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Items: 1 to 50 of 107

1.

Excessive treadmill training enhances the insulin signaling pathway and glycogen deposition in mice hearts.

Oliveira LDC, de Morais GP, da Rocha AL, Teixeira GR, Pinto AP, de Vicente LG, Pauli JR, de Moura LP, Mekary RA, Ropelle ER, Cintra DE, da Silva ASR.

J Cell Biochem. 2018 Oct 15. doi: 10.1002/jcb.27092. [Epub ahead of print]

PMID:
30324688
2.

Omega-3 from Flaxseed Oil Protects Obese Mice Against Diabetic Retinopathy Through GPR120 Receptor.

Dátilo MN, Sant'Ana MR, Formigari GP, Rodrigues PB, de Moura LP, da Silva ASR, Ropelle ER, Pauli JR, Cintra DE.

Sci Rep. 2018 Sep 25;8(1):14318. doi: 10.1038/s41598-018-32553-5.

3.

Acute physical exercise increases leptin-induced hypothalamic extracellular signal-regulated kinase1/2 phosphorylation and thermogenesis of obese mice.

Gaspar RC, Muñoz VR, Kuga GK, Nakandakari SCBR, Minuzzi LG, Botezelli JD, da Silva ASR, Cintra DE, de Moura LP, Ropelle ER, Pauli JR.

J Cell Biochem. 2018 Sep 11. doi: 10.1002/jcb.27426. [Epub ahead of print]

PMID:
30206970
4.

Nicotinamide riboside induces a thermogenic response in lean mice.

Crisol BM, Veiga CB, Lenhare L, Braga RR, Silva VRR, da Silva ASR, Cintra DE, Moura LP, Pauli JR, Ropelle ER.

Life Sci. 2018 Oct 15;211:1-7. doi: 10.1016/j.lfs.2018.09.015. Epub 2018 Sep 6.

PMID:
30195617
5.

The reversal effect of physical exercise on aging-related increases in APPL2 content in skeletal muscle.

Canciglieri PH, Kuga GK, Muñoz VR, Gaspar RC, da Rocha AL, Breda L, Anaruma CP, Minuzzi LG, da Silva ASR, Cintra DE, de Moura LP, Ropelle ER, Pauli JR.

Life Sci. 2018 Oct 1;210:209-213. doi: 10.1016/j.lfs.2018.09.006. Epub 2018 Sep 3.

PMID:
30189216
6.

Endurance training prevents inflammation and apoptosis in hypothalamic neurons of obese mice.

Marinho R, Munõz VR, Pauli LSS, Ropelle ECC, de Moura LP, Moraes JC, Moura-Assis A, Cintra DE, da Silva ASR, Ropelle ER, Pauli JR.

J Cell Physiol. 2018 Jan;234(1):880-890. doi: 10.1002/jcp.26909. Epub 2018 Aug 4.

PMID:
30078194
7.

Exercise activates the hypothalamic S1PR1-STAT3 axis through the central action of interleukin 6 in mice.

Silva VRR, Micheletti TO, Katashima CK, Lenhare L, Morari J, Moura-Assis A, de Lima-Júnior JC, Camargo JA, Passos GR, Gaspar RS, Velloso LA, Saad MJ, da Silva ASR, Moura LP, Cintra DE, Pauli JR, Ropelle ER.

J Cell Physiol. 2018 Dec;233(12):9426-9436. doi: 10.1002/jcp.26818. Epub 2018 Jul 31.

PMID:
30063084
8.

Downregulation of HIF complex in the hypothalamus exacerbates diet-induced obesity.

Gaspar JM, Mendes NF, Corrêa-da-Silva F, Lima-Junior JC, Gaspar RC, Ropelle ER, Araujo EP, Carvalho HM, Velloso LA.

Brain Behav Immun. 2018 Oct;73:550-561. doi: 10.1016/j.bbi.2018.06.020. Epub 2018 Jun 21.

PMID:
29935943
9.

Excessive training induces molecular signs of pathologic cardiac hypertrophy.

da Rocha AL, Teixeira GR, Pinto AP, de Morais GP, Oliveira LDC, de Vicente LG, da Silva LECM, Pauli JR, Cintra DE, Ropelle ER, de Moura LP, Mekary RA, de Freitas EC, da Silva ASR.

J Cell Physiol. 2018 Nov;233(11):8850-8861. doi: 10.1002/jcp.26799. Epub 2018 May 24.

PMID:
29797568
10.

Acute physical exercise increases the adaptor protein APPL1 in the hypothalamus of obese mice.

Gaspar RC, Muñoz VR, Formigari GP, Kuga GK, Nakandakari SCBR, Botezelli JD, da Silva ASR, Cintra DE, de Moura LP, Ropelle ER, Pauli JR.

Cytokine. 2018 Oct;110:87-93. doi: 10.1016/j.cyto.2018.04.013. Epub 2018 Apr 26.

PMID:
29705396
11.

The Role of Physical Exercise to Improve the Browning of White Adipose Tissue via POMC Neurons.

Rodrigues KCDC, Pereira RM, de Campos TDP, de Moura RF, da Silva ASR, Cintra DE, Ropelle ER, Pauli JR, de Araújo MB, de Moura LP.

Front Cell Neurosci. 2018 Mar 28;12:88. doi: 10.3389/fncel.2018.00088. eCollection 2018. Review.

12.

Exercise decreases CLK2 in the liver of obese mice and prevents hepatic fat accumulation.

Muñoz VR, Gaspar RC, Kuga GK, Nakandakari SCBR, Baptista IL, Mekary RA, da Silva ASR, de Moura LP, Ropelle ER, Cintra DE, Pauli JR.

J Cell Biochem. 2018 Jul;119(7):5885-5892. doi: 10.1002/jcb.26780. Epub 2018 Mar 25.

PMID:
29575149
13.

Impaired insulin signaling and spatial learning in middle-aged rats: The role of PTP1B.

Kuga GK, Muñoz VR, Gaspar RC, Nakandakari SCBR, da Silva ASR, Botezelli JD, Leme JACA, Gomes RJ, de Moura LP, Cintra DE, Ropelle ER, Pauli JR.

Exp Gerontol. 2018 Apr;104:66-71. doi: 10.1016/j.exger.2018.02.005. Epub 2018 Feb 5.

PMID:
29421605
14.

Positive effects of total recovery period on anti- and pro-inflammatory cytokines are not linked to performance re-establishment in overtrained mice.

da Rocha AL, Pinto AP, Pereira BC, Kohama EB, Morais GP, de Vicente LG, Pauli JR, Cintra DE, Ropelle ER, de Moura LP, Filho HT, da Silva ASR.

Cytokine. 2018 Mar;103:69-76. doi: 10.1016/j.cyto.2018.01.005. Epub 2018 Jan 10.

PMID:
29331586
15.

Retraction notice to "Reversion of hepatic steatosis by exercise training in obese mice: The role of sterol regulatory element-binding protein-1c" [Life Sci. Title 91/11-12 (2012) 395-401].

Cintra DE, Ropelle ER, Vitto MF, Luciano TF, Souza DR, Engelmann J, Marques SO, Lira FS, de Pinho RA, Pauli JR, De Souza CT.

Life Sci. 2018 Jan 15;193:309. doi: 10.1016/j.lfs.2017.12.028. No abstract available.

PMID:
29295739
16.

The role of physical exercise on Sestrin1 and 2 accumulations in the skeletal muscle of mice.

Crisol BM, Lenhare L, Gaspar RS, Gaspar RC, Muñoz VR, da Silva ASR, Cintra DE, de Moura LP, Pauli JR, Ropelle ER.

Life Sci. 2018 Feb 1;194:98-103. doi: 10.1016/j.lfs.2017.12.023. Epub 2017 Dec 19.

PMID:
29273527
17.

Exercise increases Rho-kinase activity and insulin signaling in skeletal muscle.

Muñoz VR, Gaspar RC, Kuga GK, da Rocha AL, Crisol BM, Botezelli JD, Baptista IL, Mekary RA, da Silva ASR, Cintra DE, de Moura LP, Ropelle ER, Pauli JR.

J Cell Physiol. 2018 Jun;233(6):4791-4800. doi: 10.1002/jcp.26278. Epub 2018 Jan 15.

PMID:
29219181
18.

Flaxseed oil rich in omega-3 protects aorta against inflammation and endoplasmic reticulum stress partially mediated by GPR120 receptor in obese, diabetic and dyslipidemic mice models.

Moura-Assis A, Afonso MS, de Oliveira V, Morari J, Dos Santos GA, Koike M, Lottenberg AM, Ramos Catharino R, Velloso LA, Sanchez Ramos da Silva A, de Moura LP, Ropelle ER, Pauli JR, Cintra DEC.

J Nutr Biochem. 2018 Mar;53:9-19. doi: 10.1016/j.jnutbio.2017.09.015. Epub 2017 Oct 18.

PMID:
29175142
19.

Treadmill Slope Modulates Inflammation, Fiber Type Composition, Androgen, and Glucocorticoid Receptors in the Skeletal Muscle of Overtrained Mice.

da Rocha AL, Pereira BC, Teixeira GR, Pinto AP, Frantz FG, Elias LLK, Lira FS, Pauli JR, Cintra DE, Ropelle ER, de Moura LP, Mekary RA, de Freitas EC, da Silva ASR.

Front Immunol. 2017 Oct 25;8:1378. doi: 10.3389/fimmu.2017.01378. eCollection 2017.

20.

Obesity Increases Mitogen-Activated Protein Kinase Phosphatase-3 Levels in the Hypothalamus of Mice.

Rodrigues BA, Muñoz VR, Kuga GK, Gaspar RC, Nakandakari SCBR, Crisol BM, Botezelli JD, Pauli LSS, da Silva ASR, de Moura LP, Cintra DE, Ropelle ER, Pauli JR.

Front Cell Neurosci. 2017 Oct 9;11:313. doi: 10.3389/fncel.2017.00313. eCollection 2017.

21.

Levels of Hepatic Activating Transcription Factor 6 and Caspase-3 Are Downregulated in Mice after Excessive Training.

Pinto AP, da Rocha AL, Oliveira LDC, Morais GP, de Vicente LG, Cintra DE, Pauli JR, Moura LP, Ropelle ER, da Silva ASR.

Front Endocrinol (Lausanne). 2017 Sep 26;8:247. doi: 10.3389/fendo.2017.00247. eCollection 2017.

22.

Protective molecular mechanisms of clusterin against apoptosis in cardiomyocytes.

Pereira RM, Mekary RA, da Cruz Rodrigues KC, Anaruma CP, Ropelle ER, da Silva ASR, Cintra DE, Pauli JR, de Moura LP.

Heart Fail Rev. 2018 Jan;23(1):123-129. doi: 10.1007/s10741-017-9654-z. Review.

PMID:
28948410
23.

Overexpression of Mitogen-activated protein kinase phosphatase-3 (MKP-3) reduces FoxO1 phosphorylation in mice hypothalamus.

Rodrigues BA, Kuga GK, Muñoz VR, Gaspar RC, Tavares MR, Botezelli JD, da Silva ASR, Cintra DE, de Moura LP, Simabuco FM, Ropelle ER, Pauli JR.

Neurosci Lett. 2017 Oct 17;659:14-17. doi: 10.1016/j.neulet.2017.08.067. Epub 2017 Sep 1.

PMID:
28866049
24.

Retraction notice to "Obesity-Induced Increase in Tumor Necrosis Factor-α Leads to Development of Colon Cancer in Mice" Gastroenterology 2012;143:741-753.e4.

Flores MBS, Rocha GZ, Damas-Souza DM, Osório-Costa F, Dias MM, Ropelle ER, Camargo JA, de Carvalho RB, Carvalho HF, Saad MJA, Carvalheira JBC.

Gastroenterology. 2017 Sep;153(3):871. doi: 10.1053/j.gastro.2017.08.027.

PMID:
28864274
25.

Chronic exercise reduces hypothalamic transforming growth factor-β1 in middle-aged obese mice.

Silva VRR, Katashima CK, Lenhare L, Silva CGB, Morari J, Camargo RL, Velloso LA, Saad MA, da Silva ASR, Pauli JR, Ropelle ER.

Aging (Albany NY). 2017 Aug 28;9(8):1926-1940. doi: 10.18632/aging.101281.

26.

Physical exercise increases Sestrin 2 protein levels and induces autophagy in the skeletal muscle of old mice.

Lenhare L, Crisol BM, Silva VRR, Katashima CK, Cordeiro AV, Pereira KD, Luchessi AD, da Silva ASR, Cintra DE, Moura LP, Pauli JR, Ropelle ER.

Exp Gerontol. 2017 Oct 15;97:17-21. doi: 10.1016/j.exger.2017.07.009. Epub 2017 Jul 17.

PMID:
28729213
27.

High Dosage of Vitamin D Regulates the Energy Metabolism and Increases Insulin Sensitivity, but are Associated with High Levels of Kidney Damage.

Gaspar RC, Botezelli JD, Kuga GK, Muñoz VR, Coope A, Pereira RM, da Silva ASR, Cintra DE, de Moura LP, Ropelle ER, Pauli JR.

Drug Dev Res. 2017 Aug;78(5):203-209. doi: 10.1002/ddr.21394. Epub 2017 Jul 18.

PMID:
28718949
28.

Physical exercise reduces pyruvate carboxylase (PCB) and contributes to hyperglycemia reduction in obese mice.

Muñoz VR, Gaspar RC, Crisol BM, Formigari GP, Sant'Ana MR, Botezelli JD, Gaspar RS, da Silva ASR, Cintra DE, de Moura LP, Ropelle ER, Pauli JR.

J Physiol Sci. 2018 Jul;68(4):493-501. doi: 10.1007/s12576-017-0559-3. Epub 2017 Jul 14.

PMID:
28710665
29.

Expression of Concern: Aspirin attenuates insulin resistance in muscle of diet-induced obese rats by inhibiting inducible nitric oxide synthase production and S-nitrosylation of IRβ/IRS-1 and Akt.

Carvalho-Filho MA, Ropelle ER, Pauli RJ, Cintra DE, Tsukumo DML, Silveira LR, Curi R, Carvalheira JBC, Velloso LA, Saad MJA.

Diabetologia. 2017 May 17. doi: 10.1007/s00125-017-4292-5. [Epub ahead of print] No abstract available.

PMID:
28516213
30.

Statement of Retraction. EGFR Tyrosine Kinase Inhibitor (PD153035) Improves Glucose Tolerance and Insulin Action in High-Fat Diet-Fed Mice. Diabetes 2009;58:2910-2919. DOI: 10.2337/db08-0506. PMID: 19696185.

Prada PO, Ropelle ER, Mourão RH, de Souza CT, Pauli JR, Cintra DE, Schenka A, Rocco SA, Rittner R, Franchini KG, Vassallo J, Velloso LA, Carvalheira JB, Saad MJA.

Diabetes. 2017 Jul;66(7):2059. doi: 10.2337/db17-rt07a. Epub 2017 Apr 27. No abstract available.

31.

Fructose Consumption in the Development of Obesity and the Effects of Different Protocols of Physical Exercise on the Hepatic Metabolism.

Pereira RM, Botezelli JD, da Cruz Rodrigues KC, Mekary RA, Cintra DE, Pauli JR, da Silva ASR, Ropelle ER, de Moura LP.

Nutrients. 2017 Apr 20;9(4). pii: E405. doi: 10.3390/nu9040405. Review.

32.

Statement of Retraction. A Central Role for Neuronal AMP-Activated Protein Kinase (AMPK) and Mammalian Target of Rapamycin (mTOR) in High-Protein Diet-Induced Weight Loss. Diabetes 2008;57:594-605. DOI: 10.2337/db07-0573.

Ropelle ER, Pauli JR, Fernandes MF, Rocco SA, Marin RM, Morari J, Souza KK, Dias MM, Gomes-Marcondes MC, Gontijo JA, Franchini KG, Velloso LA, Saad MJ, Carvalheira JB.

Diabetes. 2017 Mar;66(3):786-787. doi: 10.2337/db17-rt03b. Epub 2017 Feb 10. No abstract available.

33.

Statement of Retraction. Tub Has a Key Role in Insulin and Leptin Signaling and Action In Vivo in Hypothalamic Nuclei. Diabetes 2013;62:137-148. DOI: 10.2337/db11-1388.

Prada PO, Quaresma PG, Caricilli AM, Santos AC, Guadagnini D, Morari J, Weissmann L, Ropelle ER, Carvalheira JB, Velloso LA, Saad MJ.

Diabetes. 2017 Mar;66(3):785-786. doi: 10.2337/db17-rt03a. Epub 2017 Feb 10. No abstract available.

34.

Expression of Concern. EGFR Tyrosine Kinase Inhibitor (PD153035) Improves Glucose Tolerance and Insulin Action in High-Fat Diet-Fed Mice. Diabetes 2009;58:2910-2919. DOI: 10.2337/db08-0506. PMID: 19696185.

Prada PO, Ropelle ER, Mourão RH, de Souza CT, Pauli JR, Cintra DE, Schenka A, Rocco SA, Rittner R, Franchini KG, Vassallo J, Velloso LA, Carvalheira JB, Saad MJ.

Diabetes. 2017 Apr;66(4):1098. doi: 10.2337/db17-ec04a. Epub 2017 Feb 10. No abstract available.

35.

Excessive training is associated with endoplasmic reticulum stress but not apoptosis in the hypothalamus of mice.

Pinto AP, da Rocha AL, Pereira BC, Oliveira LD, Morais GP, Moura LP, Ropelle ER, Pauli JR, da Silva AS.

Appl Physiol Nutr Metab. 2017 Apr;42(4):354-360. doi: 10.1139/apnm-2016-0542. Epub 2016 Dec 5.

PMID:
28177743
36.

Hypothalamic S1P/S1PR1 axis controls energy homeostasis in Middle-Aged Rodents: the reversal effects of physical exercise.

Silva VR, Katashima CK, Bueno Silva CG, Lenhare L, Micheletti TO, Camargo RL, Ghezzi AC, Camargo JA, Assis AM, Tobar N, Morari J, Razolli DS, Moura LP, Pauli JR, Cintra DE, Velloso LA, Saad MJ, Ropelle ER.

Aging (Albany NY). 2016 Dec 26;9(1):142-155. doi: 10.18632/aging.101138.

37.

NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation.

Ryu D, Zhang H, Ropelle ER, Sorrentino V, Mázala DA, Mouchiroud L, Marshall PL, Campbell MD, Ali AS, Knowels GM, Bellemin S, Iyer SR, Wang X, Gariani K, Sauve AA, Cantó C, Conley KE, Walter L, Lovering RM, Chin ER, Jasmin BJ, Marcinek DJ, Menzies KJ, Auwerx J.

Sci Transl Med. 2016 Oct 19;8(361):361ra139.

38.

Strength Training Prevents Hyperinsulinemia, Insulin Resistance, and Inflammation Independent of Weight Loss in Fructose-Fed Animals.

Botezelli JD, Coope A, Ghezzi AC, Cambri LT, Moura LP, Scariot PP, Gaspar RS, Mekary RA, Ropelle ER, Pauli JR.

Sci Rep. 2016 Aug 4;6:31106. doi: 10.1038/srep31106.

39.

Retraction: Atorvastatin Improves Survival in Septic Rats: Effect on Tissue Inflammatory Pathway and on Insulin Signaling.

Calisto KL, Carvalho Bde M, Ropelle ER, Mittestainer FC, Camacho AC, Guadagnini D, Carvalheira JB, Saad MJ.

PLoS One. 2016 Jul 8;11(7):e0159283. doi: 10.1371/journal.pone.0159283. eCollection 2016. No abstract available.

40.

Retraction: Gut Microbiota Is a Key Modulator of Insulin Resistance in TLR 2 Knockout Mice.

Caricilli AM, Picardi PK, de Abreu LL, Ueno M, Prada PO, Ropelle ER, Hirabara SM, Castoldi Â, Vieira P, Camara NO, Curi R, Carvalheira JB, Saad MJ.

PLoS Biol. 2016 May 23;14(5):e1002479. doi: 10.1371/journal.pbio.1002479. eCollection 2016 May. No abstract available.

41.

Statement of Retraction. Exercise Improves Insulin and Leptin Sensitivity in Hypothalamus of Wistar Rats. Diabetes 2006;55:2554-2561. DOI: 10.2337/db05-1622.

Flores MB, Fernandes MF, Ropelle ER, Faria MC, Ueno M, Velloso LA, Saad MJ, Carvalheira JB.

Diabetes. 2016 Apr;65(4):1127-8. doi: 10.2337/db16-rt04b. No abstract available.

42.

Statement of Retraction. Physical Exercise Reduces Circulating Lipopolysaccharide and TLR4 Activation and Improves Insulin Signaling in Tissues of DIO Rats. Diabetes 2011;60:784-796. DOI: 10.2337/db09-1907.

Oliveira AG, Carvalho BM, Tobar N, Ropelle ER, Pauli JR, Bagarolli RA, Guadagnini D, Carvalheira JB, Saad MJ.

Diabetes. 2016 Apr;65(4):1124-5. doi: 10.2337/db16-rt04. No abstract available.

43.

Expression of Concern. A Central Role for Neuronal AMP-Activated Protein Kinase (AMPK) and Mammalian Target of Rapamycin (mTOR) in High-Protein Diet-Induced Weight Loss. Diabetes 2008;57:594-605. DOI: 10.2337/db07-0573.

Ropelle ER, Pauli JR, Fernandes MF, Rocco SA, Marin RM, Morari J, Souza KK, Dias MM, Gomes-Marcondes MC, Gontijo JA, Franchini KG, Velloso LA, Saad MJ, Carvalheira JB.

Diabetes. 2016 Apr;65(4):1122-3. doi: 10.2337/db16-ec04a. No abstract available.

44.

Expression of Concern. Tub Has a Key Role in Insulin and Leptin Signaling and Action In Vivo in Hypothalamic Nuclei. Diabetes 2013;62:137-148. DOI: 10.2337/db11-1388.

Prada PO, Quaresma PG, Caricilli AM, Santos AC, Guadagnini D, Morari J, Weissmann L, Ropelle ER, Carvalheira JB, Velloso LA, Saad MJ.

Diabetes. 2016 Apr;65(4):1121-2. doi: 10.2337/db16-ec04. No abstract available.

45.

Corrigendum to "Reversion of hepatic steatosis by exercise training in obese mice: The role of sterol regulatory element-binding protein-1c" [Life Sci. 91(11-12) (2012) 395-401].

Cintra DE, Ropelle ER, Vitto MF, Luciano TF, Souza DR, Engelmann J, Marques SO, Lira FS, de Pinho RA, Pauli JR, De Souza CT.

Life Sci. 2016 May 1;152:178-179. doi: 10.1016/j.lfs.2016.03.050. Epub 2016 Apr 23. No abstract available.

PMID:
27178221
46.

NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice.

Zhang H, Ryu D, Wu Y, Gariani K, Wang X, Luan P, D'Amico D, Ropelle ER, Lutolf MP, Aebersold R, Schoonjans K, Menzies KJ, Auwerx J.

Science. 2016 Jun 17;352(6292):1436-43. doi: 10.1126/science.aaf2693. Epub 2016 Apr 28.

47.

Excessive eccentric exercise-induced overtraining model leads to endoplasmic reticulum stress in mice skeletal muscles.

Pereira BC, da Rocha AL, Pinto AP, Pauli JR, de Souza CT, Cintra DE, Ropelle ER, de Freitas EC, Zagatto AM, da Silva AS.

Life Sci. 2016 Jan 15;145:144-51. doi: 10.1016/j.lfs.2015.12.037. Epub 2015 Dec 18.

PMID:
26707388
48.

Melatonin Has An Ergogenic Effect But Does Not Prevent Inflammation and Damage In Exhaustive Exercise.

Beck WR, Botezelli JD, Pauli JR, Ropelle ER, Gobatto CA.

Sci Rep. 2015 Dec 16;5:18065. doi: 10.1038/srep18065.

49.

Topiramate effects lipolysis in 3T3-L1 adipocytes.

Martins GP, Souza CO, Marques S, Luciano TF, DA Silva Pieri BL, Rosa JC, DA Silva AS, Pauli JR, Cintra DE, Ropelle ER, Rodrigues B, DE Lira FS, DE Souza CT.

Biomed Rep. 2015 Nov;3(6):827-830. Epub 2015 Aug 28.

50.

Excessive eccentric exercise leads to transitory hypothalamic inflammation, which may contribute to the low body weight gain and food intake in overtrained mice.

Pereira BC, da Rocha AL, Pauli JR, Ropelle ER, de Souza CT, Cintra DE, Sant'Ana MR, da Silva AS.

Neuroscience. 2015 Dec 17;311:231-42. doi: 10.1016/j.neuroscience.2015.10.027. Epub 2015 Oct 19.

PMID:
26480811

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