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J Dairy Sci. 2019 Mar 14. pii: S0022-0302(19)30256-5. doi: 10.3168/jds.2018-15568. [Epub ahead of print]

Exogenous β-mannanase supplementation improved immunological and metabolic responses in lactating dairy cows.

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Department of Animal Science, University of California, Davis 95616.
CTCBio Inc., Seoul 05842, Republic of Korea.
Department of Animal Biosystem Sciences, Chungnam National University, Daejeon 305-764, Republic of Korea.
Department of Animal Science, University of California, Davis 95616. Electronic address:


Exogenous enzymes have been used to improve nutrient utilization in several species of livestock, particularly swine and poultry. In addition, improved immunological and metabolic traits have been reported in nonruminants. The objective of this study was to determine the effects of β-mannanase supplementation on milk yield and composition, and immunological and metabolic responses in lactating Holstein dairy cows. Two weeks after calving, 20 Holstein cows (10 multiparous and 10 primiparous) were blocked by parity and assigned to 1 of 2 diets for 182 d. All cows were housed in the same environment and fed the same basal diet. The basal diet of the treatment group was supplemented with β-mannanase (CTCBio Inc., Seoul, South Korea) at 0.1% of concentrate dry matter. No differences were detected between the control and enzyme supplement groups in milk yield parameters or milk composition. Supplementation of β-mannanase enzyme reduced blood haptoglobin levels in supplemented multiparous cows compared with controls. Furthermore, nonesterified fatty acid concentration levels tended to be lower in cows fed β-mannanase, regardless of parity. Neither immunoglobulin G nor milk somatic cell count was affected by β-mannanase supplementation, regardless of parity. The number of insemination services tended to be lower in cows fed diets supplemented with β-mannanase. Results from this study suggest that supplementation of β-mannanase exogenous enzyme could help to reduce instances of systemic inflammation and decrease fat mobilization in lactating Holstein cows. Multiparous cows are considered susceptible to acute infections and inflammation; thus, the enzyme had a greater effect in multiparous cows.


haptoglobin; immune response; lactating cow; β-mannanase


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