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Items: 1 to 50 of 274

1.

Glucose stimulates somatostatin secretion in pancreatic δ-cells by cAMP-dependent intracellular Ca2+ release.

Denwood G, Tarasov A, Salehi A, Vergari E, Ramracheya R, Takahashi H, Nikolaev VO, Seino S, Gribble F, Reimann F, Rorsman P, Zhang Q.

J Gen Physiol. 2019 Jul 29. pii: jgp.201912351. doi: 10.1085/jgp.201912351. [Epub ahead of print]

PMID:
31358556
2.

Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells.

Haythorne E, Rohm M, van de Bunt M, Brereton MF, Tarasov AI, Blacker TS, Sachse G, Silva Dos Santos M, Terron Exposito R, Davis S, Baba O, Fischer R, Duchen MR, Rorsman P, MacRae JI, Ashcroft FM.

Nat Commun. 2019 Jun 6;10(1):2474. doi: 10.1038/s41467-019-10189-x.

3.

PYY plays a key role in the resolution of diabetes following bariatric surgery in humans.

Guida C, Stephen SD, Watson M, Dempster N, Larraufie P, Marjot T, Cargill T, Rickers L, Pavlides M, Tomlinson J, Cobbold JFL, Zhao CM, Chen D, Gribble F, Reimann F, Gillies R, Sgromo B, Rorsman P, Ryan JD, Ramracheya RD.

EBioMedicine. 2019 Feb;40:67-76. doi: 10.1016/j.ebiom.2018.12.040. Epub 2019 Jan 11.

4.

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion.

Vergari E, Knudsen JG, Ramracheya R, Salehi A, Zhang Q, Adam J, Asterholm IW, Benrick A, Briant LJB, Chibalina MV, Gribble FM, Hamilton A, Hastoy B, Reimann F, Rorsman NJG, Spiliotis II, Tarasov A, Wu Y, Ashcroft FM, Rorsman P.

Nat Commun. 2019 Jan 11;10(1):139. doi: 10.1038/s41467-018-08193-8.

5.

β Cell Dysfunction in Type 2 Diabetes: Drained of Energy?

Knudsen JG, Rorsman P.

Cell Metab. 2019 Jan 8;29(1):1-2. doi: 10.1016/j.cmet.2018.12.015.

PMID:
30625305
6.

Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells.

Hastoy B, Godazgar M, Clark A, Nylander V, Spiliotis I, van de Bunt M, Chibalina MV, Barrett A, Burrows C, Tarasov AI, Scharfmann R, Gloyn AL, Rorsman P.

Sci Rep. 2018 Nov 19;8(1):16994. doi: 10.1038/s41598-018-34743-7.

7.

Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production.

Knudsen JG, Hamilton A, Ramracheya R, Tarasov AI, Brereton M, Haythorne E, Chibalina MV, Spégel P, Mulder H, Zhang Q, Ashcroft FM, Adam J, Rorsman P.

Cell Metab. 2019 Feb 5;29(2):430-442.e4. doi: 10.1016/j.cmet.2018.10.003. Epub 2018 Nov 8.

8.

GLP-1 suppresses glucagon secretion in human pancreatic alpha-cells by inhibition of P/Q-type Ca2+ channels.

Ramracheya R, Chapman C, Chibalina M, Dou H, Miranda C, González A, Moritoh Y, Shigeto M, Zhang Q, Braun M, Clark A, Johnson PR, Rorsman P, Briant LJB.

Physiol Rep. 2018 Sep;6(17):e13852. doi: 10.14814/phy2.13852.

9.

Short-term high glucose culture potentiates pancreatic beta cell function.

Rebelato E, Santos LR, Carpinelli AR, Rorsman P, Abdulkader F.

Sci Rep. 2018 Aug 30;8(1):13061. doi: 10.1038/s41598-018-31325-5.

10.

Monitoring real-time hormone release kinetics via high-content 3-D imaging of compensatory endocytosis.

Tarasov AI, Galvanovskis J, Rorsman O, Hamilton A, Vergari E, Johnson PRV, Reimann F, Ashcroft FM, Rorsman P.

Lab Chip. 2018 Sep 11;18(18):2838-2848. doi: 10.1039/c8lc00417j.

11.

Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells.

Thomsen SK, Raimondo A, Hastoy B, Sengupta S, Dai XQ, Bautista A, Censin J, Payne AJ, Umapathysivam MM, Spigelman AF, Barrett A, Groves CJ, Beer NL, Manning Fox JE, McCarthy MI, Clark A, Mahajan A, Rorsman P, MacDonald PE, Gloyn AL.

Nat Genet. 2018 Aug;50(8):1122-1131. doi: 10.1038/s41588-018-0173-1. Epub 2018 Jul 27.

12.

CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic Islets.

Briant LJB, Dodd MS, Chibalina MV, Rorsman NJG, Johnson PRV, Carmeliet P, Rorsman P, Knudsen JG.

Cell Rep. 2018 Jun 12;23(11):3300-3311. doi: 10.1016/j.celrep.2018.05.035.

13.

The somatostatin-secreting pancreatic δ-cell in health and disease.

Rorsman P, Huising MO.

Nat Rev Endocrinol. 2018 Jul;14(7):404-414. doi: 10.1038/s41574-018-0020-6. Review.

14.

Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization From Acidic Stores in Pancreatic α-Cells.

Hamilton A, Zhang Q, Salehi A, Willems M, Knudsen JG, Ringgaard AK, Chapman CE, Gonzalez-Alvarez A, Surdo NC, Zaccolo M, Basco D, Johnson PRV, Ramracheya R, Rutter GA, Galione A, Rorsman P, Tarasov AI.

Diabetes. 2018 Jun;67(6):1128-1139. doi: 10.2337/db17-1102. Epub 2018 Mar 21.

15.

Biphasic voltage-dependent inactivation of human NaV 1.3, 1.6 and 1.7 Na+ channels expressed in rodent insulin-secreting cells.

Godazgar M, Zhang Q, Chibalina MV, Rorsman P.

J Physiol. 2018 May 1;596(9):1601-1626. doi: 10.1113/JP275587. Epub 2018 Mar 30.

16.

AP2σ Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity.

Gorvin CM, Rogers A, Hastoy B, Tarasov AI, Frost M, Sposini S, Inoue A, Whyte MP, Rorsman P, Hanyaloglu AC, Breitwieser GE, Thakker RV.

Cell Rep. 2018 Jan 23;22(4):1054-1066. doi: 10.1016/j.celrep.2017.12.089. Epub 2018 Jan 28.

17.

α-cell glucokinase suppresses glucose-regulated glucagon secretion.

Basco D, Zhang Q, Salehi A, Tarasov A, Dolci W, Herrera P, Spiliotis I, Berney X, Tarussio D, Rorsman P, Thorens B.

Nat Commun. 2018 Feb 7;9(1):546. doi: 10.1038/s41467-018-03034-0.

18.

Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.

Rorsman P, Ashcroft FM.

Physiol Rev. 2018 Jan 1;98(1):117-214. doi: 10.1152/physrev.00008.2017. Review.

19.

Fusion pore in exocytosis: More than an exit gate? A β-cell perspective.

Hastoy B, Clark A, Rorsman P, Lang J.

Cell Calcium. 2017 Dec;68:45-61. doi: 10.1016/j.ceca.2017.10.005. Epub 2017 Nov 7. Review.

PMID:
29129207
20.

δ-cells and β-cells are electrically coupled and regulate α-cell activity via somatostatin.

Briant LJB, Reinbothe TM, Spiliotis I, Miranda C, Rodriguez B, Rorsman P.

J Physiol. 2018 Jan 15;596(2):197-215. doi: 10.1113/JP274581. Epub 2017 Nov 2.

21.

Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes.

Adam J, Ramracheya R, Chibalina MV, Ternette N, Hamilton A, Tarasov AI, Zhang Q, Rebelato E, Rorsman NJG, Martín-Del-Río R, Lewis A, Özkan G, Do HW, Spégel P, Saitoh K, Kato K, Igarashi K, Kessler BM, Pugh CW, Tamarit-Rodriguez J, Mulder H, Clark A, Frizzell N, Soga T, Ashcroft FM, Silver A, Pollard PJ, Rorsman P.

Cell Rep. 2017 Sep 26;20(13):3135-3148. doi: 10.1016/j.celrep.2017.08.093.

22.

A Central Small Amino Acid in the VAMP2 Transmembrane Domain Regulates the Fusion Pore in Exocytosis.

Hastoy B, Scotti PA, Milochau A, Fezoua-Boubegtiten Z, Rodas J, Megret R, Desbat B, Laguerre M, Castano S, Perrais D, Rorsman P, Oda R, Lang J.

Sci Rep. 2017 Jun 6;7(1):2835. doi: 10.1038/s41598-017-03013-3.

23.

Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy.

Babinsky VN, Hannan FM, Ramracheya RD, Zhang Q, Nesbit MA, Hugill A, Bentley L, Hough TA, Joynson E, Stewart M, Aggarwal A, Prinz-Wohlgenannt M, Gorvin CM, Kallay E, Wells S, Cox RD, Richards D, Rorsman P, Thakker RV.

Endocrinology. 2017 Aug 1;158(8):2486-2502. doi: 10.1210/en.2017-00111.

24.

Ca2+ channel clustering with insulin-containing granules is disturbed in type 2 diabetes.

Gandasi NR, Yin P, Riz M, Chibalina MV, Cortese G, Lund PE, Matveev V, Rorsman P, Sherman A, Pedersen MG, Barg S.

J Clin Invest. 2017 Jun 1;127(6):2353-2364. doi: 10.1172/JCI88491. Epub 2017 May 8.

25.

Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity.

Philippaert K, Pironet A, Mesuere M, Sones W, Vermeiren L, Kerselaers S, Pinto S, Segal A, Antoine N, Gysemans C, Laureys J, Lemaire K, Gilon P, Cuypers E, Tytgat J, Mathieu C, Schuit F, Rorsman P, Talavera K, Voets T, Vennekens R.

Nat Commun. 2017 Mar 31;8:14733. doi: 10.1038/ncomms14733.

26.

Functional identification of islet cell types by electrophysiological fingerprinting.

Briant LJ, Zhang Q, Vergari E, Kellard JA, Rodriguez B, Ashcroft FM, Rorsman P.

J R Soc Interface. 2017 Mar;14(128). pii: 20160999. doi: 10.1098/rsif.2016.0999.

27.

Anti-diabetic action of all-trans retinoic acid and the orphan G protein coupled receptor GPRC5C in pancreatic β-cells.

Amisten S, Mohammad Al-Amily I, Soni A, Hawkes R, Atanes P, Persaud SJ, Rorsman P, Salehi A.

Endocr J. 2017 Mar 31;64(3):325-338. doi: 10.1507/endocrj.EJ16-0338. Epub 2017 Feb 22.

28.

A role of PLC/PKC-dependent pathway in GLP-1-stimulated insulin secretion.

Shigeto M, Cha CY, Rorsman P, Kaku K.

J Mol Med (Berl). 2017 Apr;95(4):361-368. doi: 10.1007/s00109-017-1508-6. Epub 2017 Jan 17. Review.

PMID:
28097390
29.

Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells.

Brereton MF, Rohm M, Shimomura K, Holland C, Tornovsky-Babeay S, Dadon D, Iberl M, Chibalina MV, Lee S, Glaser B, Dor Y, Rorsman P, Clark A, Ashcroft FM.

Nat Commun. 2016 Nov 24;7:13496. doi: 10.1038/ncomms13496.

30.

Key Matrix Proteins Within the Pancreatic Islet Basement Membrane Are Differentially Digested During Human Islet Isolation.

Cross SE, Vaughan RH, Willcox AJ, McBride AJ, Abraham AA, Han B, Johnson JD, Maillard E, Bateman PA, Ramracheya RD, Rorsman P, Kadler KE, Dunne MJ, Hughes SJ, Johnson PR.

Am J Transplant. 2017 Feb;17(2):451-461. doi: 10.1111/ajt.13975. Epub 2016 Sep 6.

31.

Angular Approach Scanning Ion Conductance Microscopy.

Shevchuk A, Tokar S, Gopal S, Sanchez-Alonso JL, Tarasov AI, Vélez-Ortega AC, Chiappini C, Rorsman P, Stevens MM, Gorelik J, Frolenkov GI, Klenerman D, Korchev YE.

Biophys J. 2016 May 24;110(10):2252-65. doi: 10.1016/j.bpj.2016.04.017.

32.

PYY-Dependent Restoration of Impaired Insulin and Glucagon Secretion in Type 2 Diabetes following Roux-En-Y Gastric Bypass Surgery.

Ramracheya RD, McCulloch LJ, Clark A, Wiggins D, Johannessen H, Olsen MK, Cai X, Zhao CM, Chen D, Rorsman P.

Cell Rep. 2016 May 3;15(5):944-950. doi: 10.1016/j.celrep.2016.03.091. Epub 2016 Apr 21.

33.

Improving the physiological realism of experimental models.

Vinnakota KC, Cha CY, Rorsman P, Balaban RS, La Gerche A, Wade-Martins R, Beard DA, Jeneson JA.

Interface Focus. 2016 Apr 6;6(2):20150076. doi: 10.1098/rsfs.2015.0076. Review.

34.

Glucagon secretion from pancreatic α-cells.

Briant L, Salehi A, Vergari E, Zhang Q, Rorsman P.

Ups J Med Sci. 2016 May;121(2):113-9. doi: 10.3109/03009734.2016.1156789. Epub 2016 Apr 4. Review. Erratum in: Ups J Med Sci. 2016 May;121(2):x.

35.

High-content screening identifies a role for Na(+) channels in insulin production.

Szabat M, Modi H, Ramracheya R, Girbinger V, Chan F, Lee JT, Piske M, Kamal S, Carol Yang YH, Welling A, Rorsman P, Johnson JD.

R Soc Open Sci. 2015 Dec 2;2(12):150306. doi: 10.1098/rsos.150306. eCollection 2015 Dec.

36.

Increased Expression of the Diabetes Gene SOX4 Reduces Insulin Secretion by Impaired Fusion Pore Expansion.

Collins SC, Do HW, Hastoy B, Hugill A, Adam J, Chibalina MV, Galvanovskis J, Godazgar M, Lee S, Goldsworthy M, Salehi A, Tarasov AI, Rosengren AH, Cox R, Rorsman P.

Diabetes. 2016 Jul;65(7):1952-61. doi: 10.2337/db15-1489. Epub 2016 Mar 18.

37.

Dramatis Personae in β-Cell Mass Regulation: Enter SerpinB1.

Tarasov AI, Rorsman P.

Cell Metab. 2016 Jan 12;23(1):8-10. doi: 10.1016/j.cmet.2015.12.011.

38.

The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca²⁺ dynamics and insulin secretion.

Cane MC, Parrington J, Rorsman P, Galione A, Rutter GA.

Cell Calcium. 2016 Jan;59(1):32-40. doi: 10.1016/j.ceca.2015.12.004. Epub 2015 Dec 23.

39.

GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation.

Shigeto M, Ramracheya R, Tarasov AI, Cha CY, Chibalina MV, Hastoy B, Philippaert K, Reinbothe T, Rorsman N, Salehi A, Sones WR, Vergari E, Weston C, Gorelik J, Katsura M, Nikolaev VO, Vennekens R, Zaccolo M, Galione A, Johnson PR, Kaku K, Ladds G, Rorsman P.

J Clin Invest. 2015 Dec;125(12):4714-28. doi: 10.1172/JCI81975. Epub 2015 Nov 16.

40.

Synaptotagmin-7 phosphorylation mediates GLP-1-dependent potentiation of insulin secretion from β-cells.

Wu B, Wei S, Petersen N, Ali Y, Wang X, Bacaj T, Rorsman P, Hong W, Südhof TC, Han W.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9996-10001. doi: 10.1073/pnas.1513004112. Epub 2015 Jul 27.

41.

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.

Arredouani A, Ruas M, Collins SC, Parkesh R, Clough F, Pillinger T, Coltart G, Rietdorf K, Royle A, Johnson P, Braun M, Zhang Q, Sones W, Shimomura K, Morgan AJ, Lewis AM, Chuang KT, Tunn R, Gadea J, Teboul L, Heister PM, Tynan PW, Bellomo EA, Rutter GA, Rorsman P, Churchill GC, Parrington J, Galione A.

J Biol Chem. 2015 Aug 28;290(35):21376-92. doi: 10.1074/jbc.M115.671248. Epub 2015 Jul 7.

42.

RFX6 regulates insulin secretion by modulating Ca2+ homeostasis in human β cells.

Chandra V, Albagli-Curiel O, Hastoy B, Piccand J, Randriamampita C, Vaillant E, Cavé H, Busiah K, Froguel P, Vaxillaire M, Rorsman P, Polak M, Scharfmann R.

Cell Rep. 2014 Dec 24;9(6):2206-18. doi: 10.1016/j.celrep.2014.11.010. Epub 2014 Dec 11.

43.

Glutamate acts as a key signal linking glucose metabolism to incretin/cAMP action to amplify insulin secretion.

Gheni G, Ogura M, Iwasaki M, Yokoi N, Minami K, Nakayama Y, Harada K, Hastoy B, Wu X, Takahashi H, Kimura K, Matsubara T, Hoshikawa R, Hatano N, Sugawara K, Shibasaki T, Inagaki N, Bamba T, Mizoguchi A, Fukusaki E, Rorsman P, Seino S.

Cell Rep. 2014 Oct 23;9(2):661-73. doi: 10.1016/j.celrep.2014.09.030. Epub 2014 Oct 16.

44.

Matthias Braun, 23 July 1966-16 November 2013.

Rorsman P, Zhang Q.

Diabetologia. 2014 Dec;57(12):2431-2. doi: 10.1007/s00125-014-3401-y. No abstract available.

PMID:
25312812
45.

Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression.

Zhang Q, Chibalina MV, Bengtsson M, Groschner LN, Ramracheya R, Rorsman NJ, Leiss V, Nassar MA, Welling A, Gribble FM, Reimann F, Hofmann F, Wood JN, Ashcroft FM, Rorsman P.

J Physiol. 2014 Nov 1;592(21):4677-96. doi: 10.1113/jphysiol.2014.274209. Epub 2014 Aug 28.

46.

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose.

Brereton MF, Iberl M, Shimomura K, Zhang Q, Adriaenssens AE, Proks P, Spiliotis II, Dace W, Mattis KK, Ramracheya R, Gribble FM, Reimann F, Clark A, Rorsman P, Ashcroft FM.

Nat Commun. 2014 Aug 22;5:4639. doi: 10.1038/ncomms5639.

47.

ATP-regulated potassium channels and voltage-gated calcium channels in pancreatic alpha and beta cells: similar functions but reciprocal effects on secretion.

Rorsman P, Ramracheya R, Rorsman NJ, Zhang Q.

Diabetologia. 2014 Sep;57(9):1749-61. doi: 10.1007/s00125-014-3279-8. Epub 2014 Jun 7. Review.

PMID:
24906950
48.

MicroRNA-7a regulates pancreatic β cell function.

Latreille M, Hausser J, Stützer I, Zhang Q, Hastoy B, Gargani S, Kerr-Conte J, Pattou F, Zavolan M, Esguerra JL, Eliasson L, Rülicke T, Rorsman P, Stoffel M.

J Clin Invest. 2014 Jun;124(6):2722-35. doi: 10.1172/JCI73066. Epub 2014 May 1.

49.

GPRC5B a putative glutamate-receptor candidate is negative modulator of insulin secretion.

Soni A, Amisten S, Rorsman P, Salehi A.

Biochem Biophys Res Commun. 2013 Nov 22;441(3):643-8.

PMID:
24404583
50.

Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes.

Zhang Q, Ramracheya R, Lahmann C, Tarasov A, Bengtsson M, Braha O, Braun M, Brereton M, Collins S, Galvanovskis J, Gonzalez A, Groschner LN, Rorsman NJ, Salehi A, Travers ME, Walker JN, Gloyn AL, Gribble F, Johnson PR, Reimann F, Ashcroft FM, Rorsman P.

Cell Metab. 2013 Dec 3;18(6):871-82. doi: 10.1016/j.cmet.2013.10.014.

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