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Items: 1 to 50 of 64

1.

A DNA hypermethylation profile reveals new potential biomarkers for the evaluation of prognosis in urothelial bladder cancer.

López JI, Angulo JC, Martín A, Sánchez-Chapado M, González-Corpas A, Colás B, Ropero S.

APMIS. 2017 Sep;125(9):787-796. doi: 10.1111/apm.12719. Epub 2017 Jun 6.

PMID:
28586118
2.

Epigenetics in Schizophrenia: A Pilot Study of Global DNA Methylation in Different Brain Regions Associated with Higher Cognitive Functions.

Alelú-Paz R, Carmona FJ, Sanchez-Mut JV, Cariaga-Martínez A, González-Corpas A, Ashour N, Orea MJ, Escanilla A, Monje A, Guerrero Márquez C, Saiz-Ruiz J, Esteller M, Ropero S.

Front Psychol. 2016 Sep 30;7:1496. eCollection 2016.

3.

Survival predictors in patients with prostate adenocarcinoma with hormonal blockade.

Angulo JC, Redondo C, Sánchez-Chapado M, Colás B, Ropero S, López JI.

Pathol Res Pract. 2016 Oct;212(10):899-903. doi: 10.1016/j.prp.2016.07.012. Epub 2016 Jul 27.

PMID:
27502465
4.

DNA Methylation and Urological Cancer, a Step Towards Personalized Medicine: Current and Future Prospects.

Angulo JC, López JI, Ropero S.

Mol Diagn Ther. 2016 Dec;20(6):531-549. Review.

PMID:
27501813
5.

A DNA Hypermethylation Profile Independently Predicts Biochemical Recurrence Following Radical Prostatectomy.

Angulo JC, Lopez JI, Dorado JF, Sanchez-Chapado M, Colas B, Ropero S.

Urol Int. 2016;97(1):16-25. doi: 10.1159/000446446. Epub 2016 May 25.

PMID:
27220660
6.

Development of Castration Resistant Prostate Cancer can be Predicted by a DNA Hypermethylation Profile.

Angulo JC, Andrés G, Ashour N, Sánchez-Chapado M, López JI, Ropero S.

J Urol. 2016 Mar;195(3):619-26. doi: 10.1016/j.juro.2015.10.172. Epub 2015 Nov 6.

PMID:
26551297
7.

DNA methylation pattern of gene promoters of major neurotransmitter systems in older patients with schizophrenia with severe and mild cognitive impairment.

Alelú-Paz R, González-Corpas A, Ashour N, Escanilla A, Monje A, Guerrero Márquez C, Algora Weber M, Ropero S.

Int J Geriatr Psychiatry. 2015 Jun;30(6):558-65. doi: 10.1002/gps.4182. Epub 2014 Jul 21.

PMID:
25044034
8.

A DNA hypermethylation profile reveals new potential biomarkers for prostate cancer diagnosis and prognosis.

Ashour N, Angulo JC, Andrés G, Alelú R, González-Corpas A, Toledo MV, Rodríguez-Barbero JM, López JI, Sánchez-Chapado M, Ropero S.

Prostate. 2014 Sep;74(12):1171-82. doi: 10.1002/pros.22833. Epub 2014 Jun 24.

PMID:
24961912
9.

DNA repair genes and prognosis in sporadic forms of urothelial carcinoma of the upper urinary tract.

García-Tello A, Ramón de Fata F, Andrés G, Ropero S, López JI, Angulo JC.

Actas Urol Esp. 2014 Nov;38(9):600-7. doi: 10.1016/j.acuro.2014.03.010. Epub 2014 Jun 21. English, Spanish.

PMID:
24958312
10.

DNA methylation alterations in grade II- and anaplastic pleomorphic xanthoastrocytoma.

Martínez R, Carmona FJ, Vizoso M, Rohde V, Kirsch M, Schackert G, Ropero S, Paulus W, Barrantes A, Gomez A, Esteller M.

BMC Cancer. 2014 Mar 20;14:213. doi: 10.1186/1471-2407-14-213.

11.

Dual specificity phosphatase 1 expression inversely correlates with NF-κB activity and expression in prostate cancer and promotes apoptosis through a p38 MAPK dependent mechanism.

Gil-Araujo B, Toledo Lobo MV, Gutiérrez-Salmerón M, Gutiérrez-Pitalúa J, Ropero S, Angulo JC, Chiloeches A, Lasa M.

Mol Oncol. 2014 Feb;8(1):27-38. doi: 10.1016/j.molonc.2013.08.012. Epub 2013 Sep 14.

12.

The study of DNA methylation in urological cancer: present and future.

Andrés G, Ashour N, Sánchez-Chapado M, Ropero S, Angulo JC.

Actas Urol Esp. 2013 Jun;37(6):368-75. doi: 10.1016/j.acuro.2013.03.001. Epub 2013 May 1. Review. English, Spanish.

PMID:
23643196
13.

New gene signatures for pediatric brain tumors: a step forward in the understanding of molecular basis of CNS PNET.

Alelú-Paz R, Ropero S.

Transl Pediatr. 2013 Jan;2(1):3-4. doi: 10.3978/j.issn.2224-4336.2012.10.02. No abstract available.

14.

DNA methylation, histone modifications, and signal transduction pathways: a close relationship in malignant gliomas pathophysiology.

Alelú-Paz R, Ashour N, González-Corpas A, Ropero S.

J Signal Transduct. 2012;2012:956958. doi: 10.1155/2012/956958. Epub 2012 Jul 17.

15.

A DNA methylation fingerprint of 1628 human samples.

Fernandez AF, Assenov Y, Martin-Subero JI, Balint B, Siebert R, Taniguchi H, Yamamoto H, Hidalgo M, Tan AC, Galm O, Ferrer I, Sanchez-Cespedes M, Villanueva A, Carmona J, Sanchez-Mut JV, Berdasco M, Moreno V, Capella G, Monk D, Ballestar E, Ropero S, Martinez R, Sanchez-Carbayo M, Prosper F, Agirre X, Fraga MF, Graña O, Perez-Jurado L, Mora J, Puig S, Prat J, Badimon L, Puca AA, Meltzer SJ, Lengauer T, Bridgewater J, Bock C, Esteller M.

Genome Res. 2012 Feb;22(2):407-19. doi: 10.1101/gr.119867.110. Epub 2011 May 25.

16.

Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing.

Melo S, Villanueva A, Moutinho C, Davalos V, Spizzo R, Ivan C, Rossi S, Setien F, Casanovas O, Simo-Riudalbas L, Carmona J, Carrere J, Vidal A, Aytes A, Puertas S, Ropero S, Kalluri R, Croce CM, Calin GA, Esteller M.

Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4394-9. doi: 10.1073/pnas.1014720108. Epub 2011 Feb 28. Erratum in: Proc Natl Acad Sci U S A. 2017 Jan 17;:.

17.

A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells.

Melo SA, Moutinho C, Ropero S, Calin GA, Rossi S, Spizzo R, Fernandez AF, Davalos V, Villanueva A, Montoya G, Yamamoto H, Schwartz S Jr, Esteller M.

Cancer Cell. 2010 Oct 19;18(4):303-15. doi: 10.1016/j.ccr.2010.09.007.

18.

BRCA1 CpG island hypermethylation predicts sensitivity to poly(adenosine diphosphate)-ribose polymerase inhibitors.

Veeck J, Ropero S, Setien F, Gonzalez-Suarez E, Osorio A, Benitez J, Herman JG, Esteller M.

J Clin Oncol. 2010 Oct 10;28(29):e563-4; author reply e565-6. doi: 10.1200/JCO.2010.30.1010. Epub 2010 Aug 2. No abstract available.

PMID:
20679605
19.

Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma.

Berdasco M, Ropero S, Setien F, Fraga MF, Lapunzina P, Losson R, Alaminos M, Cheung NK, Rahman N, Esteller M.

Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21830-5. doi: 10.1073/pnas.0906831106. Epub 2009 Dec 14.

20.

Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies.

Taniguchi H, Fernández AF, Setién F, Ropero S, Ballestar E, Villanueva A, Yamamoto H, Imai K, Shinomura Y, Esteller M.

Cancer Res. 2009 Nov 1;69(21):8447-54. doi: 10.1158/0008-5472.CAN-09-0551. Epub 2009 Oct 27.

21.

Knockdown of protein tyrosine phosphatase SHP-1 inhibits G1/S progression in prostate cancer cells through the regulation of components of the cell-cycle machinery.

Rodríguez-Ubreva FJ, Cariaga-Martinez AE, Cortés MA, Romero-De Pablos M, Ropero S, López-Ruiz P, Colás B.

Oncogene. 2010 Jan 21;29(3):345-55. doi: 10.1038/onc.2009.329. Epub 2009 Oct 19.

PMID:
19838216
22.

A microarray-based DNA methylation study of glioblastoma multiforme.

Martinez R, Martin-Subero JI, Rohde V, Kirsch M, Alaminos M, Fernandez AF, Ropero S, Schackert G, Esteller M.

Epigenetics. 2009 May 16;4(4):255-64. Epub 2009 May 29.

PMID:
19550145
23.

A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function.

Melo SA, Ropero S, Moutinho C, Aaltonen LA, Yamamoto H, Calin GA, Rossi S, Fernandez AF, Carneiro F, Oliveira C, Ferreira B, Liu CG, Villanueva A, Capella G, Schwartz S Jr, Shiekhattar R, Esteller M.

Nat Genet. 2009 Mar;41(3):365-70. doi: 10.1038/ng.317. Epub 2009 Feb 15. Retraction in: Nat Genet. 2016 Feb;48(2):221. Erratum in: Nat Genet. 2010 May;42(5):464.

24.

The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer.

Fernandez AF, Rosales C, Lopez-Nieva P, Graña O, Ballestar E, Ropero S, Espada J, Melo SA, Lujambio A, Fraga MF, Pino I, Javierre B, Carmona FJ, Acquadro F, Steenbergen RD, Snijders PJ, Meijer CJ, Pineau P, Dejean A, Lloveras B, Capella G, Quer J, Buti M, Esteban JI, Allende H, Rodriguez-Frias F, Castellsague X, Minarovits J, Ponce J, Capello D, Gaidano G, Cigudosa JC, Gomez-Lopez G, Pisano DG, Valencia A, Piris MA, Bosch FX, Cahir-McFarland E, Kieff E, Esteller M.

Genome Res. 2009 Mar;19(3):438-51. doi: 10.1101/gr.083550.108. Epub 2009 Feb 10.

25.

Identification of (1H)-pyrroles as histone deacetylase inhibitors with antitumoral activity.

Zubia A, Ropero S, Otaegui D, Ballestar E, Fraga MF, Boix-Chornet M, Berdasco M, Martinez A, Coll-Mulet L, Gil J, Cossío FP, Esteller M.

Oncogene. 2009 Mar 19;28(11):1477-84. doi: 10.1038/onc.2008.501. Epub 2009 Jan 26.

PMID:
19169274
26.

Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.

Lara E, Mai A, Calvanese V, Altucci L, Lopez-Nieva P, Martinez-Chantar ML, Varela-Rey M, Rotili D, Nebbioso A, Ropero S, Montoya G, Oyarzabal J, Velasco S, Serrano M, Witt M, Villar-Garea A, Imhof A, Mato JM, Esteller M, Fraga MF.

Oncogene. 2009 Feb 12;28(6):781-91. doi: 10.1038/onc.2008.436. Epub 2008 Dec 8. Erratum in: Oncogene. 2009 Feb 26;28(8):1168. Inhof, A [corrected to Imhof, A].

PMID:
19060927
27.

A microRNA DNA methylation signature for human cancer metastasis.

Lujambio A, Calin GA, Villanueva A, Ropero S, Sánchez-Céspedes M, Blanco D, Montuenga LM, Rossi S, Nicoloso MS, Faller WJ, Gallagher WM, Eccles SA, Croce CM, Esteller M.

Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13556-61. doi: 10.1073/pnas.0803055105. Epub 2008 Sep 3.

28.

Differences and molecular immunohistochemical parameters in the subtypes of infiltrating ductal breast cancer.

Bertolo C, Guerrero D, Vicente F, Cordoba A, Esteller M, Ropero S, Guillen-Grima F, Martinez-Peñuela JM, Lera JM.

Am J Clin Pathol. 2008 Sep;130(3):414-24. doi: 10.1309/J3QV9763DYPV338D.

PMID:
18701415
29.

Epigenetic inactivation of the Groucho homologue gene TLE1 in hematologic malignancies.

Fraga MF, Berdasco M, Ballestar E, Ropero S, Lopez-Nieva P, Lopez-Serra L, Martín-Subero JI, Calasanz MJ, Lopez de Silanes I, Setien F, Casado S, Fernandez AF, Siebert R, Stifani S, Esteller M.

Cancer Res. 2008 Jun 1;68(11):4116-22. doi: 10.1158/0008-5472.CAN-08-0085.

30.

Hypermethylation of the thrombospondin-1 gene is associated with poor prognosis in penile squamous cell carcinoma.

Guerrero D, Guarch R, Ojer A, Casas JM, Ropero S, Mancha A, Pesce C, Lloveras B, Garcia-Bragado F, Puras A.

BJU Int. 2008 Sep;102(6):747-55. doi: 10.1111/j.1464-410X.2008.07603.x. Epub 2008 Mar 10.

31.

Transforming pathways unleashed by a HDAC2 mutation in human cancer.

Ropero S, Ballestar E, Alaminos M, Arango D, Schwartz S Jr, Esteller M.

Oncogene. 2008 Jun 26;27(28):4008-12. doi: 10.1038/onc.2008.31. Epub 2008 Feb 11.

PMID:
18264134
32.

Unmasking of epigenetically silenced candidate tumor suppressor genes by removal of methyl-CpG-binding domain proteins.

Lopez-Serra L, Ballestar E, Ropero S, Setien F, Billard LM, Fraga MF, Lopez-Nieva P, Alaminos M, Guerrero D, Dante R, Esteller M.

Oncogene. 2008 Jun 5;27(25):3556-66. doi: 10.1038/sj.onc.1211022. Epub 2008 Jan 28.

PMID:
18223687
33.

Discovery of epigenetically silenced genes by methylated DNA immunoprecipitation in colon cancer cells.

Jacinto FV, Ballestar E, Ropero S, Esteller M.

Cancer Res. 2007 Dec 15;67(24):11481-6.

34.

Stereospecific synthesis of (-)-neplanocin F.

Ropero SR, Edmont D, Mathé C, Périgaud C.

Nucleosides Nucleotides Nucleic Acids. 2007;26(8-9):1111-4.

PMID:
18058547
35.

Histone H3 and H4 modification profiles in a Rett syndrome mouse model.

Urdinguio RG, Pino I, Ropero S, Fraga MF, Esteller M.

Epigenetics. 2007 Jan-Mar;2(1):11-4. Epub 2006 Dec 12.

PMID:
17965622
36.

EGF prevents the neuroendocrine differentiation of LNCaP cells induced by serum deprivation: the modulator role of PI3K/Akt.

Martín-Orozco RM, Almaraz-Pro C, Rodríguez-Ubreva FJ, Cortés MA, Ropero S, Colomer R, López-Ruiz P, Colás B.

Neoplasia. 2007 Aug;9(8):614-24.

37.

Inhibition of Fatty Acid Synthase (FASN) synergistically enhances the efficacy of 5-fluorouracil in breast carcinoma cells.

Vazquez-Martin A, Ropero S, Brunet J, Colomer R, Menendez JA.

Oncol Rep. 2007 Oct;18(4):973-80.

PMID:
17786362
38.

Combinatorial effects of splice variants modulate function of Aiolos.

Caballero R, Setien F, Lopez-Serra L, Boix-Chornet M, Fraga MF, Ropero S, Megias D, Alaminos M, Sanchez-Tapia EM, Montoya MC, Esteller M, Gonzalez-Sarmiento R, Ballestar E.

J Cell Sci. 2007 Aug 1;120(Pt 15):2619-30.

39.

The role of histone deacetylases (HDACs) in human cancer.

Ropero S, Esteller M.

Mol Oncol. 2007 Jun;1(1):19-25. doi: 10.1016/j.molonc.2007.01.001. Epub 2007 Mar 7. Review.

40.

Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells.

Espada J, Ballestar E, Santoro R, Fraga MF, Villar-Garea A, Németh A, Lopez-Serra L, Ropero S, Aranda A, Orozco H, Moreno V, Juarranz A, Stockert JC, Längst G, Grummt I, Bickmore W, Esteller M.

Nucleic Acids Res. 2007;35(7):2191-8. Epub 2007 Mar 13.

41.

Genetic unmasking of an epigenetically silenced microRNA in human cancer cells.

Lujambio A, Ropero S, Ballestar E, Fraga MF, Cerrato C, Setién F, Casado S, Suarez-Gauthier A, Sanchez-Cespedes M, Git A, Spiteri I, Das PP, Caldas C, Miska E, Esteller M.

Cancer Res. 2007 Feb 15;67(4):1424-9. Erratum in: Cancer Res. 2007 Apr 1;67(7):3492. Gitt, Anna [corrected to Git, Anna].

43.

Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer.

Agrelo R, Cheng WH, Setien F, Ropero S, Espada J, Fraga MF, Herranz M, Paz MF, Sanchez-Cespedes M, Artiga MJ, Guerrero D, Castells A, von Kobbe C, Bohr VA, Esteller M.

Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8822-7. Epub 2006 May 24.

44.

A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition.

Ropero S, Fraga MF, Ballestar E, Hamelin R, Yamamoto H, Boix-Chornet M, Caballero R, Alaminos M, Setien F, Paz MF, Herranz M, Palacios J, Arango D, Orntoft TF, Aaltonen LA, Schwartz S Jr, Esteller M.

Nat Genet. 2006 May;38(5):566-9. Epub 2006 Apr 16.

PMID:
16642021
45.

Genetic variants in epigenetic genes and breast cancer risk.

Cebrian A, Pharoah PD, Ahmed S, Ropero S, Fraga MF, Smith PL, Conroy D, Luben R, Perkins B, Easton DF, Dunning AM, Esteller M, Ponder BA.

Carcinogenesis. 2006 Aug;27(8):1661-9. Epub 2006 Feb 25.

PMID:
16501248
46.

The dioxin receptor is silenced by promoter hypermethylation in human acute lymphoblastic leukemia through inhibition of Sp1 binding.

Mulero-Navarro S, Carvajal-Gonzalez JM, Herranz M, Ballestar E, Fraga MF, Ropero S, Esteller M, Fernandez-Salguero PM.

Carcinogenesis. 2006 May;27(5):1099-104. Epub 2006 Jan 12.

PMID:
16410262
47.

Epigenetic differences arise during the lifetime of monozygotic twins.

Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML, Heine-Suñer D, Cigudosa JC, Urioste M, Benitez J, Boix-Chornet M, Sanchez-Aguilera A, Ling C, Carlsson E, Poulsen P, Vaag A, Stephan Z, Spector TD, Wu YZ, Plass C, Esteller M.

Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10604-9. Epub 2005 Jul 11.

48.

Growth and molecular interactions between tamoxifen and trastuzumab.

Vázquez-Martín A, Colomer R, Ropero S, Abel Menéndez J, Argiris A, Wang CX, Koay DC, Digiovanna MP.

Clin Cancer Res. 2005 May 1;11(9):3597; author reply 3597-9. No abstract available.

49.

EMP3, a myelin-related gene located in the critical 19q13.3 region, is epigenetically silenced and exhibits features of a candidate tumor suppressor in glioma and neuroblastoma.

Alaminos M, Dávalos V, Ropero S, Setién F, Paz MF, Herranz M, Fraga MF, Mora J, Cheung NK, Gerald WL, Esteller M.

Cancer Res. 2005 Apr 1;65(7):2565-71.

50.

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer.

Fraga MF, Ballestar E, Villar-Garea A, Boix-Chornet M, Espada J, Schotta G, Bonaldi T, Haydon C, Ropero S, Petrie K, Iyer NG, Pérez-Rosado A, Calvo E, Lopez JA, Cano A, Calasanz MJ, Colomer D, Piris MA, Ahn N, Imhof A, Caldas C, Jenuwein T, Esteller M.

Nat Genet. 2005 Apr;37(4):391-400. Epub 2005 Mar 13.

PMID:
15765097

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