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Items: 45

1.

The SIAH1-HIPK2-p53ser46 Damage Response Pathway is Involved in Temozolomide-Induced Glioblastoma Cell Death.

He Y, Roos WP, Wu Q, Hofmann TG, Kaina B.

Mol Cancer Res. 2019 May;17(5):1129-1141. doi: 10.1158/1541-7786.MCR-18-1306. Epub 2019 Feb 22.

PMID:
30796178
2.

Temozolomide Induces Senescence and Repression of DNA Repair Pathways in Glioblastoma Cells via Activation of ATR-CHK1, p21, and NF-κB.

Aasland D, Götzinger L, Hauck L, Berte N, Meyer J, Effenberger M, Schneider S, Reuber EE, Roos WP, Tomicic MT, Kaina B, Christmann M.

Cancer Res. 2019 Jan 1;79(1):99-113. doi: 10.1158/0008-5472.CAN-18-1733. Epub 2018 Oct 25.

PMID:
30361254
3.

Multiple DNA damage-dependent and DNA damage-independent stress responses define the outcome of ATR/Chk1 targeting in medulloblastoma cells.

Krüger K, Geist K, Stuhldreier F, Schumacher L, Blümel L, Remke M, Wesselborg S, Stork B, Klöcker N, Bormann S, Roos WP, Honnen S, Fritz G.

Cancer Lett. 2018 Aug 28;430:34-46. doi: 10.1016/j.canlet.2018.05.011. Epub 2018 May 16.

PMID:
29753759
4.

XRCC3 contributes to temozolomide resistance of glioblastoma cells by promoting DNA double-strand break repair.

Roos WP, Frohnapfel L, Quiros S, Ringel F, Kaina B.

Cancer Lett. 2018 Jun 28;424:119-126. doi: 10.1016/j.canlet.2018.03.025. Epub 2018 Mar 22.

PMID:
29574277
5.

Chloroethylating nitrosoureas in cancer therapy: DNA damage, repair and cell death signaling.

Nikolova T, Roos WP, Krämer OH, Strik HM, Kaina B.

Biochim Biophys Acta Rev Cancer. 2017 Aug;1868(1):29-39. doi: 10.1016/j.bbcan.2017.01.004. Epub 2017 Jan 29. Review.

PMID:
28143714
7.

The multifaceted influence of histone deacetylases on DNA damage signalling and DNA repair.

Roos WP, Krumm A.

Nucleic Acids Res. 2016 Dec 1;44(21):10017-10030. Epub 2016 Oct 13. Review.

8.

Enhanced Histone Deacetylase Activity in Malignant Melanoma Provokes RAD51 and FANCD2-Triggered Drug Resistance.

Krumm A, Barckhausen C, Kücük P, Tomaszowski KH, Loquai C, Fahrer J, Krämer OH, Kaina B, Roos WP.

Cancer Res. 2016 May 15;76(10):3067-77. doi: 10.1158/0008-5472.CAN-15-2680. Epub 2016 Mar 15.

9.

DNA damage and the balance between survival and death in cancer biology.

Roos WP, Thomas AD, Kaina B.

Nat Rev Cancer. 2016 Jan;16(1):20-33. doi: 10.1038/nrc.2015.2. Epub 2015 Dec 18. Review.

PMID:
26678314
10.

The inducible E3 ubiquitin ligases SIAH1 and SIAH2 perform critical roles in breast and prostate cancers.

Knauer SK, Mahendrarajah N, Roos WP, Krämer OH.

Cytokine Growth Factor Rev. 2015 Aug;26(4):405-13. doi: 10.1016/j.cytogfr.2015.04.002. Epub 2015 May 12. Review.

PMID:
26028498
11.

B-Raf inhibitor vemurafenib in combination with temozolomide and fotemustine in the killing response of malignant melanoma cells.

Roos WP, Quiros S, Krumm A, Merz S, Switzeny OJ, Christmann M, Loquai C, Kaina B.

Oncotarget. 2014 Dec 30;5(24):12607-20.

12.

Cytolethal distending toxin (CDT) is a radiomimetic agent and induces persistent levels of DNA double-strand breaks in human fibroblasts.

Fahrer J, Huelsenbeck J, Jaurich H, Dörsam B, Frisan T, Eich M, Roos WP, Kaina B, Fritz G.

DNA Repair (Amst). 2014 Jun;18:31-43. doi: 10.1016/j.dnarep.2014.03.002. Epub 2014 Mar 25.

PMID:
24680221
13.

Targeting components of the alternative NHEJ pathway sensitizes KRAS mutant leukemic cells to chemotherapy.

Hähnel PS, Enders B, Sasca D, Roos WP, Kaina B, Bullinger L, Theobald M, Kindler T.

Blood. 2014 Apr 10;123(15):2355-66. doi: 10.1182/blood-2013-01-477620. Epub 2014 Feb 6.

PMID:
24505083
14.

Contribution of ATM and ATR to the resistance of glioblastoma and malignant melanoma cells to the methylating anticancer drug temozolomide.

Eich M, Roos WP, Nikolova T, Kaina B.

Mol Cancer Ther. 2013 Nov;12(11):2529-40. doi: 10.1158/1535-7163.MCT-13-0136. Epub 2013 Aug 19.

15.

Malignant melanoma cells acquire resistance to DNA interstrand cross-linking chemotherapeutics by p53-triggered upregulation of DDB2/XPC-mediated DNA repair.

Barckhausen C, Roos WP, Naumann SC, Kaina B.

Oncogene. 2014 Apr 10;33(15):1964-74. doi: 10.1038/onc.2013.141. Epub 2013 Apr 22.

PMID:
23604128
16.

Survival and death strategies in glioma cells: autophagy, senescence and apoptosis triggered by a single type of temozolomide-induced DNA damage.

Knizhnik AV, Roos WP, Nikolova T, Quiros S, Tomaszowski KH, Christmann M, Kaina B.

PLoS One. 2013;8(1):e55665. doi: 10.1371/journal.pone.0055665. Epub 2013 Jan 30.

17.

Rac1 protein signaling is required for DNA damage response stimulated by topoisomerase II poisons.

Huelsenbeck SC, Schorr A, Roos WP, Huelsenbeck J, Henninger C, Kaina B, Fritz G.

J Biol Chem. 2012 Nov 9;287(46):38590-9. doi: 10.1074/jbc.M112.377903. Epub 2012 Sep 25.

18.

DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis.

Roos WP, Kaina B.

Cancer Lett. 2013 May 28;332(2):237-48. doi: 10.1016/j.canlet.2012.01.007. Epub 2012 Jan 17. Review.

PMID:
22261329
19.

Rad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylating anticancer drugs.

Quiros S, Roos WP, Kaina B.

PLoS One. 2011;6(11):e27183. doi: 10.1371/journal.pone.0027183. Epub 2011 Nov 2.

20.

O(6)-Methylguanine-DNA methyltransferase (MGMT) in normal tissues and tumors: enzyme activity, promoter methylation and immunohistochemistry.

Christmann M, Verbeek B, Roos WP, Kaina B.

Biochim Biophys Acta. 2011 Dec;1816(2):179-90. doi: 10.1016/j.bbcan.2011.06.002. Epub 2011 Jul 1. Review.

PMID:
21745538
21.

Intrinsic anticancer drug resistance of malignant melanoma cells is abrogated by IFN-β and valproic acid.

Roos WP, Jöst E, Belohlavek C, Nagel G, Fritz G, Kaina B.

Cancer Res. 2011 Jun 15;71(12):4150-60. doi: 10.1158/0008-5472.CAN-10-3498. Epub 2011 Apr 14.

22.

Nijmegen breakage syndrome protein (NBN) causes resistance to methylating anticancer drugs such as temozolomide.

Eich M, Roos WP, Dianov GL, Digweed M, Kaina B.

Mol Pharmacol. 2010 Nov;78(5):943-51. doi: 10.1124/mol.110.066076. Epub 2010 Aug 20.

PMID:
20729302
23.

Response of pancreatic cancer cells treated with interferon-alpha or beta and co-exposed to ionising radiation.

Jöst E, Roos WP, Kaina B, Schmidberger H.

Int J Radiat Biol. 2010 Sep;86(9):732-41. doi: 10.3109/09553002.2010.481321.

PMID:
20586542
24.
25.

The translesion polymerase Rev3L in the tolerance of alkylating anticancer drugs.

Roos WP, Tsaalbi-Shtylik A, Tsaryk R, Güvercin F, de Wind N, Kaina B.

Mol Pharmacol. 2009 Oct;76(4):927-34. doi: 10.1124/mol.109.058131. Epub 2009 Jul 29.

PMID:
19641035
26.

Cisplatin sensitivity is related to late DNA damage processing and checkpoint control rather than to the early DNA damage response.

Brozovic A, Damrot J, Tsaryk R, Helbig L, Nikolova T, Hartig C, Osmak M, Roos WP, Kaina B, Fritz G.

Mutat Res. 2009 Nov 2;670(1-2):32-41. doi: 10.1016/j.mrfmmm.2009.07.002. Epub 2009 Jul 16.

PMID:
19616017
27.

p53 mutant human glioma cells are sensitive to UV-C-induced apoptosis due to impaired cyclobutane pyrimidine dimer removal.

Batista LF, Roos WP, Kaina B, Menck CF.

Mol Cancer Res. 2009 Feb;7(2):237-46. doi: 10.1158/1541-7786.MCR-08-0428. Epub 2009 Feb 10.

28.

Temozolomide- and fotemustine-induced apoptosis in human malignant melanoma cells: response related to MGMT, MMR, DSBs, and p53.

Naumann SC, Roos WP, Jöst E, Belohlavek C, Lennerz V, Schmidt CW, Christmann M, Kaina B.

Br J Cancer. 2009 Jan 27;100(2):322-33. doi: 10.1038/sj.bjc.6604856. Epub 2009 Jan 6.

29.

DNA replication arrest in response to genotoxic stress provokes early activation of stress-activated protein kinases (SAPK/JNK).

Damrot J, Helbig L, Roos WP, Barrantes SQ, Kaina B, Fritz G.

J Mol Biol. 2009 Feb 6;385(5):1409-21. doi: 10.1016/j.jmb.2008.12.015. Epub 2008 Dec 14.

PMID:
19109974
30.

Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs.

Roos WP, Nikolova T, Quiros S, Naumann SC, Kiedron O, Zdzienicka MZ, Kaina B.

DNA Repair (Amst). 2009 Jan 1;8(1):72-86. doi: 10.1016/j.dnarep.2008.09.003. Epub 2008 Oct 21.

PMID:
18840549
31.

WRN protects against topo I but not topo II inhibitors by preventing DNA break formation.

Christmann M, Tomicic MT, Gestrich C, Roos WP, Bohr VA, Kaina B.

DNA Repair (Amst). 2008 Dec 1;7(12):1999-2009. doi: 10.1016/j.dnarep.2008.08.008. Epub 2008 Oct 15.

32.

Artesunate derived from traditional Chinese medicine induces DNA damage and repair.

Li PC, Lam E, Roos WP, Zdzienicka MZ, Kaina B, Efferth T.

Cancer Res. 2008 Jun 1;68(11):4347-51. doi: 10.1158/0008-5472.CAN-07-2970.

33.

Apoptotic death induced by the cyclophosphamide analogue mafosfamide in human lymphoblastoid cells: contribution of DNA replication, transcription inhibition and Chk/p53 signaling.

Goldstein M, Roos WP, Kaina B.

Toxicol Appl Pharmacol. 2008 May 15;229(1):20-32. doi: 10.1016/j.taap.2008.01.001. Epub 2008 Jan 17.

PMID:
18289623
35.

MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents.

Kaina B, Christmann M, Naumann S, Roos WP.

DNA Repair (Amst). 2007 Aug 1;6(8):1079-99. Epub 2007 May 7. Review.

PMID:
17485253
36.

Mouse embryonic stem cells are hypersensitive to apoptosis triggered by the DNA damage O(6)-methylguanine due to high E2F1 regulated mismatch repair.

Roos WP, Christmann M, Fraser ST, Kaina B.

Cell Death Differ. 2007 Aug;14(8):1422-32. Epub 2007 Apr 27.

37.

Lovastatin protects human endothelial cells from the genotoxic and cytotoxic effects of the anticancer drugs doxorubicin and etoposide.

Damrot J, Nübel T, Epe B, Roos WP, Kaina B, Fritz G.

Br J Pharmacol. 2006 Dec;149(8):988-97. Epub 2006 Nov 6.

38.

DNA damage-induced cell death by apoptosis.

Roos WP, Kaina B.

Trends Mol Med. 2006 Sep;12(9):440-50. Epub 2006 Aug 8. Review.

PMID:
16899408
39.

Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine.

Roos WP, Batista LF, Naumann SC, Wick W, Weller M, Menck CF, Kaina B.

Oncogene. 2007 Jan 11;26(2):186-97. Epub 2006 Jul 3.

PMID:
16819506
40.
41.

Inhibition of DNA repair by Pentoxifylline and related methylxanthine derivatives.

Böhm L, Roos WP, Serafin AM.

Toxicology. 2003 Nov 15;193(1-2):153-60. Review.

PMID:
14599774
42.

Mechanisms of human DNA repair: an update.

Christmann M, Tomicic MT, Roos WP, Kaina B.

Toxicology. 2003 Nov 15;193(1-2):3-34. Review.

PMID:
14599765
43.
44.

The influence of chromatin structure on initial DNA damage and radiosensitivity in CHO-K1 and xrs1 cells at low doses of irradiation 1-10 Gy.

Roos WP, Binder A, Böhm L.

Radiat Environ Biophys. 2002 Sep;41(3):199-206. Epub 2002 Sep 7.

PMID:
12373329
45.

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