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Active Tonic mTORC1 Signals Shape Baseline Translation in Naive T Cells.

Myers DR, Norlin E, Vercoulen Y, Roose JP.

Cell Rep. 2019 May 7;27(6):1858-1874.e6. doi: 10.1016/j.celrep.2019.04.037.


High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions.

Mues M, Karra L, Romero-Moya D, Wandler A, Hangauer MJ, Ksionda O, Thus Y, Lindenbergh M, Shannon K, McManus MT, Roose JP.

Cell Rep. 2019 Apr 9;27(2):631-647.e5. doi: 10.1016/j.celrep.2019.03.045.


Combination drug treatment prolongs survival of experimentally infected mice with silver-haired bat rabies virus.

Martina BEE, Smreczak M, Orlowska A, Marzec A, Trebas P, Roose JM, Zmudzinski J, Gerhauser I, Wohlsein P, Baumgärtner W, Osterhaus ADME, Koraka P.

Vaccine. 2018 May 26. pii: S0264-410X(18)30705-9. doi: 10.1016/j.vaccine.2018.05.065. [Epub ahead of print]


Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy.

Ksionda O, Mues M, Wandler AM, Donker L, Tenhagen M, Jun J, Ducker GS, Matlawska-Wasowska K, Shannon K, Shokat KM, Roose JP.

PLoS One. 2018 May 25;13(5):e0193849. doi: 10.1371/journal.pone.0193849. eCollection 2018.


Inhibition of caspase-1 prolongs survival of mice infected with rabies virus.

Koraka P, Martina BEE, Smreczak M, Orlowska A, Marzec A, Trebas P, Roose JM, Begeman L, Gerhauser I, Wohlsein P, Baumgärtner W, Zmudzinski J, D M E Osterhaus A.

Vaccine. 2018 Apr 10. pii: S0264-410X(18)30470-5. doi: 10.1016/j.vaccine.2018.04.002. [Epub ahead of print]


Analysis of Mouse Brain Transcriptome After Experimental Duvenhage Virus Infection Shows Activation of Innate Immune Response and Pyroptotic Cell Death Pathway.

Koraka P, Martina BEE, van den Ham HJ, Zaaraoui-Boutahar F, van IJcken W, Roose J, van Amerongen G, Andeweg A, Osterhaus ADME.

Front Microbiol. 2018 Mar 20;9:397. doi: 10.3389/fmicb.2018.00397. eCollection 2018.


Modified Measles: A Diagnostic Challenge.

Roose J, Rohaert C, Jadoul A, Fölster-Holst R, van Gysel D.

Acta Derm Venereol. 2018 Feb 7;98(2):289-290. doi: 10.2340/00015555-2825. No abstract available.


A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1.

Vercoulen Y, Kondo Y, Iwig JS, Janssen AB, White KA, Amini M, Barber DL, Kuriyan J, Roose JP.

Elife. 2017 Sep 27;6. pii: e29002. doi: 10.7554/eLife.29002.


Transcriptomic Analyses Reveal Differential Gene Expression of Immune and Cell Death Pathways in the Brains of Mice Infected with West Nile Virus and Chikungunya Virus.

Lim SM, van den Ham HJ, Oduber M, Martina E, Zaaraoui-Boutahar F, Roose JM, van IJcken WFJ, Osterhaus ADME, Andeweg AC, Koraka P, Martina BEE.

Front Microbiol. 2017 Aug 17;8:1556. doi: 10.3389/fmicb.2017.01556. eCollection 2017.


Tonic Signals: Why Do Lymphocytes Bother?

Myers DR, Zikherman J, Roose JP.

Trends Immunol. 2017 Nov;38(11):844-857. doi: 10.1016/ Epub 2017 Jul 25. Review.


Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells.

Myers DR, Lau T, Markegard E, Lim HW, Kasler H, Zhu M, Barczak A, Huizar JP, Zikherman J, Erle DJ, Zhang W, Verdin E, Roose JP.

Cell Rep. 2017 May 23;19(8):1558-1571. doi: 10.1016/j.celrep.2017.04.076.


RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma.

Chen X, Wu Q, Depeille P, Chen P, Thornton S, Kalirai H, Coupland SE, Roose JP, Bastian BC.

Cancer Cell. 2017 May 8;31(5):685-696.e6. doi: 10.1016/j.ccell.2017.04.002.


Lost GRP on cytotoxicity?

Roose JP.

Nat Immunol. 2016 Nov 16;17(12):1339-1340. doi: 10.1038/ni.3620. No abstract available.


N-Terminal Lipid Modification Is Required for the Stable Accumulation of CyanoQ in Synechocystis sp. PCC 6803.

Juneau AD, Frankel LK, Bricker TM, Roose JL.

PLoS One. 2016 Sep 22;11(9):e0163646. doi: 10.1371/journal.pone.0163646. eCollection 2016.


A colour-tunable chiral AIEgen: reversible coordination, enantiomer discrimination and morphology visualization.

Roose J, Leung ACS, Wang J, Peng Q, Sung HH, Williams ID, Tang BZ.

Chem Sci. 2016 Sep 1;7(9):6106-6114. doi: 10.1039/c6sc01614f. Epub 2016 Jun 2.


One-way membrane trafficking of SOS in receptor-triggered Ras activation.

Christensen SM, Tu HL, Jun JE, Alvarez S, Triplet MG, Iwig JS, Yadav KK, Bar-Sagi D, Roose JP, Groves JT.

Nat Struct Mol Biol. 2016 Sep;23(9):838-46. doi: 10.1038/nsmb.3275. Epub 2016 Aug 8.


Circularly-Polarized Luminescence (CPL) from Chiral AIE Molecules and Macrostructures.

Roose J, Tang BZ, Wong KS.

Small. 2016 Dec;12(47):6495-6512. doi: 10.1002/smll.201601455. Epub 2016 Jul 11.


Distinct oncogenic Ras signals characterized by profound differences in flux through the RasGDP/RasGTP cycle.

Mues M, Roose JP.

Small GTPases. 2017 Jan 2;8(1):20-25. doi: 10.1080/21541248.2016.1187323. Epub 2016 May 9.


Aggregation-induced emissive nanoparticles for fluorescence signaling in a low cost paper-based immunoassay.

Engels JF, Roose J, Zhai DS, Yip KM, Lee MS, Tang BZ, Renneberg R.

Colloids Surf B Biointerfaces. 2016 Jul 1;143:440-446. doi: 10.1016/j.colsurfb.2016.03.051. Epub 2016 Mar 18.


The extrinsic proteins of photosystem II: update.

Roose JL, Frankel LK, Mummadisetti MP, Bricker TM.

Planta. 2016 Apr;243(4):889-908. doi: 10.1007/s00425-015-2462-6. Epub 2016 Jan 12. Review.


Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome.

Rooney GE, Goodwin AF, Depeille P, Sharir A, Schofield CM, Yeh E, Roose JP, Klein OD, Rauen KA, Weiss LA, Ullian EM.

J Neurosci. 2016 Jan 6;36(1):142-52. doi: 10.1523/JNEUROSCI.1547-15.2016.


Acupuncture-Analgesia Following a Single Treatment Session in Chronic Whiplash is Unrelated to Autonomic Nervous System Changes: A Randomized Cross-over Trial.

De Kooning M, Tobbackx Y, Meeus M, Wauters L, Ickmans K, De Vilder P, Roose J, Verhaeghe T, Nijs J.

Pain Physician. 2015 Nov;18(6):527-36.


MSH1 Is a Plant Organellar DNA Binding and Thylakoid Protein under Precise Spatial Regulation to Alter Development.

Virdi KS, Wamboldt Y, Kundariya H, Laurie JD, Keren I, Kumar KRS, Block A, Basset G, Luebker S, Elowsky C, Day PM, Roose JL, Bricker TM, Elthon T, Mackenzie SA.

Mol Plant. 2016 Feb 1;9(2):245-260. doi: 10.1016/j.molp.2015.10.011. Epub 2015 Nov 14.


RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines.

Ksionda O, Melton AA, Bache J, Tenhagen M, Bakker J, Harvey R, Winter SS, Rubio I, Roose JP.

Oncogene. 2016 Jul 14;35(28):3658-68. doi: 10.1038/onc.2015.431. Epub 2015 Nov 9.


A Luminescent Nitrogen-Containing Polycyclic Aromatic Hydrocarbon Synthesized by Photocyclodehydrogenation with Unprecedented Regioselectivity.

Gu X, Wang H, Roose J, He Z, Zhou Y, Yan Y, Cai Y, Shi H, Zhang Y, Sung HH, Lam JW, Miao Q, Zhao Y, Wong KS, Williams ID, Tang BZ.

Chemistry. 2015 Dec 1;21(49):17973-80. doi: 10.1002/chem.201503147. Epub 2015 Oct 22.


Unexpected insights for anti-EGFR cancer therapy.

Depeille P, Warren RS, Roose JP.

Oncotarget. 2015 Aug 7;6(22):18746-7. No abstract available.


Flavors of EGFR-Ras signals impacting intestinal homeostasis.

Depeille P, Roose JP.

Cell Cycle. 2015;14(20):3205-6. doi: 10.1080/15384101.2015.1084203. No abstract available.


RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth.

Depeille P, Henricks LM, van de Ven RA, Lemmens E, Wang CY, Matli M, Werb Z, Haigis KM, Donner D, Warren R, Roose JP.

Nat Cell Biol. 2015 Jun;17(6):804-15. doi: 10.1038/ncb3175. Epub 2015 May 25.


Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia.

Lubeck BA, Lapinski PE, Oliver JA, Ksionda O, Parada LF, Zhu Y, Maillard I, Chiang M, Roose J, King PD.

J Immunol. 2015 Jul 1;195(1):31-5. doi: 10.4049/jimmunol.1402639. Epub 2015 May 22.


Effect of Puumala hantavirus infection on human umbilical vein endothelial cell hemostatic function: platelet interactions, increased tissue factor expression and fibrinolysis regulator release.

Goeijenbier M, Meijers JC, Anfasa F, Roose JM, van de Weg CA, Bakhtiari K, Henttonen H, Vaheri A, Osterhaus AD, van Gorp EC, Martina BE.

Front Microbiol. 2015 Mar 24;6:220. doi: 10.3389/fmicb.2015.00220. eCollection 2015.


Editorial overview: lymphocyte development and activation: lymphocytes, integrators of information.

Roose J, Fagarasan S.

Curr Opin Immunol. 2015 Apr;33:v-vii. doi: 10.1016/j.coi.2015.03.003. Epub 2015 Mar 13. No abstract available.


Recombinant modified vaccinia virus Ankara expressing glycoprotein E2 of Chikungunya virus protects AG129 mice against lethal challenge.

van den Doel P, Volz A, Roose JM, Sewbalaksing VD, Pijlman GP, van Middelkoop I, Duiverman V, van de Wetering E, Sutter G, Osterhaus AD, Martina BE.

PLoS Negl Trop Dis. 2014 Sep 4;8(9):e3101. doi: 10.1371/journal.pntd.0003101. eCollection 2014 Sep.


The PsbP domain protein 1 functions in the assembly of lumenal domains in photosystem I.

Roose JL, Frankel LK, Bricker TM.

J Biol Chem. 2014 Aug 22;289(34):23776-85. doi: 10.1074/jbc.M114.589085. Epub 2014 Jul 9.


A recombinant rabies vaccine expressing the trimeric form of the glycoprotein confers enhanced immunogenicity and protection in outbred mice.

Koraka P, Bosch BJ, Cox M, Chubet R, Amerongen Gv, Lövgren-Bengtsson K, Martina BE, Roose J, Rottier PJ, Osterhaus AD.

Vaccine. 2014 Aug 6;32(36):4644-50. doi: 10.1016/j.vaccine.2014.06.058. Epub 2014 Jun 21.


RasGRP Ras guanine nucleotide exchange factors in cancer.

Ksionda O, Limnander A, Roose JP.

Front Biol (Beijing). 2013 Oct 1;8(5):508-532.


Protein kinase Cδ promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance.

Limnander A, Zikherman J, Lau T, Leitges M, Weiss A, Roose JP.

Mol Cell Biol. 2014 Apr;34(8):1474-85. doi: 10.1128/MCB.01699-13. Epub 2014 Feb 10.


Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies.

Daley SR, Coakley KM, Hu DY, Randall KL, Jenne CN, Limnander A, Myers DR, Polakos NK, Enders A, Roots C, Balakishnan B, Miosge LA, Sjollema G, Bertram EM, Field MA, Shao Y, Andrews TD, Whittle B, Barnes SW, Walker JR, Cyster JG, Goodnow CC, Roose JP.

Elife. 2013 Dec 12;2:e01020. doi: 10.7554/eLife.01020.


PLC-γ and PI3K link cytokines to ERK activation in hematopoietic cells with normal and oncogenic Kras.

Diaz-Flores E, Goldschmidt H, Depeille P, Ng V, Akutagawa J, Krisman K, Crone M, Burgess MR, Williams O, Houseman B, Shokat K, Sampath D, Bollag G, Roose JP, Braun BS, Shannon K.

Sci Signal. 2013 Dec 3;6(304):ra105. doi: 10.1126/scisignal.2004125.


Chirality transfer in 1D self-assemblies: influence of H-bonding vs metal coordination between dicyano[7]helicene enantiomers.

Shchyrba A, Nguyen MT, Wäckerlin C, Martens S, Nowakowska S, Ivas T, Roose J, Nijs T, Boz S, Schär M, Stöhr M, Pignedoli CA, Thilgen C, Diederich F, Passerone D, Jung TA.

J Am Chem Soc. 2013 Oct 16;135(41):15270-3. doi: 10.1021/ja407315f. Epub 2013 Oct 3.


Characterization of the mouse neuroinvasiveness of selected European strains of West Nile virus.

Lim SM, Koraka P, van Boheemen S, Roose JM, Jaarsma D, van de Vijver DA, Osterhaus AD, Martina BE.

PLoS One. 2013 Sep 18;8(9):e74575. doi: 10.1371/journal.pone.0074575. eCollection 2013.


Regulation of ras exchange factors and cellular localization of ras activation by lipid messengers in T cells.

Jun JE, Rubio I, Roose JP.

Front Immunol. 2013 Sep 4;4:239. doi: 10.3389/fimmu.2013.00239. Review.


Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1.

Iwig JS, Vercoulen Y, Das R, Barros T, Limnander A, Che Y, Pelton JG, Wemmer DE, Roose JP, Kuriyan J.

Elife. 2013 Jul 30;2:e00813. doi: 10.7554/eLife.00813.


Biochemical heterogeneity and developmental varieties in T-cell leukemia.

Chakraborty AK, Roose JP.

Cell Cycle. 2013 May 15;12(10):1480-1. doi: 10.4161/cc.24858. Epub 2013 Apr 29. No abstract available.


Activation of extracellular signal-regulated kinase but not of p38 mitogen-activated protein kinase pathways in lymphocytes requires allosteric activation of SOS.

Jun JE, Yang M, Chen H, Chakraborty AK, Roose JP.

Mol Cell Biol. 2013 Jun;33(12):2470-84. doi: 10.1128/MCB.01593-12. Epub 2013 Apr 15.


The PsbP family of proteins.

Bricker TM, Roose JL, Zhang P, Frankel LK.

Photosynth Res. 2013 Oct;116(2-3):235-50. doi: 10.1007/s11120-013-9820-7. Epub 2013 Apr 7. Review.


Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis.

Hartzell C, Ksionda O, Lemmens E, Coakley K, Yang M, Dail M, Harvey RC, Govern C, Bakker J, Lenstra TL, Ammon K, Boeter A, Winter SS, Loh M, Shannon K, Chakraborty AK, Wabl M, Roose JP.

Sci Signal. 2013 Mar 26;6(268):ra21. doi: 10.1126/scisignal.2003848.


A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice.

Kortum RL, Rouquette-Jazdanian AK, Miyaji M, Merrill RK, Markegard E, Pinski JM, Wesselink A, Nath NN, Alexander CP, Li W, Kedei N, Roose JP, Blumberg PM, Samelson LE, Sommers CL.

J Immunol. 2013 Jan 1;190(1):147-58. doi: 10.4049/jimmunol.1201458. Epub 2012 Dec 3.


Does acupuncture activate endogenous analgesia in chronic whiplash-associated disorders? A randomized crossover trial.

Tobbackx Y, Meeus M, Wauters L, De Vilder P, Roose J, Verhaeghe T, Nijs J.

Eur J Pain. 2013 Feb;17(2):279-89. doi: 10.1002/j.1532-2149.2012.00215.x. Epub 2012 Sep 11. Erratum in: Eur J Pain. 2014 Jan;18(1):147.


In vitro and in vivo isolation and characterization of Duvenhage virus.

Koraka P, Martina BE, Roose JM, van Thiel PP, van Amerongen G, Kuiken T, Osterhaus AD.

PLoS Pathog. 2012;8(5):e1002682. doi: 10.1371/journal.ppat.1002682. Epub 2012 May 24.


The membrane environment can promote or suppress bistability in cell signaling networks.

Abel SM, Roose JP, Groves JT, Weiss A, Chakraborty AK.

J Phys Chem B. 2012 Mar 22;116(11):3630-40. doi: 10.1021/jp2102385. Epub 2012 Mar 13.

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