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Items: 18

1.

A Model Mechanism-Based Explanation of an In Vitro-In Vivo Disconnect for Improving Extrapolation and Translation.

Smith AK, Xu Y, Ropella GEP, Hunt CA.

J Pharmacol Exp Ther. 2018 Apr;365(1):127-138. doi: 10.1124/jpet.117.245019. Epub 2018 Feb 6.

PMID:
29434053
2.

Competing Mechanistic Hypotheses of Acetaminophen-Induced Hepatotoxicity Challenged by Virtual Experiments.

Smith AK, Petersen BK, Ropella GE, Kennedy RC, Kaplowitz N, Ookhtens M, Hunt CA.

PLoS Comput Biol. 2016 Dec 16;12(12):e1005253. doi: 10.1371/journal.pcbi.1005253. eCollection 2016 Dec.

3.

Virtual Experiments Enable Exploring and Challenging Explanatory Mechanisms of Immune-Mediated P450 Down-Regulation.

Petersen BK, Ropella GE, Hunt CA.

PLoS One. 2016 May 26;11(5):e0155855. doi: 10.1371/journal.pone.0155855. eCollection 2016.

4.

A cell-centered, agent-based framework that enables flexible environment granularities.

Kennedy RC, Ropella GE, Hunt CA.

Theor Biol Med Model. 2016 Feb 2;13:4. doi: 10.1186/s12976-016-0030-9.

5.

Toward modular biological models: defining analog modules based on referent physiological mechanisms.

Petersen BK, Ropella GE, Hunt CA.

BMC Syst Biol. 2014 Aug 16;8:95. doi: 10.1186/s12918-014-0095-1.

6.

Agent-based modeling: a systematic assessment of use cases and requirements for enhancing pharmaceutical research and development productivity.

Hunt CA, Kennedy RC, Kim SH, Ropella GE.

Wiley Interdiscip Rev Syst Biol Med. 2013 Jul-Aug;5(4):461-80. doi: 10.1002/wsbm.1222. Epub 2013 Jun 4. Review.

7.

Relational grounding facilitates development of scientifically useful multiscale models.

Hunt CA, Ropella GE, Lam Tn, Gewitz AD.

Theor Biol Med Model. 2011 Sep 27;8:35. doi: 10.1186/1742-4682-8-35. Review.

8.

Cloud computing and validation of expandable in silico livers.

Ropella GE, Hunt CA.

BMC Syst Biol. 2010 Dec 3;4:168. doi: 10.1186/1752-0509-4-168.

9.

Tracing multiscale mechanisms of drug disposition in normal and diseased livers.

Park S, Kim SH, Ropella GE, Roberts MS, Hunt CA.

J Pharmacol Exp Ther. 2010 Jul;334(1):124-36. doi: 10.1124/jpet.110.168526. Epub 2010 Apr 20.

10.

At the biological modeling and simulation frontier.

Hunt CA, Ropella GE, Lam TN, Tang J, Kim SH, Engelberg JA, Sheikh-Bahaei S.

Pharm Res. 2009 Nov;26(11):2369-400. doi: 10.1007/s11095-009-9958-3. Epub 2009 Sep 9. Review.

11.

Using an in silico liver to evaluate a hepatic enzyme induction mechanism.

Hunt C, Ropella GE.

Conf Proc IEEE Eng Med Biol Soc. 2008;2008:2415-8. doi: 10.1109/IEMBS.2008.4649686.

PMID:
19163189
12.

Essential operating principles for tumor spheroid growth.

Engelberg JA, Ropella GE, Hunt CA.

BMC Syst Biol. 2008 Dec 23;2:110. doi: 10.1186/1752-0509-2-110.

13.

Computational strategies unravel and trace how liver disease changes hepatic drug disposition.

Park S, Ropella GE, Kim SH, Roberts MS, Hunt CA.

J Pharmacol Exp Ther. 2009 Jan;328(1):294-305. doi: 10.1124/jpet.108.142497. Epub 2008 Oct 23.

14.

Dichotomies between computational and mathematical models.

Hunt CA, Ropella GE, Park S, Engelberg J.

Nat Biotechnol. 2008 Jul;26(7):737-8; author reply 738-9. doi: 10.1038/nbt0708-737. No abstract available.

PMID:
18612289
15.

Predictions of hepatic disposition properties using a mechanistically realistic, physiologically based model.

Yan L, Sheihk-Bahaei S, Park S, Ropella GE, Hunt CA.

Drug Metab Dispos. 2008 Apr;36(4):759-68. doi: 10.1124/dmd.107.019067. Epub 2008 Jan 28.

16.

Modeling and simulation of hepatic drug disposition using a physiologically based, multi-agent in silico liver.

Yan L, Ropella GE, Park S, Roberts MS, Hunt CA.

Pharm Res. 2008 May;25(5):1023-36. Epub 2007 Nov 28.

PMID:
18044012
17.

In silico representation of the liver-connecting function to anatomy, physiology and heterogeneous microenvironments.

Yan L, Hunt CA, Ropella GE, Roberts MS.

Conf Proc IEEE Eng Med Biol Soc. 2004;2:853-6.

PMID:
17271811
18.

Physiologically based synthetic models of hepatic disposition.

Hunt CA, Ropella GE, Yan L, Hung DY, Roberts MS.

J Pharmacokinet Pharmacodyn. 2006 Dec;33(6):737-72. Epub 2006 Oct 19.

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