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Items: 9


Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection.

Xu RH, Wong EB, Rubio D, Roscoe F, Ma X, Nair S, Remakus S, Schwendener R, John S, Shlomchik M, Sigal LJ.

Immunity. 2015 Dec 15;43(6):1148-59. doi: 10.1016/j.immuni.2015.11.015.


CD4+ T cell help is dispensable for protective CD8+ T cell memory against mousepox virus following vaccinia virus immunization.

Fang M, Remakus S, Roscoe F, Ma X, Sigal LJ.

J Virol. 2015 Jan;89(1):776-83. doi: 10.1128/JVI.02176-14. Epub 2014 Oct 29.


MyD88-dependent immunity to a natural model of vaccinia virus infection does not involve Toll-like receptor 2.

Davies ML, Sei JJ, Siciliano NA, Xu RH, Roscoe F, Sigal LJ, Eisenlohr LC, Norbury CC.

J Virol. 2014 Mar;88(6):3557-67. doi: 10.1128/JVI.02776-13. Epub 2014 Jan 8.


The mature virion of ectromelia virus, a pathogenic poxvirus, is capable of intrahepatic spread and can serve as a target for delayed therapy.

Ma X, Xu RH, Roscoe F, Whitbeck JC, Eisenberg RJ, Cohen GH, Sigal LJ.

J Virol. 2013 Jun;87(12):7046-53. doi: 10.1128/JVI.03158-12. Epub 2013 Apr 17.


Perforin-dependent CD4+ T-cell cytotoxicity contributes to control a murine poxvirus infection.

Fang M, Siciliano NA, Hersperger AR, Roscoe F, Hu A, Ma X, Shamsedeen AR, Eisenlohr LC, Sigal LJ.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9983-8. doi: 10.1073/pnas.1202143109. Epub 2012 Jun 4.


Antibody inhibition of a viral type 1 interferon decoy receptor cures a viral disease by restoring interferon signaling in the liver.

Xu RH, Rubio D, Roscoe F, Krouse TE, Truckenmiller ME, Norbury CC, Hudson PN, Damon IK, Alcamí A, Sigal LJ.

PLoS Pathog. 2012 Jan;8(1):e1002475. doi: 10.1371/journal.ppat.1002475. Epub 2012 Jan 5.


Age-dependent susceptibility to a viral disease due to decreased natural killer cell numbers and trafficking.

Fang M, Roscoe F, Sigal LJ.

J Exp Med. 2010 Oct 25;207(11):2369-81. doi: 10.1084/jem.20100282. Epub 2010 Sep 27.


Direct presentation is sufficient for an efficient anti-viral CD8+ T cell response.

Xu RH, Remakus S, Ma X, Roscoe F, Sigal LJ.

PLoS Pathog. 2010 Feb 12;6(2):e1000768. doi: 10.1371/journal.ppat.1000768.

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