ciarpaglini C, Huerta M, Roselló S, Castillo J, Roda D, Cervantes A.

Ann Oncol. 2019 Aug 1;30(8):1254-1264. doi: 10.1093/annonc/mdz143.


FT-MIR determination of taste-related compounds in tomato: a high throughput phenotyping analysis for selection programs.

Ibáñez G, Valcárcel M, Cebolla-Cornejo J, Roselló S.

J Sci Food Agric. 2019 Aug 30;99(11):5140-5148. doi: 10.1002/jsfa.9760. Epub 2019 May 24.


Prognostic Impact of pT Stage and Peritoneal Invasion in Locally Advanced Colon Cancer.

Baguena G, Pellino G, Frasson M, Roselló S, Cervantes A, García-Granero A, Giner F, García-Granero E.

Dis Colon Rectum. 2019 Jun;62(6):684-693. doi: 10.1097/DCR.0000000000001367.


NRF2 through RPS6 Activation Is Related to Anti-HER2 Drug Resistance in HER2-Amplified Gastric Cancer.

Gambardella V, Gimeno-Valiente F, Tarazona N, Martinez-Ciarpaglini C, Roda D, Fleitas T, Tolosa P, Cejalvo JM, Huerta M, Roselló S, Castillo J, Cervantes A.

Clin Cancer Res. 2019 Mar 1;25(5):1639-1649. doi: 10.1158/1078-0432.CCR-18-2421. Epub 2018 Nov 30.


Maintenance with single agent bevacizumab fails to improve disease-control in metastatic colorectal cancer.

Roselló S, Borrás R, Cervantes A.

Hepatobiliary Surg Nutr. 2018 Oct;7(5):395-398. doi: 10.21037/hbsn.2018.08.02. No abstract available.


Corrections to "Management of infusion reactions to systemic anticancer therapy: ESMO Clinical Practice Guidelines".

Roselló S, Blasco I, García Fabregat L, Cervantes A, Jordan K; ESMO Guidelines Committee.

Ann Oncol. 2018 Oct;29 Suppl 4:iv260. doi: 10.1093/annonc/mdy158. Epub 2020 Jan 7. No abstract available.


Outcomes after neoadjuvant treatment with gemcitabine and erlotinib followed by gemcitabine-erlotinib and radiotherapy for resectable pancreatic cancer (GEMCAD 10-03 trial).

Maurel J, Sánchez-Cabús S, Laquente B, Gaba L, Visa L, Fabregat J, Povés I, Roselló S, Díaz-Beveridge R, Martín-Richard M, Rodriguez J, Sabater L, Conill C, Cambray M, Reig A, Ayuso JR, Valls C, Ferrández A, Bombí JA, Ginés A, García-Albéniz X, Fernández-Cruz L.

Cancer Chemother Pharmacol. 2018 Dec;82(6):935-943. doi: 10.1007/s00280-018-3682-9. Epub 2018 Sep 17.


Low miR200c expression in tumor budding of invasive front predicts worse survival in patients with localized colon cancer and is related to PD-L1 overexpression.

Martinez-Ciarpaglini C, Oltra S, Roselló S, Roda D, Mongort C, Carrasco F, Gonzalez J, Santonja F, Tarazona N, Huerta M, Espí A, Ribas G, Ferrández A, Navarro S, Cervantes A.

Mod Pathol. 2019 Feb;32(2):306-313. doi: 10.1038/s41379-018-0124-5. Epub 2018 Sep 11.


RPS6 through the activation of NRF2 causes resistance to antiHER2 drugs in HER2 amplified gastric cancer (GC) models.

Gambardella V, Valiente FG, Tarazona N, Roda D, Tolosa P, Fleitas Kanonnikoff T, Garcia Mico B, Huerta M, Rosello S, Martinez-Ciarpaglini C, Cervantes A, Castillo J.

Ann Oncol. 2018 Sep;29 Suppl 6:vi31-vi32. doi: 10.1093/annonc/mdy314.039. Epub 2020 Jan 7. No abstract available.


Borderline resectable pancreatic cancer. Challenges and controversies.

Sabater L, Muñoz E, Roselló S, Dorcaratto D, Garcés-Albir M, Huerta M, Roda D, Gómez-Mateo MC, Ferrández-Izquierdo A, Darder A, Cervantes A.

Cancer Treat Rev. 2018 Jul;68:124-135. doi: 10.1016/j.ctrv.2018.06.006. Epub 2018 Jun 13. Review.


Neoadjuvant score in locally advanced rectal cancer: integrating downstaging in risk assessment and looking for new valuable end points.

Roselló S, Cervantes A.

Ann Oncol. 2018 Jul 1;29(7):1493-1494. doi: 10.1093/annonc/mdy182. No abstract available.


Management of infusion reactions to systemic anticancer therapy: ESMO Clinical Practice Guidelines.

Roselló S, Blasco I, García Fabregat L, Cervantes A, Jordan K; ESMO Guidelines Committee.

Ann Oncol. 2018 Oct 1;29(Suppl 4):iv260. doi: 10.1093/annonc/mdy158. No abstract available.


Influence of controlled deficit irrigation on tomato functional value.

Martí R, Valcárcel M, Leiva-Brondo M, Lahoz I, Campillo C, Roselló S, Cebolla-Cornejo J.

Food Chem. 2018 Jun 30;252:250-257. doi: 10.1016/j.foodchem.2018.01.098. Epub 2018 Feb 2.


The role of chemotherapy in localized and locally advanced rectal cancer: A systematic revision.

Roselló S, Papaccio F, Roda D, Tarazona N, Cervantes A.

Cancer Treat Rev. 2018 Feb;63:156-171. doi: 10.1016/j.ctrv.2018.01.001. Epub 2018 Jan 11. Review.


Integrating Downstaging in the Risk Assessment of Patients With Locally Advanced Rectal Cancer Treated With Neoadjuvant Chemoradiotherapy: Validation of Valentini's Nomograms and the Neoadjuvant Rectal Score.

Roselló S, Frasson M, García-Granero E, Roda D, Jordá E, Navarro S, Campos S, Esclápez P, García-Botello S, Flor B, Espí A, Masciocchi C, Valentini V, Cervantes A.

Clin Colorectal Cancer. 2018 Jun;17(2):104-112.e2. doi: 10.1016/j.clcc.2017.10.014. Epub 2017 Oct 28.


Comparison between MRI and pathology in the assessment of tumour regression grade in rectal cancer.

Sclafani F, Brown G, Cunningham D, Wotherspoon A, Mendes LST, Balyasnikova S, Evans J, Peckitt C, Begum R, Tait D, Tabernero J, Glimelius B, Roselló S, Thomas J, Oates J, Chau I.

Br J Cancer. 2017 Nov 7;117(10):1478-1485. doi: 10.1038/bjc.2017.320. Epub 2017 Sep 21.


Management of infusion reactions to systemic anticancer therapy: ESMO Clinical Practice Guidelines.

Roselló S, Blasco I, García Fabregat L, Cervantes A, Jordan K; ESMO Guidelines Committee.

Ann Oncol. 2017 Jul 1;28(suppl_4):iv100-iv118. doi: 10.1093/annonc/mdx216. No abstract available. Erratum in: Ann Oncol. 2018 Oct 1;29(Suppl 4):iv260. Ann Oncol. 2018 Oct;29 Suppl 4:iv260.


Polyphenol and l-ascorbic acid content in tomato as influenced by high lycopene genotypes and organic farming at different environments.

Martí R, Leiva-Brondo M, Lahoz I, Campillo C, Cebolla-Cornejo J, Roselló S.

Food Chem. 2018 Jan 15;239:148-156. doi: 10.1016/j.foodchem.2017.06.102. Epub 2017 Jun 20.


Simultaneous determination of main phenolic acids and flavonoids in tomato by micellar electrokinetic capillary electrophoresis.

Martí R, Valcárcel M, Herrero-Martínez JM, Cebolla-Cornejo J, Roselló S.

Food Chem. 2017 Apr 15;221:439-446. doi: 10.1016/j.foodchem.2016.10.105. Epub 2016 Oct 24.


SEOM Clinical Guideline of localized rectal cancer (2016).

González-Flores E, Losa F, Pericay C, Polo E, Roselló S, Safont MJ, Vera R, Aparicio J, Cano MT, Fernández-Martos C.

Clin Transl Oncol. 2016 Dec;18(12):1163-1171. doi: 10.1007/s12094-016-1591-0. Epub 2016 Nov 30.


A First-in-Human Phase I Study of the ATP-Competitive AKT Inhibitor Ipatasertib Demonstrates Robust and Safe Targeting of AKT in Patients with Solid Tumors.

Saura C, Roda D, Roselló S, Oliveira M, Macarulla T, Pérez-Fidalgo JA, Morales-Barrera R, Sanchis-García JM, Musib L, Budha N, Zhu J, Nannini M, Chan WY, Sanabria Bohórquez SM, Meng RD, Lin K, Yan Y, Patel P, Baselga J, Tabernero J, Cervantes A.

Cancer Discov. 2017 Jan;7(1):102-113. doi: 10.1158/2159-8290.CD-16-0512. Epub 2016 Nov 21. Erratum in: Cancer Discov. 2018 Nov;8(11):1490.


Erratum to «Non-surgical treatment of localized rectal cancer is an experimental option».

Roselló S, Cervantes A.

Cir Esp. 2016 Dec;94(10):617. doi: 10.1016/j.ciresp.2016.07.003. Epub 2016 Sep 22. English, Spanish. No abstract available.


Epigenetic changes in localized gastric cancer: the role of RUNX3 in tumor progression and the immune microenvironment.

Llorca-Cardeñosa MJ, Fleitas T, Ibarrola-Villava M, Peña-Chilet M, Mongort C, Martinez-Ciarpaglini C, Navarro L, Gambardella V, Castillo J, Roselló S, Navarro S, Ribas G, Cervantes A.

Oncotarget. 2016 Sep 27;7(39):63424-63436. doi: 10.18632/oncotarget.11520.


Fruit quality assessment of watermelons grafted onto citron melon rootstock.

Fredes A, Roselló S, Beltrán J, Cebolla-Cornejo J, Pérez-de-Castro A, Gisbert C, Picó MB.

J Sci Food Agric. 2017 Mar;97(5):1646-1655. doi: 10.1002/jsfa.7915. Epub 2016 Sep 2.


Tomato as a Source of Carotenoids and Polyphenols Targeted to Cancer Prevention.

Martí R, Roselló S, Cebolla-Cornejo J.

Cancers (Basel). 2016 Jun 20;8(6). pii: E58. doi: 10.3390/cancers8060058. Review.


Personalised Treatment in Gastric Cancer: Myth or Reality?

Tarazona N, Gambardella V, Huerta M, Roselló S, Cervantes A.

Curr Oncol Rep. 2016 Jul;18(7):41. doi: 10.1007/s11912-016-0525-x. Review.


Non-surgical treatment of localized rectal cancer is an experimental option.

Roselló S, Cervantes A.

Cir Esp. 2016 Jun-Jul;94(6):311-2. doi: 10.1016/j.ciresp.2016.03.003. Epub 2016 Apr 26. English, Spanish. No abstract available. Erratum in: Cir Esp. 2016 Dec;94(10):617.


Determination of somatic oncogenic mutations linked to target-based therapies using MassARRAY technology.

Ibarrola-Villava M, Fleitas T, Llorca-Cardeñosa MJ, Mongort C, Alonso E, Navarro S, Burgues O, Vivancos A, Cejalvo JM, Perez-Fidalgo JA, Roselló S, Ribas G, Cervantes A.

Oncotarget. 2016 Apr 19;7(16):22543-55. doi: 10.18632/oncotarget.8002.


Clinical pharmacokinetics and pharmacodynamics of ramucirumab in the treatment of colorectal cancer.

Gambardella V, Tarazona N, Cejalvo JM, Roselló S, Cervantes A.

Expert Opin Drug Metab Toxicol. 2016;12(4):449-56. doi: 10.1517/17425255.2016.1156084. Epub 2016 Mar 10. Review.


Deregulation of ARID1A, CDH1, cMET and PIK3CA and target-related microRNA expression in gastric cancer.

Ibarrola-Villava M, Llorca-Cardeñosa MJ, Tarazona N, Mongort C, Fleitas T, Perez-Fidalgo JA, Roselló S, Navarro S, Ribas G, Cervantes A.

Oncotarget. 2015 Sep 29;6(29):26935-45. doi: 10.18632/oncotarget.4775.


Quantification of prominent volatile compounds responsible for muskmelon and watermelon aroma by purge and trap extraction followed by gas chromatography-mass spectrometry determination.

Fredes A, Sales C, Barreda M, Valcárcel M, Roselló S, Beltrán J.

Food Chem. 2016 Jan 1;190:689-700. doi: 10.1016/j.foodchem.2015.06.011. Epub 2015 Jun 4.


Extending neoadjuvant chemotherapy in rectal cancer.

Roselló S, Cervantes A.

Lancet Oncol. 2015 Aug;16(8):880-1. doi: 10.1016/S1470-2045(15)00092-3. Epub 2015 Jul 14. No abstract available.


EGF-Induced Acetylation of Heterogeneous Nuclear Ribonucleoproteins Is Dependent on KRAS Mutational Status in Colorectal Cancer Cells.

Roda D, Castillo J, Telechea-Fernández M, Gil A, López-Rodas G, Franco L, González-Rodríguez P, Roselló S, Pérez-Fidalgo JA, García-Trevijano ER, Cervantes A, Zaragozá R.

PLoS One. 2015 Jun 25;10(6):e0130543. doi: 10.1371/journal.pone.0130543. eCollection 2015.


Phase I study of FOLFIRI plus pimasertib as second-line treatment for KRAS-mutated metastatic colorectal cancer.

Macarulla T, Cervantes A, Tabernero J, Roselló S, Van Cutsem E, Tejpar S, Prenen H, Martinelli E, Troiani T, Laffranchi B, Jego V, von Richter O, Ciardiello F.

Br J Cancer. 2015 Jun 9;112(12):1874-81. doi: 10.1038/bjc.2015.144. Epub 2015 May 19.


Safety and Activity of the First-in-Class Sym004 Anti-EGFR Antibody Mixture in Patients with Refractory Colorectal Cancer.

Dienstmann R, Patnaik A, Garcia-Carbonero R, Cervantes A, Benavent M, Roselló S, Tops BB, van der Post RS, Argilés G, Skartved NJ, Hansen UH, Hald R, Pedersen MW, Kragh M, Horak ID, Braun S, Van Cutsem E, Tolcher AW, Tabernero J.

Cancer Discov. 2015 Jun;5(6):598-609. doi: 10.1158/2159-8290.CD-14-1432. Epub 2015 May 11.


Selective approach for upper rectal cancer treatment: total mesorectal excision and preoperative chemoradiation are seldom necessary.

Marinello FG, Frasson M, Baguena G, Flor-Lorente B, Cervantes A, Roselló S, Espí A, García-Granero E.

Dis Colon Rectum. 2015 Jun;58(6):556-65. doi: 10.1097/DCR.0000000000000349.


Fast simultaneous determination of prominent polyphenols in vegetables and fruits by reversed phase liquid chromatography using a fused-core column.

Martí R, Valcárcel M, Herrero-Martínez JM, Cebolla-Cornejo J, Roselló S.

Food Chem. 2015 Feb 15;169:169-79. doi: 10.1016/j.foodchem.2014.07.151. Epub 2014 Aug 7.


Implementation and assessment of a fast-track programme to improve communication between primary and specialized care in patients with suspected cancer: how to shorten time between initial symptoms of cancer, diagnosis and initiation of treatment.

Martínez MT, González I, Tarazona N, Roselló S, Saiz R, Sanmartín A, Martínez-Agulló Á, Caballero A, Mas P, Franco J, Martínez-Jabaloyas J, García-Callejo J, Martín V, Navarro J, Teruel A, Lluch A, Chirivella I.

Clin Transl Oncol. 2015 Feb;17(2):167-72. doi: 10.1007/s12094-014-1209-3. Epub 2014 Aug 7.


Prognostic implications of the standardized study of resection margins in pancreatic cancers.

Sabater L, Gómez-Mateo Mdel C, López-Sebastián J, Muñoz-Forner E, Morera-Ocón F, Cervantes A, Roselló S, Camps-Vilata B, Ferrández A, Ortega J.

Cir Esp. 2014 Oct;92(8):532-8. doi: 10.1016/j.ciresp.2013.07.014. Epub 2014 May 28. English, Spanish.


Step-along power vector method for astigmatic wavefront propagation.

Roselló S, Thibos L, Micó V.

Ophthalmic Physiol Opt. 2014 May;34(3):295-308. doi: 10.1111/opo.12120.


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