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Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks.

Galligan JJ, Wepy JA, Streeter MD, Kingsley PJ, Mitchener MM, Wauchope OR, Beavers WN, Rose KL, Wang T, Spiegel DA, Marnett LJ.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9228-9233. doi: 10.1073/pnas.1802901115. Epub 2018 Aug 27.


Phosphorylation of XIAP at threonine 180 controls its activity in Wnt signaling.

Ng VH, Hang BI, Sawyer LM, Neitzel LR, Crispi EE, Rose KL, Popay TM, Zhong A, Lee LA, Tansey WP, Huppert S, Lee E.

J Cell Sci. 2018 May 22;131(10). pii: jcs210575. doi: 10.1242/jcs.210575.


Integrated molecular imaging reveals tissue heterogeneity driving host-pathogen interactions.

Cassat JE, Moore JL, Wilson KJ, Stark Z, Prentice BM, Van de Plas R, Perry WJ, Zhang Y, Virostko J, Colvin DC, Rose KL, Judd AM, Reyzer ML, Spraggins JM, Grunenwald CM, Gore JC, Caprioli RM, Skaar EP.

Sci Transl Med. 2018 Mar 14;10(432). pii: eaan6361. doi: 10.1126/scitranslmed.aan6361.


Protein identification in imaging mass spectrometry through spatially targeted liquid micro-extractions.

Ryan DJ, Nei D, Prentice BM, Rose KL, Caprioli RM, Spraggins JM.

Rapid Commun Mass Spectrom. 2018 Mar 15;32(5):442-450. doi: 10.1002/rcm.8042.


Loss of αB-crystallin function in zebrafish reveals critical roles in the development of the lens and stress resistance of the heart.

Mishra S, Wu SY, Fuller AW, Wang Z, Rose KL, Schey KL, Mchaourab HS.

J Biol Chem. 2018 Jan 12;293(2):740-753. doi: 10.1074/jbc.M117.808634. Epub 2017 Nov 21.


Critical role of SIK3 in mediating high salt and IL-17 synergy leading to breast cancer cell proliferation.

Amara S, Majors C, Roy B, Hill S, Rose KL, Myles EL, Tiriveedhi V.

PLoS One. 2017 Jun 28;12(6):e0180097. doi: 10.1371/journal.pone.0180097. eCollection 2017.


Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the Spinophilin/Neurofilament Medium Interaction.

Hiday AC, Edler MC, Salek AB, Morris CW, Thang M, Rentz TJ, Rose KL, Jones LM, Baucum AJ 2nd.

Neural Plast. 2017;2017:4153076. doi: 10.1155/2017/4153076. Epub 2017 May 28.


Protein Modification by Endogenously Generated Lipid Electrophiles: Mitochondria as the Source and Target.

Beavers WN, Rose KL, Galligan JJ, Mitchener MM, Rouzer CA, Tallman KA, Lamberson CR, Wang X, Hill S, Ivanova PT, Brown HA, Zhang B, Porter NA, Marnett LJ.

ACS Chem Biol. 2017 Aug 18;12(8):2062-2069. doi: 10.1021/acschembio.7b00480. Epub 2017 Jun 28.


Non-alcoholic fatty liver disease phosphoproteomics: A functional piece of the precision puzzle.

Wattacheril J, Rose KL, Hill S, Lanciault C, Murray CR, Washington K, Williams B, English W, Spann M, Clements R, Abumrad N, Flynn CR.

Hepatol Res. 2017 Dec;47(13):1469-1483. doi: 10.1111/hepr.12885. Epub 2017 Apr 19.


Integrated, High-Throughput, Multiomics Platform Enables Data-Driven Construction of Cellular Responses and Reveals Global Drug Mechanisms of Action.

Norris JL, Farrow MA, Gutierrez DB, Palmer LD, Muszynski N, Sherrod SD, Pino JC, Allen JL, Spraggins JM, Lubbock AL, Jordan A, Burns W, Poland JC, Romer C, Manier ML, Nei YW, Prentice BM, Rose KL, Hill S, Van de Plas R, Tsui T, Braman NM, Keller MR, Rutherford SA, Lobdell N, Lopez CF, Lacy DB, McLean JA, Wikswo JP, Skaar EP, Caprioli RM.

J Proteome Res. 2017 Mar 3;16(3):1364-1375. doi: 10.1021/acs.jproteome.6b01004. Epub 2017 Feb 9.


Electrophilic Modification of PKM2 by 4-Hydroxynonenal and 4-Oxononenal Results in Protein Cross-Linking and Kinase Inhibition.

Camarillo JM, Ullery JC, Rose KL, Marnett LJ.

Chem Res Toxicol. 2017 Feb 20;30(2):635-641. doi: 10.1021/acs.chemrestox.6b00374. Epub 2017 Jan 3.


3-D imaging mass spectrometry of protein distributions in mouse Neurofibromatosis 1 (NF1)-associated optic glioma.

Anderson DM, Van de Plas R, Rose KL, Hill S, Schey KL, Solga AC, Gutmann DH, Caprioli RM.

J Proteomics. 2016 Oct 21;149:77-84. doi: 10.1016/j.jprot.2016.02.004. Epub 2016 Feb 13.


MALDI imaging mass spectrometry of Pacific White Shrimp L. vannamei and identification of abdominal muscle proteins.

Schey KL, Hachey AJ, Rose KL, Grey AC.

Proteomics. 2016 Jun;16(11-12):1767-74. doi: 10.1002/pmic.201500531. Epub 2016 May 9.


Covalent Modification of CDK2 by 4-Hydroxynonenal as a Mechanism of Inhibition of Cell Cycle Progression.

Camarillo JM, Rose KL, Galligan JJ, Xu S, Marnett LJ.

Chem Res Toxicol. 2016 Mar 21;29(3):323-32. doi: 10.1021/acs.chemrestox.5b00485. Epub 2016 Mar 11.


MALDI Imaging Mass Spectrometry Spatially Maps Age-Related Deamidation and Truncation of Human Lens Aquaporin-0.

Wenke JL, Rose KL, Spraggins JM, Schey KL.

Invest Ophthalmol Vis Sci. 2015 Nov;56(12):7398-405. doi: 10.1167/iovs.15-18117.


The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability.

Dungrawala H, Rose KL, Bhat KP, Mohni KN, Glick GG, Couch FB, Cortez D.

Mol Cell. 2015 Sep 17;59(6):998-1010. doi: 10.1016/j.molcel.2015.07.030. Epub 2015 Sep 10.


Pyridoxamine protects proteins from damage by hypohalous acids in vitro and in vivo.

Madu H, Avance J, Chetyrkin S, Darris C, Rose KL, Sanchez OA, Hudson B, Voziyan P.

Free Radic Biol Med. 2015 Dec;89:83-90. doi: 10.1016/j.freeradbiomed.2015.07.001. Epub 2015 Jul 6.


Activation of the Endogenous Renin-Angiotensin-Aldosterone System or Aldosterone Administration Increases Urinary Exosomal Sodium Channel Excretion.

Qi Y, Wang X, Rose KL, MacDonald WH, Zhang B, Schey KL, Luther JM.

J Am Soc Nephrol. 2016 Feb;27(2):646-56. doi: 10.1681/ASN.2014111137. Epub 2015 Jun 25.


Alteration of the Helicobacter pylori membrane proteome in response to changes in environmental salt concentration.

Voss BJ, Loh JT, Hill S, Rose KL, McDonald WH, Cover TL.

Proteomics Clin Appl. 2015 Dec;9(11-12):1021-34. doi: 10.1002/prca.201400176. Epub 2015 Sep 14.


Simulated diabetic ketoacidosis therapy in vitro elicits brain cell swelling via sodium-hydrogen exchange and anion transport.

Rose KL, Watson AJ, Drysdale TA, Cepinskas G, Chan M, Rupar CA, Fraser DD.

Am J Physiol Endocrinol Metab. 2015 Aug 15;309(4):E370-9. doi: 10.1152/ajpendo.00107.2015. Epub 2015 Jun 16.


Biochemical and Proteomic Analysis of Ubiquitination of Hsc70 and Hsp70 by the E3 Ligase CHIP.

Soss SE, Rose KL, Hill S, Jouan S, Chazin WJ.

PLoS One. 2015 May 26;10(5):e0128240. doi: 10.1371/journal.pone.0128240. eCollection 2015.


MALDI FTICR IMS of Intact Proteins: Using Mass Accuracy to Link Protein Images with Proteomics Data.

Spraggins JM, Rizzo DG, Moore JL, Rose KL, Hammer ND, Skaar EP, Caprioli RM.

J Am Soc Mass Spectrom. 2015 Jun;26(6):974-85. doi: 10.1007/s13361-015-1147-5. Epub 2015 Apr 23.


High spatial resolution imaging mass spectrometry of human optic nerve lipids and proteins.

Anderson DM, Spraggins JM, Rose KL, Schey KL.

J Am Soc Mass Spectrom. 2015 Jun;26(6):940-7. doi: 10.1007/s13361-015-1143-9. Epub 2015 Apr 17.


Proteomics characterization of exosome cargo.

Schey KL, Luther JM, Rose KL.

Methods. 2015 Oct 1;87:75-82. doi: 10.1016/j.ymeth.2015.03.018. Epub 2015 Mar 31. Review.


Site-specific, intramolecular cross-linking of Pin1 active site residues by the lipid electrophile 4-oxo-2-nonenal.

Aluise CD, Camarillo JM, Shimozu Y, Galligan JJ, Rose KL, Tallman KA, Marnett LJ.

Chem Res Toxicol. 2015 Apr 20;28(4):817-27. doi: 10.1021/acs.chemrestox.5b00038. Epub 2015 Mar 18.


Quantitative proteomics analysis of CaMKII phosphorylation and the CaMKII interactome in the mouse forebrain.

Baucum AJ 2nd, Shonesy BC, Rose KL, Colbran RJ.

ACS Chem Neurosci. 2015 Apr 15;6(4):615-31. doi: 10.1021/cn500337u. Epub 2015 Feb 24.


Human phospholipase D activity transiently regulates pyrimidine biosynthesis in malignant gliomas.

Mathews TP, Hill S, Rose KL, Ivanova PT, Lindsley CW, Brown HA.

ACS Chem Biol. 2015 May 15;10(5):1258-68. doi: 10.1021/cb500772c. Epub 2015 Feb 17.


Hypohalous acids contribute to renal extracellular matrix damage in experimental diabetes.

Brown KL, Darris C, Rose KL, Sanchez OA, Madu H, Avance J, Brooks N, Zhang MZ, Fogo A, Harris R, Hudson BG, Voziyan P.

Diabetes. 2015 Jun;64(6):2242-53. doi: 10.2337/db14-1001. Epub 2015 Jan 20.


A five-gene hedgehog signature developed as a patient preselection tool for hedgehog inhibitor therapy in medulloblastoma.

Shou Y, Robinson DM, Amakye DD, Rose KL, Cho YJ, Ligon KL, Sharp T, Haider AS, Bandaru R, Ando Y, Geoerger B, Doz F, Ashley DM, Hargrave DR, Casanova M, Tawbi HA, Rodon J, Thomas AL, Mita AC, MacDonald TJ, Kieran MW.

Clin Cancer Res. 2015 Feb 1;21(3):585-93. doi: 10.1158/1078-0432.CCR-13-1711. Epub 2014 Dec 3.


Protein modification by adenine propenal.

Shuck SC, Wauchope OR, Rose KL, Kingsley PJ, Rouzer CA, Shell SM, Sugitani N, Chazin WJ, Zagol-Ikapitte I, Boutaud O, Oates JA, Galligan JJ, Beavers WN, Marnett LJ.

Chem Res Toxicol. 2014 Oct 20;27(10):1732-42. doi: 10.1021/tx500218g. Epub 2014 Sep 24.


Stable histone adduction by 4-oxo-2-nonenal: a potential link between oxidative stress and epigenetics.

Galligan JJ, Rose KL, Beavers WN, Hill S, Tallman KA, Tansey WP, Marnett LJ.

J Am Chem Soc. 2014 Aug 27;136(34):11864-6. doi: 10.1021/ja503604t. Epub 2014 Aug 11.


Supramolecular organization of the α121-α565 collagen IV network.

Robertson WE, Rose KL, Hudson BG, Vanacore RM.

J Biol Chem. 2014 Sep 12;289(37):25601-10. doi: 10.1074/jbc.M114.571844. Epub 2014 Jul 8.


Primitive neural stem cells in the adult mammalian brain give rise to GFAP-expressing neural stem cells.

Sachewsky N, Leeder R, Xu W, Rose KL, Yu F, van der Kooy D, Morshead CM.

Stem Cell Reports. 2014 May 22;2(6):810-24. doi: 10.1016/j.stemcr.2014.04.008. eCollection 2014 Jun 3.


Phosphorylation of serine 106 in Asef2 regulates cell migration and adhesion turnover.

Evans JC, Hines KM, Forsythe JG, Erdogan B, Shi M, Hill S, Rose KL, McLean JA, Webb DJ.

J Proteome Res. 2014 Jul 3;13(7):3303-13. doi: 10.1021/pr5001384. Epub 2014 Jun 13.


Differential localization of G protein βγ subunits.

Betke KM, Rose KL, Friedman DB, Baucum AJ 2nd, Hyde K, Schey KL, Hamm HE.

Biochemistry. 2014 Apr 15;53(14):2329-43. doi: 10.1021/bi500091p. Epub 2014 Apr 1.


Activation of EGFR and ERBB2 by Helicobacter pylori results in survival of gastric epithelial cells with DNA damage.

Chaturvedi R, Asim M, Piazuelo MB, Yan F, Barry DP, Sierra JC, Delgado AG, Hill S, Casero RA Jr, Bravo LE, Dominguez RL, Correa P, Polk DB, Washington MK, Rose KL, Schey KL, Morgan DR, Peek RM Jr, Wilson KT.

Gastroenterology. 2014 Jun;146(7):1739-51.e14. doi: 10.1053/j.gastro.2014.02.005. Epub 2014 Feb 13.


A phase I, multicenter, open-label, first-in-human, dose-escalation study of the oral smoothened inhibitor Sonidegib (LDE225) in patients with advanced solid tumors.

Rodon J, Tawbi HA, Thomas AL, Stoller RG, Turtschi CP, Baselga J, Sarantopoulos J, Mahalingam D, Shou Y, Moles MA, Yang L, Granvil C, Hurh E, Rose KL, Amakye DD, Dummer R, Mita AC.

Clin Cancer Res. 2014 Apr 1;20(7):1900-9. doi: 10.1158/1078-0432.CCR-13-1710. Epub 2014 Feb 12.


Sepp1(UF) forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1.

Kurokawa S, Eriksson S, Rose KL, Wu S, Motley AK, Hill S, Winfrey VP, McDonald WH, Capecchi MR, Atkins JF, Arnér ES, Hill KE, Burk RF.

Free Radic Biol Med. 2014 Apr;69:67-76. doi: 10.1016/j.freeradbiomed.2014.01.010. Epub 2014 Jan 14.


Mass spectrometric methods for the analysis of nucleoside-protein cross-links: application to oxopropenyl-deoxyadenosine.

Shuck SC, Rose KL, Marnett LJ.

Chem Res Toxicol. 2014 Jan 21;27(1):136-46. doi: 10.1021/tx400384e. Epub 2013 Dec 20.


A unique covalent bond in basement membrane is a primordial innovation for tissue evolution.

Fidler AL, Vanacore RM, Chetyrkin SV, Pedchenko VK, Bhave G, Yin VP, Stothers CL, Rose KL, McDonald WH, Clark TA, Borza DB, Steele RE, Ivy MT; Aspirnauts, Hudson JK, Hudson BG.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):331-6. doi: 10.1073/pnas.1318499111. Epub 2013 Dec 16.


Evaluation of funding gastroenterology research in Canada illustrates the beneficial role of partnerships.

Sherman PM, Banks Hart K, Rose KL, Bosompra K, Manuel C, Belanger P, Daniels S, Sinclair P, Vanner S, Buret A.

Can J Gastroenterol. 2013 Dec;27(12):717-20.


SIRT3 deacetylates ATP synthase F1 complex proteins in response to nutrient- and exercise-induced stress.

Vassilopoulos A, Pennington JD, Andresson T, Rees DM, Bosley AD, Fearnley IM, Ham A, Flynn CR, Hill S, Rose KL, Kim HS, Deng CX, Walker JE, Gius D.

Antioxid Redox Signal. 2014 Aug 1;21(4):551-64. doi: 10.1089/ars.2013.5420. Epub 2014 Mar 6.


Spatially-directed protein identification from tissue sections by top-down LC-MS/MS with electron transfer dissociation.

Schey KL, Anderson DM, Rose KL.

Anal Chem. 2013 Jul 16;85(14):6767-74. doi: 10.1021/ac400832w. Epub 2013 Jul 2.


Augmented cardiac formation of oxidatively-induced carbonylated proteins accompanies the increased functional severity of post-myocardial infarction heart failure in the setting of type 1 diabetes mellitus.

Dennis KE, Hill S, Rose KL, Sampson UK, Hill MF.

Cardiovasc Pathol. 2013 Nov-Dec;22(6):473-80. doi: 10.1016/j.carpath.2013.03.001. Epub 2013 Apr 6.


CaMKII regulates diacylglycerol lipase-α and striatal endocannabinoid signaling.

Shonesy BC, Wang X, Rose KL, Ramikie TS, Cavener VS, Rentz T, Baucum AJ 2nd, Jalan-Sakrikar N, Mackie K, Winder DG, Patel S, Colbran RJ.

Nat Neurosci. 2013 Apr;16(4):456-63. doi: 10.1038/nn.3353. Epub 2013 Mar 17.


Basophile: accurate fragment charge state prediction improves peptide identification rates.

Wang D, Dasari S, Chambers MC, Holman JD, Chen K, Liebler DC, Orton DJ, Purvine SO, Monroe ME, Chung CY, Rose KL, Tabb DL.

Genomics Proteomics Bioinformatics. 2013 Apr;11(2):86-95. doi: 10.1016/j.gpb.2012.11.004. Epub 2013 Mar 8.


Diabetic ketoacidosis elicits systemic inflammation associated with cerebrovascular endothelial cell dysfunction.

Close TE, Cepinskas G, Omatsu T, Rose KL, Summers K, Patterson EK, Fraser DD.

Microcirculation. 2013 Aug;20(6):534-43. doi: 10.1111/micc.12053.


Interlaboratory studies and initiatives developing standards for proteomics.

Ivanov AR, Colangelo CM, Dufresne CP, Friedman DB, Lilley KS, Mechtler K, Phinney BS, Rose KL, Rudnick PA, Searle BC, Shaffer SA, Weintraub ST.

Proteomics. 2013 Mar;13(6):904-9. doi: 10.1002/pmic.201200532. Epub 2013 Feb 19.


Monitoring the inflammatory response to infection through the integration of MALDI IMS and MRI.

Attia AS, Schroeder KA, Seeley EH, Wilson KJ, Hammer ND, Colvin DC, Manier ML, Nicklay JJ, Rose KL, Gore JC, Caprioli RM, Skaar EP.

Cell Host Microbe. 2012 Jun 14;11(6):664-73. doi: 10.1016/j.chom.2012.04.018.


A hybrid CFHR3-1 gene causes familial C3 glomerulopathy.

Malik TH, Lavin PJ, Goicoechea de Jorge E, Vernon KA, Rose KL, Patel MP, de Leeuw M, Neary JJ, Conlon PJ, Winn MP, Pickering MC.

J Am Soc Nephrol. 2012 Jul;23(7):1155-60. doi: 10.1681/ASN.2012020166. Epub 2012 May 24.

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