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Items: 1 to 50 of 96

1.

Quantitative determination of cellular [Na+] by fluorescence lifetime imaging with CoroNaGreen.

Meyer J, Untiet V, Fahlke C, Gensch T, Rose CR.

J Gen Physiol. 2019 Oct 9. pii: jgp.201912404. doi: 10.1085/jgp.201912404. [Epub ahead of print]

PMID:
31597684
2.

Relation between activity-induced intracellular sodium transients and ATP dynamics in mouse hippocampal neurons.

Gerkau NJ, Lerchundi R, Nelson JSE, Lantermann M, Meyer J, Hirrlinger J, Rose CR.

J Physiol. 2019 Sep 23. doi: 10.1113/JP278658. [Epub ahead of print]

PMID:
31549401
3.

Heterogeneity of Activity-Induced Sodium Transients between Astrocytes of the Mouse Hippocampus and Neocortex: Mechanisms and Consequences.

Ziemens D, Oschmann F, Gerkau NJ, Rose CR.

J Neurosci. 2019 Apr 3;39(14):2620-2634. doi: 10.1523/JNEUROSCI.2029-18.2019. Epub 2019 Feb 8.

4.

Ionic signalling in astroglia beyond calcium.

Verkhratsky A, Untiet V, Rose CR.

J Physiol. 2019 Feb 7. doi: 10.1113/JP277478. [Epub ahead of print]

PMID:
30734296
5.

Imaging of Local and Global Sodium Signals in Astrocytes.

Gerkau NJ, Kafitz KW, Rose CR.

Methods Mol Biol. 2019;1938:187-202. doi: 10.1007/978-1-4939-9068-9_13.

PMID:
30617981
6.

Anisotropic Panglial Coupling Reflects Tonotopic Organization in the Inferior Colliculus.

Wadle SL, Augustin V, Langer J, Jabs R, Philippot C, Weingarten DJ, Rose CR, Steinhäuser C, Stephan J.

Front Cell Neurosci. 2018 Nov 27;12:431. doi: 10.3389/fncel.2018.00431. eCollection 2018.

7.

FRET-based imaging of intracellular ATP in organotypic brain slices.

Lerchundi R, Kafitz KW, Winkler U, Färfers M, Hirrlinger J, Rose CR.

J Neurosci Res. 2019 Aug;97(8):933-945. doi: 10.1002/jnr.24361. Epub 2018 Dec 1.

PMID:
30506574
8.

Cotransporter-mediated water transport underlying cerebrospinal fluid formation.

Steffensen AB, Oernbo EK, Stoica A, Gerkau NJ, Barbuskaite D, Tritsaris K, Rose CR, MacAulay N.

Nat Commun. 2018 Jun 4;9(1):2167. doi: 10.1038/s41467-018-04677-9.

9.

Epithelial Sodium Channel Regulates Adult Neural Stem Cell Proliferation in a Flow-Dependent Manner.

Petrik D, Myoga MH, Grade S, Gerkau NJ, Pusch M, Rose CR, Grothe B, Götz M.

Cell Stem Cell. 2018 Jun 1;22(6):865-878.e8. doi: 10.1016/j.stem.2018.04.016. Epub 2018 May 17.

10.

Astroglial Glutamate Signaling and Uptake in the Hippocampus.

Rose CR, Felix L, Zeug A, Dietrich D, Reiner A, Henneberger C.

Front Mol Neurosci. 2018 Jan 17;10:451. doi: 10.3389/fnmol.2017.00451. eCollection 2017. Review.

11.

Reverse NCX Attenuates Cellular Sodium Loading in Metabolically Compromised Cortex.

Gerkau NJ, Rakers C, Durry S, Petzold GC, Rose CR.

Cereb Cortex. 2018 Dec 1;28(12):4264-4280. doi: 10.1093/cercor/bhx280.

PMID:
29136153
12.

Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes.

Storer RI, Pike A, Swain NA, Alexandrou AJ, Bechle BM, Blakemore DC, Brown AD, Castle NA, Corbett MS, Flanagan NJ, Fengas D, Johnson MS, Jones LH, Marron BE, Payne CE, Printzenhoff D, Rawson DJ, Rose CR, Ryckmans T, Sun J, Theile JW, Torella R, Tseng E, Warmus JS.

Bioorg Med Chem Lett. 2017 Nov 1;27(21):4805-4811. doi: 10.1016/j.bmcl.2017.09.056. Epub 2017 Sep 28.

PMID:
29029933
13.

CD73-derived adenosine and tenascin-C control cytokine production by epicardium-derived cells formed after myocardial infarction.

Hesse J, Leberling S, Boden E, Friebe D, Schmidt T, Ding Z, Dieterich P, Deussen A, Roderigo C, Rose CR, Floss DM, Scheller J, Schrader J.

FASEB J. 2017 Jul;31(7):3040-3053. doi: 10.1096/fj.201601307R. Epub 2017 Mar 31.

PMID:
28363952
14.

Two-Photon Na+ Imaging Reports Somatically Evoked Action Potentials in Rat Olfactory Bulb Mitral and Granule Cell Neurites.

Ona-Jodar T, Gerkau NJ, Sara Aghvami S, Rose CR, Egger V.

Front Cell Neurosci. 2017 Feb 28;11:50. doi: 10.3389/fncel.2017.00050. eCollection 2017.

15.

Astrocyte Sodium Signalling and Panglial Spread of Sodium Signals in Brain White Matter.

Moshrefi-Ravasdjani B, Hammel EL, Kafitz KW, Rose CR.

Neurochem Res. 2017 Sep;42(9):2505-2518. doi: 10.1007/s11064-017-2197-9. Epub 2017 Feb 18.

PMID:
28214986
16.

One-Pot Synthesis of α-Branched N-Acylamines via Titanium-Mediated Condensation of Amides, Aldehydes, and Organometallics.

Dai C, Genovino J, Bechle BM, Corbett MS, Huh CW, Rose CR, Sun J, Warmus JS, Blakemore DC.

Org Lett. 2017 Mar 3;19(5):1064-1067. doi: 10.1021/acs.orglett.7b00082. Epub 2017 Feb 15.

PMID:
28199125
17.

Differential effects of energy deprivation on intracellular sodium homeostasis in neurons and astrocytes.

Gerkau NJ, Rakers C, Petzold GC, Rose CR.

J Neurosci Res. 2017 Nov;95(11):2275-2285. doi: 10.1002/jnr.23995. Epub 2017 Feb 2. Review.

PMID:
28150887
18.

Molecular and cellular physiology of sodium-dependent glutamate transporters.

Rose CR, Ziemens D, Untiet V, Fahlke C.

Brain Res Bull. 2018 Jan;136:3-16. doi: 10.1016/j.brainresbull.2016.12.013. Epub 2016 Dec 28. Review.

PMID:
28040508
19.

Practical synthesis of capromorelin, a growth hormone secretagogue, via a crystallization-induced dynamic resolution.

Rose CR, Zawistoski MP, Lefker BA, Mangano FM, Wright AS, Carpino PA.

Bioorg Med Chem. 2017 Feb 1;25(3):1000-1003. doi: 10.1016/j.bmc.2016.12.015. Epub 2016 Dec 10.

PMID:
28012686
20.

Glutamate transporter-associated anion channels adjust intracellular chloride concentrations during glial maturation.

Untiet V, Kovermann P, Gerkau NJ, Gensch T, Rose CR, Fahlke C.

Glia. 2017 Feb;65(2):388-400. doi: 10.1002/glia.23098. Epub 2016 Nov 18.

PMID:
27859594
21.

Rapid sodium signaling couples glutamate uptake to breakdown of ATP in perivascular astrocyte endfeet.

Langer J, Gerkau NJ, Derouiche A, Kleinhans C, Moshrefi-Ravasdjani B, Fredrich M, Kafitz KW, Seifert G, Steinhäuser C, Rose CR.

Glia. 2017 Feb;65(2):293-308. doi: 10.1002/glia.23092. Epub 2016 Oct 27.

PMID:
27785828
22.

Glial ionic excitability: The role for sodium.

Rose CR, Verkhratsky A.

Glia. 2016 Oct;64(10):1609-10. doi: 10.1002/glia.23012. No abstract available.

PMID:
27509366
23.

Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy.

Cameron KO, Kung DW, Kalgutkar AS, Kurumbail RG, Miller R, Salatto CT, Ward J, Withka JM, Bhattacharya SK, Boehm M, Borzilleri KA, Brown JA, Calabrese M, Caspers NL, Cokorinos E, Conn EL, Dowling MS, Edmonds DJ, Eng H, Fernando DP, Frisbie R, Hepworth D, Landro J, Mao Y, Rajamohan F, Reyes AR, Rose CR, Ryder T, Shavnya A, Smith AC, Tu M, Wolford AC, Xiao J.

J Med Chem. 2016 Sep 8;59(17):8068-81. doi: 10.1021/acs.jmedchem.6b00866. Epub 2016 Aug 20.

PMID:
27490827
24.

Functional anisotropic panglial networks in the lateral superior olive.

Augustin V, Bold C, Wadle SL, Langer J, Jabs R, Philippot C, Weingarten DJ, Rose CR, Steinhäuser C, Stephan J.

Glia. 2016 Nov;64(11):1892-911. doi: 10.1002/glia.23031. Epub 2016 Jul 26.

PMID:
27458984
25.

Changes in the proliferative capacity of NG2 cell subpopulations during postnatal development of the mouse hippocampus.

Moshrefi-Ravasdjani B, Dublin P, Seifert G, Jennissen K, Steinhäuser C, Kafitz KW, Rose CR.

Brain Struct Funct. 2017 Mar;222(2):831-847. doi: 10.1007/s00429-016-1249-2. Epub 2016 Jun 15.

PMID:
27306788
26.

Extrusion versus diffusion: mechanisms for recovery from sodium loads in mouse CA1 pyramidal neurons.

Mondragão MA, Schmidt H, Kleinhans C, Langer J, Kafitz KW, Rose CR.

J Physiol. 2016 Oct 1;594(19):5507-27. doi: 10.1113/JP272431. Epub 2016 May 27.

27.

The Synthesis of Methyl-Substituted Spirocyclic Piperidine-Azetidine (2,7-Diazaspiro[3.5]nonane) and Spirocyclic Piperidine-Pyrrolidine (2,8-Diazaspiro[4.5]decane) Ring Systems.

Smith AC, Cabral S, Kung DW, Rose CR, Southers JA, García-Irizarry CN, Damon DB, Bagley SW, Griffith DA.

J Org Chem. 2016 May 6;81(9):3509-19. doi: 10.1021/acs.joc.5b02890. Epub 2016 Apr 25.

PMID:
27056793
28.

Design and development of histone deacetylase (HDAC) chemical probes for cell-based profiling.

Albrow VE, Grimley RL, Clulow J, Rose CR, Sun J, Warmus JS, Tate EW, Jones LH, Storer RI.

Mol Biosyst. 2016 May 24;12(6):1781-9. doi: 10.1039/c6mb00109b.

PMID:
27021930
29.

Principles of sodium homeostasis and sodium signalling in astroglia.

Rose CR, Verkhratsky A.

Glia. 2016 Oct;64(10):1611-27. doi: 10.1002/glia.22964. Epub 2016 Feb 26. Review.

PMID:
26919326
30.

Lactate rescues neuronal sodium homeostasis during impaired energy metabolism.

Karus C, Ziemens D, Rose CR.

Channels (Austin). 2015;9(4):200-8. doi: 10.1080/19336950.2015.1050163. Epub 2015 Jun 3. Erratum in: Channels (Austin). 2015;9(5):334.

31.

Astrocyte sodium signaling and neuro-metabolic coupling in the brain.

Rose CR, Chatton JY.

Neuroscience. 2016 May 26;323:121-34. doi: 10.1016/j.neuroscience.2015.03.002. Epub 2015 Mar 16. Review.

32.

Astrocytes restrict discharge duration and neuronal sodium loads during recurrent network activity.

Karus C, Mondragão MA, Ziemens D, Rose CR.

Glia. 2015 Jun;63(6):936-57. doi: 10.1002/glia.22793. Epub 2015 Jan 29.

PMID:
25639699
33.

Roles of astrocytic Na(+),K(+)-ATPase and glycogenolysis for K(+) homeostasis in mammalian brain.

Hertz L, Gerkau NJ, Xu J, Durry S, Song D, Rose CR, Peng L.

J Neurosci Res. 2015 Jul;93(7):1019-30. doi: 10.1002/jnr.23499. Epub 2014 Oct 29. Review.

PMID:
25352321
34.

Multi-photon intracellular sodium imaging combined with UV-mediated focal uncaging of glutamate in CA1 pyramidal neurons.

Kleinhans C, Kafitz KW, Rose CR.

J Vis Exp. 2014 Oct 8;(92):e52038. doi: 10.3791/52038.

35.

Dysbalance of astrocyte calcium under hyperammonemic conditions.

Haack N, Dublin P, Rose CR.

PLoS One. 2014 Aug 25;9(8):e105832. doi: 10.1371/journal.pone.0105832. eCollection 2014.

36.

BDE-47 and 6-OH-BDE-47 modulate calcium homeostasis in primary fetal human neural progenitor cells via ryanodine receptor-independent mechanisms.

Gassmann K, Schreiber T, Dingemans MM, Krause G, Roderigo C, Giersiefer S, Schuwald J, Moors M, Unfried K, Bergman Å, Westerink RH, Rose CR, Fritsche E.

Arch Toxicol. 2014 Aug;88(8):1537-48. doi: 10.1007/s00204-014-1217-7. Epub 2014 Mar 6.

PMID:
24599297
37.

Lesion-induced alterations in astrocyte glutamate transporter expression and function in the hippocampus.

Schreiner AE, Berlinger E, Langer J, Kafitz KW, Rose CR.

ISRN Neurol. 2013 Sep 3;2013:893605. doi: 10.1155/2013/893605. eCollection 2013.

38.

Laminar and subcellular heterogeneity of GLAST and GLT-1 immunoreactivity in the developing postnatal mouse hippocampus.

Schreiner AE, Durry S, Aida T, Stock MC, Rüther U, Tanaka K, Rose CR, Kafitz KW.

J Comp Neurol. 2014 Jan 1;522(1):204-24. doi: 10.1002/cne.23450.

PMID:
23939750
39.

Two sides of the same coin: sodium homeostasis and signaling in astrocytes under physiological and pathophysiological conditions.

Rose CR, Karus C.

Glia. 2013 Aug;61(8):1191-205. doi: 10.1002/glia.22492. Epub 2013 Apr 2. Review.

PMID:
23553639
40.

Diastereoselective synthesis of β-heteroaryl syn-α-methyl-β-amino acid derivatives via a double chiral auxiliary approach.

Bian J, Blakemore D, Warmus JS, Sun J, Corbett M, Rose CR, Bechle BM.

Org Lett. 2013 Feb 1;15(3):562-5. doi: 10.1021/ol3033785. Epub 2013 Jan 23.

PMID:
23343056
41.

Two-photon sodium imaging in dendritic spines.

Rose CR.

Cold Spring Harb Protoc. 2012 Nov 1;2012(11):1161-5. doi: 10.1101/pdb.prot072074.

PMID:
23118361
42.

Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor.

Kung DW, Coffey SB, Jones RM, Cabral S, Jiao W, Fichtner M, Carpino PA, Rose CR, Hank RF, Lopaze MG, Swartz R, Chen HT, Hendsch Z, Posner B, Wielis CF, Manning B, Dubins J, Stock IA, Varma S, Campbell M, DeBartola D, Kosa-Maines R, Steyn SJ, McClure KF.

Bioorg Med Chem Lett. 2012 Jul 1;22(13):4281-7. doi: 10.1016/j.bmcl.2012.05.024. Epub 2012 May 17.

PMID:
22677316
43.

Kir4.1 channels mediate a depolarization of hippocampal astrocytes under hyperammonemic conditions in situ.

Stephan J, Haack N, Kafitz KW, Durry S, Koch D, Hochstrate P, Seifert G, Steinhäuser C, Rose CR.

Glia. 2012 May;60(6):965-78. doi: 10.1002/glia.22328. Epub 2012 Mar 19.

PMID:
22431254
44.

Synthesis of 7-oxo-dihydrospiro[indazole-5,4'-piperidine] acetyl-CoA carboxylase inhibitors.

Bagley SW, Southers JA, Cabral S, Rose CR, Bernhardson DJ, Edmonds DJ, Polivkova J, Yang X, Kung DW, Griffith DA, Bader SJ.

J Org Chem. 2012 Feb 3;77(3):1497-506. doi: 10.1021/jo202377g. Epub 2012 Jan 25.

PMID:
22239115
45.

Thrombin-induced ATP release from human umbilical vein endothelial cells.

Gödecke S, Roderigo C, Rose CR, Rauch BH, Gödecke A, Schrader J.

Am J Physiol Cell Physiol. 2012 Mar 15;302(6):C915-23. doi: 10.1152/ajpcell.00283.2010. Epub 2011 Dec 7.

46.

Gap junctions mediate intercellular spread of sodium between hippocampal astrocytes in situ.

Langer J, Stephan J, Theis M, Rose CR.

Glia. 2012 Feb;60(2):239-52. doi: 10.1002/glia.21259. Epub 2011 Oct 24.

PMID:
22025386
47.

Levetiracetam exhibits protective properties on rat Schwann cells in vitro.

Stettner M, Dehmel T, Mausberg AK, Köhne A, Rose CR, Kieseier BC.

J Peripher Nerv Syst. 2011 Sep;16(3):250-60. doi: 10.1111/j.1529-8027.2011.00355.x.

PMID:
22003940
48.

Contrasting macrophage activation by fine and ultrafine titanium dioxide particles is associated with different uptake mechanisms.

Scherbart AM, Langer J, Bushmelev A, van Berlo D, Haberzettl P, van Schooten FJ, Schmidt AM, Rose CR, Schins RP, Albrecht C.

Part Fibre Toxicol. 2011 Oct 13;8:31. doi: 10.1186/1743-8977-8-31.

49.

A new role for interferon gamma in neural stem/precursor cell dysregulation.

Walter J, Honsek SD, Illes S, Wellen JM, Hartung HP, Rose CR, Dihné M.

Mol Neurodegener. 2011 Mar 3;6:18. doi: 10.1186/1750-1326-6-18.

50.

Discovery and evaluation of pyrazolo[1,5-a]pyrimidines as neuropeptide Y1 receptor antagonists.

Griffith DA, Hargrove DM, Maurer TS, Blum CA, De Lombaert S, Inthavongsay JK, Klade LE, Mack CM, Rose CR, Sanders MJ, Carpino PA.

Bioorg Med Chem Lett. 2011 May 1;21(9):2641-5. doi: 10.1016/j.bmcl.2010.12.116. Epub 2011 Jan 7.

PMID:
21295475

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