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Phylogenetic analysis reveals key residues in substrate hydrolysis in the isomaltase domain of sucrase-isomaltase and its role in starch digestion.

Chaudet MM, Amiri M, Marth N, Naim HY, Rose DR.

Biochim Biophys Acta Gen Subj. 2019 Sep;1863(9):1410-1416. doi: 10.1016/j.bbagen.2019.06.011. Epub 2019 Jun 27.


Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms.

Sanctuary MR, Kain JN, Chen SY, Kalanetra K, Lemay DG, Rose DR, Yang HT, Tancredi DJ, German JB, Slupsky CM, Ashwood P, Mills DA, Smilowitz JT, Angkustsiri K.

PLoS One. 2019 Jan 9;14(1):e0210064. doi: 10.1371/journal.pone.0210064. eCollection 2019.


Cytokine alterations in first-episode schizophrenia and bipolar disorder: relationships to brain structure and symptoms.

Lesh TA, Careaga M, Rose DR, McAllister AK, Van de Water J, Carter CS, Ashwood P.

J Neuroinflammation. 2018 May 26;15(1):165. doi: 10.1186/s12974-018-1197-2.


Structural Studies of the Intestinal α-Glucosidases, Maltase-glucoamylase and Sucrase-isomaltase.

Rose DR, Chaudet MM, Jones K.

J Pediatr Gastroenterol Nutr. 2018 Jun;66 Suppl 3:S11-S13. doi: 10.1097/MPG.0000000000001953. Review.


Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms.

Rose DR, Yang H, Serena G, Sturgeon C, Ma B, Careaga M, Hughes HK, Angkustsiri K, Rose M, Hertz-Picciotto I, Van de Water J, Hansen RL, Ravel J, Fasano A, Ashwood P.

Brain Behav Immun. 2018 May;70:354-368. doi: 10.1016/j.bbi.2018.03.025. Epub 2018 Mar 20.


Indole acetic acid overproduction transformants of the rhizobacterium Pseudomonas sp. UW4.

Duca DR, Rose DR, Glick BR.

Antonie Van Leeuwenhoek. 2018 Sep;111(9):1645-1660. doi: 10.1007/s10482-018-1051-7. Epub 2018 Feb 28.


Clinical Reasoning: Two see or not two see-Is it really double vision?

Murphy RR, Al Sawaf A, Rose DR Jr, Goldstein LB, Smith CD.

Neurology. 2017 Aug 8;89(6):e56-e60. doi: 10.1212/WNL.0000000000004196. No abstract available.


Functional metagenomics reveals novel β-galactosidases not predictable from gene sequences.

Cheng J, Romantsov T, Engel K, Doxey AC, Rose DR, Neufeld JD, Charles TC.

PLoS One. 2017 Mar 8;12(3):e0172545. doi: 10.1371/journal.pone.0172545. eCollection 2017.


Long-term altered immune responses following fetal priming in a non-human primate model of maternal immune activation.

Rose DR, Careaga M, Van de Water J, McAllister K, Bauman MD, Ashwood P.

Brain Behav Immun. 2017 Jul;63:60-70. doi: 10.1016/j.bbi.2016.11.020. Epub 2016 Nov 19.


Behavioral impact of maternal allergic-asthma in two genetically distinct mouse strains.

Schwartzer JJ, Careaga M, Coburn MA, Rose DR, Hughes HK, Ashwood P.

Brain Behav Immun. 2017 Jul;63:99-107. doi: 10.1016/j.bbi.2016.09.007. Epub 2016 Sep 10.


Contribution of the Individual Small Intestinal α-Glucosidases to Digestion of Unusual α-Linked Glycemic Disaccharides.

Lee BH, Rose DR, Lin AH, Quezada-Calvillo R, Nichols BL, Hamaker BR.

J Agric Food Chem. 2016 Aug 24;64(33):6487-94. doi: 10.1021/acs.jafc.6b01816. Epub 2016 Aug 9.


Divergent evolution for diverse substrate recognition by family 31 glycoside hydrolases.

Chaudet MM, Rose DR.

Biochem Cell Biol. 2016 Aug;94(4):323-30. doi: 10.1139/bcb-2016-0022. Epub 2016 Apr 21.


Suggested alternative starch utilization system from the human gut bacterium Bacteroides thetaiotaomicron.

Chaudet MM, Rose DR.

Biochem Cell Biol. 2016 Jun;94(3):241-6. doi: 10.1139/bcb-2016-0002. Epub 2016 Feb 10.


Multisubstrate isotope labeling and metagenomic analysis of active soil bacterial communities.

Verastegui Y, Cheng J, Engel K, Kolczynski D, Mortimer S, Lavigne J, Montalibet J, Romantsov T, Hall M, McConkey BJ, Rose DR, Tomashek JJ, Scott BR, Charles TC, Neufeld JD.

MBio. 2014 Jul 15;5(4):e01157-14. doi: 10.1128/mBio.01157-14.


Crystallographic structure of ChitA, a glycoside hydrolase family 19, plant class IV chitinase from Zea mays.

Chaudet MM, Naumann TA, Price NP, Rose DR.

Protein Sci. 2014 May;23(5):586-93. doi: 10.1002/pro.2437. Epub 2014 Mar 10.


Bacterial ice crystal controlling proteins.

Lorv JS, Rose DR, Glick BR.

Scientifica (Cairo). 2014;2014:976895. doi: 10.1155/2014/976895. Epub 2014 Jan 20. Review.


Mucosal C-terminal maltase-glucoamylase hydrolyzes large size starch digestion products that may contribute to rapid postprandial glucose generation.

Lee BH, Lin AH, Nichols BL, Jones K, Rose DR, Quezada-Calvillo R, Hamaker BR.

Mol Nutr Food Res. 2014 May;58(5):1111-21. doi: 10.1002/mnfr.201300599. Epub 2014 Jan 20.


Cutaneous metastasis as an initial presentation of lung adenocarcinoma with KRAS mutation: a case report and literature review.

Liao H, Wu S, Karbowitz SR, Morgenstern N, Rose DR.

Stem Cell Investig. 2014 Mar 5;1:6. doi: 10.3978/j.issn.2306-9759.2014.03.04. eCollection 2014.


Meeting report: 1st international functional metagenomics workshop may 7-8, 2012, st. Jacobs, ontario, Canada.

Engel K, Ashby D, Brady SF, Cowan DA, Doemer J, Edwards EA, Fiebig K, Martens EC, McCormac D, Mead DA, Miyazaki K, Moreno-Hagelsieb G, O'Gara F, Reid A, Rose DR, Simonet P, Sjöling S, Smalla K, Streit WR, Tedman-Jones J, Valla S, Wellington EM, Wu CC, Liles MR, Neufeld JD, Sessitsch A, Charles TC.

Stand Genomic Sci. 2013 Apr 15;8(1):106-11. doi: 10.4056/sigs.3406845. eCollection 2013 Apr 15.


Identification of an allosteric modulator of the serotonin transporter with novel mechanism of action.

Kortagere S, Fontana AC, Rose DR, Mortensen OV.

Neuropharmacology. 2013 Sep;72:282-90. doi: 10.1016/j.neuropharm.2013.04.026. Epub 2013 Apr 28.


Enzyme-synthesized highly branched maltodextrins have slow glucose generation at the mucosal α-glucosidase level and are slowly digestible in vivo.

Lee BH, Yan L, Phillips RJ, Reuhs BL, Jones K, Rose DR, Nichols BL, Quezada-Calvillo R, Yoo SH, Hamaker BR.

PLoS One. 2013;8(4):e59745. doi: 10.1371/journal.pone.0059745. Epub 2013 Apr 2.


Specificity of Processing α-glucosidase I is guided by the substrate conformation: crystallographic and in silico studies.

Barker MK, Rose DR.

J Biol Chem. 2013 May 10;288(19):13563-74. doi: 10.1074/jbc.M113.460436. Epub 2013 Mar 27.


Inhibition of maltase-glucoamylase activity to hydrolyze α-1,4 linkages by the presence of undigested sucrose.

Lee BH, Quezada-Calvillo R, Nichols BL Jr, Rose DR, Hamaker BR.

J Pediatr Gastroenterol Nutr. 2012 Nov;55 Suppl 2:S45-7. doi: 10.1097/01.mpg.0000421415.95751.f7. No abstract available.


The nature of raw starch digestion.

Ao Z, Quezada-Calvillo R, Nichols BL Jr, Rose DR, Sterchi EE, Hamaker BR.

J Pediatr Gastroenterol Nutr. 2012 Nov;55 Suppl 2:S42-3. doi: 10.1097/01.mpg.0000421413.18623.f9. No abstract available.


Investigations of the structures and inhibitory properties of intestinal maltase glucoamylase and sucrase isomaltase.

Jones K, Eskandari R, Naim HY, Pinto BM, Rose DR.

J Pediatr Gastroenterol Nutr. 2012 Nov;55 Suppl 2:S20-4. doi: 10.1097/01.mpg.0000421403.34763.71. No abstract available.


Research progress reported at the 50th Anniversary of the Discovery of Congenital Sucrase-Isomaltase Deficiency Workshop.

Gilger M, Hamaker B, Nichols BL Jr, Auricchio S, Treem WR, Naim HY, Heine M, Zimmer KP, Jones K, Eskandari R, Pinto BM, Rose DR, Lee BH, Quezada-Calvillo R, Adams B, Roach CM, Ma CX, Baker SS, Slawson MH, Robayo-Torres CC, Chumpitazi BP, Lecea CE, Opekun AR, Uhrich S, Wu Z, Huang JY, Scott CR, Chumpitazi BP, McMeans AR, Scholz D, Shulman RJ, Ao Z, Sterchi EE, Lin AH.

J Pediatr Gastroenterol Nutr. 2012 Nov;55 Suppl 2:S1. doi: 10.1097/01.mpg.0000422151.38401.69. No abstract available.


Expression of recombinant Atlantic salmon serum C-type lectin in Drosophila melanogaster Schneider 2 cells.

Uribe E, Venkatesan M, Rose DR, Ewart KV.

Cytotechnology. 2013 Aug;65(4):513-21. doi: 10.1007/s10616-012-9505-7. Epub 2012 Oct 18.


Expression and purification of two Family GH31 α-glucosidases from Bacteroides thetaiotaomicron.

Chaudet MM, Allen JL, Rose DR.

Protein Expr Purif. 2012 Dec;86(2):135-41. doi: 10.1016/j.pep.2012.09.009. Epub 2012 Oct 2.


Starch source influences dietary glucose generation at the mucosal α-glucosidase level.

Lin AH, Lee BH, Nichols BL, Quezada-Calvillo R, Rose DR, Naim HY, Hamaker BR.

J Biol Chem. 2012 Oct 26;287(44):36917-21. doi: 10.1074/jbc.M112.378331. Epub 2012 Sep 17.


Suppression of cancer progression by MGAT1 shRNA knockdown.

Beheshti Zavareh R, Sukhai MA, Hurren R, Gronda M, Wang X, Simpson CD, Maclean N, Zih F, Ketela T, Swallow CJ, Moffat J, Rose DR, Schachter H, Schimmer AD, Dennis JW.

PLoS One. 2012;7(9):e43721. doi: 10.1371/journal.pone.0043721. Epub 2012 Sep 5.


Random mutagenesis reveals residues of JAK2 critical in evading inhibition by a tyrosine kinase inhibitor.

Marit MR, Chohan M, Matthew N, Huang K, Kuntz DA, Rose DR, Barber DL.

PLoS One. 2012;7(8):e43437. doi: 10.1371/journal.pone.0043437. Epub 2012 Aug 16.


Modulation of starch digestion for slow glucose release through "toggling" of activities of mucosal α-glucosidases.

Lee BH, Eskandari R, Jones K, Reddy KR, Quezada-Calvillo R, Nichols BL, Rose DR, Hamaker BR, Pinto BM.

J Biol Chem. 2012 Sep 14;287(38):31929-38. doi: 10.1074/jbc.M112.351858. Epub 2012 Jul 31.


Structure, mechanism and inhibition of Golgi α-mannosidase II.

Rose DR.

Curr Opin Struct Biol. 2012 Oct;22(5):558-62. doi: 10.1016/ Epub 2012 Jul 20. Review.


Unexpected high digestion rate of cooked starch by the Ct-maltase-glucoamylase small intestine mucosal α-glucosidase subunit.

Lin AH, Nichols BL, Quezada-Calvillo R, Avery SE, Sim L, Rose DR, Naim HY, Hamaker BR.

PLoS One. 2012;7(5):e35473. doi: 10.1371/journal.pone.0035473. Epub 2012 May 1.


Characterizing and identifying risk for falls in the LEAPS study: a randomized clinical trial of interventions to improve walking poststroke.

Tilson JK, Wu SS, Cen SY, Feng Q, Rose DR, Behrman AL, Azen SP, Duncan PW.

Stroke. 2012 Feb;43(2):446-52. doi: 10.1161/STROKEAHA.111.636258. Epub 2012 Jan 12.


Open resource metagenomics: a model for sharing metagenomic libraries.

Neufeld JD, Engel K, Cheng J, Moreno-Hagelsieb G, Rose DR, Charles TC.

Stand Genomic Sci. 2011 Nov 30;5(2):203-10. doi: 10.4056/sigs.1974654. Epub 2011 Nov 23.


Modular evolution and the origins of symmetry: reconstruction of a three-fold symmetric globular protein.

Broom A, Doxey AC, Lobsanov YD, Berthin LG, Rose DR, Howell PL, McConkey BJ, Meiering EM.

Structure. 2012 Jan 11;20(1):161-71. doi: 10.1016/j.str.2011.10.021. Epub 2011 Dec 15.


Probing the intestinal α-glucosidase enzyme specificities of starch-digesting maltase-glucoamylase and sucrase-isomaltase: synthesis and inhibitory properties of 3'- and 5'-maltose-extended de-O-sulfonated ponkoranol.

Eskandari R, Jones K, Reddy KR, Jayakanthan K, Chaudet M, Rose DR, Pinto BM.

Chemistry. 2011 Dec 23;17(52):14817-25. doi: 10.1002/chem.201102109. Epub 2011 Nov 30.


Cutting-hedge research into bacterial invasion.

Kuntz DA, Rose DR.

Structure. 2011 Nov 9;19(11):1535-6. doi: 10.1016/j.str.2011.10.006.


Selectivity of 3'-O-methylponkoranol for inhibition of N- and C-terminal maltase glucoamylase and sucrase isomaltase, potential therapeutics for digestive disorders or their sequelae.

Eskandari R, Jones K, Rose DR, Pinto BM.

Bioorg Med Chem Lett. 2011 Nov 1;21(21):6491-4. doi: 10.1016/j.bmcl.2011.08.069. Epub 2011 Aug 22.


The effect of heteroatom substitution of sulfur for selenium in glucosidase inhibitors on intestinal α-glucosidase activities.

Eskandari R, Jones K, Rose DR, Pinto BM.

Chem Commun (Camb). 2011 Aug 28;47(32):9134-6. doi: 10.1039/c1cc13052h. Epub 2011 Jul 13.


Mapping the intestinal alpha-glucogenic enzyme specificities of starch digesting maltase-glucoamylase and sucrase-isomaltase.

Jones K, Sim L, Mohan S, Kumarasamy J, Liu H, Avery S, Naim HY, Quezada-Calvillo R, Nichols BL, Pinto BM, Rose DR.

Bioorg Med Chem. 2011 Jul 1;19(13):3929-34. doi: 10.1016/j.bmc.2011.05.033. Epub 2011 May 24.


Production and crystallization of processing α-glucosidase I: Pichia pastoris expression and a two-step purification toward structural determination.

Barker MK, Wilkinson BL, Faridmoayer A, Scaman CH, Fairbanks AJ, Rose DR.

Protein Expr Purif. 2011 Sep;79(1):96-101. doi: 10.1016/j.pep.2011.05.015. Epub 2011 May 27.


Probing the active-site requirements of human intestinal N-terminal maltase glucoamylase: the effect of replacing the sulfate moiety by a methyl ether in ponkoranol, a naturally occurring α-glucosidase inhibitor.

Eskandari R, Jones K, Rose DR, Pinto BM.

Bioorg Med Chem Lett. 2010 Oct 1;20(19):5686-9. doi: 10.1016/j.bmcl.2010.08.020. Epub 2010 Aug 11.


Effect of noncompetitive proteasome inhibition on bortezomib resistance.

Li X, Wood TE, Sprangers R, Jansen G, Franke NE, Mao X, Wang X, Zhang Y, Verbrugge SE, Adomat H, Li ZH, Trudel S, Chen C, Religa TL, Jamal N, Messner H, Cloos J, Rose DR, Navon A, Guns E, Batey RA, Kay LE, Schimmer AD.

J Natl Cancer Inst. 2010 Jul 21;102(14):1069-82. doi: 10.1093/jnci/djq198. Epub 2010 May 26.


Synthesis of a biologically active isomer of kotalanol, a naturally occurring glucosidase inhibitor.

Eskandari R, Jayakanthan K, Kuntz DA, Rose DR, Pinto BM.

Bioorg Med Chem. 2010 Apr 15;18(8):2829-35. doi: 10.1016/j.bmc.2010.03.027. Epub 2010 Mar 15.


Structural basis for substrate selectivity in human maltase-glucoamylase and sucrase-isomaltase N-terminal domains.

Sim L, Willemsma C, Mohan S, Naim HY, Pinto BM, Rose DR.

J Biol Chem. 2010 Jun 4;285(23):17763-70. doi: 10.1074/jbc.M109.078980. Epub 2010 Mar 31.


Potent glucosidase inhibitors: de-O-sulfonated ponkoranol and its stereoisomer.

Eskandari R, Kuntz DA, Rose DR, Pinto BM.

Org Lett. 2010 Apr 2;12(7):1632-5. doi: 10.1021/ol1004005.


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