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Genomic programming of IRF4-expressing human Langerhans cells.

Sirvent S, Vallejo AF, Davies J, Clayton K, Wu Z, Woo J, Riddell J, Chaudhri VK, Stumpf P, Nazlamova LA, Wheway G, Rose-Zerilli M, West J, Pujato M, Chen X, Woelk CH, MacArthur B, Ardern-Jones M, Friedmann PS, Weirauch MT, Singh H, Polak ME.

Nat Commun. 2020 Jan 16;11(1):313. doi: 10.1038/s41467-019-14125-x.


Single-cell analysis based dissection of clonality in myelofibrosis.

Mylonas E, Yoshida K, Frick M, Hoyer K, Christen F, Kaeda J, Obenaus M, Noerenberg D, Hennch C, Chan W, Ochi Y, Shiraishi Y, Shiozawa Y, Zenz T, Oakes CC, Sawitzki B, Schwarz M, Bullinger L, le Coutre P, Rose-Zerilli MJJ, Ogawa S, Damm F.

Nat Commun. 2020 Jan 7;11(1):73. doi: 10.1038/s41467-019-13892-x.


Clinical significance of DNA methylation in chronic lymphocytic leukemia patients: results from 3 UK clinical trials.

Wojdacz TK, Amarasinghe HE, Kadalayil L, Beattie A, Forster J, Blakemore SJ, Parker H, Bryant D, Larrayoz M, Clifford R, Robbe P, Davis ZA, Else M, Howard DR, Stamatopoulos B, Steele AJ, Rosenquist R, Collins A, Pettitt AR, Hillmen P, Plass C, Schuh A, Catovsky D, Oscier DG, Rose-Zerilli MJJ, Oakes CC, Strefford JC.

Blood Adv. 2019 Aug 27;3(16):2474-2481. doi: 10.1182/bloodadvances.2019000237.


An optimised tissue disaggregation and data processing pipeline for characterising fibroblast phenotypes using single-cell RNA sequencing.

Waise S, Parker R, Rose-Zerilli MJJ, Layfield DM, Wood O, West J, Ottensmeier CH, Thomas GJ, Hanley CJ.

Sci Rep. 2019 Jul 3;9(1):9580. doi: 10.1038/s41598-019-45842-4.


Author Correction: Authentication and characterisation of a new oesophageal adenocarcinoma cell line: MFD-1.

Garcia E, Hayden A, Birts C, Britton E, Rogerson C, Bleaney CW, Cowie A, Pickard K, Mellone M, Choh C, Derouet M, Duriez P, Noble F, White MJ, Primrose JN, Strefford JC, Rose-Zerilli M, Thomas GJ, Ang Y, Sharrocks AD, Fitzgerald RC, Underwood TJ; OCCAMS consortium.

Sci Rep. 2019 Jan 22;9(1):318. doi: 10.1038/s41598-018-37591-7.


Stem cell-like breast cancer cells with acquired resistance to metformin are sensitive to inhibitors of NADH-dependent CtBP dimerization.

Banerjee A, Birts CN, Darley M, Parker R, Mirnezami AH, West J, Cutress RI, Beers SA, Rose-Zerilli MJJ, Blaydes JP.

Carcinogenesis. 2019 Jul 20;40(7):871-882. doi: 10.1093/carcin/bgy174.


The effects of restricted glycolysis on stem-cell like characteristics of breast cancer cells.

Banerjee A, Arvinrad P, Darley M, Laversin SA, Parker R, Rose-Zerilli MJJ, Townsend PA, Cutress RI, Beers SA, Houghton FD, Birts CN, Blaydes JP.

Oncotarget. 2018 May 1;9(33):23274-23288. doi: 10.18632/oncotarget.25299. eCollection 2018 May 1.


CBL-MZ is not a single biological entity: evidence from genomic analysis and prolonged clinical follow-up.

Parker H, McIver-Brown NR, Davis ZA, Parry M, Rose-Zerilli MJJ, Xochelli A, Gibson J, Walewska R, Strefford JC, Oscier DG.

Blood Adv. 2018 May 22;2(10):1116-1119. doi: 10.1182/bloodadvances.2018019760. No abstract available.


Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment.

Turaj AH, Hussain K, Cox KL, Rose-Zerilli MJJ, Testa J, Dahal LN, Chan HTC, James S, Field VL, Carter MJ, Kim HJ, West JJ, Thomas LJ, He LZ, Keler T, Johnson PWM, Al-Shamkhani A, Thirdborough SM, Beers SA, Cragg MS, Glennie MJ, Lim SH.

Cancer Cell. 2017 Dec 11;32(6):777-791.e6. doi: 10.1016/j.ccell.2017.11.001. Epub 2017 Nov 30.


Subclonal Evolution of Cancer-Related Gene Mutations in p53 Immunopositive Patches in Human Skin.

Albibas AA, Rose-Zerilli MJJ, Lai C, Pengelly RJ, Lockett GA, Theaker J, Ennis S, Holloway JW, Healy E.

J Invest Dermatol. 2018 Jan;138(1):189-198. doi: 10.1016/j.jid.2017.07.844. Epub 2017 Aug 24.


Identification of a functionally significant tri-allelic genotype in the Tyrosinase gene (TYR) causing hypomorphic oculocutaneous albinism (OCA1B).

Norman CS, O'Gorman L, Gibson J, Pengelly RJ, Baralle D, Ratnayaka JA, Griffiths H, Rose-Zerilli M, Ranger M, Bunyan D, Lee H, Page R, Newall T, Shawkat F, Mattocks C, Ward D, Ennis S, Self JE.

Sci Rep. 2017 Jun 30;7(1):4415. doi: 10.1038/s41598-017-04401-5.


Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia.

Parker H, Rose-Zerilli MJ, Larrayoz M, Clifford R, Edelmann J, Blakemore S, Gibson J, Wang J, Ljungström V, Wojdacz TK, Chaplin T, Roghanian A, Davis Z, Parker A, Tausch E, Ntoufa S, Ramos S, Robbe P, Alsolami R, Steele AJ, Packham G, Rodríguez-Vicente AE, Brown L, McNicholl F, Forconi F, Pettitt A, Hillmen P, Dyer M, Cragg MS, Chelala C, Oakes CC, Rosenquist R, Stamatopoulos K, Stilgenbauer S, Knight S, Schuh A, Oscier DG, Strefford JC.

Leukemia. 2016 Nov;30(11):2179-2186. doi: 10.1038/leu.2016.134. Epub 2016 May 20.


Non-coding NOTCH1 mutations in chronic lymphocytic leukemia; their clinical impact in the UK CLL4 trial.

Larrayoz M, Rose-Zerilli MJ, Kadalayil L, Parker H, Blakemore S, Forster J, Davis Z, Steele AJ, Collins A, Else M, Catovsky D, Oscier DG, Strefford JC.

Leukemia. 2017 Feb;31(2):510-514. doi: 10.1038/leu.2016.298. Epub 2016 Oct 26. No abstract available.


Authentication and characterisation of a new oesophageal adenocarcinoma cell line: MFD-1.

Garcia E, Hayden A, Birts C, Britton E, Cowie A, Pickard K, Mellone M, Choh C, Derouet M, Duriez P, Noble F, White MJ, Primrose JN, Strefford JC, Rose-Zerilli M, Thomas GJ, Ang Y, Sharrocks AD, Fitzgerald RC, Underwood TJ; OCCAMS consortium.

Sci Rep. 2016 Sep 7;6:32417. doi: 10.1038/srep32417. Erratum in: Sci Rep. 2019 Jan 22;9(1):318.


Surface IgM expression and function are associated with clinical behavior, genetic abnormalities, and DNA methylation in CLL.

D'Avola A, Drennan S, Tracy I, Henderson I, Chiecchio L, Larrayoz M, Rose-Zerilli M, Strefford J, Plass C, Johnson PW, Steele AJ, Packham G, Stevenson FK, Oakes CC, Forconi F.

Blood. 2016 Aug 11;128(6):816-26. doi: 10.1182/blood-2016-03-707786. Epub 2016 Jun 14.


Correction: Evaluation of High-Throughput Genomic Assays for the Fc Gamma Receptor Locus.

Hargreaves CE, Iriyama C, Rose-Zerilli MJ, Nagelkerke SQ, Hussain K, Ganderton R, Lee C, Machado LR, Hollox EJ, Parker H, Latham KV, Kuijpers TW, Potter KN, Coupland SE, Davies A, Stackpole M, Oates M, Pettitt AR, Glennie MJ, Cragg MS, Strefford JC.

PLoS One. 2016 Mar 23;11(3):e0145040. doi: 10.1371/journal.pone.0145040. eCollection 2016. No abstract available.


Longitudinal copy number, whole exome and targeted deep sequencing of 'good risk' IGHV-mutated CLL patients with progressive disease.

Rose-Zerilli MJ, Gibson J, Wang J, Tapper W, Davis Z, Parker H, Larrayoz M, McCarthy H, Walewska R, Forster J, Gardiner A, Steele AJ, Chelala C, Ennis S, Collins A, Oakes CC, Oscier DG, Strefford JC.

Leukemia. 2016 Jun;30(6):1301-10. doi: 10.1038/leu.2016.10. Epub 2016 Feb 5.


The outcome of Chronic lymphocytic leukaemia patients with 97% IGHV gene identity to germline is distinct from cases with <97% identity and similar to those with 98% identity.

Davis Z, Forconi F, Parker A, Gardiner A, Thomas P, Catovsky D, Rose-Zerilli M, Strefford JC, Oscier D.

Br J Haematol. 2016 Apr;173(1):127-36. doi: 10.1111/bjh.13940. Epub 2016 Feb 5.


Evaluation of High-Throughput Genomic Assays for the Fc Gamma Receptor Locus.

Hargreaves CE, Iriyama C, Rose-Zerilli MJ, Nagelkerke SQ, Hussain K, Ganderton R, Lee C, Machado LR, Hollox EJ, Parker H, Latham KV, Kuijpers TW, Potter KN, Coupland SE, Davies A, Stackpole M, Oates M, Pettitt AR, Glennie MJ, Cragg MS, Strefford JC.

PLoS One. 2015 Nov 6;10(11):e0142379. doi: 10.1371/journal.pone.0142379. eCollection 2015. Erratum in: PLoS One. 2016;11(3):e0145040.


Fcγ receptors: genetic variation, function, and disease.

Hargreaves CE, Rose-Zerilli MJ, Machado LR, Iriyama C, Hollox EJ, Cragg MS, Strefford JC.

Immunol Rev. 2015 Nov;268(1):6-24. doi: 10.1111/imr.12341. Review.


The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukaemia cells through downregulation of Mcl-1.

Larrayoz M, Blakemore SJ, Dobson RC, Blunt MD, Rose-Zerilli MJ, Walewska R, Duncombe A, Oscier D, Koide K, Forconi F, Packham G, Yoshida M, Cragg MS, Strefford JC, Steele AJ.

Leukemia. 2016 Feb;30(2):351-60. doi: 10.1038/leu.2015.286. Epub 2015 Oct 21.


Telomere length predicts progression and overall survival in chronic lymphocytic leukemia: data from the UK LRF CLL4 trial.

Strefford JC, Kadalayil L, Forster J, Rose-Zerilli MJ, Parker A, Lin TT, Heppel N, Norris K, Gardiner A, Davies Z, Gonzalez de Castro D, Else M, Steele AJ, Parker H, Stankovic T, Pepper C, Fegan C, Baird D, Collins A, Catovsky D, Oscier DG.

Leukemia. 2015 Dec;29(12):2411-4. doi: 10.1038/leu.2015.217. Epub 2015 Aug 10. No abstract available.


Genetics and Prognostication in Splenic Marginal Zone Lymphoma: Revelations from Deep Sequencing.

Parry M, Rose-Zerilli MJ, Ljungström V, Gibson J, Wang J, Walewska R, Parker H, Parker A, Davis Z, Gardiner A, McIver-Brown N, Kalpadakis C, Xochelli A, Anagnostopoulos A, Fazi C, de Castro DG, Dearden C, Pratt G, Rosenquist R, Ashton-Key M, Forconi F, Collins A, Ghia P, Matutes E, Pangalis G, Stamatopoulos K, Oscier D, Strefford JC.

Clin Cancer Res. 2015 Sep 15;21(18):4174-4183. doi: 10.1158/1078-0432.CCR-14-2759. Epub 2015 Mar 16.


Low frequency mutations independently predict poor treatment-free survival in early stage chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis.

Winkelmann N, Rose-Zerilli M, Forster J, Parry M, Parker A, Gardiner A, Davies Z, Steele AJ, Parker H, Cross NC, Oscier DG, Strefford JC.

Haematologica. 2015 Jun;100(6):e237-9. doi: 10.3324/haematol.2014.120238. Epub 2015 Feb 20. No abstract available.


Exome sequence read depth methods for identifying copy number changes.

Kadalayil L, Rafiq S, Rose-Zerilli MJ, Pengelly RJ, Parker H, Oscier D, Strefford JC, Tapper WJ, Gibson J, Ennis S, Collins A.

Brief Bioinform. 2015 May;16(3):380-92. doi: 10.1093/bib/bbu027. Epub 2014 Aug 28. Review.


Recurrent mutations refine prognosis in chronic lymphocytic leukemia.

Baliakas P, Hadzidimitriou A, Sutton LA, Rossi D, Minga E, Villamor N, Larrayoz M, Kminkova J, Agathangelidis A, Davis Z, Tausch E, Stalika E, Kantorova B, Mansouri L, Scarfò L, Cortese D, Navrkalova V, Rose-Zerilli MJ, Smedby KE, Juliusson G, Anagnostopoulos A, Makris AM, Navarro A, Delgado J, Oscier D, Belessi C, Stilgenbauer S, Ghia P, Pospisilova S, Gaidano G, Campo E, Strefford JC, Stamatopoulos K, Rosenquist R; European Research Initiative on CLL (ERIC).

Leukemia. 2015 Feb;29(2):329-36. doi: 10.1038/leu.2014.196. Epub 2014 Jun 19.


ATM mutation rather than BIRC3 deletion and/or mutation predicts reduced survival in 11q-deleted chronic lymphocytic leukemia: data from the UK LRF CLL4 trial.

Rose-Zerilli MJ, Forster J, Parker H, Parker A, Rodríguez AE, Chaplin T, Gardiner A, Steele AJ, Collins A, Young BD, Skowronska A, Catovsky D, Stankovic T, Oscier DG, Strefford JC.

Haematologica. 2014 Apr;99(4):736-42. doi: 10.3324/haematol.2013.098574. Epub 2014 Feb 28.


Alpha-tryptase gene variation is associated with levels of circulating IgE and lung function in asthma.

Abdelmotelb AM, Rose-Zerilli MJ, Barton SJ, Holgate ST, Walls AF, Holloway JW.

Clin Exp Allergy. 2014 Jun;44(6):822-30. doi: 10.1111/cea.12259.


Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma.

Parry M, Rose-Zerilli MJ, Gibson J, Ennis S, Walewska R, Forster J, Parker H, Davis Z, Gardiner A, Collins A, Oscier DG, Strefford JC.

PLoS One. 2013 Dec 13;8(12):e83244. doi: 10.1371/journal.pone.0083244. eCollection 2013.


The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial.

Oscier DG, Rose-Zerilli MJ, Winkelmann N, Gonzalez de Castro D, Gomez B, Forster J, Parker H, Parker A, Gardiner A, Collins A, Else M, Cross NC, Catovsky D, Strefford JC.

Blood. 2013 Jan 17;121(3):468-75. doi: 10.1182/blood-2012-05-429282. Epub 2012 Oct 18.


Evidence of association between interferon regulatory factor 5 gene polymorphisms and asthma.

Wang C, Rose-Zerilli MJ, Koppelman GH, Sandling JK, Holloway JW, Postma DS, Holgate ST, Bours V, Syvänen AC, Dideberg V.

Gene. 2012 Aug 10;504(2):220-5. doi: 10.1016/j.gene.2012.05.021. Epub 2012 May 18.


Identification of ATPAF1 as a novel candidate gene for asthma in children.

Schauberger EM, Ewart SL, Arshad SH, Huebner M, Karmaus W, Holloway JW, Friderici KH, Ziegler JT, Zhang H, Rose-Zerilli MJ, Barton SJ, Holgate ST, Kilpatrick JR, Harley JB, Lajoie-Kadoch S, Harley IT, Hamid Q, Kurukulaaratchy RJ, Seibold MA, Avila PC, Rodriguez-Cintrón W, Rodriguez-Santana JR, Hu D, Gignoux C, Romieu I, London SJ, Burchard EG, Langefeld CD, Wills-Karp M.

J Allergy Clin Immunol. 2011 Oct;128(4):753-760.e11. doi: 10.1016/j.jaci.2011.04.058. Epub 2011 Jun 22.


Neurophysiological evidence for cognitive and brain functional adaptation in adolescents living at high altitude.

Richardson C, Hogan AM, Bucks RS, Baya A, Virues-Ortega J, Holloway JW, Rose-Zerilli M, Palmer LJ, Webster RJ, Kirkham FJ, Baldeweg T.

Clin Neurophysiol. 2011 Sep;122(9):1726-34. doi: 10.1016/j.clinph.2011.02.001. Epub 2011 Mar 4.


13q deletion anatomy and disease progression in patients with chronic lymphocytic leukemia.

Parker H, Rose-Zerilli MJ, Parker A, Chaplin T, Wade R, Gardiner A, Griffiths M, Collins A, Young BD, Oscier DG, Strefford JC.

Leukemia. 2011 Mar;25(3):489-97. doi: 10.1038/leu.2010.288. Epub 2010 Dec 10.


Prenatal and infant acetaminophen exposure, antioxidant gene polymorphisms, and childhood asthma.

Shaheen SO, Newson RB, Ring SM, Rose-Zerilli MJ, Holloway JW, Henderson AJ.

J Allergy Clin Immunol. 2010 Dec;126(6):1141-8.e7. doi: 10.1016/j.jaci.2010.08.047. Epub 2010 Nov 4.


The relationship between infant lung function and the risk of wheeze in the preschool years.

Pike KC, Rose-Zerilli MJ, Osvald EC, Inskip HM, Godfrey KM, Crozier SR, Roberts G, Clough JB, Holloway JW, Lucas JS; Southampton Women's Survey Study Group.

Pediatr Pulmonol. 2011 Jan;46(1):75-82. doi: 10.1002/ppul.21327. Epub 2010 Sep 16.


Maternal Nrf2 and gluthathione-S-transferase polymorphisms do not modify associations of prenatal tobacco smoke exposure with asthma and lung function in school-aged children.

Henderson AJ, Newson RB, Rose-Zerilli M, Ring SM, Holloway JW, Shaheen SO.

Thorax. 2010 Oct;65(10):897-902. doi: 10.1136/thx.2009.125856. Epub 2010 Aug 30.


The role of histamine degradation gene polymorphisms in moderating the effects of food additives on children's ADHD symptoms.

Stevenson J, Sonuga-Barke E, McCann D, Grimshaw K, Parker KM, Rose-Zerilli MJ, Holloway JW, Warner JO.

Am J Psychiatry. 2010 Sep;167(9):1108-15. doi: 10.1176/appi.ajp.2010.09101529. Epub 2010 Jun 15.


Development of aptitude at altitude.

Hogan AM, Virues-Ortega J, Botti AB, Bucks R, Holloway JW, Rose-Zerilli MJ, Palmer LJ, Webster RJ, Baldeweg T, Kirkham FJ.

Dev Sci. 2010 May;13(3):533-544. doi: 10.1111/j.1467-7687.2009.00909.x.


ADAM33 expression in atherosclerotic lesions and relationship of ADAM33 gene variation with atherosclerosis.

Holloway JW, Laxton RC, Rose-Zerilli MJ, Holloway JA, Andrews AL, Riaz Z, Wilson SJ, Simpson IA, Ye S.

Atherosclerosis. 2010 Jul;211(1):224-30. doi: 10.1016/j.atherosclerosis.2010.02.023. Epub 2010 Feb 24.


Glutathione-S-transferase genes and asthma phenotypes: a Human Genome Epidemiology (HuGE) systematic review and meta-analysis including unpublished data.

Minelli C, Granell R, Newson R, Rose-Zerilli MJ, Torrent M, Ring SM, Holloway JW, Shaheen SO, Henderson JA.

Int J Epidemiol. 2010 Apr;39(2):539-62. doi: 10.1093/ije/dyp337. Epub 2009 Dec 23. Review.


Mortality in adult intensive care patients with severe systemic inflammatory response syndromes is strongly associated with the hypo-immune TNF -238A polymorphism.

Pappachan JV, Coulson TG, Child NJ, Markham DJ, Nour SM, Pulletz MC, Rose-Zerilli MJ, de Courcey-Golder K, Barton SJ, Yang IA, Holloway JW.

Immunogenetics. 2009 Oct;61(10):657-62. doi: 10.1007/s00251-009-0395-6. Epub 2009 Aug 28.


Copy-number variation genotyping of GSTT1 and GSTM1 gene deletions by real-time PCR.

Rose-Zerilli MJ, Barton SJ, Henderson AJ, Shaheen SO, Holloway JW.

Clin Chem. 2009 Sep;55(9):1680-5. doi: 10.1373/clinchem.2008.120105. Epub 2009 Jul 9.


PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline.

Barton SJ, Koppelman GH, Vonk JM, Browning CA, Nolte IM, Stewart CE, Bainbridge S, Mutch S, Rose-Zerilli MJ, Postma DS, Maniatis N, Henry AP, Hall IP, Holgate ST, Tighe P, Holloway JW, Sayers I.

J Allergy Clin Immunol. 2009 Jun;123(6):1391-400.e17. doi: 10.1016/j.jaci.2009.03.014. Epub 2009 May 13.


Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic families.

Szczepankiewicz A, Rose-Zerilli MJ, Barton SJ, Holgate ST, Holloway JW.

Int Arch Allergy Immunol. 2009;149(4):343-9. doi: 10.1159/000205580. Epub 2009 Mar 17.


Cancer cachexia is associated with the IL10 -1082 gene promoter polymorphism in patients with gastroesophageal malignancy.

Deans DA, Tan BH, Ross JA, Rose-Zerilli M, Wigmore SJ, Howell WM, Grimble RF, Fearon KC.

Am J Clin Nutr. 2009 Apr;89(4):1164-72. doi: 10.3945/ajcn.2008.27025. Epub 2009 Feb 25.


A single-nucleotide polymorphism in intelectin 1 is associated with increased asthma risk.

Pemberton AD, Rose-Zerilli MJ, Holloway JW, Gray RD, Holgate ST.

J Allergy Clin Immunol. 2008 Nov;122(5):1033-4. doi: 10.1016/j.jaci.2008.08.037. No abstract available.


The role of LTA4H and ALOX5AP polymorphism in asthma and allergy susceptibility.

Holloway JW, Barton SJ, Holgate ST, Rose-Zerilli MJ, Sayers I.

Allergy. 2008 Aug;63(8):1046-53. doi: 10.1111/j.1398-9995.2008.01667.x. Epub 2008 Jun 10.


Level of ex vivo interleukin 6 expression in human peripheral fat compared with other tissues.

Sonnenberg S, Shearman CP, Baxter S, Morris GE, Cumming DV, Montgomery HE, Rose-Zerilli MJ, Day IN.

Eur J Vasc Endovasc Surg. 2008 Mar;35(3):314-9. Epub 2007 Dec 26.


Quantitated transcript haplotypes (QTH) of AGTR1, reduced abundance of mRNA haplotypes containing 1166C (rs5186:A>C), and relevance to metabolic syndrome traits.

Abdollahi MR, Lewis RM, Gaunt TR, Cumming DV, Rodriguez S, Rose-Zerilli M, Collins AR, Syddall HE, Howell WM, Cooper C, Godfrey KM, Cameron IT, Day IN.

Hum Mutat. 2007 Apr;28(4):365-73.


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