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The lectin-specific activity of Toxoplasma gondii microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune priming.

Sardinha-Silva A, Mendonça-Natividade FC, Pinzan CF, Lopes CD, Costa DL, Jacot D, Fernandes FF, Zorzetto-Fernandes ALV, Gay NJ, Sher A, Jankovic D, Soldati-Favre D, Grigg ME, Roque-Barreira MC.

PLoS Pathog. 2019 Jun 21;15(6):e1007871. doi: 10.1371/journal.ppat.1007871. eCollection 2019 Jun.


Galectin-3 Inhibits Paracoccidioides brasiliensis Growth and Impacts Paracoccidioidomycosis through Multiple Mechanisms.

Hatanaka O, Rezende CP, Moreno P, Freitas Fernandes F, Oliveira Brito PKM, Martinez R, Coelho C, Roque-Barreira MC, Casadevall A, Almeida F.

mSphere. 2019 Apr 24;4(2). pii: e00209-19. doi: 10.1128/mSphere.00209-19.


The Response of IL-17-Producing B Cells to ArtinM Is Independent of Its Interaction with TLR2 and CD14.

Oliveira-Brito PKM, Roque-Barreira MC, da Silva TA.

Molecules. 2018 Sep 13;23(9). pii: E2339. doi: 10.3390/molecules23092339.


HU-Lacking Mutants of Salmonella enterica Enteritidis Are Highly Attenuated and Can Induce Protection in Murine Model of Infection.

Milanez GP, Werle CH, Amorim MR, Ribeiro RA, Tibo LHS, Roque-Barreira MC, Oliveira AF, Brocchi M.

Front Microbiol. 2018 Aug 22;9:1780. doi: 10.3389/fmicb.2018.01780. eCollection 2018.


Effect of ArtinM on Human Blood Cells During Infection With Paracoccidioides brasiliensis.

Ruas LP, Genaro LM, Justo-Junior AS, Coser LO, de Castro LF, Trabasso P, Mamoni RL, Roque-Barreira MC, Blotta MHSL.

Front Microbiol. 2018 May 4;9:867. doi: 10.3389/fmicb.2018.00867. eCollection 2018.


Targeting and Recognition of Toll-Like Receptors by Plant and Pathogen Lectins.

Ricci-Azevedo R, Roque-Barreira MC, Gay NJ.

Front Immunol. 2017 Dec 18;8:1820. doi: 10.3389/fimmu.2017.01820. eCollection 2017.


Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects.

Almeida F, Wolf JM, da Silva TA, DeLeon-Rodriguez CM, Rezende CP, Pessoni AM, Fernandes FF, Silva-Rocha R, Martinez R, Rodrigues ML, Roque-Barreira MC, Casadevall A.

Nat Commun. 2017 Dec 6;8(1):1968. doi: 10.1038/s41467-017-02126-7.


Galectin-3: A Friend but Not a Foe during Trypanosoma cruzi Experimental Infection.

da Silva AA, Teixeira TL, Teixeira SC, Machado FC, Dos Santos MA, Tomiosso TC, Tavares PCB, Brígido RTES, Martins FA, Silva NSL, Rodrigues CC, Roque-Barreira MC, Mortara RA, Lopes DS, Ávila VMR, da Silva CV.

Front Cell Infect Microbiol. 2017 Nov 3;7:463. doi: 10.3389/fcimb.2017.00463. eCollection 2017.


Systemic effects in naïve mice injected with immunomodulatory lectin ArtinM.

Oliveira Brito PKM, Gonçalves TE, Fernandes FF, Miguel CB, Rodrigues WF, Lazo Chica JE, Roque-Barreira MC, da Silva TA.

PLoS One. 2017 Oct 30;12(10):e0187151. doi: 10.1371/journal.pone.0187151. eCollection 2017.


Human neutrophils are targets to paracoccin, a lectin expressed by Paracoccidioides brasiliensis.

Ricci-Azevedo R, Gonçales RA, Roque-Barreira MC, Girard D.

Inflamm Res. 2018 Jan;67(1):31-41. doi: 10.1007/s00011-017-1093-8. Epub 2017 Oct 10.


Paracoccin distribution supports its role in Paracoccidioides brasiliensis growth and dimorphic transformation.

Oliveira AF, Fernandes FF, Mariano VS, Almeida F, Ruas LP, Oliveira LL, Oliver C, Jamur MC, Roque-Barreira MC.

PLoS One. 2017 Aug 28;12(8):e0184010. doi: 10.1371/journal.pone.0184010. eCollection 2017.


CD14 is critical for TLR2-mediated M1 macrophage activation triggered by N-glycan recognition.

da Silva TA, Zorzetto-Fernandes ALV, Cecílio NT, Sardinha-Silva A, Fernandes FF, Roque-Barreira MC.

Sci Rep. 2017 Aug 1;7(1):7083. doi: 10.1038/s41598-017-07397-0.


Impact of Paracoccin Gene Silencing on Paracoccidioides brasiliensis Virulence.

Fernandes FF, Oliveira AF, Landgraf TN, Cunha C, Carvalho A, Vendruscolo PE, Gonçales RA, Almeida F, da Silva TA, Rodrigues F, Roque-Barreira MC.

MBio. 2017 Jul 18;8(4). pii: e00537-17. doi: 10.1128/mBio.00537-17.


ArtinM Mediates Murine T Cell Activation and Induces Cell Death in Jurkat Human Leukemic T Cells.

da Silva TA, Oliveira-Brito PKM, Gonçalves TE, Vendruscolo PE, Roque-Barreira MC.

Int J Mol Sci. 2017 Jun 30;18(7). pii: E1400. doi: 10.3390/ijms18071400.


Th1-Inducing Agents in Prophylaxis and Therapy for Paracoccidioidomycosis.

da Silva TA, Fernandes FF, Landgraf TN, Panunto-Castelo A, Roque-Barreira MC.

Methods Mol Biol. 2017;1625:159-167. doi: 10.1007/978-1-4939-7104-6_12.


Vaccination of Mice with Virulence-Associated Protein G (VapG) Antigen Confers Partial Protection against Rhodococcus equi Infection through Induced Humoral Immunity.

Trevisani MM, Hanna ES, Oliveira AF, Cardoso SA, Roque-Barreira MC, Soares SG.

Front Microbiol. 2017 May 11;8:857. doi: 10.3389/fmicb.2017.00857. eCollection 2017.


Inhibition of Hepatocarcinogenesis by ArtinM via Anti-proliferative and Pro-apoptotic Mechanisms.

Braz MM, Roque-Barreira MC, Ramalho FS, Oliveira CA, Augusto MJ, Ramalho LN.

In Vivo. 2016 11-12;30(6):845-852.


Extracellular vesicles from Paracoccidioides brasiliensis induced M1 polarization in vitro.

da Silva TA, Roque-Barreira MC, Casadevall A, Almeida F.

Sci Rep. 2016 Oct 24;6:35867. doi: 10.1038/srep35867.


Detrimental Effect of Fungal 60-kDa Heat Shock Protein on Experimental Paracoccidioides brasiliensis Infection.

Fernandes FF, Oliveira LL, Landgraf TN, Peron G, Costa MV, Coelho-Castelo AA, Bonato VL, Roque-Barreira MC, Panunto-Castelo A.

PLoS One. 2016 Sep 6;11(9):e0162486. doi: 10.1371/journal.pone.0162486. eCollection 2016.


Paracoccin Induces M1 Polarization of Macrophages via Interaction with TLR4.

Freitas MS, Oliveira AF, da Silva TA, Fernandes FF, Gonçales RA, Almeida F, Roque-Barreira MC.

Front Microbiol. 2016 Jul 5;7:1003. doi: 10.3389/fmicb.2016.01003. eCollection 2016.


Recombinant ArtinM activates mast cells.

Barbosa-Lorenzi VC, Cecilio NT, de Almeida Buranello PA, Pranchevicius MC, Goldman MH, Pereira-da-Silva G, Roque-Barreira MC, Jamur MC, Oliver C.

BMC Immunol. 2016 Jul 4;17(1):22. doi: 10.1186/s12865-016-0161-0.


Lack of galectin-3 increases Jagged1/Notch activation in bone marrow-derived dendritic cells and promotes dysregulation of T helper cell polarization.

Fermino ML, Dylon LS, Cecílio NT, Santos SN, Toscano MA, Dias-Baruffi M, Roque-Barreira MC, Rabinovich GA, Bernardes ES.

Mol Immunol. 2016 Aug;76:22-34. doi: 10.1016/j.molimm.2016.06.005. Epub 2016 Jun 22.


Influence of N-glycans on Expression of Cell Wall Remodeling Related Genes in Paracoccidioides brasiliensis Yeast Cells.

Almeida F, Antoniêto AC, Pessoni AM, Monteiro VN, Alegre-Maller AC, Pigosso LL, Pereira M, Soares CM, Roque-Barreira MC.

Curr Genomics. 2016 Apr;17(2):112-8. doi: 10.2174/1389202917666151116212705.


Data on IL-17 production induced by plant lectins.

da Silva TA, Fernandes FF, Roque-Barreira MC.

Data Brief. 2016 Apr 27;7:1584-7. doi: 10.1016/j.dib.2016.04.053. eCollection 2016 Jun.


Jacalin-Activated Macrophages Exhibit an Antitumor Phenotype.

Danella Polli C, Pereira Ruas L, Chain Veronez L, Herrero Geraldino T, Rossetto de Morais F, Roque-Barreira MC, Pereira-da-Silva G.

Biomed Res Int. 2016;2016:2925657. doi: 10.1155/2016/2925657. Epub 2016 Mar 29.


Neutrophils Contribute to the Protection Conferred by ArtinM against Intracellular Pathogens: A Study on Leishmania major.

Ricci-Azevedo R, Oliveira AF, Conrado MC, Carvalho FC, Roque-Barreira MC.

PLoS Negl Trop Dis. 2016 Apr 8;10(4):e0004609. doi: 10.1371/journal.pntd.0004609. eCollection 2016 Apr.


IL-17 Induction by ArtinM is Due to Stimulation of IL-23 and IL-1 Release and/or Interaction with CD3 in CD4+ T Cells.

da Silva TA, Mariano VS, Sardinha-Silva A, de Souza MA, Mineo TW, Roque-Barreira MC.

PLoS One. 2016 Feb 22;11(2):e0149721. doi: 10.1371/journal.pone.0149721. eCollection 2016.


Glycan microarray analysis of the carbohydrate-recognition specificity of native and recombinant forms of the lectin ArtinM.

Liu Y, Cecílio NT, Carvalho FC, Roque-Barreira MC, Feizi T.

Data Brief. 2015 Nov 18;5:1035-47. doi: 10.1016/j.dib.2015.11.014. eCollection 2015 Dec.


Toxoplasma gondii Chitinase Induces Macrophage Activation.

Almeida F, Sardinha-Silva A, da Silva TA, Pessoni AM, Pinzan CF, Alegre-Maller AC, Cecílio NT, Moretti NS, Damásio AR, Pedersoli WR, Mineo JR, Silva RN, Roque-Barreira MC.

PLoS One. 2015 Dec 10;10(12):e0144507. doi: 10.1371/journal.pone.0144507. eCollection 2015.


Vaccination with Recombinant Microneme Proteins Confers Protection against Experimental Toxoplasmosis in Mice.

Pinzan CF, Sardinha-Silva A, Almeida F, Lai L, Lopes CD, Lourenço EV, Panunto-Castelo A, Matthews S, Roque-Barreira MC.

PLoS One. 2015 Nov 17;10(11):e0143087. doi: 10.1371/journal.pone.0143087. eCollection 2015.


Evidence for Conformational Mechanism on the Binding of TgMIC4 with β-Galactose-Containing Carbohydrate Ligand.

Santos A, Carvalho FC, Roque-Barreira MC, Zorzetto-Fernandes AL, Gimenez-Romero D, Monzó I, Bueno PR.

Langmuir. 2015 Nov 10;31(44):12111-9. doi: 10.1021/acs.langmuir.5b03141. Epub 2015 Oct 29.


Yeast expressed ArtinM shares structure, carbohydrate recognition, and biological effects with native ArtinM.

Cecílio NT, Carvalho FC, Liu Y, Moncrieffe M, Buranello PA, Zorzetto-Fernandes AL, Luche DD, Hanna ES, Soares SG, Feizi T, Gay NJ, Goldman MH, Roque-Barreira MC.

Int J Biol Macromol. 2016 Jan;82:22-30. doi: 10.1016/j.ijbiomac.2015.09.062. Epub 2015 Oct 1.


Saccharomyces cerevisiae expressing Gp43 protects mice against Paracoccidioides brasiliensis infection.

Assis-Marques MA, Oliveira AF, Ruas LP, dos Reis TF, Roque-Barreira MC, Coelho PS.

PLoS One. 2015 Mar 19;10(3):e0120201. doi: 10.1371/journal.pone.0120201. eCollection 2015.


IL10, TGF beta1, and IFN gamma modulate intracellular signaling pathways and cytokine production to control Toxoplasma gondii infection in BeWo trophoblast cells.

Barbosa BF, Lopes-Maria JB, Gomes AO, Angeloni MB, Castro AS, Franco PS, Fermino ML, Roque-Barreira MC, Ietta F, Martins-Filho OA, Silva DA, Mineo JR, Ferro EA.

Biol Reprod. 2015 Mar;92(3):82. doi: 10.1095/biolreprod.114.124115. Epub 2015 Feb 11.


Evaluating the Equilibrium Association Constant between ArtinM Lectin and Myeloid Leukemia Cells by Impedimetric and Piezoelectric Label Free Approaches.

Carvalho FC, Martins DC, Santos A, Roque-Barreira MC, Bueno PR.

Biosensors (Basel). 2014 Oct 3;4(4):358-69. doi: 10.3390/bios4040358. eCollection 2014 Dec.


Therapeutic administration of recombinant Paracoccin confers protection against paracoccidioides brasiliensis infection: involvement of TLRs.

Alegre-Maller AC, Mendonça FC, da Silva TA, Oliveira AF, Freitas MS, Hanna ES, Almeida IC, Gay NJ, Roque-Barreira MC.

PLoS Negl Trop Dis. 2014 Dec 4;8(12):e3317. doi: 10.1371/journal.pntd.0003317. eCollection 2014 Dec.


Impedance-derived electrochemical capacitance spectroscopy for the evaluation of lectin-glycoprotein binding affinity.

Santos A, Carvalho FC, Roque-Barreira MC, Bueno PR.

Biosens Bioelectron. 2014 Dec 15;62:102-5. doi: 10.1016/j.bios.2014.06.034. Epub 2014 Jun 20.


Recognition of TLR2 N-glycans: critical role in ArtinM immunomodulatory activity.

Mariano VS, Zorzetto-Fernandes AL, da Silva TA, Ruas LP, Nohara LL, Almeida IC, Roque-Barreira MC.

PLoS One. 2014 Jun 3;9(6):e98512. doi: 10.1371/journal.pone.0098512. eCollection 2014.


Activation of spleen cells by ArtinM may account for its immunomodulatory properties.

Silva TA, Souza MA, Cecílio NT, Roque-Barreira MC.

Cell Tissue Res. 2014 Sep;357(3):719-30. doi: 10.1007/s00441-014-1879-8. Epub 2014 May 20.


Toxoplasma gondii 70 kDa heat shock protein: systemic detection is associated with the death of the parasites by the immune response and its increased expression in the brain is associated with parasite replication.

Barenco PV, Lourenço EV, Cunha-Júnior JP, Almeida KC, Roque-Barreira MC, Silva DA, Araújo EC, Coutinho LB, Oliveira MC, Mineo TW, Mineo JR, Silva NM.

PLoS One. 2014 May 6;9(5):e96527. doi: 10.1371/journal.pone.0096527. eCollection 2014.


Recombinant paracoccin reproduces the biological properties of the native protein and induces protective Th1 immunity against Paracoccidioides brasiliensis infection.

Alegre AC, Oliveira AF, Dos Reis Almeida FB, Roque-Barreira MC, Hanna ES.

PLoS Negl Trop Dis. 2014 Apr 17;8(4):e2788. doi: 10.1371/journal.pntd.0002788. eCollection 2014 Apr.


Eutirucallin, a RIP-2 type lectin from the latex of Euphorbia tirucalli L. presents proinflammatory properties.

Santana SS, Gennari-Cardoso ML, Carvalho FC, Roque-Barreira MC, Santiago Ada S, Alvim FC, Pirovani CP.

PLoS One. 2014 Feb 18;9(2):e88422. doi: 10.1371/journal.pone.0088422. eCollection 2014.


Recruitment of galectin-3 during cell invasion and intracellular trafficking of Trypanosoma cruzi extracellular amastigotes.

Machado FC, Cruz L, da Silva AA, Cruz MC, Mortara RA, Roque-Barreira MC, da Silva CV.

Glycobiology. 2014 Feb;24(2):179-84. doi: 10.1093/glycob/cwt097. Epub 2013 Nov 12.


α-(1,4)-Amylase, but not α- and β-(1,3)-glucanases, may be responsible for the impaired growth and morphogenesis of Paracoccidioides brasiliensis induced by N-glycosylation inhibition.

Dos Reis Almeida FB, Pigosso LL, de Lima Damásio AR, Monteiro VN, de Almeida Soares CM, Silva RN, Roque-Barreira MC.

Yeast. 2014 Jan;31(1):1-11. doi: 10.1002/yea.2983. Epub 2013 Nov 28.


Monocyte Migration Driven by Galectin-3 Occurs through Distinct Mechanisms Involving Selective Interactions with the Extracellular Matrix.

Danella Polli C, Alves Toledo K, Franco LH, Sammartino Mariano V, de Oliveira LL, Soares Bernardes E, Roque-Barreira MC, Pereira-da-Silva G.

ISRN Inflamm. 2013 Feb 25;2013:259256. doi: 10.1155/2013/259256. eCollection 2013.


Nasal vaccination with attenuated Salmonella expressing VapA: TLR2 activation is not essential for protection against R. equi infection.

Cardoso SA, Oliveira AF, Ruas LP, Trevisani MM, De Oliveira LL, Hanna ES, Roque-Barreira MC, Soares SG.

Vaccine. 2013 Sep 23;31(41):4528-35. doi: 10.1016/j.vaccine.2013.07.067. Epub 2013 Aug 7.


Topical application of the lectin Artin M accelerates wound healing in rat oral mucosa by enhancing TGF-β and VEGF production.

Kim YJ, Carvalho FC, Souza JA, Gonçalves PC, Nogueira AV, Spolidório LC, Roque-Barreira MC, Cirelli JA.

Wound Repair Regen. 2013 May-Jun;21(3):456-63. doi: 10.1111/wrr.12041. Epub 2013 Apr 29.


Galectin-3 negatively regulates the frequency and function of CD4(+) CD25(+) Foxp3(+) regulatory T cells and influences the course of Leishmania major infection.

Fermino ML, Dias FC, Lopes CD, Souza MA, Cruz ÂK, Liu FT, Chammas R, Roque-Barreira MC, Rabinovich GA, Bernardes ES.

Eur J Immunol. 2013 Jul;43(7):1806-17. doi: 10.1002/eji.201343381. Epub 2013 May 17.


The immunomodulatory effect of plant lectins: a review with emphasis on ArtinM properties.

Souza MA, Carvalho FC, Ruas LP, Ricci-Azevedo R, Roque-Barreira MC.

Glycoconj J. 2013 Oct;30(7):641-57. doi: 10.1007/s10719-012-9464-4. Epub 2013 Jan 9. Review.


Characterization of PbPga1, an antigenic GPI-protein in the pathogenic fungus Paracoccidioides brasiliensis.

Valim CX, Basso LR Jr, dos Reis Almeida FB, Reis TF, Damásio AR, Arruda LK, Martinez R, Roque-Barreira MC, Oliver C, Jamur MC, Coelho PS.

PLoS One. 2012;7(9):e44792. Epub 2012 Sep 14.

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